메뉴 건너뛰기




Volumn 150, Issue 7, 2009, Pages 3177-3185

Use of the metallothionein promoter-human growth hormone-releasing hormone (GHRH) mouse to identify regulatory pathways that suppress pituitary somatotrope hyperplasia and adenoma formation due to GHRH-receptor hyperactivation

Author keywords

[No Author keywords available]

Indexed keywords

BROXURIDINE; INTERLEUKIN 1BETA CONVERTING ENZYME; KI 67 ANTIGEN; MESSENGER RNA; METALLOTHIONEIN; MITOGEN ACTIVATED PROTEIN KINASE KINASE KINASE 2; PROTEIN P27; SOMATOSTATIN; SOMATOSTATIN RECEPTOR 1; SOMATOSTATIN RECEPTOR 5; TUMOR NECROSIS FACTOR RECEPTOR 2;

EID: 67649648242     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2008-1482     Document Type: Article
Times cited : (15)

References (40)
  • 1
    • 0030464704 scopus 로고    scopus 로고
    • The growth-hormone-releasing hormone receptor: Signal transduction, gene expression, and physiological function in growth regulation
    • Mayo KE, Miller TL, DeAlmeida V, Zheng J, Godfrey PA 1996 The growth-hormone-releasing hormone receptor: signal transduction, gene expression and physiological function in growth regulation. Ann NY Acad Sci 805:184-203 (Pubitemid 27058021)
    • (1996) Annals of the New York Academy of Sciences , vol.805 , pp. 184-203
    • Mayo, K.E.1    Miller, T.L.2    Dealmeida, V.3    Zheng, J.4    Godfrey, P.A.5
  • 2
    • 0001236026 scopus 로고    scopus 로고
    • Growth hormone-releasing hormone: Discovery, regulation, and actions
    • Kostyo J, ed. New York: Oxford University Press
    • Frohman LA, Kineman RD 1999 Growth hormone-releasing hormone: discovery, regulation, and actions. In: Kostyo J, ed. Handbook of physiology: hormonal control of growth. New York: Oxford University Press; 189-221
    • (1999) Handbook of Physiology: Hormonal Control of Growth , pp. 189-221
    • Frohman, L.A.1    Kineman, R.D.2
  • 4
    • 0021228284 scopus 로고
    • Extrahypothalamic growth-hormone-releasing factor (GRF) secretion is a rare cause of acromegaly: Plasma GRF levels in 177 acromegalic patients
    • Thorner MO, Frohman LA, Leong DA, Thominet J, Downs T, Hellman P, Chitwood J, Vaughan JM, Vale W 1984 Extra-hypothalamic growth hormone-releasing factor (GRF) secretion is a rare cause of acromegaly: plasma GRF levels in l77 acromegalic patients. J Clin Endocrinol Metab 59:846-849 (Pubitemid 14020682)
    • (1984) Journal of Clinical Endocrinology and Metabolism , vol.59 , Issue.5 , pp. 846-849
    • Thorner, M.O.1    Frohman, L.A.2    Leong, D.A.3
  • 5
    • 0024065111 scopus 로고
    • Growth hormone-releasing hormone-producing tumors: Clinical, biochemical, and morphological manifestations
    • Sano T, Asa SL, Kovacs K 1988 Growth hormone-releasing hormone-producing tumors: clinical, biochemical, and morphological manifestations. Endocr Rev 9:357-373
    • (1988) Endocr Rev , vol.9 , pp. 357-373
    • Sano, T.1    Asa, S.L.2    Kovacs, K.3
  • 7
    • 0028069053 scopus 로고
    • Combined sellar gangliocytoma and pituitary adenoma in acromegaly or Cushing's disease: A report of 3 cases
    • Saeger W, Puchner MJ, Lüdecke DK 1994 Combined sellar gangliocytoma and pituitary adenoma in acromegaly or Cushing's disease. A report of 3 cases. Virchows Arch 425:93-99 (Pubitemid 24295513)
    • (1994) Virchows Archiv , vol.425 , Issue.1 , pp. 93-99
    • Saeger, W.1    Puchner, M.J.A.2    Ludecke, D.K.3
  • 10
    • 39149135836 scopus 로고    scopus 로고
