Elevated GH/IGF-I, due to somatotrope-specific loss of both IGF-I and insulin receptors, alters glucose homeostasis and insulin sensitivity in a diet-dependent manner

Endocrinology

Volumn 152, Issue 12, 2011, Pages 4825-4837

  Gahete, Manuel D ^a,b   Córdoba Chacón, José ^a,b   Anadumaka, Chike V ^a,b   Lin, Qing ^a,b   Brüning, Jens C ^c,d   Kahn, C Ronald ^e   Luque, Raúl M ^f,g   Kineman, Rhonda D ^a,b  

^a JESSE BROWN VA MEDICAL CENTER   (United States)

^b UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^c MAX PLANCK INSTITUTE FOR NEUROLOGICAL RESEARCH   (Germany)

^d UNIVERSITY HOSPITAL OF COLOGNE   (Germany)

^e JOSLIN DIABETES CENTER   (United States)

^f UNIVERSITY OF CÓRDOBA   (Spain)

^g Instituto de Salud Carlos III   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

3 HYDROXYBUTYRIC ACID; CORTICOSTERONE; CRE RECOMBINASE; FATTY ACID; GLUCOSE; GROWTH HORMONE; INSULIN RECEPTOR; KETONE; PROLACTIN; SOMATOMEDIN BINDING PROTEIN 1; SOMATOMEDIN BINDING PROTEIN 2; SOMATOMEDIN BINDING PROTEIN 3; SOMATOMEDIN BINDING PROTEIN 5; SOMATOMEDIN BINDING PROTEIN 6; SOMATOMEDIN C; SOMATOMEDIN C RECEPTOR; TRIACYLGLYCEROL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY COMPOSITION; BODY WEIGHT; CALORIC INTAKE; CONTROLLED STUDY; DIET; FEMALE; GENE EXPRESSION; GLUCOSE HOMEOSTASIS; HETEROLOGOUS EXPRESSION; HYPERGLYCEMIA; HYPOPHYSIS TUMOR; INSULIN RESISTANCE; INSULIN SENSITIVITY; KETOACIDOSIS; LEAN BODY WEIGHT; LIPID LIVER LEVEL; LIPID OXIDATION; LIPID STORAGE; MALE; MOUSE; NEGATIVE FEEDBACK; NONHUMAN; OBESITY; PHENOTYPE; PRIORITY JOURNAL; RESPIRATORY QUOTIENT; TRANSGENE;

ADIPOSITY; ANIMALS; DIET; GLUCOSE; GROWTH HORMONE; HOMEOSTASIS; INSULIN RESISTANCE; INSULIN-LIKE GROWTH FACTOR I; LIPID METABOLISM; MICE; ORGAN SPECIFICITY; RECEPTOR, IGF TYPE 1; RECEPTOR, INSULIN;

EID: 82355165082     PISSN: 00137227     EISSN: 19457170     Source Type: Journal    
DOI: 10.1210/en.2011-1447     Document Type: Article

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