Neural correlates of the multiple-object tracking deficit in amblyopia

Vision Research

Volumn 51, Issue 23-24, 2011, Pages 2517-2527

  Secen, John ^a   Culham, Jody ^b   Ho, Cindy ^a   Giaschi, Deborah ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b UNIVERSITY OF WESTERN ONTARIO   (Canada)

Author keywords

Amblyopia; Attention; Functional MRI; Motion; MT+; Multiple object tracking

Indexed keywords

ADOLESCENT; ADULT; AMBLYOPIA; ARTICLE; ATTENTION; CLINICAL ARTICLE; CONTROLLED STUDY; EYE FIXATION; EYE TRACKING; FEMALE; FRONTAL EYE FIELD; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HUMAN; INTRAPARIETAL SULCUS; MALE; MOTION; MOVEMENT PERCEPTION; PRIORITY JOURNAL; SUPERIOR PARIETAL LOBULE; TEMPORAL CORTEX;

ADULT; AMBLYOPIA; ATTENTION; BRAIN MAPPING; CEREBRAL CORTEX; CHILD; EYE MOVEMENTS; FEMALE; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MOTION PERCEPTION; PHOTIC STIMULATION; PSYCHOPHYSICS; YOUNG ADULT;

EID: 82455199163     PISSN: 00426989     EISSN: 18785646     Source Type: Journal    
DOI: 10.1016/j.visres.2011.10.011     Document Type: Article

References (79)

