Glutathione utilization by Candida albicans requires a functional glutathione degradation (DUG) pathway and OPT7, an unusual member of the oligopeptide transporter family

Journal of Biological Chemistry

Volumn 286, Issue 48, 2011, Pages 41183-41194

  Desai, Prashant Ramesh ^a,d   Thakur, Anil ^a   Ganguli, Dwaipayan ^a,e   Paul, Sanjoy ^a,f   Morschhäuser, Joachim ^b   Bachhawat, Anand K ^a,c  

^a INSTITUTE OF MICROBIAL TECHNOLOGY   (India)

^b UNIVERSITY OF WÜRZBURG   (Germany)

^c INDIAN INSTITUTE OF SCIENCE EDUCATION AND RESEARCH MOHALI   (India)

^d HEINRICH HEINE UNIVERSITY   (Germany)

^e EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^f UNIVERSITY OF IOWA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALBICANS; AUXOTROPHY; BIOCHEMICAL STUDIES; CANDIDA ALBICANS; GENOMIC LIBRARIES; GLUTATHIONE BIOSYNTHESIS; GLUTATHIONES; HIGH AFFINITY; IN-VIVO; IN-VIVO EXPERIMENTS; MAMMALIAN HOSTS; OLIGOPEPTIDES; ORGANIC SULFUR; ORTHOLOGUES; PATHOGENIC YEAST; SULFUR SOURCE; TRI-PEPTIDES;

AMINO ACIDS; BIOCHEMISTRY; CANDIDA; DEGRADATION; MAMMALS; SULFUR; YEAST;

PEPTIDES;

CYSTEINE; FUNGAL PROTEIN; GLUTATHIONE; OLIGOPEPTIDE TRANSPORTER 7; PROTEIN DUG; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BIOCHEMISTRY; CANDIDA ALBICANS; CANDIDIASIS; CONTROLLED STUDY; DEGRADATION; FUNGAL VIRULENCE; GLUTATHIONE METABOLISM; IN VIVO STUDY; ISOTOPE LABELING; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REGULATORY MECHANISM;

CANDIDA ALBICANS; FUNGAL PROTEINS; GENE EXPRESSION REGULATION, FUNGAL; GLUTATHIONE; MEMBRANE TRANSPORT PROTEINS; MULTIGENE FAMILY; SACCHAROMYCES CEREVISIAE;

EID: 82355184471     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.272377     Document Type: Article

References (34)

1. Pfaller, M. A., Diekema, D. J., Gibbs, D. L., Newell, V. A., Ellis, D., Tullio, V., Rodloff, A., Fu, W., and Ling, T. A. (2010) J. Clin. Microbiol. 48, 1366-1377
2. Hazen, K. C. (1995) Clin. Microbiol. Rev. 8, 462-478
3. Pfaller, M. A., and Diekema, D. J. (2007) Clin. Microbiol. Rev. 20, 133-163
4. Chauhan, N., Latge, J. P., and Calderone, R. (2006) Nat. Rev. Microbiol. 4, 435-444
5. Michán, C., and Pueyo, C. (2009) FEMS Yeast Res. 9, 1078-1090
6. Muller, E. G. (1996) Mol. Biol. Cell 7, 1805-1813
7. Sharma, K. G., Sharma, V., Bourbouloux, A., Delrot, S., and Bachhawat, A. K. (2000) Curr. Genet. 38, 71-77
8. da Silva Dantas, A., Patterson, M. J., Smith, D. A., Maccallum, D. M., Erwig, L. P., Morgan, B. A., and Quinn, J. (2010) Mol. Cell. Biol. 30, 4550-4563
9. Yadav, A. K., Desai, P. R., Rai, M. N., Kaur, R., Ganesan, K., and Bachhawat, A. K. (2011) Microbiology 157, 484-495
10. Hwang, C., Sinskey, A. J., and Lodish, H. F. (1992) Science 257, 1496-1502
11. Bourbouloux, A., Shahi, P., Chakladar, A., Delrot, S., and Bachhawat, A. K. (2000) J. Biol. Chem. 275, 13259-13265
12. Thakur, A., Kaur, J., and Bachhawat, A. K. (2008) FEMS Yeast Res. 8, 916-929
13. Thakur, A., and Bachhawat, A. K. (2010) Biochem. J. 429, 593-602
14. Ganguli, D., Kumar, C., and Bachhawat, A. K. (2007) Genetics 175, 1137-1151
15. Kaur, H., Kumar, C., Junot, C., Toledano, M. B., and Bachhawat, A. K. (2009) J. Biol. Chem. 284, 14493-14502
16. Reuss, O., and and Morschhäuser, J. (2006) Mol. Microbiol. 60, 795-812
17. Guthrie, C., and Fink, G. R. (1991) Methods Enzymol. 194, 3-37
18. Sambrook, J., Fritsch E. F., and Maniatis T. (1989) Molecular Cloning: A Laboratory Manual, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York
19. Reuss, O., Vik, A., Kolter, R., and Morschhäuser, J. (2004) Gene 341, 119-127
20. Mumberg, D., Müller, R., and Funk, M. (1995) Gene 156, 119-122
21. Kaur, J., Srikanth, C. V., and Bachhawat, A. K. (2009) FEMS Yeast Res. 9, 849-866
22. Thompson, J. D., Gibson, T. J., Plewniak, F., Jeanmougin, F., and Higgins, D. G. (1997) Nucleic Acids Res. 25, 4876-4882
23. Kumar, S., Nei, M., Dudley, J., and Tamura, K. (2008) Brief Bioinform. 9, 299-306
24. Viaene, J., Tiels, P., Logghe, M., Dewaele, S., Martinet, W., and Contreras, R. (2000) Yeast 16, 1205-1215
25. Lubkowitz, M. A., Hauser, L., Breslav, M., Naider, F., and Becker, J. M. (1997) Microbiology 143, 387-396
26. Enjalbert, B., Smith, D. A., Cornell, M. J., Alam, I., Nicholls, S., Brown, A. J., and Quinn, J. (2006) Mol. Biol. Cell 17, 1018-1032
27. Baudouin-Cornu, P., and Labarre, J. (2006) Biochimie 88, 1673-1685
28. Biswas, K., Rieger, K. J., and Morschhäuser, J. (2003) Gene 323, 43-55
29. Staib, P., Kretschmar, M., Nichterlein, T., Hof, H., and Morschhäuser, J. (2000) Proc. Natl. Acad. Sci. U.S.A. 97, 6102-6107
30. Staib, P., Kretschmar, M., Nichterlein, T., Köhler, G., Michel, S., Hof, H., Hacker, J., and Morschhäuser, J. (1999) Mol. Microbiol. 32, 533-546
31. Kaur, J., and Bachhawat, A. K. (2009) J. Biol. Chem. 284, 23872-23884
32. Chen, Y. L., Kauffman, S., and Reynolds, T. B. (2008) Infect. Immun. 76, 2793-2801
33. Rodaki, A., Young, T., and Brown, A. J. (2006) Eukaryot. Cell 5, 1371-1377
34. Gillum, A. M., Tsay, E. Y., and Kirsch, D. R. (1984) Mol. Gen. Genet. 198, 179-182