메뉴 건너뛰기




Volumn 12, Issue 12, 2011, Pages 1729-1740

Single and combined IL28B, ITPA and SLC28A3 host genetic markers modulating response to anti-hepatitis C therapy

Author keywords

hepatitis C; IL28B; ITPA; peginterferon; pharmacogenomics; ribavirin; SLC28A3; therapy success

Indexed keywords

GAMMA INTERFERON; NUCLEOSIDE; PEGINTERFERON ALPHA; RIBAVIRIN;

EID: 82255196200     PISSN: 14622416     EISSN: 17448042     Source Type: Journal    
DOI: 10.2217/pgs.11.99     Document Type: Article
Times cited : (11)

References (93)
  • 1
    • 78751508078 scopus 로고    scopus 로고
    • Hepatitis C pharmacogenetics: State of the art in 2010
    • Afdhal NH, McHutchison JG, Zeuzem S et al. Hepatitis C pharmacogenetics: state of the art in 2010. Hepatology 53 (1), 336-345 (2011).
    • (2011) Hepatology , vol.53 , Issue.1 , pp. 336-345
    • Afdhal, N.H.1    McHutchison, J.G.2    Zeuzem, S.3
  • 3
    • 70349548852 scopus 로고    scopus 로고
    • IL28B is associated with response to chronic hepatitis C interferon-a and ribavirin therapy
    • Suppiah V, Moldovan M, Ahlenstiel G et al. IL28B is associated with response to chronic hepatitis C interferon-a and ribavirin therapy. Nat. Genet. 41 (10), 1100-1104 (2009).
    • (2009) Nat. Genet. , vol.41 , Issue.10 , pp. 1100-1104
    • Suppiah, V.1    Moldovan, M.2    Ahlenstiel, G.3
  • 4
    • 70349966196 scopus 로고    scopus 로고
    • Genetic variation in IL28B and spontaneous clearance of hepatitis C virus
    • Thomas DL, Thio CL, Martin MP et al. Genetic variation in IL28B and spontaneous clearance of hepatitis C virus. Nature 461 (7265), 798-801 (2009).
    • (2009) Nature , vol.461 , Issue.7265 , pp. 798-801
    • Thomas, D.L.1    Thio, C.L.2    Martin, M.P.3
  • 5
    • 70349533037 scopus 로고    scopus 로고
    • Genome-wide association of IL28B with response to pegylated interferon-a and ribavirin therapy for chronic hepatitis C
    • Tanaka Y, Nishida N, Sugiyama M et al. Genome-wide association of IL28B with response to pegylated interferon-a and ribavirin therapy for chronic hepatitis C. Nat. Genet. 41 (10), 1105-1109 (2009).
    • (2009) Nat. Genet. , vol.41 , Issue.10 , pp. 1105-1109
    • Tanaka, Y.1    Nishida, N.2    Sugiyama, M.3
  • 6
    • 70349292099 scopus 로고    scopus 로고
    • Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance
    • Ge D, Fellay J, Thompson AJ et al. Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance. Nature 461 (7262), 399-401 (2009).
    • (2009) Nature , vol.461 , Issue.7262 , pp. 399-401
    • Ge, D.1    Fellay, J.2    Thompson, A.J.3
  • 7
    • 77954407332 scopus 로고    scopus 로고
    • Genomewide association studies and assessment of the risk of disease
    • Manolio TA. Genomewide association studies and assessment of the risk of disease. N. Engl. J. Med. 363 (2), 166-176 (2010).
    • (2010) N. Engl. J. Med. , vol.363 , Issue.2 , pp. 166-176
    • Manolio, T.A.1
  • 8
    • 67149095078 scopus 로고    scopus 로고
    • Designing genome-wide association studies: Sample size, power, imputation, and the choice of genotyping chip
    • Spencer CC, Su Z, Donnelly P, Marchini J. Designing genome-wide association studies: sample size, power, imputation, and the choice of genotyping chip. PLoS Genet. 5 (5), e1000477 (2009).
    • (2009) PLoS Genet. , vol.5 , Issue.5
    • Spencer, C.C.1    Su, Z.2    Donnelly, P.3    Marchini, J.4
  • 9
    • 68849124573 scopus 로고    scopus 로고
    • Interferon-l: The modulators of antivirus, antitumor, and immune responses
    • Li M, Liu X, Zhou Y, Su SB. Interferon-l: the modulators of antivirus, antitumor, and immune responses. J. Leukoc. Biol. 86 (1), 23-32 (2009).
    • (2009) J. Leukoc. Biol. , vol.86 , Issue.1 , pp. 23-32
    • Li, M.1    Liu, X.2    Zhou, Y.3    Su, S.B.4
  • 10
    • 0036829649 scopus 로고    scopus 로고
    • NIH: National Institutes of Health Consensus Development Conference Statement
    • NIH: National Institutes of Health Consensus Development Conference Statement. Management of hepatitis C. Hepatology 36 (5 Suppl. 1), S3-S20 (2002).
    • (2002) Management of Hepatitis C. Hepatology , vol.36 , Issue.5 SUPPL. 1
  • 11
    • 77958614232 scopus 로고    scopus 로고
    • Hepatitis C treatment: Current and future perspectives
    • Munir S, Saleem S, Idrees M et al. Hepatitis C treatment: current and future perspectives. Virol. J. 7, 296 (2010).
    • (2010) Virol. J. , vol.7 , pp. 296
    • Munir, S.1    Saleem, S.2    Idrees, M.3
  • 12
    • 77952268322 scopus 로고    scopus 로고
    • Development of novel therapies for hepatitis C
    • Lemon SM, McKeating JA, Pietschmann T et al. Development of novel therapies for hepatitis C. Antiviral. Res. 86 (1), 79-92 (2010).
    • (2010) Antiviral. Res. , vol.86 , Issue.1 , pp. 79-92
    • Lemon, S.M.1    McKeating, J.A.2    Pietschmann, T.3
  • 13
    • 0035379753 scopus 로고    scopus 로고
    • Cloning, expression, and characterization of a human inosine triphosphate pyrophosphatase encoded by the itpa gene
    • Lin S, McLennan AG, Ying K et al. Cloning, expression, and characterization of a human inosine triphosphate pyrophosphatase encoded by the itpa gene. J. Biol. Chem. 276 (22), 18695-18701 (2001).