1. Aaen-Stockdale C., Hess R.F. The amblyopic deficit for global motion is spatial scale invariant. Vision Research 2008, 48(19):1965-1971.
2. Aaen-Stockdale C., Ledgeway T., Hess R.F. Second-order optic flow deficits in amblyopia. Investigative Ophthalmology and Visual Science 2007, 48(12):5532-5538.
3. Alvarez G.A., Franconeri S.L. How many objects can you track? Evidence for a resource-limited attentive tracking mechanism. Journal of Vision 2007, 7(13):1-10. (article no. 14).
4. Asper L., Crewther D., Crewther S. Strabismic amblyopia - Part 1: Psychophysics. Clinical and Experimental Optometry 2000, 83:49-58.
5. Asper L.J., Crewther D.P., Crewther S. Do different amblyopes have different attentional blinks?. Investigative Ophthalmology and Visual Science 2003, 44:S4094.
6. Barnes G.R., Hess R.F., Dumoulin S.O., Achtman R.L., Pike G.B. The cortical deficit in humans with strabismic amblyopia. The Journal of Physiology 2001, 533(Pt 1):281-297.
7. Barrett B.T., Bradley A., McGraw P.V. Understanding the neural basis of amblyopia. Neuroscientist 2004, 10(2):106-117.
8. Battelli L., Cavanagh P., Intriligator J., Tramo M.J., Henaff M.A., Michel F., et al. Unilateral right parietal damage leads to bilateral deficit for high-level motion. Neuron 2001, 32(6):985-995.
9. Bonhomme G.R., Liu G.T., Miki A., Francis E., Dobre M.C., Modestino E.J., et al. Decreased cortical activation in response to a motion stimulus in anisometropic amblyopic eyes using functional magnetic resonance imaging. Journal of AAPOS: American Association for Pediatric Ophthalmology and Strabismus 2006, 10(6):540-546.
10. Buckingham T., Watkins R., Bansal P., Bamford K. Hyperacuity thresholds for oscillatory movement are abnormal in strabismic and anisometropic amblyopes. Optometry and Vision Science 1991, 68:351-356.
11. Burman D.D., Bruce C.J. Suppression of task-related saccades by electrical stimulation in the primate's frontal eye field. Journal of Neurophysiology 1997, 77(5):2252-2267.
12. Cavanagh P. Short-range vs long-range motion: Not a valid distinction. Spatial Vision 1991, 5(4):303-309.
13. Cavanagh P. Attention-based motion perception. Science 1992, 257:1563-1565.
14. Cavanagh P., Alvarez G.A. Tracking multiple targets with multifocal attention. Trends in Cognitive Sciences 2005, 9(7):349-354.
15. Chatzistefanou K.I., Theodossiadis G.P., Damanakis A.G., Ladas I.D., Moschos M.N., Chimonidou E. Contrast sensitivity in amblyopia: The fellow eye of untreated and successfully treated amblyopes. Journal of AAPOS: American Association for Pediatric Ophthalmology and Strabismus 2005, 9:468-474.
16. Choi M.Y., Lee K.M., Hwang J.M., Choi D.G., Lee D.S., Park K.H., et al. Comparison between anisometropic and strabismic amblyopia using functional magnetic resonance imaging. The British Journal of Ophthalmology 2001, 85(9):1052-1056.
17. Conner I.P., Odom J.V., Schwartz T.L., Mendola J.D. Monocular activation of V1 and V2 in amblyopic adults measured with functional magnetic resonance imaging. Journal of AAPOS: American Association for Pediatric Ophthalmology and Strabismus 2007, 11(4):341-350.
18. Constantinescu T., Schmidt L., Watson R., Hess R.F. A residual deficit for global motion processing after acuity recovery in deprivation amblyopia. Investigative Ophthalmology and Vision Science 2005, 46:3008-3012.
19. Culham J.C., Brandt S.A., Cavanagh P., Kanwisher N.G., Dale A.M., Tootell R.B. Cortical fMRI activation produced by attentive tracking of moving targets. Journal of Neurophysiology 1998, 80(5):2657-2670.
20. Culham J.C., Cavanagh P., Kanwisher N.G. Attention response functions: Characterizing brain areas using fMRI activation during parametric variations of attentional load. Neuron 2001, 32(4):737-745.
21. Doricchi F., Perani D., Incoccia C., Grassi F., Cappa S.F., Bettinardi V., et al. Neural control of fast-regular saccades and antisaccades: An investigation using positron emission tomography. Experimental Brain Research 1997, 116(1):50-62.
22. Dumoulin S.O., Bittar R.G., Kabani N.J., Baker C.L., Le Goualher G., Bruce Pike G., et al. A new anatomical landmark for reliable identification of human area V5/MT: A quantitative analysis of sulcal patterning. Cerebral Cortex 2000, 10:454-463.
23. Dupont P., Orban G.A., De Bruyn B., Verbruggen A., Mortelmans L. Many areas in the human brain respond to visual motion. Journal of Neurophysiology 1994, 72:1420-1424.
24. Ellemberg D., Lewis T.L., Maurer D., Brar S., Brent H.P. Better perception of global motion after monocular than after binocular deprivation. Vision Research 2002, 42:169-179.
