메뉴 건너뛰기




Volumn 6, Issue 1, 2011, Pages

Epidermal growth factor receptor in breast carcinoma: Association between gene copy number and mutations

Author keywords

Breast cancer; EGFR; Epidermal growth factor receptor; FISH; Gene amplification; Gene mutation; Real time PCR

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR;

EID: 82455168229     PISSN: None     EISSN: 17461596     Source Type: Journal    
DOI: 10.1186/1746-1596-6-118     Document Type: Article
Times cited : (31)

References (56)
  • 1
    • 0020068317 scopus 로고
    • A native 170, 000 epidermal growth factor receptor-kinase complex from shed plasma membrane vesicles
    • Cohen S, Ushiro H, Stoscheck C, Chinkers M. A native 170, 000 epidermal growth factor receptor-kinase complex from shed plasma membrane vesicles. J Biol Chem 1982, 257:1523-1531.
    • (1982) J Biol Chem , vol.257 , pp. 1523-1531
    • Cohen, S.1    Ushiro, H.2    Stoscheck, C.3    Chinkers, M.4
  • 2
    • 0024442943 scopus 로고
    • The epidermal growth factor receptor tyrosine kinase in liver epithelial cells. The effect of ligand-dependent changes in cellular location
    • McCune BK, Earp HS. The epidermal growth factor receptor tyrosine kinase in liver epithelial cells. The effect of ligand-dependent changes in cellular location. J Biol Chem 1989, 264:15501-15507.
    • (1989) J Biol Chem , vol.264 , pp. 15501-15507
    • McCune, B.K.1    Earp, H.S.2
  • 3
    • 18644370411 scopus 로고    scopus 로고
    • Crystal structure of a truncated epidermal growth factor receptor extracellular domain bound to transforming growth factor alpha
    • 10.1016/S0092-8674(02)00940-6, 12297049
    • Garrett TP, McKern NM, Lou M, Elleman TC, Adams TE, Lovrecz GO, Zhu HJ, Walker F, Frenkel MJ, Hoyne PA, et al. Crystal structure of a truncated epidermal growth factor receptor extracellular domain bound to transforming growth factor alpha. Cell 2002, 110:763-773. 10.1016/S0092-8674(02)00940-6, 12297049.
    • (2002) Cell , vol.110 , pp. 763-773
    • Garrett, T.P.1    McKern, N.M.2    Lou, M.3    Elleman, T.C.4    Adams, T.E.5    Lovrecz, G.O.6    Zhu, H.J.7    Walker, F.8    Frenkel, M.J.9    Hoyne, P.A.10
  • 5
    • 0036632368 scopus 로고    scopus 로고
    • The phosphatidylinositol 3-Kinase AKT pathway in human cancer
    • 10.1038/nrc839, 12094235
    • Vivanco I, Sawyers CL. The phosphatidylinositol 3-Kinase AKT pathway in human cancer. Nat Rev Cancer 2002, 2:489-501. 10.1038/nrc839, 12094235.
    • (2002) Nat Rev Cancer , vol.2 , pp. 489-501
    • Vivanco, I.1    Sawyers, C.L.2
  • 6
    • 0032881288 scopus 로고    scopus 로고
    • AKT/PKB and other D3 phosphoinositide-regulated kinases: kinase activation by phosphoinositide-dependent phosphorylation
    • 10.1146/annurev.biochem.68.1.965, 10872470
    • Chan TO, Rittenhouse SE, Tsichlis PN. AKT/PKB and other D3 phosphoinositide-regulated kinases: kinase activation by phosphoinositide-dependent phosphorylation. Annu Rev Biochem 1999, 68:965-1014. 10.1146/annurev.biochem.68.1.965, 10872470.
    • (1999) Annu Rev Biochem , vol.68 , pp. 965-1014
    • Chan, T.O.1    Rittenhouse, S.E.2    Tsichlis, P.N.3
  • 7
    • 0028040812 scopus 로고
    • Hierarchy of binding sites for Grb2 and Shc on the epidermal growth factor receptor
    • 359038, 7518560
    • Batzer AG, Rotin D, Urena JM, Skolnik EY, Schlessinger J. Hierarchy of binding sites for Grb2 and Shc on the epidermal growth factor receptor. Mol Cell Biol 1994, 14:5192-5201. 359038, 7518560.
