Novel high-throughput assay to assess cellular manganese levels in a striatal cell line model of Huntington's disease confirms a deficit in manganese accumulation

NeuroToxicology

Volumn 32, Issue 5, 2011, Pages 630-639

  Kwakye, Gunnar F ^a,b   Li, Daphne ^b   Bowman, Aaron B ^a,b  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Fura 2; High throughput assay; Huntington's disease; Manganese; Metal transport

Indexed keywords

FURA 2; MANGANESE;

ACCURACY; ARTICLE; BINDING KINETICS; BIOACCUMULATION; BRAIN CELL; CELL LINE; CELLULAR FURA 2 MANGANESE EXTRACTION ASSAY; CONTROLLED STUDY; CORPUS STRIATUM; FLUORESCENCE; HIGH THROUGHPUT SCREENING; HUNTINGTON CHOREA; NERVE CELL CULTURE; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; TRANSPORT KINETICS; WILD TYPE;

ANIMALS; CELL LINE; CORPUS STRIATUM; FURA-2; HIGH-THROUGHPUT SCREENING ASSAYS; HUNTINGTON DISEASE; MANGANESE; MICE; MICE, MUTANT STRAINS; MUTATION;

EID: 82455175260     PISSN: 0161813X     EISSN: 18729711     Source Type: Journal    
DOI: 10.1016/j.neuro.2011.01.002     Document Type: Article

References (33)

1. Aschner M., Guilarte T.R., Schneider J.S., Zheng W. Manganese: recent advances in understanding its transport and neurotoxicity. Toxicol Appl Pharmacol 2007, 221:131-147.
2. Butterworth J. Changes in nine enzyme markers for neurons, glia, and endothelial cells in agonal state and Huntington's disease caudate nucleus. J Neurochem 1986, 47:583-587.
3. Cattaneo E., Conti L. Generation and characterization of embryonic striatal conditionally immortalized ST14A cells. J Neurosci Res 1998, 53:223-234.
4. Cobbold P.H., Rink T.J. Fluorescence and bioluminescence measurement of cytoplasmic free calcium. Biochem J 1987, 248:313-328.
5. Coyle P., Zalewski P.D., Philcox J.C., Forbes I.J., Ward A.D., Lincoln S.F., et al. Measurement of zinc in hepatocytes by using a fluorescent probe, Zinquin: relationship to metallothionein and intracellular zinc. Biochem J 1994, 303:781-786.
6. Dobson A.W., Erikson K.M., Aschner M. Manganese neurotoxicity. Ann N Y Acad Sci 2004, 1012:115-128.
7. Ensing J.G. Bazooka: cocaine-base and manganese carbonate. J Anal Toxicol 1985, 9:45-46.
8. Erikson K.M., Aschner M. Manganese neurotoxicity and glutamate-GABA interaction. Neurochem Int 2003, 43:475-480.
9. Erikson K.M., Syversen T., Aschner J., Aschner M. Interactions between excessive manganese-exposure and dietary iron-deficiency in neurodegeneration. Environ Toxicol Pharmacol 2005, 19:415-421.
10. Forbes J.R., Gros P. Iron, manganese, and cobalt transport by Nramp1 (Slc11a1) and Nramp2 (Slc11a2) expressed at the plasma membrane. Blood 2003, 102:1884-1892.
11. 2+ indicators with greatly improved fluorescence properties. J Biol Chem 1985, 260:3440-3450.
12. Hughes M.N. In comprehensive coordination chemistry. The synthesis, reactions, properties and applications of coordination compounds. Coordination compounds in biology 1987, Pergamon Press, Oxford. G. Wilkinson, R.D. Gillard, J.A. McCleverty (Eds.).
13. Hurley L.S., Keen C.L. Manganese. Trace elements in human health and animal nutrition 1987, 185-225. Academic Press, New York. E. Underwood, W. Mertz (Eds.).
14. Lim D., Feedrizzi L., Tartari M., Zuccato C., Cattaneo E., Brini M., et al. Calcium homeostasis and mitochondrial dysfunction in striatal neurons of Huntington disease. J Biol Chem 2007, 283:5780-5789.
15. 2+ in monolayers and suspensions of various types of animal cells. J Cell Biol 1987, 105:2145-2155.
16. Merritt J.E., Jacob R., Hallam T.J. Use of manganese to discriminate between calcium influx and mobilization from internal stores in stimulated human neutrophils. J Biol Chem 1989, 264:1522-1527.
17. Milakovic T., Johnson G.V. Mitochondrial respiration and ATP production are significantly impaired in striatal cells expressing mutant huntingtin. J Biol Chem 2005, 280:30773-30782.
18. Olanow C.W. Manganese-induced parkinsonism and Parkinson's disease. Ann N Y Acad Sci 2004, 1012:209-223.
19. 2+ handling in Huntington's disease striatal cells: effect of histone deacetylase inhibitors. J Neurosci 2006, 26:11174-11186.
20. Picard V., Govoni G., Jabado N., Gros P. Nramp 2 (DCT1/DMT1) expressed at the plasma membrane transports iron and other divalent cations into a calcein-accessible cytoplasmic pool. J Biol Chem 2000, 275:35738-35745.
21. Plieth C., Hansen U. Methodological aspects of pressure loading of fura-2 into characean cells. J Exp Bot 1996, 47:1601-1612.
22. Poenie M., Alderton J., Steinhardt R., Tsien R.Y. Calcium rises abruptly and briefly throughout the cell at the onset of anaphase. Science 1986, 233.
23. Reynolds J.A., Tanford C. Binding of dodecyl sulfate to proteins at high binding ratios. Possible implications for the state of proteins in biological membranes. Proc Natl Acad Sci U S A 1970, 66:1002-1007.
24. Roth J.A., Garrick M.D. Iron interactions and other biological reactions mediating the physiological and toxic actions of manganese. Biochem Pharmacol 2003, 66:1-13.
25. 2+ signals. Biophys J 1996, 71:1048-1056.
26. Tang T.S., Tu H., Maximov A., Wang Z., Wellington C.L., Hayden M.R., et al. Huntingtin and huntingtin-associated protein 1 influence neuronal calcium signaling mediated by inositol-(1,4,5) triphosphate receptor type 1. Neuron 2003, 39:227-239.
27. Trettel F., Rigamonti D., Hilditch-Maguire P., Wheeler V.C., Sharp A.H., Persichetti F., et al. Dominant phenotypes produced by the HD mutation in STHdh(Q111) striatal cells. Hum Mol Genet 2000, 9:2799-2809.
28. 2+ with quin2. Methods Enzymol 1989, 172:230-262.
29. Tsien R.W., Malinow R. Changes in presynaptic function during long-term potentiation. Ann N Y Acad Sci 1991, 635:208-220.
30. Tsien R.Y. Fluorescent probes of cell signaling. Annu Rev Neurosci 1989, 12:227-253.
31. Williams B.B., Kwakye G.F., Wegrzynowicz M., Li D., Aschner M., Erikson K.M., et al. Altered manganese homeostasis and manganese toxicity in a Huntington's disease striatal cell model are not explained by defects in the iron transport system. Toxicol Sci 2010, 117:169-179.
32. Williams B.B., Li D., Wegrzynowicz M., Vadodaria B.K., Anderson J.G., Kwakye G.F., et al. Disease-toxicant screen reveals a neuroprotective interaction between Huntington's disease and manganese exposure. J Neurochem 2010, 112:227-237.
33. 2+ homeostasis and expression of NMDA receptor subunits in primary cultured neurons. Neurotoxicology 2009, 30:941-949.