    • Clinical and molecular genetics of acromegaly: MEN1, Carney complex, McCune-Albright syndrome, familial acromegaly and genetic defects in sporadic tumors
    • Horvath A, Stratakis CA 2008 Clinical and molecular genetics of acromegaly: MEN1, Carney complex, McCune-Albright syndrome, familial acromegaly and genetic defects in sporadic tumors. Rev Endocr Metab Disord 9:1-11
    • (2008) Rev Endocr Metab Disord , vol.9 , pp. 1-11
    • Horvath, A.1    Stratakis, C.A.2
  • 11
    • 0029017174 scopus 로고
    • The cyclic adenosine 3′,5′-monophosphate-responsive factor CREB is constitutively activated in human somatotroph adenomas
    • Bertherat J, Chanson P, Montminy M 1995 The cyclic adenosine 3′,5′-monophosphate-responsive factor CREB is constitutively activated in human somatotroph adenomas. Mol Endocrinol 9:777-783
    • (1995) Mol Endocrinol , vol.9 , pp. 777-783
    • Bertherat, J.1    Chanson, P.2    Montminy, M.3
  • 12
    • 0033767048 scopus 로고    scopus 로고
    • Genetic and histologic studies of somatomammotropic pituitary tumors in patients with the "complex of spotty skin pigmentation, myxomas, endocrine overactivity and Schwannomas" (Carney Complex)
    • Pack SD, Kirschner LS, Pak E, Zhuang Z, Carney JA, Stratakis CA 2000 Genetic and histologic studies of somatomammotropic pituitary tumors in patients with the "complex of spotty skin pigmentation, myxomas, endocrine overactivity and Schwannomas" (Carney Complex). J Clin Endocrinol Metab 85:3860-3865
    • (2000) J Clin Endocrinol Metab , vol.85 , pp. 3860-3865
    • Pack, S.D.1    Kirschner, L.S.2    Pak, E.3    Zhuang, Z.4    Carney, J.A.5    Stratakis, C.A.6
  • 13
    • 38749106141 scopus 로고    scopus 로고
    • Pituitary-specific knockout of the carney complex gene Prkar1a leads to pituitary tumorigenesis
    • DOI 10.1210/me.2006-0428
    • Yin Z, Williams-Simons L, Parlow AF, Asa S, Kirschner LS 2008 Pituitary-specific knockout of the Carney Complex gene Prkar1a leads to pituitary tumorigenesis. Mol Endocrinol 22:380-387 (Pubitemid 351185937)
    • (2008) Molecular Endocrinology , vol.22 , Issue.2 , pp. 380-387
    • Yin, Z.1    Williams-Simons, L.2    Parlow, A.F.3    Asa, S.4    Kirschner, L.S.5
  • 14
    • 0021847770 scopus 로고
    • Expression of human growth hormone-releasing factor in transgenic mice results in increased somatic growth
    • DOI 10.1038/315413a0
    • Hammer RE, Brinster RL, Rosenfeld MG, Evans RM, Mayo KE 1985 Expression of human growth hormone-releasing factor in transgenic mice results in increased somatic growth. Nature 315:413-416 (Pubitemid 15031551)
    • (1985) Nature , vol.315 , Issue.6018 , pp. 413-416
    • Hammer, R.E.1    Brinster, R.L.2    Rosenfeld, M.G.3
  • 16
    • 0024464381 scopus 로고
    • Adenohypophysial changes in mice transgenic for human growth hormone-releasing factor: A histological, immunocytochemical, and electron microscopic investigation
    • Stefaneanu L, Kovacs K, Horvath E, Asa SL, Losinski NE, Billestrup N, Price J, Vale W 1989 Adenohypophysial changes in mice transgenic for human growth hormone-releasing factor: a histological, immunocytochemical, and electron microscopic investigation. Endocrinology 125:2710-2718 (Pubitemid 19279463)
    • (1989) Endocrinology , vol.125 , Issue.5 , pp. 2710-2718
    • Stefaneanu, L.1    Kovacs, K.2    Horvath, E.3    Asa, S.L.4    Losinski, N.E.5    Billestrup, N.6    Price, J.7    Vale, W.8
  • 17
    • 0026764938 scopus 로고