    • (1994) Mol Cell Biol , vol.14 , pp. 5192-5201
    • Batzer, A.G.1    Rotin, D.2    Urena, J.M.3    Skolnik, E.Y.4    Schlessinger, J.5
  • 9
    • 40849147041 scopus 로고    scopus 로고
    • EGFR antagonists in cancer treatment
    • 10.1056/NEJMra0707704, 18337605
    • Ciardiello F, Tortora G. EGFR antagonists in cancer treatment. N Engl J Med 2008, 358:1160-1174. 10.1056/NEJMra0707704, 18337605.
    • (2008) N Engl J Med , vol.358 , pp. 1160-1174
    • Ciardiello, F.1    Tortora, G.2
  • 10
    • 34547410311 scopus 로고    scopus 로고
    • Cellular responses to EGFR inhibitors and their relevance to cancer therapy
    • 10.1016/j.canlet.2007.02.006, 1986742, 17367921
    • Dutta PR, Maity A. Cellular responses to EGFR inhibitors and their relevance to cancer therapy. Cancer Lett 2007, 254:165-177. 10.1016/j.canlet.2007.02.006, 1986742, 17367921.
    • (2007) Cancer Lett , vol.254 , pp. 165-177
    • Dutta, P.R.1    Maity, A.2
  • 11
    • 0036164390 scopus 로고    scopus 로고
    • Prognostic value of epidermal growth factor receptor (EGFR) and its relationship to the estrogen receptor status in 1029 patients with breast cancer
    • 10.1023/A:1013397232011, 11859875
    • Tsutsui S, Ohno S, Murakami S, Hachitanda Y, Oda S. Prognostic value of epidermal growth factor receptor (EGFR) and its relationship to the estrogen receptor status in 1029 patients with breast cancer. Breast Cancer Res Treat 2002, 71:67-75. 10.1023/A:1013397232011, 11859875.
    • (2002) Breast Cancer Res Treat , vol.71 , pp. 67-75
    • Tsutsui, S.1    Ohno, S.2    Murakami, S.3    Hachitanda, Y.4    Oda, S.5
  • 12
    • 23944476155 scopus 로고    scopus 로고
    • Phase I safety, pharmacokinetics, and clinical activity study of lapatinib (GW572016), a reversible dual inhibitor of epidermal growth factor receptor tyrosine kinases, in heavily pretreated patients with metastatic carcinomas
    • 10.1200/JCO.2005.16.584, 15955900
    • Burris HA, Hurwitz HI, Dees EC, Dowlati A, Blackwell KL, O'Neil B, Marcom PK, Ellis MJ, Overmoyer B, Jones SF, et al. Phase I safety, pharmacokinetics, and clinical activity study of lapatinib (GW572016), a reversible dual inhibitor of epidermal growth factor receptor tyrosine kinases, in heavily pretreated patients with metastatic carcinomas. J Clin Oncol 2005, 23:5305-5313. 10.1200/JCO.2005.16.584, 15955900.
    • (2005) J Clin Oncol , vol.23 , pp. 5305-5313
    • Burris, H.A.1    Hurwitz, H.I.2    Dees, E.C.3    Dowlati, A.4    Blackwell, K.L.5    O'Neil, B.6    Marcom, P.K.7    Ellis, M.J.8    Overmoyer, B.9    Jones, S.F.10
  • 13
    • 20244388653 scopus 로고    scopus 로고
    • Study of the biologic effects of lapatinib, a reversible inhibitor of ErbB1 and ErbB2 tyrosine kinases, on tumor growth and survival pathways in patients with advanced malignancies
    • 10.1200/JCO.2005.12.157, 15684311
    • Spector NL, Xia W, Burris H, Hurwitz H, Dees EC, Dowlati A, O'Neil B, Overmoyer B, Marcom PK, Blackwell KL, et al. Study of the biologic effects of lapatinib, a reversible inhibitor of ErbB1 and ErbB2 tyrosine kinases, on tumor growth and survival pathways in patients with advanced malignancies. J Clin Oncol 2005, 23:2502-2512. 10.1200/JCO.2005.12.157, 15684311.
