The influence of bisnaphthalimidopropyl polyamines on DNA instability and repair in Caco-2 colon epithelial cells

Cell Biology and Toxicology

Volumn 27, Issue 6, 2011, Pages 455-463

  Bestwick, Charles Stuart ^a   Ralton, Lynda D ^a,b   Milne, Lesley ^a   Kong Thoo Lin, Paul ^b   Duthie, Susan J ^a  

^a ROWETT RESEARCH INSTITUTE   (United Kingdom)

^b ROBERT GORDON UNIVERSITY   (United Kingdom)

Author keywords

Bisnaphthalimides; Bisnaphthalimidopropyl polyamines; Chemotherapy; Cytotoxicity; DNA damage; DNA repair

Indexed keywords

ANTINEOPLASTIC AGENT; BISNAPHTHALIMIDOPROPYL POLYAMINE DERIVATIVE; BISNAPHTHALIMIDOPROPYLOXASPERMINE; BISNAPHTHALIMIDOPROPYLSPERMIDINE; BISNAPHTHALIMIDOPROPYLSPERMINE; DNA; HYDROGEN PEROXIDE; POLYAMINE DERIVATIVE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL INTERACTION; CELL STRAIN CACO 2; CELLULAR DISTRIBUTION; COLON ADENOCARCINOMA; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA DAMAGE; DNA INSTABILITY; DNA REPAIR; DNA STRAND BREAKAGE; DRUG CYTOTOXICITY; DRUG EXPOSURE; DRUG STRUCTURE; FLUORESCENCE ANALYSIS; GENOMIC INSTABILITY; GENOTOXICITY; IC 50; INCUBATION TIME; OXIDATIVE STRESS; PRIORITY JOURNAL;

ADENOCARCINOMA; APOPTOSIS; CACO-2 CELLS; CELL SURVIVAL; COLONIC NEOPLASMS; COMET ASSAY; DNA; DNA DAMAGE; DNA REPAIR; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; HYDROGEN PEROXIDE; INHIBITORY CONCENTRATION 50; INTERCALATING AGENTS; NAPHTHALIMIDES; OXIDATION-REDUCTION; QUINOLONES; SPERMINE;

EID: 82455164226     PISSN: 07422091     EISSN: 15736822     Source Type: Journal    
DOI: 10.1007/s10565-011-9199-1     Document Type: Article

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