    • (2001) J. Biol. Chem. , vol.276 , Issue.22 , pp. 18695-18701
    • Lin, S.1    McLennan, A.G.2    Ying, K.3
  • 14
    • 77949773445 scopus 로고    scopus 로고
    • ITPA gene variants protect against anaemia in patients treated for chronic hepatitis C
    • Fellay J, Thompson AJ, Ge D et al. ITPA gene variants protect against anaemia in patients treated for chronic hepatitis C. Nature 464 (7287), 405-408 (2010).
    • (2010) Nature , vol.464 , Issue.7287 , pp. 405-408
    • Fellay, J.1    Thompson, A.J.2    Ge, D.3
  • 15
    • 0036830454 scopus 로고    scopus 로고
    • Side effects of therapy of hepatitis C and their management
    • DOI 10.1053/jhep.2002.36810
    • Fried MW. Side effects of therapy of hepatitis C and their management. Hepatology 36 (5Suppl. 1), S237-S244 (2002). (Pubitemid 35253486)
    • (2002) Hepatology , vol.36 , Issue.5
    • Fried, M.W.1
  • 16
    • 33750571888 scopus 로고    scopus 로고
    • Ribavirin-induced anemia: Mechanisms, risk factors and related targets for future research
    • DOI 10.2174/092986706778773059
    • Russmann S, Grattagliano I, Portincasa P, PalmieriVO, Palasciano G. Ribavirin-induced anemia: mechanisms, risk factors and related targets for future research. Curr. Med. Chem. 13 (27), 3351-3357 (2006). (Pubitemid 44669779)
    • (2006) Current Medicinal Chemistry , vol.13 , Issue.27 , pp. 3351-3357
    • Russmann, S.1    Grattagliano, I.2    Portincasa, P.3    Palmieri, V.O.4    Palasciano, G.5
  • 17
    • 0037179698 scopus 로고    scopus 로고
    • Peginterferon a-2a plus ribavirin for chronic hepatitis C virus infection
    • Fried MW, Shiffman ML, Reddy KR et al. Peginterferon a-2a plus ribavirin for chronic hepatitis C virus infection. N. Engl. J. Med. 347 (13), 975-982 (2002).
    • (2002) N. Engl. J. Med. , vol.347 , Issue.13 , pp. 975-982
    • Fried, M.W.1    Shiffman, M.L.2    Reddy, K.R.3
  • 18
    • 1542378867 scopus 로고    scopus 로고
    • Peginterferon-a2a and ribavirin combination therapy in chronic hepatitis C: A randomized study of treatment duration and ribavirin dose
    • Hadziyannis SJ, Sette H Jr, Morgan TR et al. Peginterferon-a2a and ribavirin combination therapy in chronic hepatitis C: a randomized study of treatment duration and ribavirin dose. Ann. Intern. Med. 140 (5), 346-355 (2004).
    • (2004) Ann. Intern. Med. , vol.140 , Issue.5 , pp. 346-355
    • Hadziyannis, S.J.1    Sette Jr., H.2    Morgan, T.R.3
  • 19
    • 65449171953 scopus 로고    scopus 로고
    • Telaprevir and peginterferon with or without ribavirin for chronic HCV infection
    • Hezode C, Forestier N, Dusheiko G et al. Telaprevir and peginterferon with or without ribavirin for chronic HCV infection. N. Engl. J. Med. 360 (18), 1839-1850 (2009).
    • (2009) N. Engl. J. Med. , vol.360 , Issue.18 , pp. 1839-1850
    • Hezode, C.1    Forestier, N.2    Dusheiko, G.3
  • 20
    • 79955482297 scopus 로고    scopus 로고
    • Role of nucleoside transporters SLC28A2/3 and SLC29A1/2 genetics in ribavirin therapy: Protection against anemia in patients with chronic hepatitis C
    • Doehring A, Hofmann WP, Schlecker C et al. Role of nucleoside transporters SLC28A2/3 and SLC29A1/2 genetics in ribavirin therapy: protection against anemia in patients with chronic hepatitis C. Pharmacogenet. Genomics 21 (5), 289-296 (2011).
    • (2011) Pharmacogenet. Genomics , vol.21 , Issue.5 , pp. 289-296
    • Doehring, A.1    Hofmann, W.P.2    Schlecker, C.3
  • 21
    • 0035951808 scopus 로고    scopus 로고
    • +-nucleoside cotransporter proteins (hCNT3 and mCNT3) broadly selective for purine and pyrimidine nucleosides (system cib)
    • Ritzel MW, Ng AM, Yao SY et al. Molecular identification and characterization of novel human and mouse concentrative Na+-nucleoside cotransporter proteins (hCNT3 and mCNT3) broadly selective for purine and pyrimidine nucleosides (system cib). J. Biol. Chem. 276 (4), 2914-2927 (2001).
    • (2001) J. Biol. Chem. , vol.276 , Issue.4 , pp. 2914-2927
    • Ritzel, M.W.1    Ng, A.M.2    Yao, S.Y.3
  • 22
    • 57749199462 scopus 로고    scopus 로고
    • The consequence of concomitantly present functional genetic variants for the identification of functional genotype-phenotype associations in pain
    • Lötsch J, Flühr K, Neddermayer T, Doehring A, Geisslinger G. The consequence of concomitantly present functional genetic variants for the identification of functional genotype-phenotype associations in pain. Clin. Pharmacol. Ther. 85 (1), 25-30 (2009).
