Two serine residues of the glutamate transporter GLT-1 are crucial for coupling the fluxes of sodium and the neurotransmitter

Proceedings of the National Academy of Sciences of the United States of America

Volumn 96, Issue 4, 1999, Pages 1710-1715

  Zhang, Yumin ^a   Kanner, Baruch I ^a  

^a HEBREW UNIVERSITY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

CARRIER PROTEIN; DIHYDROKAINIC ACID; GLYCINE; LITHIUM ION; SERINE; SODIUM ION; UNCLASSIFIED DRUG; VESICULAR GLUTAMATE TRANSPORTER 1;

AMINO ACID TRANSPORT; ARTICLE; BINDING SITE; HELA CELL; HUMAN; HUMAN CELL; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; SODIUM TRANSPORT;

AMINO ACID SUBSTITUTION; AMINO ACID TRANSPORT SYSTEM X-AG; ASPARTIC ACID; ATP-BINDING CASSETTE TRANSPORTERS; BINDING SITES; BIOLOGICAL TRANSPORT; GLUTAMIC ACID; GLYCINE; HELA CELLS; HUMANS; KAINIC ACID; KINETICS; MUTAGENESIS, SITE-DIRECTED; NEUROTRANSMITTER AGENTS; RECOMBINANT PROTEINS; SERINE; SODIUM;

EID: 0033573907     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.96.4.1710     Document Type: Article

References (43)

