Progestin represses human connexin43 gene expression similarly in primary cultures of myometrial and uterine leiomyoma cells

Biology of Reproduction

Volumn 54, Issue 3, 1996, Pages 607-615

  Zhao, Kun ^a   Kuperman, Laura ^a   Geimonen, Erika ^a   Andersen, Janet ^a  

^a STONY BROOK UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CONNEXIN 43; DESMIN; ETHINYLESTRADIOL; GESTAGEN; MEDROXYPROGESTERONE ACETATE; MESSENGER RNA; PROGESTERONE RECEPTOR;

ARTICLE; CONTROLLED STUDY; FEMALE; GENE EXPRESSION REGULATION; GENE REPRESSION; HUMAN; HUMAN CELL; MYOMETRIUM; NORTHERN BLOTTING; PRIORITY JOURNAL; PROTEIN SYNTHESIS INHIBITION; TRANSCRIPTION REGULATION; UTERUS MYOMA;

CELLS, CULTURED; CONNEXIN 43; FEMALE; GENE EXPRESSION; HUMANS; LEIOMYOMA; MUSCLE, SMOOTH; MYOMETRIUM; PROGESTINS; RECEPTORS, PROGESTERONE; RNA, MESSENGER; TRANSCRIPTION, GENETIC; UTERINE NEOPLASMS;

EID: 0030047444     PISSN: 00063363     EISSN: None     Source Type: Journal    
DOI: 10.1095/biolreprod54.3.607     Document Type: Article

References (46)