    • (2009) Clin. Pharmacol. Ther. , vol.85 , Issue.1 , pp. 25-30
    • Lötsch, J.1    Flühr, K.2    Neddermayer, T.3    Doehring, A.4    Geisslinger, G.5
  • 25
    • 34248148471 scopus 로고    scopus 로고
    • Effect of interferon-lambda on replication of hepatitis B virus in human hepatoma cells
    • DOI 10.1016/j.virusres.2007.03.006, PII S0168170207000949
    • Hong SH, Cho O, Kim K, Shin HJ, Kotenko SV, Park S. Effect of interferon-l on replication of hepatitis B virus in human hepatoma cells. Virus Res. 126 (1-2), 245-249 (2007). (Pubitemid 46726717)
    • (2007) Virus Research , vol.126 , Issue.1-2 , pp. 245-249
    • Hong, S.-H.1    Cho, O.2    Kim, K.3    Shin, H.-J.4    Kotenko, S.V.5    Park, S.6
  • 26
    • 33845605155 scopus 로고    scopus 로고
    • Interferons α and λ Inhibit Hepatitis C Virus Replication With Distinct Signal Transduction and Gene Regulation Kinetics
    • DOI 10.1053/j.gastro.2006.09.052, PII S0016508506022207
    • Marcello T, Grakoui A, Barba-Spaeth G et al. Interferons a and l inhibit hepatitis C virus replication with distinct signal transduction and gene regulation kinetics. Gastroenterology 131 (6), 1887-1898 (2006). (Pubitemid 44958521)
    • (2006) Gastroenterology , vol.131 , Issue.6 , pp. 1887-1898
    • Marcello, T.1    Grakoui, A.2    Barba-Spaeth, G.3    Machlin, E.S.4    Kotenko, S.V.5    Macdonald, M.R.6    Rice, C.M.7
  • 27
    • 14744276042 scopus 로고    scopus 로고
    • Lambda interferon inhibits hepatitis B and C virus replication
    • DOI 10.1128/JVI.79.6.3851-3854.2005
    • Robek MD, Boyd BS, Chisari FV. l interferon inhibits hepatitis B and C virus replication. J. Virol. 79 (6), 3851-3854 (2005). (Pubitemid 40327973)
    • (2005) Journal of Virology , vol.79 , Issue.6 , pp. 3851-3854
    • Robek, M.D.1    Boyd, B.S.2    Chisari, F.V.3
  • 29
    • 77949831342 scopus 로고    scopus 로고
    • Genetic variation in IL28B is associated with chronic hepatitis C and treatment failure: A genome-wide association study
    • 1345.e1-e7
    • Rauch A, Kutalik Z, Descombes P et al. Genetic variation in IL28B is associated with chronic hepatitis C and treatment failure: a genome-wide association study. Gastroenterology 138 (4), 1338-1345, 1345.e1-e7 (2010).
    • (2010) Gastroenterology , vol.138 , Issue.4 , pp. 1338-1345
    • Rauch, A.1    Kutalik, Z.2    Descombes, P.3
  • 30
    • 79955040564 scopus 로고    scopus 로고
    • Innate immune genes synergize to predict increased risk of chronic disease in hepatitis C virus infection
    • Dring MM, Morrison MH, McSharry BP et al. Innate immune genes synergize to predict increased risk of chronic disease in hepatitis C virus infection. Proc. Natl Acad. Sci. USA 108 (14), 5736-5741 (2011).
    • (2011) Proc. Natl Acad. Sci. USA , vol.108 , Issue.14 , pp. 5736-5741
    • Dring, M.M.1    Morrison, M.H.2    McSharry, B.P.3
  • 31
    • 77951880384 scopus 로고    scopus 로고
    • Association of a single nucleotide polymorphism near the interleukin-28B gene with response to hepatitis C therapy in HIV/hepatitis C virus-coinfected patients
    • Rallon NI, Naggie S, Benito JM et al. Association of a single nucleotide polymorphism near the interleukin-28B gene with response to hepatitis C therapy in HIV/hepatitis C virus-coinfected patients. AIDS 24 (8), F23-F29 (2010).
    • (2010) AIDS , vol.24 , Issue.8
    • Rallon, N.I.1    Naggie, S.2    Benito, J.M.3
  • 32
    • 79960452181 scopus 로고    scopus 로고
    • Impact of donor and recipient IL28B rs12979860 genotypes on hepatitis C virus liver graft reinfection
    • Lange CM, Moradpour D, Doehring A et al. Impact of donor and recipient IL28B rs12979860 genotypes on hepatitis C virus liver graft reinfection. J. Hepatol. 55 (2), 322-327 (2010).
    • (2010) J. Hepatol. , vol.55 , Issue.2 , pp. 322-327
    • Lange, C.M.1    Moradpour, D.2    Doehring, A.3
  • 33
    • 79953731812 scopus 로고    scopus 로고
    • Association between IL28B gene polymorphisms and plasma HCV-RNA levels in HIV/HCV-co-infected patients
    • Labarga P, Soriano V, Caruz A et al. Association between IL28B gene polymorphisms and plasma HCV-RNA levels in HIV/HCV-co-infected patients. AIDS 25 (6), 761-766 (2011).
    • (2011) AIDS , vol.25 , Issue.6 , pp. 761-766
    • Labarga, P.1    Soriano, V.2    Caruz, A.3
  • 34
    • 79952214262 scopus 로고    scopus 로고
    • IL28B genetic variation and treatment response in patients with hepatitis C virus genotype 3 infection
    • Moghaddam A, Melum E, Reinton N et al. IL28B genetic variation and treatment response in patients with hepatitis C virus genotype 3 infection. Hepatology 53 (3), 746-754 (2011).
    • (2011) Hepatology , vol.53 , Issue.3 , pp. 746-754
    • Moghaddam, A.1    Melum, E.2    Reinton, N.3
  • 35
    • 79951679619 scopus 로고    scopus 로고
    • Importance of IL28B gene polymorphisms in hepatitis C virus genotype 2 and 3 infected patients
    • Sarrazin C, Susser S, Doehring A et al. Importance of IL28B gene polymorphisms in hepatitis C virus genotype 2 and 3 infected patients. J. Hepatol. 54 (3), 415-421 (2011).
