Uterine Leiomyomas, Current Concepts: Pathogenesis, Impact on Reproductive Health, and Medical, Procedural, and Surgical Management

Obstetrics and Gynecology Clinics of North America

Volumn 38, Issue 4, 2011, Pages 703-731

  Munro, Malcolm G ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b KAISER PERMANENTE   (United States)

Author keywords

Abnormal uterine bleeding; Hysterectomy; Myomectomy; Uterine artery embolization; Uterine fibroids; Uterine leiomyoma

Indexed keywords

AROMATASE INHIBITOR; GESTAGEN; GONADORELIN AGONIST; IRON; LEVONORGESTREL; MEDROXYPROGESTERONE ACETATE; MIFEPRISTONE; PLACEBO;

ANEMIA; ENDOMETRIUM HYPERPLASIA; FEMALE INFERTILITY; HIGH INTENSITY FOCUSED ULTRASOUND; HUMAN; HYPOESTROGENEMIA; HYPOTHERMIC LEIOMYOMA ABLATION; HYSTERECTOMY; HYSTEROSCOPY; LAPAROSCOPIC MYOMECTOMY; LAPAROTOMIC MYOMECTOMY; LASER SURGERY; LEIOMYOMA; LEIOMYOMA ABLATION; MINILAPAROTOMY; MYOLYSIS; MYOMECTOMY; MYOMETRIUM; NUCLEAR MAGNETIC RESONANCE IMAGING; OSTEOPENIA; PATHOGENESIS; PREOPERATIVE EVALUATION; PRIORITY JOURNAL; RADIOFREQUENCY ABLATION; REPRODUCTIVE HEALTH; RESECTOSCOPIC MYOMECTOMY; REVIEW; SURGICAL APPROACH; TRANSVAGINAL ECHOGRAPHY; TUMOR CLASSIFICATION; TUMOR GROWTH; URINE INCONTINENCE; UTERINE ARTERY EMBOLIZATION; UTERUS BLEEDING; UTERUS MYOMA; VAGINA ATROPHY; VAGINAL MYOMECTOMY; VASOMOTOR DISORDER;

FEMALE; HUMANS; LEIOMYOMA; REPRODUCTIVE HEALTH; UTERINE NEOPLASMS;

EID: 82455203875     PISSN: 08898545     EISSN: 15580474     Source Type: Journal    
DOI: 10.1016/j.ogc.2011.09.006     Document Type: Review

References (148)

1. Day Baird D., Dunson D.B., Hill M.C., et al. High cumulative incidence of uterine leiomyoma in black and white women: ultrasound evidence. Am J Obstet Gynecol 2003, 188:100-107.
2. Wu J.M., Wechter M.E., Geller E.J., et al. Hysterectomy rates in the United States, 2003. Obstet Gnecol 2007, 110:1091-1095.
3. Carlson K.J., Miller B.A., Fowler F.J. The Maine Women's Health Study: I. Outcomes of hysterectomy. Obstet Gynecol 1994, 83:556-565.
4. Garry R., Fountain J., Mason S., et al. The eVALuate study: two parallel randomised trials, one comparing laparoscopic with abdominal hysterectomy, the other comparing laparoscopic with vaginal hysterectomy. BMJ 2004, 328:129.
5. Shimomura Y., Matsuo H., Samoto T., et al. Up-regulation by progesterone of proliferating cell nuclear antigen and epidermal growth factor expression in human uterine leiomyoma. J Clin Endocrinol Metab 1998, 83:2192-2198.
6. Yin P., Lin Z., Cheng Y.H., et al. Progesterone receptor regulates Bcl-2 gene expression through direct binding to its promoter region in uterine leiomyoma cells. J Clin Endocrinol Metab 2007, 92:4459-4466.
7. Murphy A.A., Kettel L.M., Morales A.J., et al. Regression of uterine leiomyomata in response to the antiprogesterone RU 486. J Clin Endocrinol Metab 1993, 76:513-517.
8. Friedman A.J., Daly M., Juneau-Norcross M., et al. Long-term medical therapy for leiomyomata uteri: a prospective, randomized study of leuprolide acetate depot plus either oestrogen-progestin or progestin 'add-back' for 2 years. Hum Reprod 1994, 9:1618-1625.
