Comparison of the in vitro release characteristics of mucosal freeze-dried wafers and solvent-cast films containing an insoluble drug

Drug Development and Industrial Pharmacy

Volumn 38, Issue 1, 2012, Pages 47-54

  Boateng, Joshua S ^a   Matthews, Kerr H ^b   Auffret, Anthony D ^c   Humphrey, Mike J ^c   Eccleston, Gillian M ^d   Stevens, Howard N ^d  

^a UNIVERSITY OF GREENWICH   (United Kingdom)

^b ROBERT GORDON UNIVERSITY   (United Kingdom)

^c PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

^d UNIVERSITY OF STRATHCLYDE   (United Kingdom)

Author keywords

Carboxymethylcellulose; Drug dissolution; Hydrochlorothiazide; Mucosal delivery; Release mechanism

Indexed keywords

CARBOXYMETHYLCELLULOSE; GLYCEROL; HYDROCHLOROTHIAZIDE; POLYMER;

ARTICLE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG DOSAGE FORM COMPARISON; DRUG SOLUBILITY; IN VITRO STUDY; MATHEMATICAL MODEL; SUSTAINED DRUG RELEASE; SUSTAINED RELEASE FORMULATION; ULTRAVIOLET SPECTROSCOPY;

CARBOXYMETHYLCELLULOSE SODIUM; CHEMISTRY, PHARMACEUTICAL; DELAYED-ACTION PREPARATIONS; DRUG DELIVERY SYSTEMS; FREEZE DRYING; GLYCEROL; HYDROGEN-ION CONCENTRATION; PHARMACEUTICAL PREPARATIONS; PHARMACOKINETICS; POLYMERS; SOLUBILITY; SOLVENTS; WATER;

EID: 82455188337     PISSN: 03639045     EISSN: 15205762     Source Type: Journal    
DOI: 10.3109/03639045.2011.590496     Document Type: Article

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