    • (2011) J. Hepatol. , vol.54 , Issue.3 , pp. 415-421
    • Sarrazin, C.1    Susser, S.2    Doehring, A.3
  • 36
    • 77955475888 scopus 로고    scopus 로고
    • Hepatic ISG expression is associated with genetic variation in interleukin 28B and the outcome of IFN therapy for chronic hepatitis C
    • Honda M, Sakai A, Yamashita T et al. Hepatic ISG expression is associated with genetic variation in interleukin 28B and the outcome of IFN therapy for chronic hepatitis C. Gastroenterology 139 (2), 499-509 (2010).
    • (2010) Gastroenterology , vol.139 , Issue.2 , pp. 499-509
    • Honda, M.1    Sakai, A.2    Yamashita, T.3
  • 38
    • 79952304368 scopus 로고    scopus 로고
    • IL28B polymorphism is associated with both side effects and clearance of hepatitis C during interferon-A therapy
    • doi:10.1089/jir.2010.0074 Epub ahead of print
    • Lotrich FE, Loftis JM, Ferrell RE, Rabinovitz M, Hauser P. IL28B polymorphism is associated with both side effects and clearance of hepatitis C during interferon-A therapy. J. Interferon Cytokine Res. doi:10.1089/jir.2010. 0074 (2010) (Epub ahead of print).
    • (2010) J. Interferon Cytokine Res.
    • Lotrich, F.E.1    Loftis, J.M.2    Ferrell, R.E.3    Rabinovitz, M.4    Hauser, P.5
  • 39
    • 0025236704 scopus 로고
    • The metabolism of ribavirin in erythrocytes and nucleated cells
    • DOI 10.1016/0020-711X(90)90140-X
    • Page T, Connor JD. The metabolism of ribavirin in erythrocytes and nucleated cells. Int. J. Biochem. 22 (4), 379-383 (1990). (Pubitemid 20158850)
    • (1990) International Journal of Biochemistry , vol.22 , Issue.4 , pp. 379-383
    • Page, T.1    Connor, J.D.2
  • 41
    • 66149132168 scopus 로고    scopus 로고
    • Reduced ribavirin antiviral efficacy via nucleoside transporter-mediated drug resistance
    • Ibarra KD, Pfeiffer JK. Reduced ribavirin antiviral efficacy via nucleoside transporter-mediated drug resistance. J. Virol. 83 (9), 4538-4547 (2009).
    • (2009) J. Virol. , vol.83 , Issue.9 , pp. 4538-4547
    • Ibarra, K.D.1    Pfeiffer, J.K.2
  • 42
    • 53449102537 scopus 로고    scopus 로고
    • Expression and hepatobiliary transport characteristics of the concentrative and equilibrative nucleoside transporters in sandwich-cultured human hepatocytes
    • Govindarajan R, Endres CJ, Whittington D et al. Expression and hepatobiliary transport characteristics of the concentrative and equilibrative nucleoside transporters in sandwich-cultured human hepatocytes. Am. J. Physiol. Gastrointest. Liver Physiol. 295 (3), G570-G580 (2008).
    • (2008) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.295 , Issue.3
    • Govindarajan, R.1    Endres, C.J.2    Whittington, D.3
  • 43
    • 79953208979 scopus 로고    scopus 로고
    • Inosine triphosphate protects against ribavirin-induced adenosine triphosphate loss by restoring adenylosuccinate synthase function
    • Hitomi Y, Cirulli ET, Fellay J et al. Inosine triphosphate protects against ribavirin-induced adenosine triphosphate loss by restoring adenylosuccinate synthase function. Gastroenterology 140 (4), 1314-1321 (2011).
    • (2011) Gastroenterology , vol.140 , Issue.4 , pp. 1314-1321
    • Hitomi, Y.1    Cirulli, E.T.2    Fellay, J.3
  • 45
    • 77957326039 scopus 로고    scopus 로고
    • Variants in the ITPA gene protect against ribavirin-induced hemolytic anemia and decrease the need for ribavirin dose reduction
    • Thompson AJ, Fellay J, Patel K et al. Variants in the ITPA gene protect against ribavirin-induced hemolytic anemia and decrease the need for ribavirin dose reduction. Gastroenterology 139 (4), 1181-1189 (2010).
    • (2010) Gastroenterology , vol.139 , Issue.4 , pp. 1181-1189
    • Thompson, A.J.1    Fellay, J.2    Patel, K.3
  • 46
    • 77958609097 scopus 로고    scopus 로고
    • ITPA gene variant protects against anemia induced by pegylated interferon-a and ribavirin therapy for Japanese patients with chronic hepatitis C
    • Sakamoto N, Tanaka Y, Nakagawa M et al. ITPA gene variant protects against anemia induced by pegylated interferon-a and ribavirin therapy for Japanese patients with chronic hepatitis C. Hepatol. Res. 40 (11), 1063-1071 (2010).
    • (2010) Hepatol. Res. , vol.40 , Issue.11 , pp. 1063-1071
    • Sakamoto, N.1    Tanaka, Y.2    Nakagawa, M.3
  • 47
    • 79251518906 scopus 로고    scopus 로고
    • Inosine triphosphatase genetic variants are protective against anemia during antiviral therapy for HCV2/3 but do not decrease dose reductions of RBV or increase SVR
    • Thompson AJ, Santoro R, Piazzolla V et al. Inosine triphosphatase genetic variants are protective against anemia during antiviral therapy for HCV2/3 but do not decrease dose reductions of RBV or increase SVR. Hepatology 53 (2), 389-395 (2011).
    • (2011) Hepatology , vol.53 , Issue.2 , pp. 389-395
    • Thompson, A.J.1    Santoro, R.2    Piazzolla, V.3
  • 48
    • 79961038504 scopus 로고    scopus 로고
    • HCV-GenoFibrotest: A combination of viral, liver and genomic (IL28b, ITPA, UGT1A1) biomarkers for predicting treatment response in patients with chronic hepatitis C
    • Costa JM, Telehin D, Munteanu M et al. HCV-GenoFibrotest: a combination of viral, liver and genomic (IL28b, ITPA, UGT1A1) biomarkers for predicting treatment response in patients with chronic hepatitis C. Clin. Res. Hepatol. Gastroenterol. 35 (3), 204-213 (2011).