    • (2005) J Clin Oncol , vol.23 , pp. 2502-2512
    • Spector, N.L.1    Xia, W.2    Burris, H.3    Hurwitz, H.4    Dees, E.C.5    Dowlati, A.6    O'Neil, B.7    Overmoyer, B.8    Marcom, P.K.9    Blackwell, K.L.10
  • 14
    • 38749087923 scopus 로고    scopus 로고
    • Erlotinib in combination with capecitabine and docetaxel in patients with metastatic breast cancer: a dose-escalation study
    • 10.1016/j.ejca.2007.12.011, 18249110
    • Twelves C, Trigo JM, Jones R, De Rosa F, Rakhit A, Fettner S, Wright T, Baselga J. Erlotinib in combination with capecitabine and docetaxel in patients with metastatic breast cancer: a dose-escalation study. Eur J Cancer 2008, 44:419-426. 10.1016/j.ejca.2007.12.011, 18249110.
    • (2008) Eur J Cancer , vol.44 , pp. 419-426
    • Twelves, C.1    Trigo, J.M.2    Jones, R.3    De Rosa, F.4    Rakhit, A.5    Fettner, S.6    Wright, T.7    Baselga, J.8
  • 17
    • 0036848757 scopus 로고    scopus 로고
    • Prognostic and predictive value of epidermal growth factor receptor in recurrent breast cancer
    • Tsutsui S, Kataoka A, Ohno S, Murakami S, Kinoshita J, Hachitanda Y. Prognostic and predictive value of epidermal growth factor receptor in recurrent breast cancer. Clin Cancer Res 2002, 8:3454-3460.
    • (2002) Clin Cancer Res , vol.8 , pp. 3454-3460
    • Tsutsui, S.1    Kataoka, A.2    Ohno, S.3    Murakami, S.4    Kinoshita, J.5    Hachitanda, Y.6
  • 18
    • 20044381463 scopus 로고    scopus 로고
    • Correlation of KIT and EGFR overexpression with invasive ductal breast carcinoma of the solid-tubular subtype, nuclear grade 3, and mesenchymal or myoepithelial differentiation
    • 10.1111/j.1349-7006.2005.00009.x, 15649255
    • Tsuda H, Morita D, Kimura M, Shinto E, Ohtsuka Y, Matsubara O, Inazawa J, Tamaki K, Mochizuki H, Tamai S, Hiraide H. Correlation of KIT and EGFR overexpression with invasive ductal breast carcinoma of the solid-tubular subtype, nuclear grade 3, and mesenchymal or myoepithelial differentiation. Cancer Sci 2005, 96:48-53. 10.1111/j.1349-7006.2005.00009.x, 15649255.
    • (2005) Cancer Sci , vol.96 , pp. 48-53
    • Tsuda, H.1    Morita, D.2    Kimura, M.3    Shinto, E.4    Ohtsuka, Y.5    Matsubara, O.6    Inazawa, J.7    Tamaki, K.8    Mochizuki, H.9    Tamai, S.10    Hiraide, H.11
  • 19
    • 0032927489 scopus 로고    scopus 로고
    • Expression of epidermal growth factor receptor mRNA and protein in primary breast carcinomas
    • 10.1023/A:1006194700667, 10326794
    • Walker RA, Dearing SJ. Expression of epidermal growth factor receptor mRNA and protein in primary breast carcinomas. Breast Cancer Res Treat 1999, 53:167-176. 10.1023/A:1006194700667, 10326794.
