Adipose-derived stem cells accelerate neovascularization in ischaemic diabetic skin flapviaexpression of hypoxia-inducible factor-1α

Journal of Cellular and Molecular Medicine

Volumn 15, Issue 12, 2011, Pages 2575-2585

  Gao, Weicheng ^a   Qiao, Xing ^a   Ma, Shaolin ^a   Cui, Lei ^a  

^a XINJIANG MEDICAL UNIVERSITY   (China)

Author keywords

Adipose derived stem cells; Diabetes mellitus; Skin flaps

Indexed keywords

HIF1A PROTEIN, MOUSE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; VASCULOTROPIN A;

ADIPOCYTE; ADULT; ANIMAL; ANOXIA; APOPTOSIS; ARTICLE; BAGG ALBINO MOUSE; CELL ADHESION; CELL CULTURE; CELL MOTION; CELL PROLIFERATION; CYTOLOGY; ENZYME IMMUNOASSAY; ENZYME LINKED IMMUNOSORBENT ASSAY; EXPERIMENTAL DIABETES MELLITUS; FLOW CYTOMETRY; GRAFT SURVIVAL; HUMAN; ISCHEMIA; MALE; METABOLISM; MOUSE; NEOVASCULARIZATION (PATHOLOGY); PATHOLOGY; PHYSIOLOGY; PLASTIC SURGERY; SKIN TRANSPLANTATION; STEM CELL; VASCULARIZATION; WESTERN BLOTTING;

ADIPOCYTES; ADULT; ANIMALS; ANOXIA; APOPTOSIS; BLOTTING, WESTERN; CELL ADHESION; CELL MOVEMENT; CELL PROLIFERATION; CELLS, CULTURED; DIABETES MELLITUS, EXPERIMENTAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; GRAFT SURVIVAL; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; IMMUNOENZYME TECHNIQUES; ISCHEMIA; MALE; MICE; MICE, INBRED BALB C; NEOVASCULARIZATION, PATHOLOGIC; SKIN TRANSPLANTATION; STEM CELLS; SURGICAL FLAPS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 82455220312     PISSN: 15821838     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1582-4934.2011.01313.x     Document Type: Article

References (37)