    • (2011) Clin. Res. Hepatol. Gastroenterol. , vol.35 , Issue.3 , pp. 204-213
    • Costa, J.M.1    Telehin, D.2    Munteanu, M.3
  • 49
    • 79954585482 scopus 로고    scopus 로고
    • Common genetic polymorphism of ITPA gene affects ribavirin-induced anemia and effect of peg-interferon plus ribavirin therapy
    • Azakami T, Hayes CN, Sezaki H et al. Common genetic polymorphism of ITPA gene affects ribavirin-induced anemia and effect of peg-interferon plus ribavirin therapy. J. Med. Virol. 83 (6), 1048-1057 (2011).
    • (2011) J. Med. Virol. , vol.83 , Issue.6 , pp. 1048-1057
    • Azakami, T.1    Hayes, C.N.2    Sezaki, H.3
  • 50
    • 77957346513 scopus 로고    scopus 로고
    • ITPA polymorphism affects ribavirin-induced anemia and outcomes of therapy-a genome-wide study of Japanese HCV virus patients
    • Ochi H, Maekawa T, Abe H et al. ITPA polymorphism affects ribavirin-induced anemia and outcomes of therapy-a genome-wide study of Japanese HCV virus patients. Gastroenterology 139 (4), 1190-1197 (2010).
    • (2010) Gastroenterology , vol.139 , Issue.4 , pp. 1190-1197
    • Ochi, H.1    Maekawa, T.2    Abe, H.3
  • 51
    • 79151483121 scopus 로고    scopus 로고
    • Influence of ITPA polymorphisms on decreases of hemoglobin during treatment with pegylated interferon, ribavirin, and telaprevir
    • Suzuki F, Suzuki Y, Akuta N et al. Influence of ITPA polymorphisms on decreases of hemoglobin during treatment with pegylated interferon, ribavirin, and telaprevir. Hepatology 53 (2), 415-421 (2011).
    • (2011) Hepatology , vol.53 , Issue.2 , pp. 415-421
    • Suzuki, F.1    Suzuki, Y.2    Akuta, N.3
  • 52
    • 75149151884 scopus 로고    scopus 로고
    • Resistance to direct antiviral agents in patients with hepatitis C virus infection
    • Sarrazin C, Zeuzem S. Resistance to direct antiviral agents in patients with hepatitis C virus infection. Gastroenterology 138 (2), 447-462 (2010).
    • (2010) Gastroenterology , vol.138 , Issue.2 , pp. 447-462
    • Sarrazin, C.1    Zeuzem, S.2
  • 53
    • 19444370232 scopus 로고    scopus 로고
    • Assessing the quality of case-control association studies on the genetic basis of sepsis
    • DOI 10.1097/01.PCC.0000161572.12676.91
    • Vitali SH, Randolph AG. Assessing the quality of case-control association studies on the genetic basis of sepsis. Pediatr. Crit. Care Med. 6 (Suppl. 3), S74-S77 (2005). (Pubitemid 40724256)
    • (2005) Pediatric Critical Care Medicine , vol.6 , Issue.SUPPL.
    • Vitali, S.H.1    Randolph, A.G.2
  • 56
    • 69349100176 scopus 로고    scopus 로고
    • Functional study of the P32T ITPA variant associated with drug sensitivity in humans
    • Stepchenkova EI, Tarakhovskaya ER, Spitler K et al. Functional study of the P32T ITPA variant associated with drug sensitivity in humans. J. Mol. Biol. 392 (3), 602-613 (2009).
    • (2009) J. Mol. Biol. , vol.392 , Issue.3 , pp. 602-613
    • Stepchenkova, E.I.1    Tarakhovskaya, E.R.2    Spitler, K.3
  • 57
    • 7044274525 scopus 로고    scopus 로고
    • Rapid detection of ITPA 94C>A and IVS2 + 21A>C gene mutations by real-time fluorescence PCR and in vitro demonstration of effect of ITPA IVS2 + 21A>C polymorphism on splicing efficiency
    • DOI 10.1373/clinchem.2004.039685
    • Heller T, Oellerich M, Armstrong VW, von Ahsen N. Rapid detection of ITPA 94C〉A and IVS2 + 21A〉C gene mutations by real-time fluorescence PCR and invitro demonstration of effect of ITPA IVS2 + 21A〉C polymorphism on splicing efficiency. Clin. Chem. 50 (11), 2182-2184 (2004). (Pubitemid 39425868)
    • (2004) Clinical Chemistry , vol.50 , Issue.11 , pp. 2182-2184
    • Heller, T.1    Oellerich, M.2    Armstrong, V.W.3    Von Ahsen, N.4
  • 58
    • 78649608515 scopus 로고    scopus 로고
    • IL28B genotype is associated with differential expression of intrahepatic interferon-stimulated genes in patients with chronic hepatitis C
    • Urban TJ, Thompson AJ, Bradrick SS et al. IL28B genotype is associated with differential expression of intrahepatic interferon-stimulated genes in patients with chronic hepatitis C. Hepatology 52 (6), 1888-1896 (2010).
    • (2010) Hepatology , vol.52 , Issue.6 , pp. 1888-1896
    • Urban, T.J.1    Thompson, A.J.2    Bradrick, S.S.3
  • 59
    • 68949117721 scopus 로고    scopus 로고
    • Variants in interferon-a pathway genes and response to pegylated interferon-A2a plus ribavirin for treatment of chronic hepatitis C virus infection in the hepatitis C antiviral long-term treatment against cirrhosis trial
    • Welzel TM, Morgan TR, Bonkovsky HL et al. Variants in interferon-a pathway genes and response to pegylated interferon-A2a plus ribavirin for treatment of chronic hepatitis C virus infection in the hepatitis C antiviral long-term treatment against cirrhosis trial. Hepatology 49 (6), 1847-1858 (2009).
