메뉴 건너뛰기




Volumn 806, Issue , 2012, Pages 87-97

Evaluation of cytochrome P450 activities in human hepatocytes in vitro

Author keywords

ADME; Cytochrome P450; HPLC MS MS; Human hepatocytes; Mass spectrometry; Substrates cocktail

Indexed keywords

CYTOCHROME P450;

EID: 82355193820     PISSN: 10643745     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-61779-367-7_7     Document Type: Article
Times cited : (14)

References (18)
  • 1
    • 19244373921 scopus 로고    scopus 로고
    • Functional consequences of polymorphism of xenobiotic metabolising enzymes
    • DOI 10.1016/S0378-4274(98)00301-4, PII S0378427498003014
    • Ingelman-Sundberg M. (1998) Functional consequences of polymorphism of xenobiotic metabolising enzymes. Toxicol Lett. 102 - 103, 155-160. (Pubitemid 29021216)
    • (1998) Toxicology Letters , vol.102-103 , pp. 155-160
    • Ingelman-Sundberg, M.1
  • 2
    • 70149110672 scopus 로고    scopus 로고
    • Polymorphism of human cytochrome P450 enzymes and its clinical impact
    • Zhou S.F, Liu J.P, and Chowbay B. (2009) Polymorphism of human cytochrome P450 enzymes and its clinical impact. Drug Metab Rev. 41, 89-295.
    • (2009) Drug Metab Rev , vol.41 , pp. 89-295
    • Zhou, S.F.1    Liu, J.P.2    Chowbay, B.3
  • 3
    • 34247510665 scopus 로고    scopus 로고
    • Hepatocytes-the choice to investigate drug metabolism and toxicity in man: In vitro variability as a reflection of in vivo
    • DOI 10.1016/j.cbi.2006.10.013, PII S0009279706003243
    • Gómez-Lechón M.J., Castell J.V., and Donato M.T. (2007) Hepatocytes-the choice to investigate drug metabolism and toxicity in man: in vitro variability as a reflection of in vivo. Chem Biol Interact. 168, 30-50. (Pubitemid 46659918)
    • (2007) Chemico-Biological Interactions , vol.168 , Issue.1 , pp. 30-50
    • Gomez-Lechon, M.J.1    Castell, J.V.2    Donato, M.T.3
  • 4
    • 38849153472 scopus 로고    scopus 로고
    • Strategies to in vitro assessment of major human CYP enzyme activities by using liquid chromatography tandem mass spectrometry
    • DOI 10.2174/138920008783331112
    • Lahoz A., Donato M.T., Castell J.V., and Gómez-Lechón M.J. (2008) Strategies to in vitro assessment of major human CYP enzyme activities by using liquid chromatography tandem mass spectrometry. Curr Drug Metab. 9, 12-19. (Pubitemid 351201666)
    • (2008) Current Drug Metabolism , vol.9 , Issue.1 , pp. 12-19
    • Lahoz, A.1    Donato, M.T.2    Castell, J.V.3    Gomez-Lechon, M.J.4
  • 5
    • 56949090796 scopus 로고    scopus 로고
    • Analysis of nine drugs and their cytochrome P450-specific probe metabolites from urine by liquid chromatographytandem mass spectrometry utilizing sub 2 microm particle size column
    • Petsalo A., Turpeinen M., Pelkonen O., and Tolonen A. (2008) Analysis of nine drugs and their cytochrome P450-specific probe metabolites from urine by liquid chromatographytandem mass spectrometry utilizing sub 2 microm particle size column. J Chromatogr A. 1215, 107-115.
    • (2008) J Chromatogr A , vol.1215 , pp. 107-115
    • Petsalo, A.1    Turpeinen, M.2    Pelkonen, O.3    Tolonen, A.4
  • 6
    • 77955507698 scopus 로고    scopus 로고
    • A review of LC-MS techniques and high-throughput approaches used to investigate drug metabolism by cytochrome P450s
    • [Epub ahead of print]
    • Youdim K.A., Saunders K.C. (2010) A review of LC-MS techniques and high-throughput approaches used to investigate drug metabolism by cytochrome P450s. Chromatogr B Analyt Technol Biomed Life Sci. [Epub ahead of print].
    • (2010) Chromatogr B Analyt Technol Biomed Life Sci.
    • Youdim, K.A.1    Saunders, K.C.2
  • 7
    • 53749100013 scopus 로고    scopus 로고
    • Assessment of cytochrome P450 induction in human hepatocytes using the cocktail strategy plus liquid chromatography tandem mass spectrometry
    • Lahoz A., Donato M.T., Picazo L., Castell J.V., and Gómez- Lechón M.J. (2008) Assessment of cytochrome P450 induction in human hepatocytes using the cocktail strategy plus liquid chromatography tandem mass spectrometry. Drug Metab Lett. 2, 205-209.
    • (2008) Drug Metab Lett , vol.2 , pp. 205-209
