Discovery of amino acid motifs for thrombin cleavage and validation using a model substrate

Biochemistry

Volumn 50, Issue 48, 2011, Pages 10499-10507

  Ng, Natasha M ^a   Pierce, James D ^b   Webb, Geoffrey I ^a   Ratnikov, Boris I ^b   Wijeyewickrema, Lakshmi C ^a   Duncan, Renee C ^a   Robertson, Amy L ^a   Bottomley, Stephen P ^a   Boyd, Sarah E ^a   Pike, Robert N ^a  

^a MONASH UNIVERSITY   (Australia)

^b BURNHAM INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; AMINO ACID MOTIFS; ASSOCIATION RULE DISCOVERY; CLEAVAGE EFFICIENCY; CLEAVAGE SITES; COOPERATIVE EFFECTS; GAINING INSIGHTS; LOOP REGIONS; MODEL SUBSTRATES; PEPTIDE BONDS; PEPTIDE LIBRARY; PEPTIDE MOTIFS; PROTEIN G; PROTEIN SUBSTRATE; SUBSITES;

AMINO ACIDS; EFFICIENCY; ENZYMES; PEPTIDES;

SUBSTRATES;

AMINO ACID; AMINO ACID DERIVATIVE; BINDING PROTEIN; IMMUNOGLOBULIN G B1 BINDING PROTEIN; LYSYLARGINYLSERINE; PEPTIDE; PEPTIDE LIBRARY; PROTEIN G; THROMBIN; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME SPECIFICITY; FEEDBACK SYSTEM; HYPOTHESIS; NONHUMAN; PHAGE DISPLAY; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN DOMAIN; PROTEIN HYDROLYSIS; PROTEIN MOTIF; VALIDATION STUDY;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; BACTERIAL PROTEINS; BACTERIOPHAGE M13; HYDROLYSIS; MODELS, CHEMICAL; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PEPTIDE LIBRARY; PROTEIN ENGINEERING; RANDOM ALLOCATION; REPRODUCIBILITY OF RESULTS; STREPTOCOCCUS; SUBSTRATE SPECIFICITY; THROMBIN; VIRAL PROTEINS;

EID: 82455192430     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi201333g     Document Type: Article

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