    • (2009) Hepatology , vol.49 , Issue.6 , pp. 1847-1858
    • Welzel, T.M.1    Morgan, T.R.2    Bonkovsky, H.L.3
  • 60
    • 38649096600 scopus 로고    scopus 로고
    • Mechanisms of action of interferon and ribavirin in chronic hepatitis C: Summary of a workshop
    • DOI 10.1002/hep.22070
    • Chung RT, Gale M Jr, Polyak SJ et al. Mechanisms of action of interferon and ribavirin in chronic hepatitis C: summary of a workshop. Hepatology 47 (1), 306-320 (2008). (Pubitemid 351171068)
    • (2008) Hepatology , vol.47 , Issue.1 , pp. 306-320
    • Chung, R.T.1    Gale Jr., M.2    Polyak, S.J.3    Lemon, S.M.4    Liang, T.J.5    Hoofnagle, J.H.6
  • 64
    • 0033824231 scopus 로고    scopus 로고
    • Identification of a single nucleotide polymorphism in the MxA gene promoter (G/T at nt-88) correlated with the response of hepatitis C patients to interferon
    • Hijikata M, Ohta Y, Mishiro S. Identification of a single nucleotide polymorphism in the MxA gene promoter (G/T at nt-88) correlated with the response of hepatitis C patients to interferon. Intervirology 43 (2), 124-127 (2000).
    • (2000) Intervirology , vol.43 , Issue.2 , pp. 124-127
    • Hijikata, M.1    Ohta, Y.2    Mishiro, S.3
  • 65
    • 0032769836 scopus 로고    scopus 로고
    • Interleukin-10 promoter polymorphism predicts initial response of chronic hepatitis C to interferon alfa
    • DOI 10.1002/hep.510300207
    • Edwards-Smith CJ, Jonsson JR, Purdie DM, Bansal A, Shorthouse C, Powell EE. Interleukin-10 promoter polymorphism predicts initial response of chronic hepatitis C to interferon a. Hepatology 30 (2), 526-530 (1999). (Pubitemid 29357520)
    • (1999) Hepatology , vol.30 , Issue.2 , pp. 526-530
    • Edwards-Smith, C.J.1    Jonsson, J.R.2    Purdie, D.M.3    Bansal, A.4    Shorthouse, C.5    Powell, E.E.6
  • 66
    • 85081150878 scopus 로고    scopus 로고
    • Apolipoprotein E4 allele is associated with poor treatment response in hepatitis C virus (HCV) genotype 1
    • author reply 1593
    • Mueller T, Gessner R, Sarrazin C et al. Apolipoprotein E4 allele is associated with poor treatment response in hepatitis C virus (HCV) genotype 1. Hepatology (Letter) 38 (6), 1592, author reply 1593 (2003).
    • (2003) Hepatology (Letter) , vol.38 , Issue.6 , pp. 1592
    • Mueller, T.1    Gessner, R.2    Sarrazin, C.3
  • 68
    • 37049251476 scopus 로고
    • Mendelian proportions in a mixed population
    • Hardy GH. Mendelian proportions in a mixed population. Science 28, 49-50 (1908).
    • (1908) Science , vol.28 , pp. 49-50
    • Hardy, G.H.1
  • 69
    • 77955691994 scopus 로고    scopus 로고
    • Amino acid substitution in hepatitis C virus core region and genetic variation near the interleukin 28B gene predict viral response to telaprevir with peginterferon and ribavirin
    • Akuta N, Suzuki F, Hirakawa M et al. Amino acid substitution in hepatitis C virus core region and genetic variation near the interleukin 28B gene predict viral response to telaprevir with peginterferon and ribavirin. Hepatology 52 (2), 421-429 (2010).
    • (2010) Hepatology , vol.52 , Issue.2 , pp. 421-429
    • Akuta, N.1    Suzuki, F.2    Hirakawa, M.3
  • 70
    • 79960720423 scopus 로고    scopus 로고
    • Telaprevir substantially improved SVR rates across all IL28B genotypes in the advance trial
    • Jacobson IM, Catlett I, Marcellin P et al. Telaprevir substantially improved SVR rates across all IL28B genotypes in the advance trial. J. Hepatol. 54, S542-S543 (2011).
    • (2011) J. Hepatol. , vol.54
    • Jacobson, I.M.1    Catlett, I.2    Marcellin, P.3
  • 71
    • 79960447952 scopus 로고    scopus 로고
    • Similar SVR rates in IL28B CC CT or TT prior relapser partial-or null-responder patients treated with telaprevir/peginterferon/ribavirin: Retrospective analysis of the realize study
    • Pol S, Aerssens J, Zeuzem S et al. Similar SVR rates in IL28B CC, CT or TT prior relapser partial-or null-responder patients treated with telaprevir/peginterferon/ribavirin: retrospective analysis of the realize study. J. Hepatol. 54, S6-S7 (2011).
    • (2011) J. Hepatol. , vol.54
    • Pol, S.1    Aerssens, J.2    Zeuzem, S.3
  • 72
    • 79960449077 scopus 로고    scopus 로고
    • IL28B polymorphism predicts virologic response in patients with hepatitis C genotype 1 treated with boceprevir (boc) combination therapy
    • Poordad F, Bronowicki JP, Gordon SC et al. IL28B polymorphism predicts virologic response in patients with hepatitis C genotype 1 treated with boceprevir (boc) combination therapy. J. Hepatol. 54, S6 (2011).
    • (2011) J. Hepatol. , vol.54
    • Poordad, F.1    Bronowicki, J.P.2    Gordon, S.C.3
  • 73
    • 79952712673 scopus 로고    scopus 로고
    • Association of IL28B variants with response to pegylated-interferon a plus ribavirin combination therapy reveals intersubgenotypic differences between genotypes 2a and 2b
    • Sakamoto N, Nakagawa M, Tanaka Y et al. Association of IL28B variants with response to pegylated-interferon a plus ribavirin combination therapy reveals intersubgenotypic differences between genotypes 2a and 2b. J. Med. Virol. 83 (5), 871-878 (2011).