1. Willecke K, Hennemann H, Dahl E, Jungbluth S, Heynkes R. The diversity of connexin genes encoding gap junctional proteins. Eur J Cell Biol 1991, 56 1-7
2. Fishman GI Connexins and the heart. Trends Cardiovasc Med 1992; 2:50-55
3. Garfield RE, Hayashi RH. Appearance of gap junctions in the myometrium of women during labor Am J Obstet Gynecol 1981, 140.254-260
4. Rennick RE, Connat J-L, Burnstock G, Rothery S, Severs NJ, Green CR. Expression of connexin43 gap junctions between cultured vascular smooth muscle cells is dependent on phenotype. Cell Tissue Res 1993; 271:323-332.
5. Schirrmacher K, Schmitz I, Winterhager E, Traub O, Brummer F, Jones D, Bingmann D Characterization of gap junctions between osteoblast-like cells in culture Calcif Tissue Int 1992; 51:285-290.
6. Weisen JF, Rees Midgley A Jr. Expression of connexin43 gap junction messenger ribonucleic acid and protein during follicular atresia. Biol Reprod 1994; 50.336-348
7. Risek B, Guthrie S, Kumar N, Gilula NB. Modulation of gap junction transcripts and protein expression during pregnancy in the rat J Cell Biol 1990; 110:269-282
8. Claire Wathers D, Porter DG Effect of uterine distention and oestrogen treatment on gap junction formation in the myometrium of the rat. J Reprod Fertil 1982, 65.497-505.
9. Garfield RE, Kannan MS, Daniel EE Gap junction formation in myometrium: control by estrogens progesterone and prostaglandins. Am J Physiol 1980; 238: Cell Physiol 7 C81-C89
10. Garfield RE, Kannan MS, Daniel EE Gap junction formation in myometrium: control by estrogens progesterone and prostaglandins. Am J Physiol 1980; 238: Cell Physiol 7 C81-C89
11. Hendrix EM, Mao SJT, Everson W, Larsen WJ. Myometrial connexin43 trafficking and gap junction assembly at term and in preterm labor Mol Reprod Dev 1992; 33 27-38
12. Balducci J, Risek B, Gilula NB, Hand A, Egan JFX, Vintzileos AM Gap junction formation in human myometrium: a key to preterm labor? Am J Obstet Gynecol 1993; 108:1609-1615
13. Garfield RE Cell-to-cell communication in smooth muscle. In: Grover AK, Daniel EE (eds), Calcium and Contractility - Smooth Muscle Clifton, NJ: Humana Press, 1985: 143-173.
14. Andersen J, Grine EA, Eng CL-Y, Zhao K, Barbieri RL, Chumas J, Brink P Expression of connexin43 in human myometrium and leiomyomas. Am J Obstet Gynecol 1993; 169:1266-1276.
15. Andersen J, Barbieri RL Abnormal gene expression in uterine leiomyomas J Soc Gynecol Invest 1995; 2:663-672
16. Cramer SF, Robertson AL Jr, Ziats NP, Pearson OH Growth potential of human uterine leiomyomas: some in vitro observations and their implications Obstet Gynecol 1985; 66 36-41.
17. Maheux R. Treatment of uterine leiomyomata: past present and future. Horm Res 1989, 32.125-133.
18. Benagiano G Uterine fibroids: literature review and summary of posters. Horm Res 1989; 32(suppl 1):120-124.
19. Friedman AJ, Lobel SM, Rein MS, Barbieri RL. Efficacy and safety considerations in women with uterine leiomyomas treated with gonadotropin-releasing hormone agonists: the estrogen threshold hypothesis Am J Obstet Gynecol 1990; 163:1114-1119
20. Stovall TG, Ling FW, Henry LC, Woodruff MR A randomized trial evaluating leuprolide acetate before hysterectomy as treatment for leiomyomas Am J Obstet Gynecol 1991, 164:1420-1425.
21. Tiltman A. The effect of progestins on the mitotic activity of uterine fibromyomas Int J Gynecol Pathol 1985, 4 89-96
22. Kawaguchi K, Fujii S, Konishi I, Nanbu Y, Nonogake H, Mori T. Mitotic activity in uterine leiomyomas during the menstrual cycle. Am J Obstet Gynecol 1989, 160 637-641.
23. Andersen J, DyReyes V, Barbieri RL, Coachman D, Miksicek R Leiomyoma primary cultures have elevated transcriptional response to estrogen compared to autologous myometrial cultures J Soc Gynecol Invest 1995; 2:542-551
24. Brandon DD, Bethers CL, Strawn ET, Novy MJ, Burry KA, Harrington MS, Erickson TE, Warner C, Keenan EJ, Clinton GM Progesterone receptor messenger ribonucleic acid and protein are overexpressed in human uterine leiomyomas Am J Obstet Gynecol 1993; 169 78-85.
25. Kastner P, Krust A, Turcotte B, Stropp U, Tora L, Gronemeyer H, Chambon P. Two distinct estrogen-regulated promoters generate transcripts encoding the two functionally different human progesterone receptor forms A and B EMBO J 1990, 9 1603-1614
26. Navarro D, Cabrera JJ, Falcón O, Jiménez P, Ruiz A, Chirino R, López A, Rivero JF, Díaz-Chico JC, Díaz-Chico BN. Monoclonal antibody characterization of progesterone receptors, estrogen receptors and the stress-responsive protein of 27 kDa (SRP27) in human uterine leiomyoma. J Steroid Biochem 1989, 34:491-498.
27. Vegeto E, Shahbaz MM, Wen DX, Goldman ME, O'Malley BW, McDonnell DP Human progesterone receptor A form is a cell- and promoter-specific repressor of progesterone receptor B function. Mol Endocrinol 1993, 7.1244-1255
28. Berthois Y, Katzenellenbogen JA, Katzenellenbogen BS Phenol red in tissue culture media is a weak estrogen: implications concerning the study of estrogen-responsive cells in culture. Proc Natl Acad Sci USA 1986; 83:2496-2500.
29. Gao JG, Mazella J, Powell DR, Tseng L. Identification of a distal regulatory sequence of the human IGFBP-1 gene promoter and regulation by the progesterone receptor in a human endometrial adenocarcrnoma cell line. DNA & Cell Biol 1994, 13.829-837
30. Dahlberg E Characterization of the cytosolic estrogen receptor in rat skeletal muscle Biochim Biophys Acta 1982, 717:65-75
31. Tulchinsky D, Hobel CJ, Yeager E, Marshall JR. Plasma estrone estradiol estriol progesterone and 17-hydroxyprogesterone in human pregnancy. Am J Obstet Gynecol 1972, 112 1095-1100.
32. Cleveland DW, Lopata MA, MacDonald RJ, Cowan NJ, Rutter WJ, Kirschner MW. Number and evolutionary conservation of α- and β-tubulin and cytoplasmic β- and γ genes using specific cloned cDNA probes. Cell 1980, 20 95-105
33. Fort P, Marty L, Piechaczyk M, Sabrouty ES, Dani C Jeanteur P, Blanchard JM. Various rat adult tissues express only one major mRNA species from the glyceraldehyde-3-phosphate dehydrogenase multigene family Nucleic Acids Res 1985; 13:1431-1442.
34. Fishman GI, Eddy RL, Shows TB, Rosenthal L, Leinwand LA. The human connexin gene family of gap junction proteins, distinct chromosomal locations but similar structures Genomics 1991, 10:250-256.
35. Jeltsch JM, Krozowski Z, Quirin-Stricker C, Gronemeyer H, Simpson RJ, Garnier JM, Krust A, Jacob F, Chambon P Cloning of the chicken progesterone receptor. Proc Natl Acad Sci USA 1986; 83 5424-5428.
36. Norrander J, Kempe T, Messing J Construction of improved M13 vectors using oligodeoxynucleotide mutagenesis Gene 1983, 26:101-106.
37. Klock G, Strahle U, Schütz G. Oestrogen and glucocorticoid-responsive gene are closely related but distinct Nature 1987; 329 734-736
38. Sambrook J, Fritsch EF, Maniatis T. In. Nolan C (ed), Molecular Cloning - A Laboratory Manual, 2nd ed New York. Cold Spring Harbor Laboratory Press; 1989
39. Larner AC, Jonak G, Cheng Y-SE, Korant B, Knight E, Darnell JE Jr. Transcriptional induction of two genes in human cells by β interferon. Proc Natl Acad Sci USA 1984, 81:6733-6737
40. Babich A, Feldman LT, Nevins JR, Darnell JE Jr, Weinberger C Effect of adenovirus on metabolism of specific host mRNAs, transport control and specific translational discrimination. Mol Cell Biol 1983; 3:1212-1221
41. Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction Anal Biochem 1987, 162:156-159
42. Andersen J, Forst SA, Zhao K, Inouye M, Delihas N. The Function of micF RNA J Biol Chem 1989; 264 17961-17970.
43. Murphy AA, Kettel LM, Morales AJ, Roberts VJ, Yen SSC Regression of uterine leiomyomas in response to the antiprogesterone RU 486. J Clin Endocrinol & Metab 1993; 76:513-517
44. Alexander IE, Clarke CL, Shine J, Sutherland RL. Progestin inhibition of progesterone receptor gene expression in human breast cancer cells Mol Endocrinol 1989, 3.1377-1389
45. Akerblom IE, Slater EP, Beato M, Baxter JD, Mellon PL Negative regulation by glucocorticoids through interference with a cAMP responsive enhancer Science 1988, 224.350-353.
46. Tsai MJ, O'Malley BW. Molecular mechanisms of action of steroid/thyroid receptor superfamily members. Annu Rev Biochem 1994, 63 451-486.