9. Steinauer J., Pritts E.A., Jackson R., et al. Systematic review of mifepristone for the treatment of uterine leiomyomata. Obstet Gynecol 2004, 103:1331-1336.
10. Fiscella K., Eisinger S.H., Meldrum S., et al. Effect of mifepristone for symptomatic leiomyomata on quality of life and uterine size: a randomized controlled trial. Obstet Gynecol 2006, 108:1381-1387.
11. Munro M.G., Critchley H.O., Broder M.S., et al. The FIGO classification system (PALM-COEIN) for causes of abnormal uterine bleeding in non-gravid women in the reproductive years, including guidelines for clinical investigation. Int J Gynaecol Obstet 2011, 113:3-13.
12. Wamsteker K., Emanuel M.H., de Kruif J.H. Transcervical hysteroscopic resection of submucous fibroids for abnormal uterine bleeding: results regarding the degree of intramural extension. Obstet Gynecol 1993, 82:736-740.
13. Leibsohn S., d'Ablaing G., Mishell D.R., et al. Leiomyosarcoma in a series of hysterectomies performed for presumed uterine leiomyomas. Am J Obstet Gynecol 1990, 162:968-974. [discussion: 74-6].
14. Parker W.H., Fu Y.S., Berek J.S. Uterine sarcoma in patients operated on for presumed leiomyoma and rapidly growing leiomyoma. Obstet Gynecol 1994, 83:414-418.
15. Patterson-Keels L.M., Selvaggi S.M., Haefner H.K., et al. Morphologic assessment of endometrium overlying submucosal leiomyomas. J Reprod Med 1994, 39:579-584.
16. Stewart E.A., Nowak R.A. Leiomyoma-related bleeding: a classic hypothesis updated for the molecular era. Hum Reprod Update 1996, 2:295-306.
17. Sinclair D.C., Mastroyannis A., Taylor H.S. Leiomyoma simultaneously impair endometrial BMP-2-mediated decidualization and anticoagulant expression through secretion of TGF-beta3. Journal Clin Endocrinol Metab 2011, 96:412-421.
18. Palmer S.S., Haynes-Johnson D., Diehl T., et al. Increased expression of stromelysin 3 mRNA in leiomyomas (uterine fibroids) compared with myometrium. J Soc Gynecol Investig 1998, 5:203-209.
19. Bogusiewicz M., Stryjecka-Zimmer M., Postawski K., et al. Activity of matrix metalloproteinase-2 and -9 and contents of their tissue inhibitors in uterine leiomyoma and corresponding myometrium. Gynecol Endocrinol 2007, 23:541-546.
20. Pritts E.A., Parker W.H., Olive D.L. Fibroids and infertility: an updated systematic review of the evidence. Fertil Steril 2009, 91:1215-1223.
21. Shokeir T., El-Shafei M., Yousef H., et al. Submucous myomas and their implications in the pregnancy rates of patients with otherwise unexplained primary infertility undergoing hysteroscopic myomectomy: a randomized matched control study. Fertil Steril 2010, 94:724-729.
22. Rackow B.W., Taylor H.S. Submucosal uterine leiomyomas have a global effect on molecular determinants of endometrial receptivity. Fertil Steril 2010, 93:2027-2034.
23. Deligdish L., Loewenthal M. Endometrial changes associated with myomata of the uterus. J Clin Pathol 1970, 23:676-680.
24. Maguire M., Segars J.H. Benign uterine disease: leiomyomata and benign polyps. The endometrium: Molecular, cellular and clinical perspectices 2008, Informa Health Care, London. 2nd edition. J.D. Aplin (Ed.).
25. Stewart E.A. Uterine fibroids. Lancet 2001, 357:293-298.
26. Lippman S.A., Warner M., Samuels S., et al. Uterine fibroids and gynecologic pain symptoms in a population-based study. Fertil Steril 2003, 80:1488-1494.
27. Taran F.A., Weaver A.L., Coddington C.C., et al. Characteristics indicating adenomyosis coexisting with leiomyomas: a case-control study. Human Reprod 2010, 25:1177-1182.
