Temperature-dependent structural and functional properties of a mutant (F71L) αa-crystallin: Molecular basis for early onset of age-related cataract

FEBS Letters

Volumn 585, Issue 24, 2011, Pages 3884-3889

  Validandi, Vakdevi ^a   Sudhakar Reddy, V ^a   Srinivas, P N B S ^a   Mueller, Niklaus H ^b   Bhagyalaxmi, S G ^c   Padma, T ^c   Mark Petrash, J ^b   Bhanuprakash Reddy, G ^a  

^a NATIONAL INSTITUTE OF NUTRITION   (India)

^b UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^c OSMANIA UNIVERSITY   (India)

Author keywords

A crystallin; Age related cataract; Chaperone like activity; F71L mutation; Thermal stability

Indexed keywords

ALPHA CRYSTALLIN; ALPHAA CRYSTALLIN; ALPHAB CRYSTALLIN; UNCLASSIFIED DRUG;

AGING; ALPHA CHAIN; ARTICLE; BETA CHAIN; CATARACT; CIRCULAR DICHROISM; CONTROLLED STUDY; ENVIRONMENTAL FACTOR; GEL PERMEATION CHROMATOGRAPHY; GENE MUTATION; GENETIC ASSOCIATION; HEATING; HYDROPHOBICITY; MOLECULAR MECHANICS; MOLECULAR WEIGHT; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN FUNCTION; PROTEIN SECONDARY STRUCTURE; PROTEIN STRUCTURE; PROTEIN TERTIARY STRUCTURE; TEMPERATURE DEPENDENCE; THERMOSTABILITY; WILD TYPE;

AGE OF ONSET; AGING; ALPHA-CRYSTALLIN A CHAIN; CATARACT; HUMANS; MOLECULAR WEIGHT; MUTANT PROTEINS; MUTATION; PROTEIN STABILITY; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; TEMPERATURE;

EID: 82555176437     PISSN: 00145793     EISSN: 18733468     Source Type: Journal    
DOI: 10.1016/j.febslet.2011.10.049     Document Type: Article

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