1. Kanner, B. I. & Schuldiner, S. (1987) CRC Crit. Rev. Biochem. 22, 1-38.
2. Nicholls, D. & Attwell, D. (1990) Trends Pharmacol. Sci. 11, 462-468.
3. Rothstein, J. D., Dykes Hoberg, M., Pardo, C. A., Bristol, L. A., Jin, L., Kuncl, R. W., Kanai, Y., Hediger, M. A., Wang, Y., Schielke, J. P. & Welty, D. F. (1996) Neuron 16, 675-686.
4. Tanaka, K., Watase, K., Manabe, T., Yamada, K., Watanabe, M., Takahashi, K., Iwama, H., Nishikawa, T., Ichihara, N., Kikuchi, T., et al. (1997) Science 276, 1699-1702.
5. Mennerick, S. & Zorumski, C. F. (1994) Nature (London) 368, 59-62.
6. Tong, G. & Jahr, C. E. (1994) Neuron 13, 1195-1203.
7. Otis, T. S., Wu, Y. C. & Trussell, L. O. (1996) J. Neurosci. 16, 1634-1644.
8. Diamond, J. S. & Jahr, C. E. (1997) J. Neurosci. 17, 4672-4687.
9. Kanner, B. I. & Sharon, I. (1978) Biochemistry 17, 3949-3953.
10. Brew, H. & Attwell, D. (1987) Nature (London) 327, 707-709.
11. Wadiche, J. I., Arriza, J. L., Amara, S. G. & Kavanaugh, M. P. (1995) Neuron 14, 1019-1027.
12. Zerangue, N. & Kavanaugh, M. P. (1996) Nature (London) 383, 634-637.
13. Kanner, B. I. & Bendahan, A. (1982) Biochemistry 21, 6327-6330.
14. Pines, G. & Kanner, B. I. (1990) Biochemistry 29, 11209-11214.
15. Kavanaugh, M. P., Bendahan, A., Zerangue, N., Zhang, Y. & Kanner, B. I. (1997) J. Biol. Chem. 272, 1703-1708.
16. Grunewald, M. & Kanner, B. (1995) J. Biol. Chem. 270, 17017-17024.
17. Danbolt, N. C., Pines, G. & Kanner, B. I. (1990) Biochemistry 29, 6734-6740.
18. Danbolt, N. C., Storm-Mathisen, J. & Kanner, B. I. (1992) Neuroscience 51, 295-310.
19. Pines, G., Danbolt, N. C., Bjoras, M., Zhang, Y., Bendahan, A., Eide, L., Koepsell, H., Storm-Mathisen, J., Seeberg, E. & Kanner, B. I. (1992) Nature (London) 360, 464-467.
20. Storck, T., Schulte, S., Hofmann, K. & Stoffel, W. (1992) Proc. Natl. Acad. Sci. USA 89, 10955-10959.
21. Kanai, Y. & Hediger, M. A. (1992) Nature (London) 360, 467-471.
22. Fairman, W. A., Vandenberg, R. J., Arriza, J. L., Kavanaugh, M. P. & Amara, S. G. (1995) Nature (London) 375, 599-603.
23. Arriza, J. L., Eliasof, S., Kavanaugh, M. P. & Amara, S. G. (1997) Proc. Natl. Acad. Sci. USA 94, 4155-4160.
24. Vandenberg, R. J., Arriza, J. L., Amara, S. G. & Kavanaugh, M. P. (1995) J. Biol. Chem. 270, 17668-17671.
25. Zhang, Y., Bendahan, A., Zarbiv, R., Kavanaugh, M. P. & Kanner, B. I. (1998) Proc. Natl. Acad. Sci. USA 95, 751-755.
26. Zarbiv, R., Grunewald, M., Kavanaugh, M. P. & Kanner, B. I. (1998) J. Biol. Chem. 273, 14231-14237.
27. Arriza, J. L., Kavanaugh, M. P., Fairman, W. A., Wu, Y. N., Murdoch, G. H., North, R. A. & Amara, S. G. (1993) J. Biol. Chem. 268, 15329-15332.
28. Shafqat, S., Tamarappoo, B. K., Kilberg, M. S., Puranam, R. S., McNamara, J. O., Guadano Ferraz, A. & Fremeau, R. T., Jr. (1993) J. Biol. Chem. 268, 15351-15355.
29. Utsunomiya Tate, N., Endou, H. & Kanai, Y. (1996) J. Biol. Chem. 271, 14883-14890.
30. Kekuda, R., Prasad, P. D., Fei, Y. J., Torres Zamorano, V., Sinha, S., Yang Feng, T. L., Leibach, F. H. & Ganapathy, V. (1996) J. Biol. Chem. 271, 18657-18661.
31. Tolner, B., Ubbink Kok, T., Poolman, B. & Konings, W. N. (1995) J. Bacteriol. 177, 2863-2869.
32. Grunewald, M., Bendahan, A. & Kanner, B. I. (1998) Neuron 21, 623-632.
33. Slotboom, D. J., Lolkema, J. S. & Konings, W. N. (1996) J. Biol. Chem. 271, 31317-31321.
34. Keynan, S., Sun, Y. J., Kanner, B. I. & Rudnick, G. (1992) Biochemistry 31, 1974-1979.
35. Fuerst, T. R., Niles, E. G., Studier, F. W. & Moss, B. (1986) Proc. Natl. Acad. Sci. USA 83, 8122-8126.
36. Lowry, O. H., Rosebrough, N. J., Farr, A. L. & Randall, R. J. (1951) J. Biol. Chem. 193, 265-275.
37. Pines, G., Zhang, Y. & Kanner, B. I. (1995) J. Biol. Chem. 270, 17093-17097.
38. Kunkel, T. A., Roberts, J. D. & Zakour, R. A. (1987) Methods Enzymol. 154, 367-382.
39. Casado, M., Bendahan, A., Zafra, F., Danbolt, N. C., Aragon, C., Gimenez, C. & Kanner, B. I. (1993) J. Biol. Chem. 268, 27313-27317.
40. Mitrovic, A. D., Amara, S. G., Johnston, G. A. R. & Vandenberg, R. J. (1998) J. Biol. Chem. 273, 14698-14706.
41. Hama, H. & Wilson, T. H. (1993) J. Biol. Chem. 268, 10060-10065.
42. Wu, J. & Kaback, H. R. (1996) Proc. Natl. Acad. Sci. USA 93, 14498-14502.
43. Sun, J., Kemp, C. R. & Kaback, H. R. (1998) Biochemistry 37, 8020-8026.