28. Huang J.Q., Lathi R.B., Lemyre M., et al. Coexistence of endometriosis in women with symptomatic leiomyomas. Fertil Steril 2010, 94:720-723.
29. Valle R.F. Hysteroscopic evaluation of patients with abnormal uterine bleeding. Surg Gynecol Obstet 1981, 153:521-526.
30. Gimpelson R.J., Rappold H.O. A comparative study between panoramic hysteroscopy with directed biopsies and dilatation and curettage. A review of 276 cases. Am J Obstet Gynecol 1988, 158:489-492.
31. Loffer F.D. Hysteroscopy with selective endometrial sampling compared with D&C for abnormal uterine bleeding: the value of a negative hysteroscopic view. Obstet Gynecol 1989, 73:16-20.
32. Farquhar C., Ekeroma A., Furness S., et al. A systematic review of transvaginal ultrasonography, sonohysterography and hysteroscopy for the investigation of abnormal uterine bleeding in premenopausal women. Acta Obstet Gynecol Scand 2003, 82:493-504.
33. Widrich T., Bradley L.D., Mitchinson A.R., et al. Comparison of saline infusion sonography with office hysteroscopy for the evaluation of the endometrium. Am J Obstet Gynecol 1996, 174:1327-1334.
34. Saidi M.H., Sadler R.K., Theis V.D., et al. Comparison of sonography, sonohysterography, and hysteroscopy for evaluation of abnormal uterine bleeding. J Ultrasound Med 1997, 16:587-591.
35. Munro M.G., Brooks P.G. Use of local anesthesia for office diagnostic and operative hysteroscopy. J Minim Invasive Gynecol 2010, 17:709-718.
36. Dueholm M., Lundorf E., Hansen E.S., et al. Evaluation of the uterine cavity with magnetic resonance imaging, transvaginal sonography, hysterosonographic examination, and diagnostic hysteroscopy. Fertil Steril 2001, 76:350-357.
37. Dueholm M. Transvaginal ultrasound for diagnosis of adenomyosis: a review. Best Pract Res Clin Obstet Gynaecol 2006, 20:569-582.
38. Chiang C.H., Chang M.Y., Hsu J.J., et al. Tumor vascular pattern and blood flow impedance in the differential diagnosis of leiomyoma and adenomyosis by color Doppler sonography. J Assist Reprod Genet 1999, 16:268-275.
39. Mark A.S., Hricak H., Heinrichs L.W., et al. Adenomyosis and leiomyoma: differential diagnosis with MR imaging. Radiology 1987, 163:527-529.
40. Peddada S.D., Laughlin S.K., Miner K., et al. Growth of uterine leiomyomata among premenopausal black and white women. Proc Natl Acad Sci U S A 2008, 105:19887-19892.
41. Tropeano G., Amoroso S., Scambia G. Non-surgical management of uterine fibroids. Hum Reprod Update 2008, 14:259-274.
42. Lethaby A., Vollenhoven B., Sowter M. Pre-operative GnRH analogue therapy before hysterectomy or myomectomy for uterine fibroids. Cochrane Database Syst Rev 2001, 2. CD000547.
43. Waibel-Treber S., Minne H.W., Scharla S.H., et al. Reversible bone loss in women treated with GnRH-agonists for endometriosis and uterine leiomyoma. Hum Reprod 1989, 4:384-388.
44. Surrey E.S., Hornstein M.D. Prolonged GnRH agonist and add-back therapy for symptomatic endometriosis: long-term follow-up. Obstet Gynecol 2002, 99:709-719.
45. Stovall T.G., Muneyyirci-Delale O., Summitt R.L., et al. GnRH agonist and iron versus placebo and iron in the anemic patient before surgery for leiomyomas: a randomized controlled trial. Leuprolide Acetate Study Group. Obstet Gynecol 1995, 86:65-71.
46. Benagiano G., Kivinen S.T., Fadini R., et al. Zoladex (goserelin acetate) and the anemic patient: results of a multicenter fibroid study. Fertil Steril 1996, 66:223-229.