25. Franconeri S.L., Jonathan S.V., Scimeca J.M. Tracking multiple objects is limited only by object spacing, not by speed, time, or capacity. Psychological Science 2010, 21(7):920-925.
26. Friston K.J., Fletcher P., Josephs O., Holmes A., Rugg M.D., Turner R. Event-related fMRI: Characterizing differential responses. NeuroImage 1998, 7:30-40.
27. Gallivan J.P., Chapman C.S., Wood D.K., Milne J.L., Ansari D., Culham J.C., et al. One to four, and nothing more: Nonconscious parallel individuation of objects during action planning. Psychological Science 2011, 22(6):803-811.
28. Giaschi D.E., Regan D., Kraft S.P., Hong X.H. Defective processing of motion-defined form in the fellow eye of patients with unilateral amblyopia. Investigative Ophthalmology and Visual Science 1992, 33(8):2483-2489.
29. Giaschi D., Zwicker A., Au Young S., Bjornson B. The role of cortical area V5/MT+ in speed-tuned directional anisotropies in global motion perception. Vision Research 2007, 47:887-898.
30. Goodyear B.G., Nicolle D.A., Humphrey G.K., Menon R.S. BOLD fMRI response of early visual areas to perceived contrast in human amblyopia. Journal of Neurophysiology 2000, 84(4):1907-1913.
31. Hayward J., Truong G., Partanen M., Giaschi D. Effects of speed, age and amblyopia on the perception of motion-defined form. Vision Research 2011, 51:2216-2223.
32. Hess R.F., Demanins R., Bex P.J. A reduced motion aftereffect in strabismic amblyopia. Vision Research 1997, 37(10):1303-1311.
33. Hess R.F., Field D.J., Watt R.J. The puzzle of amblyopia. Vision: Coding and efficiency 1990, 267-280. Cambridge University Press, Cambridge. C. Blakemore (Ed.).
34. Ho C.S., Giaschi D.E. Deficient maximum motion displacement in amblyopia. Vision Research 2006, 46(28):4595-4603.
35. Ho C.S., Giaschi D.E. Stereopsis-dependent deficits in maximum motion displacement in strabismic and anisometropic amblyopia. Vision Research 2007, 47(21):2778-2785.
36. Ho C.S., Giaschi D.E. Low- and high-level motion perception deficits in anisometropic and strabismic amblyopia: Evidence from fMRI. Vision Research 2009, 49:2891-2901.
37. Ho C.S., Giaschi D.E., Boden C., Dougherty R., Cline R., Lyons C. Deficient motion perception in the fellow eye of amblyopic children. Vision Research 2005, 45(12):1615-1627.
38. Ho C.S., Paul P., Asirvatham A., Cavanagh P., Cline R., Giaschi D. Abnormal spatial selection and tracking in children with amblyopia. Vision Research 2006, 46:3274-3283.
39. Howe P.D., Horowitz T.S., Morocz I.A., Wolfe J., Livingstone M.S. Using fMRI to distinguish components of the multiple object tracking task. Journal of Vision 2009, 9(4):1-11. (article 10).
40. Huk A.C., Ress D., Heeger D.J. Neuronal basis of the motion aftereffect reconsidered. Neuron 2001, 32(1):161-172.
41. Jovicich J., Peters R.J., Koch C., Braun J., Chang L., Ernst T. Brain areas specific for attentional load in a motion-tracking task. Journal of Cognitive Neuroscience 2001, 13(8):1048-1058.
42. Kelly S.L., Buckingham T.J. Movement hyperacuity in childhood amblyopia. The British Journal of Ophthalmology 1998, 82(9):991-995.
43. Kiorpes L., McKee S.P. Neural mechanisms underlying amblyopia. Current Opinion in Neurobiology 1999, 9:480-486.
44. Kiorpes L., Movshon J.A. Peripheral and central factors limiting the development of contrast sensitivity in macaque monkeys. Vision Research 1998, 38(1):61-70.
45. Lerner Y., Hendler T., Malach R., Harel M., Leiba H., Stolovitch C., et al. Selective fovea-related deprived activation in retinotopic and high-order visual cortex of human amblyopes. Neuroimage 2006, 33:169-179.
46. Lerner Y., Pianka P., Azmon B., Leiba H., Stolovitch C., Loewenstein A., et al. Area-specific amblyopic effects in human occipitotemporal object representations. Neuron 2003, 40:1023-1029.
47. Levi D.M. Spatial vision in amblyopia. Vision and visual dysfunction 1991, Vol. 10B:21-238. Macmillan, New York.
48. Levi D.M. Visual processing in amblyopia: Human studies. Strabismus 2006, 14(1):11-19.
49. Levi D.M., Li R.W. Perceptual learning as a potential treatment for amblyopia: A mini-review. Vision Research 2009, 49(21):2535-2549.
50. Levi D.M., Tripathy S.P. Is the ability to identify deviations in multiple trajectories compromised by amblyopia?. Journal of Vision 2006, 6(12):1367-1379.
51. Li X., Dumoulin S.O., Mansouri B., Hess R.F. Cortical deficits in human amblyopia: Their regional distribution and their relationship to the contrast detection deficit. Investigative Ophthalmology and Visual Science 2007, 48(4):1575-1591.
52. Logothetis N.K. The neural basis of the blood-oxygen-level-dependent functional magnetic resonance imaging signal. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences 2002, 357(1424):1003-1037.