    • (1999) Breast Cancer Res Treat , vol.53 , pp. 167-176
    • Walker, R.A.1    Dearing, S.J.2
  • 21
    • 18244371651 scopus 로고    scopus 로고
    • Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain
    • 10.1371/journal.pmed.0020073, 549606, 15737014
    • Pao W, Miller VA, Politi KA, Riely GJ, Somwar R, Zakowski MF, Kris MG, Varmus H. Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain. PLoS Med 2005, 2:e73. 10.1371/journal.pmed.0020073, 549606, 15737014.
    • (2005) PLoS Med , vol.2
    • Pao, W.1    Miller, V.A.2    Politi, K.A.3    Riely, G.J.4    Somwar, R.5    Zakowski, M.F.6    Kris, M.G.7    Varmus, H.8
  • 22
    • 77349124901 scopus 로고    scopus 로고
    • EGFR mutations and the terminal respiratory unit
    • 10.1007/s10555-010-9205-8, 20135199
    • Yatabe Y. EGFR mutations and the terminal respiratory unit. Cancer Metastasis Rev 2010, 29:23-36. 10.1007/s10555-010-9205-8, 20135199.
    • (2010) Cancer Metastasis Rev , vol.29 , pp. 23-36
    • Yatabe, Y.1
  • 23
    • 33750302365 scopus 로고    scopus 로고
    • Analysis of epidermal growth factor receptor gene mutation in patients with non-small cell lung cancer and acquired resistance to gefitinib
    • 10.1158/1078-0432.CCR-06-0714, 17020982
    • Kosaka T, Yatabe Y, Endoh H, Yoshida K, Hida T, Tsuboi M, Tada H, Kuwano H, Mitsudomi T. Analysis of epidermal growth factor receptor gene mutation in patients with non-small cell lung cancer and acquired resistance to gefitinib. Clin Cancer Res 2006, 12:5764-5769. 10.1158/1078-0432.CCR-06-0714, 17020982.
    • (2006) Clin Cancer Res , vol.12 , pp. 5764-5769
    • Kosaka, T.1    Yatabe, Y.2    Endoh, H.3    Yoshida, K.4    Hida, T.5    Tsuboi, M.6    Tada, H.7    Kuwano, H.8    Mitsudomi, T.9
  • 24
    • 33751292685 scopus 로고    scopus 로고
    • Novel D761Y and common secondary T790M mutations in epidermal growth factor receptor-mutant lung adenocarcinomas with acquired resistance to kinase inhibitors
    • 10.1158/1078-0432.CCR-06-1570, 17085664
    • Balak MN, Gong Y, Riely GJ, Somwar R, Li AR, Zakowski MF, Chiang A, Yang G, Ouerfelli O, Kris MG, et al. Novel D761Y and common secondary T790M mutations in epidermal growth factor receptor-mutant lung adenocarcinomas with acquired resistance to kinase inhibitors. Clin Cancer Res 2006, 12:6494-6501. 10.1158/1078-0432.CCR-06-1570, 17085664.
    • (2006) Clin Cancer Res , vol.12 , pp. 6494-6501
    • Balak, M.N.1    Gong, Y.2    Riely, G.J.3    Somwar, R.4    Li, A.R.5    Zakowski, M.F.6    Chiang, A.7    Yang, G.8    Ouerfelli, O.9    Kris, M.G.10
  • 25
    • 58149333768 scopus 로고    scopus 로고
    • Acquired resistance to epidermal growth factor receptor kinase inhibitors associated with a novel T854A mutation in a patient with EGFR-mutant lung adenocarcinoma
    • 10.1158/1078-0432.CCR-08-0151, 2596620, 19010870
    • Bean J, Riely GJ, Balak M, Marks JL, Ladanyi M, Miller VA, Pao W. Acquired resistance to epidermal growth factor receptor kinase inhibitors associated with a novel T854A mutation in a patient with EGFR-mutant lung adenocarcinoma. Clin Cancer Res 2008, 14:7519-7525. 10.1158/1078-0432.CCR-08-0151, 2596620, 19010870.