47. Scialli A.R., Jestila K.J. Sustained benefits of leuprolide acetate with or without subsequent medroxyprogesterone acetate in the nonsurgical management of leiomyomata uteri. Fertil Steril 1995, 64:313-320.
48. Stovall T.G., Ling F.W., Henry L.C., et al. A randomized trial evaluating leuprolide acetate before hysterectomy as treatment for leiomyomas. Am J Obstet Gynecol 1991, 164:1420-1423. [discussion: 3-5].
49. Friedman A.J., Rein M.S., Harrison-Atlas D., et al. A randomized, placebo-controlled, double-blind study evaluating leuprolide acetate depot treatment before myomectomy. Fertil Steril 1989, 52:728-733.
50. Perino A., Chianchiano N., Petronio M., et al. Role of leuprolide acetate depot in hysteroscopic surgery: a controlled study. Fertil Steril 1993, 59:507-510.
51. Phillips D.R., Nathanson H.G., Milim S.J., et al. The effect of dilute vasopressin solution on the force needed for cervical dilatation: a randomized controlled trial. Obstet Gynecol 1997, 89:507-511.
52. Campo S., Campo V., Gambadauro P. Short-term and long-term results of resectoscopic myomectomy with and without pretreatment with GnRH analogs in premenopausal women. Acta Obstet Gynecol Scand 2005, 84:756-760.
53. Mavrelos D., Ben-Nagi J., Davies A., et al. The value of pre-operative treatment with GnRH analogues in women with submucous fibroids: a double-blind, placebo-controlled randomized trial. Hum Reprod 2010, 25:2264-2269.
54. Muzii L., Boni T., Bellati F., et al. GnRH analogue treatment before hysteroscopic resection of submucous myomas: a prospective, randomized, multicenter study. Fertil Steril 2010, 94:1496-1499.
55. Soysal S., Soysal M.E. The efficacy of levonorgestrel-releasing intrauterine device in selected cases of myoma-related menorrhagia: a prospective controlled trial. Gynecol Obstet Invest 2005, 59:29-35.
56. Grigorieva V., Chen-Mok M., Tarasova M., et al. Use of a levonorgestrel-releasing intrauterine system to treat bleeding related to uterine leiomyomas. Fertil Steril 2003, 79:1194-1198.
57. Rein M.S., Barbieri R.L., Friedman A.J. Progesterone: a critical role in the pathogenesis of uterine myomas. Am J Obstet Gynecol 1995, 172:14-18.
58. Rein M.S. Advances in uterine leiomyoma research: the progesterone hypothesis. Environ Health Perspect 2000, 108(Suppl 5):791-793.
59. Zhao K., Kuperman L., Geimonen E., et al. Progestin represses human connexin43 gene expression similarly in primary cultures of myometrial and uterine leiomyoma cells. Biol Reprod 1996, 54:607-615.
60. Eisinger S.H., Bonfiglio T., Fiscella K., et al. Twelve-month safety and efficacy of low-dose mifepristone for uterine myomas. J Minim Invasive Gynecol 2005, 12:227-233.
61. Carbonell Esteve J.L., Acosta R., Heredia B., et al. Mifepristone for the treatment of uterine leiomyomas: a randomized controlled trial. Obstet Gynecol 2008, 112:1029-1036.
62. Varelas F.K., Papanicolaou A.N., Vavatsi-Christaki N., et al. The effect of anastrazole on symptomatic uterine leiomyomata. Obstet Gynecol 2007, 110:643-649.
63. Gurates B., Parmaksiz C., Kilic G., et al. Treatment of symptomatic uterine leiomyoma with letrozole. Reprod Biomed Online 2008, 17:569-574.
64. Parsanezhad M.E., Azmoon M., Alborzi S., et al. A randomized, controlled clinical trial comparing the effects of aromatase inhibitor (letrozole) and gonadotropin-releasing hormone agonist (triptorelin) on uterine leiomyoma volume and hormonal status. Fertil Steril 2009, 93:192-198.
65. Atlee W.L. Case of successful extirpation of a fibrous tumor of the peritoneal surface of the uterus by the large peritoneal section. Am J Med Sci 1845, 9:309-335.