1. Vija L, Farge D, Gautier JF, et al. Mesenchymal stem cells: stem cell therapy perspectives for type 1 diabetes. Diabetes Metab. 2009; 35: 85-93.
2. Brem H, Tomic-Canic M. Cellular and molecular basis of wound healing in diabetes. J Clin Invest. 2007; 117: 1219-22.
3. Zhang T, Gong W, Li Z, et al. Efficacy of hyperbaric oxygen on survival of random pattern skin flap in diabetic rats. Undersea Hyperb Med. 2007; 34: 335-9.
4. Thangarajah H, Yao D, Chang EI, et al. The molecular basis for impaired hypoxia-induced VEGF expression in diabetic tissues. Proc Natl Acad Sci U S A. 2009; 106: 13505-10.
5. Ceradini DJ, Yao D, Grogan RH, et al. Decreasing intracellular superoxide corrects defective ischemia-induced new vessel formation in diabetic mice. J Biol Chem. 2008; 283: 10930-8.
6. Capla JM, Grogan RH, Callaghan MJ, et al. Diabetes impairs endothelial progenitor cell-mediated blood vessel formation in response to hypoxia. Plast Reconstr Surg. 2007; 119: 59-70.
7. Lu F, Mizuno H, Uysal CA, et al. Improved viability of random pattern skin flaps through the use of adipose-derived stem cells. Plast Reconstr Surg. 2008; 121: 50-8.
8. Lee EY, Xia Y, Kim WS, et al. Hypoxia-enhanced wound-healing function of adipose-derived stem cells: increase in stem cell proliferation and up-regulation of VEGF and bFGF. Wound Repair Regen. 2009; 17: 540-7.
9. Rehman J, Traktuev D, Li J, et al. Secretion of angiogenic and antiapoptotic factors by human adipose stromal cells. Circulation. 2004; 109: 1292-8.
10. Tapp H, Hanley EN Jr. Adipose-derived stem cells: characterization and current application in orthopaedic tissue repair. Exp Biol Med (Maywood). 2009; 234: 1-9.
11. Zuk PA, Zhu M, Ashjian P, et al. Human adipose tissue is a source of multipotent stem cells. Mol Biol Cell. 2002; 13: 4279-95.
12. Kim WS, Park BS, Sung JH, et al. Wound healing effect of adipose-derived stem cells: a critical role of secretory factors on human dermal fibroblasts. J Dermatol Sci. 2007; 48:15-24.
13. Kim WS, Park BS, Park SH, et al. Antiwrinkle effect of adipose-derived stem cell: activation of dermal fibroblast by secretory factors. J Dermatol Sci. 2009; 53: 96-102.
14. Chen L, Tredget EE, Wu PY, et al. Paracrine factors of mesenchymal stem cells recruit macrophages and endothelial lineage cells and enhance wound healing. PLoS One. 2008; 3: e1886.
15. Altman AM, Matthias N, Yan Y, et al. Dermal matrix as a carrier forin vivodelivery of human adipose-derived stem cells. Biomaterials. 2008; 29: 1431-42.
16. Amos PJ, Kapur SK, Stapor PC, et al. Human adipose-derived stromal cells accelerate diabetic wound healing: impact of cell formulation and delivery. Tissue Eng Part A. 2010; 16: 1595-606.
17. Kelly BD, Hackett SF, Hirota K, et al. Cell type-specific regulation of angiogenic growth factor gene expression and induction of angiogenesis in nonischemic tissue by a constitutively active form of hypoxia-inducible factor 1. Circ Res. 2003; 93: 1074-81.
18. Elson DA, Ryan HE, Snow JW, et al. Coordinate up-regulation of hypoxia inducible factor (HIF)-1alpha and HIF-1 target genes during multi-stage epidermal carcinogenesis and wound healing. Cancer Res. 2000; 60: 6189-95.
19. Li W, Li Y, Guan S, et al. Extracellular heat shock protein-90alpha: linking hypoxia to skin cell motility and wound healing. EMBO J. 2007; 26: 1221-33.
20. Ceradini DJ, Kulkarni AR, Callaghan MJ, et al. Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1. Nat Med. 2004; 10: 858-64.
21. Botusan IR, Sunkari VG, Savu O, et al. Stabilization of HIF-1alpha is critical to improve wound healing in diabetic mice. Proc Natl Acad Sci U S A. 2008; 105: 19426-31.
22. Cui L, Liu B, Liu G, et al. Repair of cranial bone defects with adipose derived stem cells and coral scaffold in a canine model. Biomaterials. 2007; 28: 5477-86.
23. Liu G, Zhou H, Li Y, et al. Evaluation of the viability and osteogenic differentiation of cryopreserved human adipose-derived stem cells. Cryobiology. 2008; 57: 18-24.
24. Moreno-Bueno G, Peinado H, Molina P, et al. The morphological and molecular features of the epithelial-to-mesenchymal transition. Nat Protoc. 2009; 4: 1591-613.
25. Emekli U, Tuncer S, Kabakas F, et al. The effect of short-versuslong-term administration of alpha tocopherol on the survival of random flaps in experimental diabetes mellitus. J Diabetes Complications. 2004; 18: 249-57.
26. Aronson D. Hyperglycemia and the pathobiology of diabetic complications. Adv Cardiol. 2008; 45: 1-16.
27. Zhang F, Waller W, Lineaweaver WC. Growth factors and flap survival. Microsurgery. 2004; 24: 162-7.
28. Zheng Y, Yi C, Xia W, et al. Mesenchymal stem cells transduced by vascular endothelial growth factor gene for ischemic random skin flaps. Plast Reconstr Surg. 2008; 121: 59-69.
29. Simman R, Craft C, McKinney B. Improved survival of ischemic random skin flaps through the use of bone marrow nonhematopoietic stem cells and angiogenic growth factors. Ann Plast Surg. 2005; 54: 546-52.
30. Lerman OZ, Galiano RD, Armour M, et al. Cellular dysfunction in the diabetic fibroblast: impairment in migration, vascular endothelial growth factor production, and response to hypoxia. Am J Pathol. 2003; 162: 303-12.
31. Kryger Z, Zhang F, Dogan T, et al. The effects of VEGF on survival of a random flap in the rat: examination of various routes of administration. Br J Plast Surg. 2000; 53: 234-9.
32. Hocking AM, Gibran NS. Mesenchymal stem cells: paracrine signaling and differentiation during cutaneous wound repair. Exp Cell Res. 2010; 316: 2213-9.
33. Rasmussen JG, Frobert O, Pilgaard L, et al. Prolonged hypoxic culture and trypsinization increase the pro-angiogenic potential of human adipose tissue-derived stem cells. Cytotherapy. 2010; 13: 318-28.
34. Detmar M, Brown LF, Schon MP, et al. Increased microvascular density and enhanced leukocyte rolling and adhesion in the skin of VEGF transgenic mice. J Invest Dermatol. 1998; 111: 1-6.
35. Fleming JN, Shulman HM, Nash RA, et al. Cutaneous chronic graft-versus-host disease does not have the abnormal endothelial phenotype or vascular rarefaction characteristic of systemic sclerosis. PLoS One. 2009; 4: e6203.
36. Catrina SB, Okamoto K, Pereira T, et al. Hyperglycemia regulates hypoxia-inducible factor-1alpha protein stability and function. Diabetes. 2004; 53: 3226-32.
37. Semenza GL. Hypoxia-inducible factor 1: oxygen homeostasis and disease pathophysiology. Trends Mol Med. 2001; 7: 345-50.