    • (2008) Clin Cancer Res , vol.14 , pp. 7519-7525
    • Bean, J.1    Riely, G.J.2    Balak, M.3    Marks, J.L.4    Ladanyi, M.5    Miller, V.A.6    Pao, W.7
  • 26
    • 33749435816 scopus 로고    scopus 로고
    • Allelic dilution obscures detection of a biologically significant resistance mutation in EGFR-amplified lung cancer
    • 10.1172/JCI28656, 1570180, 16906227
    • Engelman JA, Mukohara T, Zejnullahu K, Lifshits E, Borras AM, Gale CM, Naumov GN, Yeap BY, Jarrell E, Sun J, et al. Allelic dilution obscures detection of a biologically significant resistance mutation in EGFR-amplified lung cancer. J Clin Invest 2006, 116:2695-2706. 10.1172/JCI28656, 1570180, 16906227.
    • (2006) J Clin Invest , vol.116 , pp. 2695-2706
    • Engelman, J.A.1    Mukohara, T.2    Zejnullahu, K.3    Lifshits, E.4    Borras, A.M.5    Gale, C.M.6    Naumov, G.N.7    Yeap, B.Y.8    Jarrell, E.9    Sun, J.10
  • 27
    • 56449089812 scopus 로고    scopus 로고
    • Hepatocyte growth factor induces gefitinib resistance of lung adenocarcinoma with epidermal growth factor receptor-activating mutations
    • 10.1158/0008-5472.CAN-08-1643, 19010923
    • Yano S, Wang W, Li Q, Matsumoto K, Sakurama H, Nakamura T, Ogino H, Kakiuchi S, Hanibuchi M, Nishioka Y, et al. Hepatocyte growth factor induces gefitinib resistance of lung adenocarcinoma with epidermal growth factor receptor-activating mutations. Cancer Res 2008, 68:9479-9487. 10.1158/0008-5472.CAN-08-1643, 19010923.
    • (2008) Cancer Res , vol.68 , pp. 9479-9487
    • Yano, S.1    Wang, W.2    Li, Q.3    Matsumoto, K.4    Sakurama, H.5    Nakamura, T.6    Ogino, H.7    Kakiuchi, S.8    Hanibuchi, M.9    Nishioka, Y.10
  • 28
    • 65949086609 scopus 로고    scopus 로고
    • PTEN loss contributes to erlotinib resistance in EGFR-mutant lung cancer by activation of Akt and EGFR
    • 10.1158/0008-5472.CAN-08-4055, 2849653, 19351834
    • Sos ML, Koker M, Weir BA, Heynck S, Rabinovsky R, Zander T, Seeger JM, Weiss J, Fischer F, Frommolt P, et al. PTEN loss contributes to erlotinib resistance in EGFR-mutant lung cancer by activation of Akt and EGFR. Cancer Res 2009, 69:3256-3261. 10.1158/0008-5472.CAN-08-4055, 2849653, 19351834.
    • (2009) Cancer Res , vol.69 , pp. 3256-3261
    • Sos, M.L.1    Koker, M.2    Weir, B.A.3    Heynck, S.4    Rabinovsky, R.5    Zander, T.6    Seeger, J.M.7    Weiss, J.8    Fischer, F.9    Frommolt, P.10
  • 29
    • 70149110218 scopus 로고    scopus 로고
    • Clinical implications of KRAS mutations in lung cancer patients treated with tyrosine kinase inhibitors: an important role for mutations in minor clones
    • 2745674, 19794967
    • Marchetti A, Milella M, Felicioni L, Cappuzzo F, Irtelli L, Del Grammastro M, Sciarrotta M, Malatesta S, Nuzzo C, Finocchiaro G, et al. Clinical implications of KRAS mutations in lung cancer patients treated with tyrosine kinase inhibitors: an important role for mutations in minor clones. Neoplasia 2009, 11:1084-1092. 2745674, 19794967.
    • (2009) Neoplasia , vol.11 , pp. 1084-1092
    • Marchetti, A.1    Milella, M.2    Felicioni, L.3    Cappuzzo, F.4    Irtelli, L.5    Del Grammastro, M.6    Sciarrotta, M.7    Malatesta, S.8    Nuzzo, C.9    Finocchiaro, G.10
  • 31
    • 33745913034 scopus 로고    scopus 로고
    • EGFR mutations in small-cell lung cancers in patients who have never smoked
    • 10.1056/NEJMc053610, 16837691
    • Zakowski MF, Ladanyi M, Kris MG. EGFR mutations in small-cell lung cancers in patients who have never smoked. N Engl J Med 2006, 355:213-215. 10.1056/NEJMc053610, 16837691.