66. Bonney V. The technical minutia of extended myomectomy and ovarian cystectomy 1946, Cassel, London.
67. Neuwirth R.S. A new technique for and additional experience with hysteroscopic resection of submucous fibroids. Am J Obstet Gynecol 1978, 131:91-94.
68. Semm K., Mettler L. Technical progress in pelvic surgery via operative laparoscopy. Am J Obstet Gynecol 1980, 138:121-127.
69. Dubuisson J.B., Lecuru F., Foulot H., et al. Myomectomy by laparoscopy: a preliminary report of 43 cases. Fertil Steril 1991, 56:827-830.
70. Fedele L., Vercellini P., Bianchi S., et al. Treatment with GnRH agonists before myomectomy and the risk of short-term myoma recurrence. Br J Obstet Gynaecol 1990, 97:393-396.
71. Friedman A.J., Daly M., Juneau-Norcross M., et al. Recurrence of myomas after myomectomy in women pretreated with leuprolide acetate depot or placebo. Fertil Steril 1992, 58:205-208.
72. Kongnyuy E.J., van den Broek N., Wiysonge C.S. A systematic review of randomized controlled trials to reduce hemorrhage during myomectomy for uterine fibroids. Int J Gynaecol Obstet 2008, 100:4-9.
73. Emanuel M.H., Wamsteker K., Hart A.A., et al. Long-term results of hysteroscopic myomectomy for abnormal uterine bleeding. Obstet Gynecol 1999, 93:743-748.
74. Vercellini P., Zaina B., Yaylayan L., et al. Hysteroscopic myomectomy: long-term effects on menstrual pattern and fertility. Obstet Gynecol 1999, 94:341-347.
75. Fernandez H., Sefrioui O., Virelizier C., et al. Hysteroscopic resection of submucosal myomas in patients with infertility. Hum Reprod 2001, 16:1489-1492.
76. Leone F.P., Lanzani C., Ferrazzi E. Use of strict sonohysterographic methods for preoperative assessment of submucous myomas. Fertil Steril 2003, 79:998-1002.
77. Propst A.M., Liberman R.F., Harlow B.L., et al. Complications of hysteroscopic surgery: predicting patients at risk. Obstet Gynecol 2000, 96:517-520.
78. Ginsburg E.S., Benson C.B., Garfield J.M., et al. The effect of operative technique and uterine size on blood loss during myomectomy: a prospective randomized study. Fertil Steril 1993, 60:956-962.
79. DeLancey J.O. A modified technique for hemostasis during myomectomy. Surg Gynecol Obstet 1992, 174:153-154.
80. Fletcher H., Frederick J., Hardie M., et al. A randomized comparison of vasopressin and tourniquet as hemostatic agents during myomectomy. Obstet Gynecol 1996, 87:1014-1018.
81. Tulandi T., Murray C., Guralnick M. Adhesion formation and reproductive outcome after myomectomy and second-look laparoscopy. Obstet Gynecol 1993, 82:213-215.
82. March C.M., Boyers S., Franklin R., et al. Prevention of adhesion formation/reformation with the Gore-Tex Surgical Membrane. Prog Clin Biol Res 1993, 381:253-259.
83. Mais V., Ajossa S., Piras B., et al. Prevention of de-novo adhesion formation after laparoscopic myomectomy: a randomized trial to evaluate the effectiveness of an oxidized regenerated cellulose absorbable barrier. Hum Reprod 1995, 10:3133-3135.
84. LaMorte A.I., Lalwani S., Diamond M.P. Morbidity associated with abdominal myomectomy. Obstet Gynecol 1993, 82:897-900.
85. Nezhat F.R., Roemisch M., Nezhat C.H. Long-term follow-up of laparoscopic myomectomy. J Am Assoc Gynecol Laparosc 1996, 3:S35.
86. Dubuisson J.B., Chapron C., Verspyck E., et al. [Laparoscopic myomectomy. 102 cases]. Contracept Fertil Sex 1993, 21:920-922. [in French].
87. Daniell J.F., Kurtz B.R., Taylor S.N. Laparoscopic myomectomy using the argon beam coagulator. J Gynecol Surg 1993, 9:207-212.
