메뉴 건너뛰기




Volumn 12, Issue 4, 2011, Pages 300-309

IL28B genetic variations are associated with high sustained virological response (SVR) of interferon-α plus ribavirin therapy in Taiwanese chronic HCV infection

Author keywords

hepatitis C; IL28B; single nucleotide polymorphisms; sustained virological response

Indexed keywords

INTERLEUKIN 28; PEGINTERFERON ALPHA2B; RIBAVIRIN;

EID: 79957982710     PISSN: 14664879     EISSN: 14765470     Source Type: Journal    
DOI: 10.1038/gene.2011.1     Document Type: Article
Times cited : (45)

References (60)
  • 1
    • 23944506014 scopus 로고    scopus 로고
    • Global epidemiology of hepatitis C virus infection
    • DOI 10.1016/S1473-3099(05)70216-4, PII S1473309905702164
    • Shepard CW, Finelli L, Alter M. Global epidemiology of hepatitis C virus infection. Lancet Infect Dis 2005; 5: 558-567. (Pubitemid 41196755)
    • (2005) Lancet Infectious Diseases , vol.5 , Issue.9 , pp. 558-567
    • Shepard, C.W.1    Finelli, L.2    Alter, M.J.3
  • 2
    • 0033023854 scopus 로고    scopus 로고
    • Persistence of viremia and the importance of long-term follow-up after acute hepatitis C infection
    • Villano SA, Vlahov D, Nelson KE, Cohn S, Thomas DL. Persistence of viremia and the importance of long-term follow-up after acute hepatitis C infection. Hepatology 1999; 29: 908-914. (Pubitemid 29109609)
    • (1999) Hepatology , vol.29 , Issue.3 , pp. 908-914
    • Villano, S.A.1    Vlahov, D.2    Nelson, K.E.3    Cohn, S.4    Thomas, D.L.5
  • 4
    • 18044395172 scopus 로고    scopus 로고
    • Is hepatitis C virus infection of dendritic cells a mechanism facilitating viral persistence?
    • DOI 10.1016/S1473-3099(05)70114-6
    • Pachiadakis I, Pollara G, Chain BM, Naoumov NV. Is hepatitis C virus infection of dendritic cells a mechanism facilitating viral persistence? Lancet Infect Dis 2005; 5: 296-304. (Pubitemid 40602249)
    • (2005) Lancet Infectious Diseases , vol.5 , Issue.5 , pp. 296-304
    • Pachiadakis, I.1    Pollara, G.2    Chain, B.M.3    Naoumov, N.V.4
  • 5
    • 33845284536 scopus 로고    scopus 로고
    • The changing epidemiology and natural history of hepatitis C virus infection
    • DOI 10.1016/j.cld.2006.08.003, PII S1089326106000183, Hepatitis C Virus Update
    • Bialek SR, Terrault NA. The changing epidemiology and natural history of hepatitis C virus infection. Clin Liver Dis 2006; 10: 697-715. (Pubitemid 44880154)
    • (2006) Clinics in Liver Disease , vol.10 , Issue.4 , pp. 697-715
    • Bialek, S.R.1    Terrault, N.A.2
  • 6
    • 0030933395 scopus 로고    scopus 로고
    • Natural history of liver fibrosis progression in patients with chronic hepatitis C
    • DOI 10.1016/S0140-6736(96)07642-8
    • Poynard T, Bedossa P, Opolon P. Natural history of liver fibrosis progression in patients with chronic hepatitis C. Lancet 1997; 349: 825-832. (Pubitemid 27129209)
    • (1997) Lancet , vol.349 , Issue.9055 , pp. 825-832
    • Poynard, T.1    Bedossa, P.2    Opolon, P.3
  • 7
    • 46749149199 scopus 로고    scopus 로고
    • Hepatitis C virus infection and hepatocellular carcinoma
    • DOI 10.1016/j.cld.2008.03.007, PII S1089326108000366
    • Blonski W, Reddy KR. Hepatitis C virus infection and hepatocellular carcinoma. Clin Liver Dis 2008; 12: 661-674. (Pubitemid 351952471)
    • (2008) Clinics in Liver Disease , vol.12 , Issue.3 , pp. 661-674
    • Blonski, W.1    Reddy, K.R.2
  • 8
    • 31344461659 scopus 로고    scopus 로고
    • Innate immune recognition of viral infection
    • DOI 10.1038/ni1303, PII N1303
    • Kawai T, Akira S. Innate immune recognition of viral infection. Nat Immunol 2006; 7: 131-137. (Pubitemid 43135878)