    • Morphologic effects of hGRH gene expression on the pituitary, liver, and pancreas of MT-hGRH transgenic mice. An in situ hybridization analysis
    • Lloyd RV, Jin L, Chang A, Kulig E, Camper SA, Ross BD, Downs TR, Frohman LA 1992 Morphologic effects of hGRH gene expression on the pituitary, liver, and pancreas of MT-hGRH transgenic mice. An in situ hybridization analysis. Am J Pathol 141:895-906
    • (1992) Am J Pathol , vol.141 , pp. 895-906
    • Lloyd, R.V.1    Jin, L.2    Chang, A.3    Kulig, E.4    Camper, S.A.5    Ross, B.D.6    Downs, T.R.7    Frohman, L.A.8
  • 18
    • 0034864264 scopus 로고    scopus 로고
    • The effect of GHRH on somatotrope hyperplasia and tumor formation in the presence and absence of GH signaling
    • DOI 10.1210/en.142.9.3764
    • Kineman RD, Teixeira LT, Amargo GV, Coschigano KT, Kopchick JJ, Frohman LA 2001 The effect of GHRH on somatotrope hyperplasia and tumor formation in the presence and absence of GH signaling. Endocrinology 142:3764-3773 (Pubitemid 32802647)
    • (2001) Endocrinology , vol.142 , Issue.9 , pp. 3764-3773
    • Kineman, R.D.1    Teixeira, L.T.2    Amargo, G.V.3    Coschigano, K.T.4    Kopchick, J.J.5    Frohman, L.A.6
  • 19
    • 0034611474 scopus 로고    scopus 로고
    • P27(Kip1)-deficient mice exhibit accelerated growth hormone-releasing hormone (GHRH)-induced somatotrope proliferation and adenoma formation
    • Teixeira LT, Kiyokawa H, Peng X-D, Christov KT, Frohman LA, Kineman RD 2000 p27(Kip1)-deficient mice exhibit accelerated growth hormone-releasing hormone-induced somatotrope proliferation and adenoma formation. Oncogene 19:1875-1884 (Pubitemid 30219030)
    • (2000) Oncogene , vol.19 , Issue.15 , pp. 1875-1884
    • Teixeira, L.T.1    Kiyokawa, H.2    Peng, X.D.3    Christov, K.T.4    Frohman, L.A.5    Kineman, R.D.6
  • 20
    • 0035816377 scopus 로고    scopus 로고
    • Impairment in motor learning of somatostatin null mutant mice
    • DOI 10.1016/S0006-8993(01)02563-X, PII S000689930102563X
    • Zeyda T, Diehl N, Paylor R, Brennan MB, Hochgeschwender U 2001 Impairment in motor learning of somatostatin null mutant mice. Brain Res 906:107-117 (Pubitemid 32595544)
    • (2001) Brain Research , vol.906 , Issue.1-2 , pp. 107-114
    • Zeyda, T.1    Diehl, N.2    Paylor, R.3    Brennan, M.B.4    Hochgeschwender, U.5
  • 21
    • 36348999264 scopus 로고    scopus 로고
    • Gender-dependent role of endogenous somatostatin in regulating growth hormone-axis function in mice
    • DOI 10.1210/en.2007-0946
    • Luque RM, Kineman RD 2007 Gender-dependent role of endogenous somatostatin in regulating growth hormone (GH)-axis function in mice. Endocrinology 148:5998-6006 (Pubitemid 350146151)
    • (2007) Endocrinology , vol.148 , Issue.12 , pp. 5998-6006
    • Luque, R.M.1    Kineman, R.D.2
  • 23
    • 33745840485 scopus 로고    scopus 로고
    • Evidence that endogenous somatostatin (SST) inhibits adrenocorticotropin (ACTH) and ghrelin expression by independent pathways
    • Luque RM, Gahete MD, Hochgeschwender U, Kineman RD 2006 Evidence that endogenous somatostatin (SST) inhibits adrenocorticotropin (ACTH) and ghrelin expression by independent pathways. Am J Physiol Endocrinol Metab 291:E395-E403
    • (2006) Am J Physiol Endocrinol Metab , vol.291
    • Luque, R.M.1    Gahete, M.D.2    Hochgeschwender, U.3    Kineman, R.D.4
  • 24
    • 0033305064 scopus 로고    scopus 로고