88. Parker W.H., Rodi I.A. Patient selection for laparoscopic myomectomy. J Am Assoc Gynecol Laparosc 1994, 2:23-26.
89. Hasson H.M., Rotman C., Rana N., et al. Laparoscopic myomectomy. Obstet Gynecol 1992, 80:884-888.
90. Myers E.R., Barber M.D., Gustilo-Ashby T., et al. Management of uterine leiomyomata: what do we really know?. Obstet Gynecol 2002, 100:8-17.
91. Taylor A., Sharma M., Tsirkas P., et al. Reducing blood loss at open myomectomy using triple tourniquets: a randomised controlled trial. BJOG 2005, 112:340-345.
92. Zullo F., Palomba S., Corea D., et al. Bupivacaine plus epinephrine for laparoscopic myomectomy: a randomized placebo-controlled trial. Obstet Gynecol 2004, 104:243-249.
93. Dubuisson J.B., Fauconnier A., Deffarges J.V., et al. Pregnancy outcome and deliveries following laparoscopic myomectomy. Hum Reprod 2000, 15:869-873.
94. Mais V., Ajossa S., Guerriero S., et al. Laparoscopic versus abdominal myomectomy: a prospective, randomized trial to evaluate benefits in early outcome. Am J Obstet Gynecol 1996, 174:654-658.
95. Carter J.E., McCarus S. Time Savings Using the Steiner Morcellator in Laparoscopic Myomectomy. J Am Assoc Gynecol Laparosc 1996, 3:S6.
96. Nezhat C., Nezhat F., Bess O., et al. Laparoscopically assisted myomectomy: a report of a new technique in 57 cases. Int J Fertil Menopausal Stud 1994, 39:39-44.
97. Cagnacci A., Pirillo D., Malmusi S., et al. Early outcome of myomectomy by laparotomy, minilaparotomy and laparoscopically assisted minilaparotomy. A randomized prospective study. Hum Reprod 2003, 18:2590-2594.
98. Goldrath M.H. Vaginal removal of the pedunculated submucous myoma: the use of laminaria. Obstet Gynecol 1987, 70:670-672.
99. Goldrath M.H. Vaginal removal of the pedunculated submucous myoma. Historical observations and development of a new procedure. J Reprod Med 1990, 35:921-924.
100. Ravina J.H., Merland J.J., Ciraru-Vigneron N., et al. [Arterial embolization: a new treatment of menorrhagia in uterine fibroma]. Presse Med 1995, 24:1754. [in French].
101. Pinto I., Chimeno P., Romo A., et al. Uterine fibroids: uterine artery embolization versus abdominal hysterectomy for treatment-a prospective, randomized, and controlled clinical trial. Radiology 2003, 226:425-431.
102. Hehenkamp W.J., Volkers N.A., Donderwinkel P.F., et al. Uterine artery embolization versus hysterectomy in the treatment of symptomatic uterine fibroids (EMMY trial): peri- and postprocedural results from a randomized controlled trial. Am J Obstet Gynecol 2005, 193:1618-1629.
103. Spies J.B., Ascher S.A., Roth A.R., et al. Uterine artery embolization for leiomyomata. Obstet Gynecol 2001, 98:29-34.
104. Spies J.B., Bruno J., Czeyda-Pommersheim F., et al. Long-term outcome of uterine artery embolization of leiomyomata. Obstet Gynecol 2005, 106:933-939.
105. Goodwin S.C., Spies J.B., Worthington-Kirsch R., et al. Uterine artery embolization for treatment of leiomyomata: long-term outcomes from the FIBROID Registry. Obstet Gynecol 2008, 111:22-33.
106. Coleman P. Systematic review of the efficacy and safety of uterine artery embolisation in the treatment of fibroids 2004, National Institute for Clinical Excellence, London.
107. Gupta J.K., Sinha A.S., Lumsden M.A., et al. Uterine artery embolization for symptomatic uterine fibroids. Cochrane Database Syst Rev 2006, 1. CD005073.
108. Pron G., Mocarski E., Bennett J., et al. Pregnancy after uterine artery embolization for leiomyomata: the Ontario multicenter trial. Obstet Gynecol 2005, 105:67-76.
