Diclofenac fast-dissolving film: Suppression of bitterness by a taste-sensing system

Drug Development and Industrial Pharmacy

Volumn 37, Issue 3, 2011, Pages 252-259

  Cilurzo, Francesco ^a   Cupone, Irma Elisa ^a   Minghetti, Paola ^a   Buratti, Susanna ^a   Gennari, Chiara G M ^a   Montanari, Luisa ^a  

^a UNIVERSITY OF MILAN   (Italy)

Author keywords

Bitter drug; electronic tongue; maltodextrin; taste masking agent; tensile properties

Indexed keywords

DICLOFENAC; GLYCEROL; MALTODEXTRIN; MENTHOL; SACCHARIN; SORBITAN OLEATE; SUCRALOSE; XYLITOL;

AQUEOUS SOLUTION; ARTICLE; BITTER TASTE; CONTROLLED STUDY; DRUG SOLUBILITY; ELECTRONIC TONGUE; FILM COATING; FLAVOR; HUMAN; HUMAN EXPERIMENT; NORMAL HUMAN; TABLET DISINTEGRATION TIME; TABLET THICKNESS; TASTE DISCRIMINATION; TENSILE STRENGTH; TONGUE;

ADMINISTRATION, MUCOSAL; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; DICLOFENAC; DOSAGE FORMS; DRUG COMPOUNDING; DRUG DELIVERY SYSTEMS; ELECTRONICS; FLAVORING AGENTS; HUMANS; POLYSACCHARIDES; SOLUBILITY; TASTE; TECHNOLOGY, PHARMACEUTICAL; TENSILE STRENGTH; TONGUE;

EID: 79951924469     PISSN: 03639045     EISSN: 15205762     Source Type: Journal    
DOI: 10.3109/03639045.2010.505928     Document Type: Article

References (10)

1. Dixit RP, Puthli SP. (2009). Oral strip technology: Overview and future potential. J Control Rel, 139:94-107.
2. Cilurzo F, Cupone IE, Minghetti P, Selmin F, Montanari L. (2008). Fast dissolving films made of maltodextrins. Eur J Pharm Biopharm, 70(3):895-900.
3. Szejtli J, Szente L. (2005). Elimination of bitter disgusting tastes of drugs and food by cyclodextrins. Eur J Pharm Biopharm, 61(3):115-25. (Pubitemid 41427619)
4. Sohi H, Sulatna Y, Khar RK. (2004). Taste masking tachnologies in oral pharmaceuticals: Recent developments and approaches. Drug Dev Ind Pharm, 30(5):429-48. (Pubitemid 38821855)
5. Anand V, Kataria M, Kukkar V, Saharan V, Choudhury PK. (2007). The latest trends in the taste assessment of pharmaceuti-cals. Drug Discov Today, 12:257-65.
6. Yohko M, Yoshikazu K, Hidekazu I, Akira T, Takahiro U. (2002). Bitterness prediction or bitterness suppression in human medicines using a taste sensor. Sensor Mater, 14(8):455-6.
7. Lorenz JK, Reo JP, Hendl O, Worthington JH, Pretossian VD. (2009). Evaluation of a taste sensor instrument (electronic tongue) for use in formulation development. Int J Pharm, 367:65-72.
8. Uchida T, Tanigake A, Miyanaga Y, Matsuyama K, Kunitomo M, Kobayashi Y, et al. (2003). Evaluation of the bitterness of antibi-otics using a taste sensor. J Pharm Pharmacol, 55(11):1479-85. (Pubitemid 37441353)
9. Legin A, Rudnitskaya A, Chapman D, Seleznev B, Lord K, Vlasov Y. (2004). Electronic tongue for pharmaceutical analytics: Quanti-fication of taste and masking effects. Anal Bioan Chem, 380:36-45. (Pubitemid 40871465)
10. Beebe KR, Pell RJ, Seasholtz MB. (1998). Chemometrics, a practical guide. New York: Wiley.