Stable expression of native Coagulation factor VIII using the 2A self-processing sequence and furin cleavage site

Thrombosis Research

Volumn 128, Issue 6, 2011, Pages

  He, Bangshun ^a   Pan, Yuqin ^a   Chen, Liping ^a,b   Xu, Yeqiong ^a   Chen, Nuan ^c   Gu, Ling ^a,b   Nie, Zhengling ^a   Wang, Shukui ^a   Liu, Zhixue ^c  

^a THE FIRST AFFILIATED HOSPITAL OF NANJING MEDICAL UNIVERSITY   (China)

^b NANJING NORMAL UNIVERSITY   (China)

^c TONGJI UNIVERSITY   (China)

Author keywords

2A self processing sequence; furin cleavage site; FVIII; hemophilia A

Indexed keywords

BLOOD CLOTTING FACTOR 8; FURIN; OLIGOSACCHARIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; EXPRESSION VECTOR; GENE TRANSFER; HEAVY CHAIN; HEMOPHILIA A; HETEROLOGOUS EXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LIGHT CHAIN; MOUSE; NONHUMAN; OPEN READING FRAME; PRIORITY JOURNAL; STABLE EXPRESSION;

ANIMALS; BIOENGINEERING; CATALYTIC DOMAIN; CELL LINE; CELL LINE, TUMOR; CHO CELLS; CRICETINAE; DISEASE MODELS, ANIMAL; DNA, COMPLEMENTARY; FACTOR VIII; FURIN; GENE KNOCK-IN TECHNIQUES; HEK293 CELLS; HEMOPHILIA A; HUMANS; MICE; MICE, TRANSGENIC; OPEN READING FRAMES; TRANSFECTION;

EID: 82355169738     PISSN: 00493848     EISSN: 18792472     Source Type: Journal    
DOI: 10.1016/j.thromres.2011.07.015     Document Type: Article

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