    • Growth hormone-releasing hormone (GHRH) and the growth hormone secretagogue (GHS), L692,585, differentially modulate rat pituitary GHS receptor (GHS-R) and GHRH receptor (GHRH-R) mRNA levels
    • Kineman RD, Kamegai J, Frohman LA 1999 Growth hormone-releasing hormone (GHRH) and the growth hormone secretagogue (GHS), L692,585, differentially modulate rat pituitary GHS receptor (GHS-R) and GHRH receptor (GHRH-R) mRNA levels. Endocrinology 140:3581-3586
    • (1999) Endocrinology , vol.140 , pp. 3581-3586
    • Kineman, R.D.1    Kamegai, J.2    Frohman, L.A.3
  • 25
    • 0037129827 scopus 로고    scopus 로고
    • Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes
    • research0034
    • Vandesompele J, De Preter K, Pattyn F, Poppe B, Van Roy N, De Paepe A, Speleman F 2002 Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biology 3:research0034
    • (2002) Genome Biology , vol.3
    • Vandesompele, J.1    De Preter, K.2    Pattyn, F.3    Poppe, B.4    Van Roy, N.5    De Paepe, A.6    Speleman, F.7
  • 27
    • 0033054344 scopus 로고    scopus 로고
    • Increased MEN1 mRNA expression in sporadic pituitary tumours
    • DOI 10.1046/j.1365-2265.1999.00739.x
    • McCabe CJ, Gittoes NJL, Sheppard MC, Franklyn JA 1999 Increased MEN1 mRNA expression in sporadic pituitary tumors. Clin Endocrinol (Oxf) 50:727-733 (Pubitemid 29284506)
    • (1999) Clinical Endocrinology , vol.50 , Issue.6 , pp. 727-733
    • McCabe, C.J.1    Gittoes, N.J.L.2    Sheppard, M.C.3    Franklyn, J.A.4
  • 28
    • 33750070645 scopus 로고    scopus 로고
    • Growth hormone-secreting tumors: Genetic aspects and data from animal models
    • DOI 10.1159/000095525
    • Lytras A, Tolis G 2006 Growth hormone-secreting tumors: genetic aspects and data from animal models. Neuroendocrinology 83:166-178 (Pubitemid 44578869)
    • (2006) Neuroendocrinology , vol.83 , Issue.3-4 , pp. 166-178
    • Lytras, A.1    Tolis, G.2
  • 29
    • 0035090038 scopus 로고    scopus 로고
    • The growth hormone (GH)-axis of GH receptor/binding protein gene-disrupted and metallothionein-human GH-releasing hormone transgenic mice: Hypothalamic neuropeptide and pituitary receptor expression in the absence and presence of GH feedback
    • DOI 10.1210/en.142.3.1117
    • Peng X-D, Park S, Gadelha MR, Coschigano KT, Kopchick JJ, Frohman LA, Kineman RD 2001 The growth hormone (GH)-axis of GH receptor/binding protein gene-disrupted and metallothionein-human GH-releasing hormone transgenic mice: hypothalamic neuropeptide and pituitary receptor expression in the absence and presence of GH feedback. Endocrinology 142:1117-1123 (Pubitemid 32202821)
    • (2001) Endocrinology , vol.142 , Issue.3 , pp. 1117-1123
    • Peng, X.-D.1    Park, S.2    Gadelha, M.R.3    Coschigano, K.T.4    Kopchick, J.J.5    Frohman, L.A.6    Kineman, R.D.7
  • 31
    • 0032917809 scopus 로고    scopus 로고
    • Significance of growth hormone-releasing hormone receptor mRNA in non-neoplastic pituitary and pituitary adenomas: A study by RT-PCR and in situ hybridization
    • DOI 10.1023/A:1006151001536
    • Oka H, Kameya T, Sato Y, Naritaka H, Kawano N 1999 Significance of growth hormone-releasing hormone receptor mRNA in non-neoplastic pituitary and pituitary adenomas: a study by RT-PCR and in situ hybridization. J Neurooncol 41:197-204 (Pubitemid 29209807)
    • (1999) Journal of Neuro-Oncology , vol.41 , Issue.3 , pp. 197-204
    • Oka, H.1    Kameya, T.2    Sato, Y.3    Naritaka, H.4    Kawano, N.5
  • 32