109. Carpenter T.T., Walker W.J. Pregnancy following uterine artery embolisation for symptomatic fibroids: a series of 26 completed pregnancies. BJOG 2005, 112:321-325.
110. Pinto Pabon I., Magret J.P., Unzurrunzaga E.A., et al. Pregnancy after uterine fibroid embolization: follow-up of 100 patients embolized using tris-acryl gelatin microspheres. Fertil Steril 2008, 90:2356-2360.
111. Agdi M., Valenti D., Tulandi T. Intraabdominal adhesions after uterine artery embolization. American J Obstet Gynecol 2008, 199. 482 e1-3.
112. Liu W.M., Ng H.T., Wu Y.C., et al. Laparoscopic bipolar coagulation of uterine vessels: a new method for treating symptomatic fibroids. Fertil Steril 2001, 75:417-422.
113. Lichtinger M., Hallson L., Calvo P., et al. Laparoscopic uterine artery occlusion for symptomatic leiomyomas. J Am Assoc Gynecol Laparosc 2002, 9:191-198.
114. Park K.H., Kim J.Y., Shin J.S., et al. Treatment outcomes of uterine artery embolization and laparoscopic uterine artery ligation for uterine myoma. Yonsei Med J 2003, 44:694-702.
115. Hald K., Klow N.E., Qvigstad E., et al. Laparoscopic occlusion compared with embolization of uterine vessels: a randomized controlled trial. Obstet Gynecol 2007, 109:20-27.
116. Cunningham E., Barreda L., Ngo M., et al. Uterine artery embolization versus occlusion for uterine leiomyomas: a pilot randomized clinical trial. J Minim Invasive Gynecol 2008, 15:301-307.
117. Farquhar C.M., Steiner C.A. Hysterectomy rates in the United States 1990-1997. Obstet Gynecol 2002, 99:229-234.
118. Olive D.L., Rutherford T., Zreik T., et al. Cryomyolysis in the conservative treatment of uterine fibroids. J Am Assoc Gynecol Laparosc 1996, 3:S36.
119. Devireddy R.V., Coad J.E., Bischof J.C. Microscopic and calorimetric assessment of freezing processes in uterine fibroid tumor tissue. Cryobiology 2001, 42:225-243.
120. Rupp C.C., Nagel T.C., Swanlund D.J., et al. Cryothermic and hyperthermic treatments of human leiomyomata and adjacent myometrium and their implications for laparoscopic surgery. J Am Assoc Gynecol Laparosc 2003, 10:90-98.
121. Zreik T.G., Rutherford T.J., Palter S.F., et al. Cryomyolysis, a new procedure for the conservative treatment of uterine fibroids. J Am Assoc Gynecol Laparosc 1998, 5:33-38.
122. Odnusi K.O., Rutherford T.J., Olive D.L., et al. Cryomyolysis in the management of uterine fibroids: technique and complications. Surg Technol Int 2000, 8:173-178.
123. Zupi E., Piredda A., Marconi D., et al. Directed laparoscopic cryomyolysis: a possible alternative to myomectomy and/or hysterectomy for symptomatic leiomyomas. Am J Obstet Gynecol 2004, 190:639-643.
124. Ciavattini A., Tsiroglou D., Piccioni M., et al. Laparoscopic cryomyolysis: an alternative to myomectomy in women with symptomatic fibroids. Surg Endosc 2004, 18:1785-1788.
125. Zupi E., Marconi D., Sbracia M., et al. Directed laparoscopic cryomyolysis for symptomatic leiomyomata: one-year follow up. J Minim Invasive Gynecol 2005, 12:343-346.
126. Ciavattini A., Tsiroglou D., Litta P., et al. Pregnancy outcome after laparoscopic cryomyolysis of uterine myomas: report of nine cases. J Minim Invasive Gynecol 2006, 13:141-144.
127. Nisolle M., Smets M., Malvaux V., et al. Laparoscopic myolysis with the Nd:YAG laser. J Gynecol Surg 1993, 9:95-99.
128. Zaporozhan V.N. Intratissue laser thermotherapy in treatment of uterine myomata. J Am Assoc Gynecol Laparosc 1996, 3:S56.