    • (2011) J. Med. Virol. , vol.83 , Issue.5 , pp. 871-878
    • Sakamoto, N.1    Nakagawa, M.2    Tanaka, Y.3
  • 74
    • 79957982710 scopus 로고    scopus 로고
    • IL28B genetic variations are associated with high sustained virological response (SVR) of interferon-a plus ribavirin therapy in Taiwanese chronic HCV infection
    • Chen JY, Lin CY, Wang CM et al. IL28B genetic variations are associated with high sustained virological response (SVR) of interferon-a plus ribavirin therapy in Taiwanese chronic HCV infection. Genes Immun. 12 (4), 300-309 (2011).
    • (2011) Genes Immun. , vol.12 , Issue.4 , pp. 300-309
    • Chen, J.Y.1    Lin, C.Y.2    Wang, C.M.3
  • 75
    • 84983723339 scopus 로고    scopus 로고
    • Association of IL28B gene variations with mathematical modeling of viral kinetics in chronic hepatitis C patients with IFN plus ribavirin therapy
    • Hsu CS, Hsu SJ, Chen HC et al. Association of IL28B gene variations with mathematical modeling of viral kinetics in chronic hepatitis C patients with IFN plus ribavirin therapy. Proc. Natl Acad. Sci. USA 108 (9), 3719-3724 (2011).
    • (2011) Proc. Natl Acad. Sci. USA , vol.108 , Issue.9 , pp. 3719-3724
    • Hsu, C.S.1    Hsu, S.J.2    Chen, H.C.3
  • 76
    • 79751511058 scopus 로고    scopus 로고
    • Genetic variation in IL28B and treatment-induced clearance of hepatitis C virus in HIV-positive patients with acute and chronic hepatitis C
    • Nattermann J, Vogel M, Nischalke HD et al. Genetic variation in IL28B and treatment-induced clearance of hepatitis C virus in HIV-positive patients with acute and chronic hepatitis C. J. Infect. Dis. 203 (5), 595-601 (2011).
    • (2011) J. Infect. Dis. , vol.203 , Issue.5 , pp. 595-601
    • Nattermann, J.1    Vogel, M.2    Nischalke, H.D.3
  • 77
    • 78751505015 scopus 로고    scopus 로고
    • Interleukin-28B polymorphisms are associated with histological recurrence and treatment response following liver transplantation in patients with hepatitis C virus infection
    • Charlton MR, Thompson A, Veldt BJ et al. Interleukin-28B polymorphisms are associated with histological recurrence and treatment response following liver transplantation in patients with hepatitis C virus infection. Hepatology 53 (1), 317-324 (2011).
    • (2011) Hepatology , vol.53 , Issue.1 , pp. 317-324
    • Charlton, M.R.1    Thompson, A.2    Veldt, B.J.3
  • 78
    • 78751492246 scopus 로고    scopus 로고
    • Quantitation of pretreatment serum interferon-g-inducible protein-10 improves the predictive value of an IL28B gene polymorphism for hepatitis C treatment response
    • Darling JM, Aerssens J, Fanning G et al. Quantitation of pretreatment serum interferon-g-inducible protein-10 improves the predictive value of an IL28B gene polymorphism for hepatitis C treatment response. Hepatology 53 (1), 14-22 (2011).
    • (2011) Hepatology , vol.53 , Issue.1 , pp. 14-22
    • Darling, J.M.1    Aerssens, J.2    Fanning, G.3
  • 79
    • 78649320722 scopus 로고    scopus 로고
    • Role of interleukin-28B polymorphisms in the treatment of hepatitis C virus genotype 2 infection in Asian patients
    • Yu ML, Huang CF, Huang JF et al. Role of interleukin-28B polymorphisms in the treatment of hepatitis C virus genotype 2 infection in Asian patients. Hepatology 53 (1), 7-13 (2011).
    • (2011) Hepatology , vol.53 , Issue.1 , pp. 7-13
    • Yu, M.L.1    Huang, C.F.2    Huang, J.F.3
  • 80
    • 78650971350 scopus 로고    scopus 로고
    • Screening for IL28B gene variants identifies predictors of hepatitis C therapy success
    • Doehring A, Hofmann WP, Schlecker C et al. Screening for IL28B gene variants identifies predictors of hepatitis C therapy success. Antivir. Ther. 15 (8), 1099-1106 (2010).
    • (2010) Antivir. Ther. , vol.15 , Issue.8 , pp. 1099-1106
    • Doehring, A.1    Hofmann, W.P.2    Schlecker, C.3
  • 81
    • 79953856071 scopus 로고    scopus 로고
    • Early virologic response and IL28B polymorphisms in patients with chronic hepatitis C genotype 3 treated with peginterferon a-2a and ribavirin
    • Scherzer TM, Hofer H, Staettermayer AF et al. Early virologic response and IL28B polymorphisms in patients with chronic hepatitis C genotype 3 treated with peginterferon a-2a and ribavirin. J. Hepatol. 54 (5), 866-871 (2011).
    • (2011) J. Hepatol. , vol.54 , Issue.5 , pp. 866-871
    • Scherzer, T.M.1    Hofer, H.2    Staettermayer, A.F.3
  • 82
    • 79952305174 scopus 로고    scopus 로고
    • Interferon-induced gene expression is a stronger predictor of treatment response than IL28B genotype in patients with hepatitis C
    • Dill MT, Duong FH, Vogt JE et al. Interferon-induced gene expression is a stronger predictor of treatment response than IL28B genotype in patients with hepatitis C. Gastroenterology 140 (3), 1021-1031 (2011).
    • (2011) Gastroenterology , vol.140 , Issue.3 , pp. 1021-1031
    • Dill, M.T.1    Duong, F.H.2    Vogt, J.E.3
  • 83
    • 79952655262 scopus 로고    scopus 로고
    • Interleukin-28B polymorphisms are associated with hepatitis C virus clearance and viral load in a HIV-1-infected cohort
    • Clausen LN, Weis N, Astvad K et al. Interleukin-28B polymorphisms are associated with hepatitis C virus clearance and viral load in a HIV-1-infected cohort. J. Viral Hepat. 18 (4), e66-e74 (2011).