    • Lahoz, A.1    Donato, M.T.2    Picazo, L.3    Castell, J.V.4    Gómez-Lechón, M.J.5
  • 8
    • 4644341747 scopus 로고    scopus 로고
    • Human hepatocytes in primary culture: The choice to investigate drug metabolism in man
    • DOI 10.2174/1389200043335414
    • Gómez-Lechón M.J., Donato M.T., Castell J.V., and Jover R. (2004) Human hepatocytes in primary culture: the choice to invsetigate drug metabolism in man. Curr Drug Metab. 5, 443-462. (Pubitemid 39276606)
    • (2004) Current Drug Metabolism , vol.5 , Issue.5 , pp. 443-462
    • Gomez-Lechon, M.J.1    Donato, M.T.2    Castell, J.V.3    Jover, R.4
  • 11
    • 34247492532 scopus 로고    scopus 로고
    • The pivotal role of hepatocytes in drug discovery
    • DOI 10.1016/j.cbi.2006.11.002, PII S0009279706003255
    • Soars M.G., Mcginnity D.F., Grime K., and Riley R.J. (2007) The pivotal role of hepatocytes in drug discovery. Chem Biol Interact. 168, 2-15. (Pubitemid 46661937)
    • (2007) Chemico-Biological Interactions , vol.168 , Issue.1 , pp. 2-15
    • Soars, M.G.1    McGinnity, D.F.2    Grime, K.3    Riley, R.J.4
  • 12
    • 15444362827 scopus 로고    scopus 로고
    • In vitro methods to study chemically-induced hepatotoxicity: A literature review
    • DOI 10.2174/1389200053586118
    • Farkas D., Tannenbaum S.R. (2005) In vitro methods to study chemically-induced hepatotoxicity: a literature review. Curr Drug Metab. 6, 111-25. (Pubitemid 40394340)
    • (2005) Current Drug Metabolism , vol.6 , Issue.2 , pp. 111-125
    • Farkas, D.1    Tannenbaum, S.R.2
  • 14
    • 35649018168 scopus 로고    scopus 로고
    • Determination of major human cytochrome P450s activities in 96-well plates using liquid chromatography tandem mass spectrometry
    • DOI 10.1016/j.tiv.2007.03.022, PII S0887233307001324, Fourteenth International Workshop on In Vitro Toxicology
    • Lahoz A., Donato M.T., Picazo L., Gómez- Lechón M.J., and Castell J.V. (2007) Determination of major human cytochrome P450s activities in 96-well plates using liquid chromatography tandem mass spectrometry. Toxicol In Vitro 21, 1247-1252. (Pubitemid 350026238)
    • (2007) Toxicology in Vitro , vol.21 , Issue.7 , pp. 1247-1252
    • Lahoz, A.1    Donato, M.T.2    Picazo, L.3    Gomez-Lechon, M.J.4    Castell, J.V.5
  • 15
    • 0027275495 scopus 로고
    • A microassay for measuring cytochrome P450IA1 and P450IIB1 activities in intact human and rat hepatocytes cultured on 96-well plates
    • DOI 10.1006/abio.1993.1381
    • Donato M.T., Gómez-Lechón M.J., and Castell J.V. (1993) A microassay for measuring cytochrome P450IA1 and P450IIB1 activities in intact human and rat hepatocytes cultured on 96-well plates. Anal Biochem. 213, 29-33. (Pubitemid 23250612)
    • (1993) Analytical Biochemistry , vol.213 , Issue.1 , pp. 29-33
    • Donato, M.T.1    Gomez-Lechon, M.J.2    Castell, J.V.3
  • 16
    • 38549128284 scopus 로고    scopus 로고
    • A new in vitro approach for the simultaneous determination of phase I and phase II enzymatic activities of human hepatocyte preparations
    • DOI 10.1002/rcm.3359
    • Lahoz A., Donato M.T., Montero S., Castell J.V., and Gómez- Lechón M.J. (2008) A new in vitro approach for the simultaneous determination of phase I and phase II enzymatic activities of human hepatocyte preparations. Rapid Commun Mass Spectrom. 22, 240-244. (Pubitemid 351156137)
    • (2008) Rapid Communications in Mass Spectrometry , vol.22 , Issue.2 , pp. 240-244
    • Lahoz, A.1    Donato, M.T.2    Montero, S.3    Castell, J.V.4    Gomez-Lechon, M.J.5
  • 18
    • 60549117142 scopus 로고    scopus 로고
    • Functional assessment of the quality of human hepatocyte preparations for cell transplantation
    • Donato M.T., Lahoz A., Montero S., Bonora A., Pareja E., Mir J., et al. (2008) Functional assessment of the quality of human hepatocyte preparations for cell transplantation. Cell Transplant. 17, 1211-1219.
    • (2008) Cell Transplant , vol.17 , pp. 1211-1219
    • Donato, M.T.1    Lahoz, A.2    Montero, S.3    Bonora, A.4    Pareja, E.5    Mir, J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.