In vitro drug release studies of polymeric freeze-dried wafers and solvent-cast films using paracetamol as a model soluble drug

International Journal of Pharmaceutics

Volumn 378, Issue 1-2, 2009, Pages 66-72

  Boateng, Joshua S ^a   Matthews, Kerr H ^c   Auffret, Anthony D ^b   Humphrey, Mike J ^b   Stevens, Howard N ^a   Eccleston, Gillian M ^a  

^a UNIVERSITY OF STRATHCLYDE   (United Kingdom)

^b PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

^c ROBERT GORDON UNIVERSITY   (United Kingdom)

Author keywords

Carboxymethylcellulose; Drug dissolution; Films; Freeze dried wafers; Paracetamol; Release mechanism

Indexed keywords

CARBOXYMETHYLCELLULOSE; GLYCEROL; PARACETAMOL; POLYMER; SOLVENT;

ARTICLE; CAMERA; CHEMICAL COMPOSITION; CHEMICAL STRUCTURE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG RELEASE; DRUG SOLUBILITY; FREEZE DRYING; HYDRATION; IN VITRO STUDY; POROSITY; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY; SUSTAINED RELEASE FORMULATION; ULTRAVIOLET SPECTROSCOPY;

ACETAMINOPHEN; CARBOXYMETHYLCELLULOSE SODIUM; CHEMISTRY, PHARMACEUTICAL; DELAYED-ACTION PREPARATIONS; FREEZE DRYING; GELS; GLYCEROL; MICROSCOPY, ELECTRON, SCANNING; POLYMERS; POROSITY; SOLUBILITY; SOLVENTS; TIME FACTORS;

EID: 67650617690     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2009.05.038     Document Type: Article

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