    • (2011) J. Viral Hepat. , vol.18 , Issue.4
    • Clausen, L.N.1    Weis, N.2    Astvad, K.3
  • 84
    • 78651107054 scopus 로고    scopus 로고
    • HCV substitutions and IL28B polymorphisms on outcome of peg-interferon plus ribavirin combination therapy
    • Hayes CN, Kobayashi M, Akuta N et al. HCV substitutions and IL28B polymorphisms on outcome of peg-interferon plus ribavirin combination therapy. Gut 60 (2), 261-267 (2011).
    • (2011) Gut , vol.60 , Issue.2 , pp. 261-267
    • Hayes, C.N.1    Kobayashi, M.2    Akuta, N.3
  • 85
    • 78349296832 scopus 로고    scopus 로고
    • Modeling the probability of sustained virological response to therapy with pegylated interferon plus ribavirin in patients coinfected with hepatitis C virus and HIV
    • Medrano J, Neukam K, Rallon N et al. Modeling the probability of sustained virological response to therapy with pegylated interferon plus ribavirin in patients coinfected with hepatitis C virus and HIV. Clin. Infect. Dis. 51 (10), 1209-1216 (2010).
    • (2010) Clin. Infect. Dis. , vol.51 , Issue.10 , pp. 1209-1216
    • Medrano, J.1    Neukam, K.2    Rallon, N.3
  • 86
    • 77957825574 scopus 로고    scopus 로고
    • Prediction of response to pegylated interferon plus ribavirin by IL28B gene variation in patients coinfected with HIV and hepatitis C virus
    • Pineda JA, Caruz A, Rivero A et al. Prediction of response to pegylated interferon plus ribavirin by IL28B gene variation in patients coinfected with HIV and hepatitis C virus. Clin. Infect. Dis. 51 (7), 788-795 (2010).
    • (2010) Clin. Infect. Dis. , vol.51 , Issue.7 , pp. 788-795
    • Pineda, J.A.1    Caruz, A.2    Rivero, A.3
  • 87
    • 77957965687 scopus 로고    scopus 로고
    • Potential role for interleukin-28B genotype in treatment decision-making in recent hepatitis C virus infection
    • Grebely J, Petoumenos K, Hellard M et al. Potential role for interleukin-28B genotype in treatment decision-making in recent hepatitis C virus infection. Hepatology 52 (4), 1216-1224 (2010).
    • (2010) Hepatology , vol.52 , Issue.4 , pp. 1216-1224
    • Grebely, J.1    Petoumenos, K.2    Hellard, M.3
  • 88
    • 79952899824 scopus 로고    scopus 로고
    • Impact of IL28B genotype on the early and sustained virologic response in treatment-naive patients with chronic hepatitis C
    • Stattermayer AF, Stauber R, Hofer H et al. Impact of IL28B genotype on the early and sustained virologic response in treatment-naive patients with chronic hepatitis C. Clin. Gastroenterol. Hepatol. 9 (4), 344-350.e2 (2011).
    • (2011) Clin. Gastroenterol. Hepatol. , vol.9 , Issue.4
    • Stattermayer, A.F.1    Stauber, R.2    Hofer, H.3
  • 89
    • 78049470128 scopus 로고    scopus 로고
    • Variants in IL28B in liver recipients and donors correlate with response to peg-interferon and ribavirin therapy for recurrent hepatitis C
    • 1585e1-1585e3
    • Fukuhara T, Taketomi A, Motomura T et al. Variants in IL28B in liver recipients and donors correlate with response to peg-interferon and ribavirin therapy for recurrent hepatitis C. Gastroenterology 139 (5), 1577-1585, 1585.e1-e3 (2010).
    • (2010) Gastroenterology , vol.139 , Issue.5 , pp. 1577-1585
    • Fukuhara, T.1    Taketomi, A.2    Motomura, T.3
  • 90
    • 78049469161 scopus 로고    scopus 로고
    • A polymorphism near IL28B is associated with spontaneous clearance of acute hepatitis C virus and jaundice
    • 1592.e1
    • Tillmann HL, Thompson AJ, Patel K et al. A polymorphism near IL28B is associated with spontaneous clearance of acute hepatitis C virus and jaundice. Gastroenterology 139 (5), 1586-1592, 1592.e1 (2010).
    • (2010) Gastroenterology , vol.139 , Issue.5 , pp. 1586-1592
    • Tillmann, H.L.1    Thompson, A.J.2    Patel, K.3
  • 91
    • 84925580987 scopus 로고    scopus 로고
    • An IL28B polymorphism determines treatment response of hepatitis C virus genotype 2 or 3 patients who do not achieve a rapid virologic response
    • 827.e1
    • Mangia A, Thompson AJ, Santoro R et al. An IL28B polymorphism determines treatment response of hepatitis C virus genotype 2 or 3 patients who do not achieve a rapid virologic response. Gastroenterology 139 (3), 821-827, 827.e1 (2010).
    • (2010) Gastroenterology , vol.139 , Issue.3 , pp. 821-827
    • Mangia, A.1    Thompson, A.J.2    Santoro, R.3
  • 92
    • 77952693487 scopus 로고    scopus 로고
    • Replicated association between an IL28B gene variant and a sustained response to pegylated interferon and ribavirin
    • McCarthy JJ, Li JH, Thompson A et al. Replicated association between an IL28B gene variant and a sustained response to pegylated interferon and ribavirin. Gastroenterology 138 (7), 2307-2314 (2010).
    • (2010) Gastroenterology , vol.138 , Issue.7 , pp. 2307-2314
    • McCarthy, J.J.1    Li, J.H.2    Thompson, A.3
  • 93
    • 0033987736 scopus 로고    scopus 로고
    • Mutation nomenclature extensions and suggestions to describe complex mutations: A discussion
    • DOI 10.1002/(SICI)1098-1004(200001)15:1<7::AID-HUMU4>3.0.CO;2-N
    • den Dunnen JT, Antonarakis SE. Mutation nomenclature extensions and suggestions to describe complex mutations: a discussion. Hum. Mutat. 15 (1), 7-12 (2000). (Pubitemid 30036162)
    • (2000) Human Mutation , vol.15 , Issue.1 , pp. 7-12
    • Den Dunnen, J.T.1    Antonarakis, S.E.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.