129. Jourdain O., Roux D., Cambon D., et al. A new method for the treatment of fibromas: interstitial laser hyperthermia using the Nd:YAG laser. Preliminary study. Eur J Obstet Gynecol Reprod Biol 1996, 64:73-78.
130. Goldfarb H.A. Comparison of bipolar electrocoagulation and Nd:YAG laser coagulation for symptomatic reduction of uterine myomas. J Am Assoc Gynecol Laparosc 1994, 1:S13.
131. Phillips D.R., Milim S.J., Nathanson H.G., et al. Experience with laparoscopic leiomyoma coagulation and concomitant operative hysteroscopy. J Am Assoc Gynecol Laparosc 1997, 4:425-433.
132. Hurst B.S., Elliot M., Matthews M.L., et al. Ultrasound-directed transvaginal myolysis: preclinical studies. J Minim Invasive Gynecol 2007, 14:502-505.
133. Arcangeli S., Pasquarette M.M. Gravid uterine rupture after myolysis. Obstet Gynecol 1997, 89:857.
134. Vilos G.A., Daly L.J., Tse B.M. Pregnancy outcome after laparoscopic electromyolysis. J Am Assoc Gynecol Laparosc 1998, 5:289-292.
135. Tempany C.M., Stewart E.A., McDannold N., et al. MR imaging-guided focused ultrasound surgery of uterine leiomyomas: a feasibility study. Radiology 2003, 226:897-905.
136. Lynn J.G., Zwerner R.L., Chick A.J., et al. A new method for the generation and use of focused ultrasound in experimental biology. J Gen Physiol 1942, 26:179-203.
137. Hynynen K., Pomeroy O., Smith D.N., et al. MR imaging-guided focused ultrasound surgery of fibroadenomas in the breast: a feasibility study. Radiology 2001, 219:176-185.
138. McDannold N., Moss M., Killiany R., et al. MRI-guided focused ultrasound surgery in the brain: tests in a primate model. Magn Reson Med 2003, 49:1188-1191.
139. Smith N.B., Buchanan M.T., Hynynen K. Transrectal ultrasound applicator for prostate heating monitored using MRI thermometry. Int J Radiat Oncol Biol Phys 1999, 43:217-225.
140. Zhou X.D., Ren X.L., Zhang J., et al. Therapeutic response assessment of high intensity focused ultrasound therapy for uterine fibroid: utility of contrast-enhanced ultrasonography. Eur J Radiol 2007, 62:289-294.
141. Hynynen K., Freund W.R., Cline H.E., et al. A clinical, noninvasive, MR imaging-monitored ultrasound surgery method. Radiographics 1996, 16:185-195.
142. Chung A.H., Jolesz F.A., Hynynen K. Thermal dosimetry of a focused ultrasound beam in vivo by magnetic resonance imaging. Med Phys 1999, 26:2017-2026.
143. Stewart E.A., Gedroyc W.M., Tempany C.M., et al. Focused ultrasound treatment of uterine fibroid tumors: safety and feasibility of a noninvasive thermoablative technique. Am J Obstet Gynecol 2003, 189:48-54.
144. Hindley J., Gedroyc W.M., Regan L., et al. MRI guidance of focused ultrasound therapy of uterine fibroids: early results. AJR Am J Roentgenol 2004, 183:1713-1719.
145. Stewart E.A., Rabinovici J., Tempany C.M., et al. Clinical outcomes of focused ultrasound surgery for the treatment of uterine fibroids. Fertil Steril 2006, 85:22-29.
146. Smart O.C., Hindley J.T., Regan L., et al. Gonadotrophin-releasing hormone and magnetic-resonance-guided ultrasound surgery for uterine leiomyomata. Obstet Gynecol 2006, 108:49-54.
147. Smart O.C., Hindley J.T., Regan L., et al. Magnetic resonance guided focused ultrasound surgery of uterine fibroids-the tissue effects of GnRH agonist pre-treatment. Eur J Radiol 2006, 59:163-167.
148. McDannold N., Tempany C.M., Fennessy F.M., et al. Uterine leiomyomas: MR imaging-based thermometry and thermal dosimetry during focused ultrasound thermal ablation. Radiology 2006, 240:263-272.