    • (2006) N Engl J Med , vol.355 , pp. 213-215
    • Zakowski, M.F.1    Ladanyi, M.2    Kris, M.G.3
  • 32
    • 33646864481 scopus 로고    scopus 로고
    • EGFR mutation in gefitinib-responsive small-cell lung cancer
    • 10.1093/annonc/mdj114, 16357019
    • Okamoto I, Araki J, Suto R, Shimada M, Nakagawa K, Fukuoka M. EGFR mutation in gefitinib-responsive small-cell lung cancer. Ann Oncol 2006, 17:1028-1029. 10.1093/annonc/mdj114, 16357019.
    • (2006) Ann Oncol , vol.17 , pp. 1028-1029
    • Okamoto, I.1    Araki, J.2    Suto, R.3    Shimada, M.4    Nakagawa, K.5    Fukuoka, M.6
  • 33
    • 77957572836 scopus 로고    scopus 로고
    • [TNM classification of breast cancer: changes and comments on the 7th edition]
    • 10.1007/s00292-010-1307-0, 20711589
    • Sinn HP, Helmchen B, Wittekind CH. [TNM classification of breast cancer: changes and comments on the 7th edition]. Pathologe 2010, 31:361-366. 10.1007/s00292-010-1307-0, 20711589.
    • (2010) Pathologe , vol.31 , pp. 361-366
    • Sinn, H.P.1    Helmchen, B.2    Wittekind, C.H.3
  • 34
    • 79960980007 scopus 로고    scopus 로고
    • Strategies for subtypes--dealing with the diversity of breast cancer: highlights of the St Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2011
    • Goldhirsch A, Wood WC, Coates AS, Gelber RD, Thurlimann B, Senn HJ. Strategies for subtypes--dealing with the diversity of breast cancer: highlights of the St Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2011. Ann Oncol 22:1736-1747.
    • Ann Oncol , vol.22 , pp. 1736-1747
    • Goldhirsch, A.1    Wood, W.C.2    Coates, A.S.3    Gelber, R.D.4    Thurlimann, B.5    Senn, H.J.6
  • 36
    • 40949121882 scopus 로고    scopus 로고
    • Basal-like breast cancer defined by five biomarkers has superior prognostic value than triple-negative phenotype
    • 10.1158/1078-0432.CCR-07-1658, 18316557
    • Cheang MC, Voduc D, Bajdik C, Leung S, McKinney S, Chia SK, Perou CM, Nielsen TO. Basal-like breast cancer defined by five biomarkers has superior prognostic value than triple-negative phenotype. Clin Cancer Res 2008, 14:1368-1376. 10.1158/1078-0432.CCR-07-1658, 18316557.
    • (2008) Clin Cancer Res , vol.14 , pp. 1368-1376
    • Cheang, M.C.1    Voduc, D.2    Bajdik, C.3    Leung, S.4    McKinney, S.5    Chia, S.K.6    Perou, C.M.7    Nielsen, T.O.8
  • 40
    • 0142119289 scopus 로고    scopus 로고
    • Epidermal growth factor receptor in non-small-cell lung carcinomas: correlation between gene copy number and protein expression and impact on prognosis
    • 10.1200/JCO.2003.11.069, 12953099
    • Hirsch FR, Varella-Garcia M, Bunn PA, Di Maria MV, Veve R, Bremmes RM, Baron AE, Zeng C, Franklin WA. Epidermal growth factor receptor in non-small-cell lung carcinomas: correlation between gene copy number and protein expression and impact on prognosis. J Clin Oncol 2003, 21:3798-3807. 10.1200/JCO.2003.11.069, 12953099.