    • 0031754596 scopus 로고    scopus 로고
    • Constitutively active Gsα is associated with an increased phosphodiesterase activity in human growth hormone-secreting adenomas
    • DOI 10.1210/jc.83.5.1624
    • Lania A, Persani L, Ballaré E, Mantovani S, Losa M, Spada A 1998 Constitutively active Gsα is associated with an increased phosphodiesterase activity in human growth hormone-secreting adenomas. J Clin Endocrinol Metab 83:1624-1628 (Pubitemid 28501033)
    • (1998) Journal of Clinical Endocrinology and Metabolism , vol.83 , Issue.5 , pp. 1624-1628
    • Lania, A.1    Persani, L.2    Ballare, E.3    Mantovani, S.4    Losa, M.5    Spada, A.6
  • 33
    • 0031005019 scopus 로고    scopus 로고
    • Somatostatin acts by inhibiting the cyclic 3′, 5′-adenosine monophosphate (cAMP)/protein kinase A pathway, cAMP response element-binding protein (CREB) phosphorylation, and CREB transcription potency
    • Tentler JJ, Hadcock JR, Gutierrez-Hartmann A 1998 Somatostatin acts by inhibiting the cyclic 3′, 5′-adenosine monophosphate (cAMP)/protein kinase A pathway, cAMP response element-binding protein (CREB) phosphorylation, and CREB transcription potency. Mol Endocrinol 11:859-866
    • (1998) Mol Endocrinol , vol.11 , pp. 859-866
    • Tentler, J.J.1    Hadcock, J.R.2    Gutierrez-Hartmann, A.3
  • 35
    • 0020593740 scopus 로고
    • Stimulation of adenosine 3′,5′-monophosphate production by growth hormone-releasing factor and its inhibition by somatostatin in anterior pituitary cells in vitro
    • Bilezikjian LM, Vale WW 1983 Stimulation of adenosine 3′,5′-monophosphate production by growth hormone-releasing factor and its inhibition by somatostatin in anterior pituitary cells in vitro. Endocrinology 113:1726-1731
    • (1983) Endocrinology , vol.113 , pp. 1726-1731
    • Bilezikjian, L.M.1    Vale, W.W.2
  • 37
    • 15944427116 scopus 로고    scopus 로고
    • Clinical review: The antitumoral effects of somatostatin analog therapy in acromegaly
    • DOI 10.1210/jc.2004-1093
    • Bevan JS, Melmed S 2005 The antitumoral effects of somatostatin analog therapy in acromegaly. J Clin Endocrinol Metab 90:1856-1863 (Pubitemid 40464061)
    • (2005) Journal of Clinical Endocrinology and Metabolism , vol.90 , Issue.3 , pp. 1856-1863
    • Bevan, J.S.1
  • 39
    • 52949103344 scopus 로고    scopus 로고
    • Cell growth inhibition and functioning of human somatostatin receptor type 2 are modulated by receptor heterodimerization
    • Grant M, Alturaihi H, Jaquet P, Collier B, Kumar U 2008 Cell growth inhibition and functioning of human somatostatin receptor type 2 are modulated by receptor heterodimerization. Mol Endocrinol 22:2278-2292
    • (2008) Mol Endocrinol , vol.22 , pp. 2278-2292
    • Grant, M.1    Alturaihi, H.2    Jaquet, P.3    Collier, B.4    Kumar, U.5
  • 40
    • 0028823431 scopus 로고
    • Expression of mRNA for somatostatin receptor (sstr) types 2 and 5 in individual rat pituitary cells. A double labeling in situ hybridization analysis
    • Day R, Dong W, Panetta R, Kracier J, Greenwood MT, Patel YC 1995 Expression of mRNA for somatostatin receptor (sstr) types 2 and 5 in individual rat pituitary cells. A double labeling in situ hybridization analysis. Endocrinology 136:5232-5235
    • (1995) Endocrinology , vol.136 , pp. 5232-5235
    • Day, R.1    Dong, W.2    Panetta, R.3    Kracier, J.4    Greenwood, M.T.5    Patel, Y.C.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.