53. Logothetis N.K. The underpinnings of the BOLD functional magnetic resonance imaging signal. The Journal of Neuroscience 2003, 23(10):3963-3971.
54. Logothetis N.K., Wandell B.A. Interpreting the BOLD signal. Annual Review of Physiology 2004, 66:735-769.
55. Marios R., Chun M., Gore J. Neural correlates of the attentional blink. Neuron 2000, 28:299-308.
56. Mars R.B., Jbabdi S., Sallet J., O'Reilly J.X., Croxson P.L., Olivier E., et al. Diffusion-weighted imaging tractography-based parcellation of the human parietal cortex and comparison with human and macaque resting-state functional connectivity. The Journal of Neuroscience 2011, 31(11):4087-4100.
57. Muckli L., Kieb S., Tonhausen N., Singer W., Goebel R., Sireteanu R. Cerebral correlates of impaired grating perception in individual, psychophysically assessed human amblyopes. Vision Research 2006, 46:506-526.
58. Muller N.G., Mollenhauer M., Rosler A., Kleinschmidt A. The attentional field has a Mexican hat distribution. Vision Research 2005, 45(9):1129-1137.
59. Ono M., Kubik S., Abernathey C.D. Atlas of the cerebral sulci 1990, Thieme, Stuttgart.
60. Orban G.A., Claeys K., Nelissen K., Smans R., Sunaert S., Todd J.T., et al. Mapping the parietal cortex of human and non-human primates. Neuropsychology 2006, 44(13):2647-2667.
61. Orban G.A., Sunaert S., Todd J.T., Van Hecke P., Marchal G. Human cortical regions involved in extracting depth from motion. Neuron 1999, 24(4):929-940.
62. Popple A.V., Levi D.M. The attentional blink in amblyopia. Journal of Vision 2008, 8(13):1-9. (article 12).
63. Pylyshyn Z.W., Storm R.W. Tracking multiple independent targets: Evidence for a parallel tracking mechanism. Spatial Vision 1988, 3(3):179-197.
64. Regan D. Low-contrast visual acuity test for pediatric use. Canadian Journal of Ophthalmology 1988, 23:224-227.
65. Roelfsema P.R., Konig P., Engel A.K., Sireteanu R., Singer W. Reduced synchronization in the visual cortex of cats with strabismic amblyopia. European Journal of Neuroscience 1994, 6:1645-1655.
66. Sathian K., Simon T.J., Peterson S., Patel G.A., Hoffman J.M., Grafton S.T. Neural evidence linking visual object enumeration and attention. Journal of Cognitive Neuroscience 1999, 11:36-51.
67. Sharma V., Levi D.M., Klein S.A. Undercounting features and missing features: Evidence for a high-level deficit in strabismic amblyopia. Nature Neuroscience 2000, 3(5):496-501.
68. Shim W.M., Alvarez G.A., Jiang Y.V. Spatial separation between targets constrains maintenance of attention on multiple objects. Psychonomic Bulletin and Review 2008, 15(2):390-397.
69. Simmers A.J., Ledgeway T., Hess R.F., McGraw P.V. Deficits to global motion processing in human amblyopia. Vision Research 2003, 43(6):729-738.
70. Simmers A.J., Ledgeway T., Mansouri B., Hutchinson C.V., Hess R.F. The extent of the dorsal extra-striate deficit in amblyopia. Vision Research 2006, 46(16):2571-2580.
71. Stewart C.E., Moseley M.J., Fielder A.R. Defining and measuring treatment outcome for unilateral amblyopia. British Journal of Ophthalmology 2003, 87:1229-1231.
72. Sunaert S., Van Hecke P., Marchal G., Orban G.A. Motion-responsive regions of the human brain. Experimental Brain Research 1999, 127(4):355-370.
73. Talairach J., Tournoux P. Co-planar stereotaxic atlas of the human brain: 3-Dimensional proportional system: An approach to cerebral imaging 1988, G. Thieme; Thieme Medical Publishers, Stuttgart, New York; New York.
74. Tootell R.B., Mendola J.D., Hadjikhani N.K., Ledden P.J., Liu A.K., Reppas J.B., et al. Functional analysis of V3A and related areas in human visual cortex. The Journal of Neuroscience 1997, 17(18):7060-7078.
75. Tootell R.B.H., Reppas J.B., Kwong K.K., Malach R., Born R.T., Brady T.J., et al. Functional analysis of human MT and related visual cortical areas using magnetic resonance imaging. The Journal of Neuroscience 1995, 15:3215-3230.
76. Tootell R.B., Tsao D., Vanduffel W. Neuroimaging weighs in: Humans meet macaques in " primate" visual cortex. The Journal of Neuroscience 2003, 23(10):3981-3989.
77. Tripathy S.P., Levi D.M. On the effective number of tracked trajectories in amblyopic human vision. Journal of Vision 2008, 8(4):1-22. (article 8).
78. Verstraten F.A., Cavanagh P., Labianca A.T. Limits of attentive tracking reveal temporal properties of attention. Vision Research 2000, 40(26):3651-3664.
79. Zeki S., Watson J.D., Lueck C.J., Friston K.J., Kennard C., Frackowiak R.S. A direct demonstration of functional specialization in human visual cortex. The Journal of Neuroscience 1991, 11:641-649.