    • (2003) J Clin Oncol , vol.21 , pp. 3798-3807
    • Hirsch, F.R.1    Varella-Garcia, M.2    Bunn, P.A.3    Di Maria, M.V.4    Veve, R.5    Bremmes, R.M.6    Baron, A.E.7    Zeng, C.8    Franklin, W.A.9
  • 41
    • 58149343564 scopus 로고    scopus 로고
    • Frequently increased epidermal growth factor receptor (EGFR) copy numbers and decreased BRCA1 mRNA expression in Japanese triple-negative breast cancers
    • 10.1186/1471-2407-8-309, 2612006, 18950515
    • Toyama T, Yamashita H, Kondo N, Okuda K, Takahashi S, Sasaki H, Sugiura H, Iwase H, Fujii Y. Frequently increased epidermal growth factor receptor (EGFR) copy numbers and decreased BRCA1 mRNA expression in Japanese triple-negative breast cancers. BMC Cancer 2008, 8:309. 10.1186/1471-2407-8-309, 2612006, 18950515.
    • (2008) BMC Cancer , vol.8 , pp. 309
    • Toyama, T.1    Yamashita, H.2    Kondo, N.3    Okuda, K.4    Takahashi, S.5    Sasaki, H.6    Sugiura, H.7    Iwase, H.8    Fujii, Y.9
  • 42
    • 33644539850 scopus 로고    scopus 로고
    • Epidermal growth factor receptor gene mutation in non-small cell lung cancer using highly sensitive and fast TaqMan PCR assay
    • 10.1016/j.lungcan.2005.08.009, 16199108
    • Endo K, Konishi A, Sasaki H, Takada M, Tanaka H, Okumura M, Kawahara M, Sugiura H, Kuwabara Y, Fukai I, et al. Epidermal growth factor receptor gene mutation in non-small cell lung cancer using highly sensitive and fast TaqMan PCR assay. Lung Cancer 2005, 50:375-384. 10.1016/j.lungcan.2005.08.009, 16199108.
    • (2005) Lung Cancer , vol.50 , pp. 375-384
    • Endo, K.1    Konishi, A.2    Sasaki, H.3    Takada, M.4    Tanaka, H.5    Okumura, M.6    Kawahara, M.7    Sugiura, H.8    Kuwabara, Y.9    Fukai, I.10
  • 43
    • 0023949462 scopus 로고
    • Amplified and overexpressed epidermal growth factor receptor gene in uncultured primary human breast carcinoma
    • Ro J, North SM, Gallick GE, Hortobagyi GN, Gutterman JU, Blick M. Amplified and overexpressed epidermal growth factor receptor gene in uncultured primary human breast carcinoma. Cancer Res 1988, 48:161-164.
    • (1988) Cancer Res , vol.48 , pp. 161-164
    • Ro, J.1    North, S.M.2    Gallick, G.E.3    Hortobagyi, G.N.4    Gutterman, J.U.5    Blick, M.6
  • 45
    • 24044520039 scopus 로고    scopus 로고
    • EGFR gene amplification in breast cancer: correlation with epidermal growth factor receptor mRNA and protein expression and HER-2 status and absence of EGFR-activating mutations
    • 10.1038/modpathol.3800438, 15920544
    • Bhargava R, Gerald WL, Li AR, Pan Q, Lal P, Ladanyi M, Chen B. EGFR gene amplification in breast cancer: correlation with epidermal growth factor receptor mRNA and protein expression and HER-2 status and absence of EGFR-activating mutations. Mod Pathol 2005, 18:1027-1033. 10.1038/modpathol.3800438, 15920544.
    • (2005) Mod Pathol , vol.18 , pp. 1027-1033
    • Bhargava, R.1    Gerald, W.L.2    Li, A.R.3    Pan, Q.4    Lal, P.5    Ladanyi, M.6    Chen, B.7
  • 46
    • 2942629610 scopus 로고    scopus 로고
    • Gene dosage PCR and fluorescence in situ hybridization reveal low frequency of egfr amplifications despite protein overexpression in invasive breast carcinoma
    • 10.1038/labinvest.3700077, 15031710
    • Kersting C, Tidow N, Schmidt H, Liedtke C, Neumann J, Boecker W, van Diest PJ, Brandt B, Buerger H. Gene dosage PCR and fluorescence in situ hybridization reveal low frequency of egfr amplifications despite protein overexpression in invasive breast carcinoma. Lab Invest 2004, 84:582-587. 10.1038/labinvest.3700077, 15031710.
    • (2004) Lab Invest , vol.84 , pp. 582-587
    • Kersting, C.1    Tidow, N.2    Schmidt, H.3    Liedtke, C.4    Neumann, J.5    Boecker, W.6    van Diest, P.J.7    Brandt, B.8    Buerger, H.9
  • 49
    • 33748653109 scopus 로고    scopus 로고
    • Increased epidermal growth factor receptor gene copy number is associated with poor prognosis in head and neck squamous cell carcinomas
    • 10.1200/JCO.2006.07.2587, 16943533
    • Chung CH, Ely K, McGavran L, Varella-Garcia M, Parker J, Parker N, Jarrett C, Carter J, Murphy BA, Netterville J, et al. Increased epidermal growth factor receptor gene copy number is associated with poor prognosis in head and neck squamous cell carcinomas. J Clin Oncol 2006, 24:4170-4176. 10.1200/JCO.2006.07.2587, 16943533.
    • (2006) J Clin Oncol , vol.24 , pp. 4170-4176
    • Chung, C.H.1    Ely, K.2    McGavran, L.3    Varella-Garcia, M.4    Parker, J.5    Parker, N.6    Jarrett, C.7    Carter, J.8    Murphy, B.A.9    Netterville, J.10
  • 50
    • 34250155320 scopus 로고    scopus 로고
    • Epidermal growth factor receptor copy number alterations correlate with poor clinical outcome in patients with head and neck squamous cancer
    • 10.1200/JCO.2006.06.6605, 17538160
    • Temam S, Kawaguchi H, El-Naggar AK, Jelinek J, Tang H, Liu DD, Lang W, Issa JP, Lee JJ, Mao L. Epidermal growth factor receptor copy number alterations correlate with poor clinical outcome in patients with head and neck squamous cancer. J Clin Oncol 2007, 25:2164-2170. 10.1200/JCO.2006.06.6605, 17538160.
    • (2007) J Clin Oncol , vol.25 , pp. 2164-2170
    • Temam, S.1    Kawaguchi, H.2    El-Naggar, A.K.3    Jelinek, J.4    Tang, H.5    Liu, D.D.6    Lang, W.7    Issa, J.P.8    Lee, J.J.9    Mao, L.10
  • 54
    • 4444344330 scopus 로고    scopus 로고
    • EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib
    • 10.1073/pnas.0405220101, 516528, 15329413
    • Pao W, Miller V, Zakowski M, Doherty J, Politi K, Sarkaria I, Singh B, Heelan R, Rusch V, Fulton L, et al. EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib. Proc Natl Acad Sci USA 2004, 101:13306-13311. 10.1073/pnas.0405220101, 516528, 15329413.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 13306-13311
    • Pao, W.1    Miller, V.2    Zakowski, M.3    Doherty, J.4    Politi, K.5    Sarkaria, I.6    Singh, B.7    Heelan, R.8    Rusch, V.9    Fulton, L.10
  • 56
    • 10844231985 scopus 로고    scopus 로고
    • Mutations of the epidermal growth factor receptor gene in lung cancer: biological and clinical implications
    • 10.1158/0008-5472.CAN-04-2818, 15604253
    • Kosaka T, Yatabe Y, Endoh H, Kuwano H, Takahashi T, Mitsudomi T. Mutations of the epidermal growth factor receptor gene in lung cancer: biological and clinical implications. Cancer Res 2004, 64:8919-8923. 10.1158/0008-5472.CAN-04-2818, 15604253.
    • (2004) Cancer Res , vol.64 , pp. 8919-8923
    • Kosaka, T.1    Yatabe, Y.2    Endoh, H.3    Kuwano, H.4    Takahashi, T.5    Mitsudomi, T.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.