    • (2006) Nature Immunology , vol.7 , Issue.2 , pp. 131-137
    • Kawai, T.1    Akira, S.2
  • 10
    • 33747040825 scopus 로고    scopus 로고
    • Pattern recognition receptors: A contemporary view on liver diseases
    • DOI 10.1002/hep.21308
    • Szabo G, Dolganiuc A, Mandrekar P. Pattern recognition receptors: a contemporary view on liver diseases. Hepatology 2006; 44: 287-298. (Pubitemid 44214866)
    • (2006) Hepatology , vol.44 , Issue.2 , pp. 287-298
    • Szabo, G.1    Dolganiuc, A.2    Mandrekar, P.3
  • 11
    • 47949092573 scopus 로고    scopus 로고
    • Innate immunity induced by composition-dependent RIG-I recognition of hepatitis C virus RNA
    • Saito T, Owen DM, Jiang F, Marcotrigiano J, Gale Jr M. Innate immunity induced by composition-dependent RIG-I recognition of hepatitis C virus RNA. Nature 2008; 454: 523-527.
    • (2008) Nature , vol.454 , pp. 523-527
    • Saito, T.1    Owen, D.M.2    Jiang, F.3    Marcotrigiano, J.4    Gale Jr., M.5
  • 12
    • 35348850088 scopus 로고    scopus 로고
    • Innate immunity in hepatitis C virus infection: Interplay among dendritic cells, natural killer cells and natural killer T cells
    • DOI 10.1111/j.1872-034X.2007.00236.x
    • Kanto T, Hayashi N. Innate immunity in hepatitis C virus infection: Interplay among dendritic cells, natural killer cells and natural killer T cells. Hepatol Res 2007; 37 (Suppl 3): S319-S326. (Pubitemid 47570639)
    • (2007) Hepatology Research , vol.37 , Issue.SUPPL. 3
    • Kanto, T.1    Hayashi, N.2
  • 13
    • 1542350630 scopus 로고    scopus 로고
    • NIH consensus statement on management of hepatitis C
    • National Institute of Health U.S.A
    • National Institute of Health U.S.A. NIH consensus statement on management of hepatitis C. NIH Consens State Sci Statements 2002; 19: 1-46.
    • (2002) NIH Consens State Sci Statements , vol.19 , pp. 1-46
  • 16
    • 32644490562 scopus 로고    scopus 로고
    • A target on the move: Innate and adaptive immune escape strategies of hepatitis C virus
    • DOI 10.1016/j.antiviral.2005.12.001, PII S0166354205002603
    • Thimme R, Lohmann V, Weber F. A target on the move: innate and adaptive immune escape strategies of hepatitis C virus. Antiviral Res 2006; 69: 129-141. (Pubitemid 43247333)
    • (2006) Antiviral Research , vol.69 , Issue.3 , pp. 129-141
    • Thimme, R.1    Lohmann, V.2    Weber, F.3
  • 17
    • 17644382994 scopus 로고    scopus 로고
    • Role of viral and host factors in HCV persistence: Which lesson for therapeutic and preventive strategies?
    • DOI 10.1016/j.dld.2004.07.004, PII S1590865804002932
    • Missale G, Cariani E, Ferrari C. Role of viral and host factors in HCV persistence: which lesson for therapeutic and preventive strategies? Dig Liver Dis 2004; 36: 703-711. (Pubitemid 41070589)
    • (2004) Digestive and Liver Disease , vol.36 , Issue.11 , pp. 703-711
    • Missale, G.1    Cariani, E.2    Ferrari, C.3
  • 18
    • 46749128497 scopus 로고    scopus 로고
    • Hepatitis C and innate immunity: Recent advances
    • DOI 10.1016/j.cld.2008.03.003, PII S1089326108000408
    • Szabo G, Dolganiuc A. Hepatitis C and innate immunity: recent advances. Clin Liver Dis 2008; 12: 675-692. (Pubitemid 351952475)
    • (2008) Clinics in Liver Disease , vol.12 , Issue.3 , pp. 675-692
    • Szabo, G.1    Dolganiuc, A.2
  • 19
    • 68849111675 scopus 로고    scopus 로고
    • Hepatitis C virus versus innate and adaptive immune responses: A tale of coevolution and coexistence
    • Rehermann B. Hepatitis C virus versus innate and adaptive immune responses: a tale of coevolution and coexistence. J Clin Invest 2009; 119: 1745-1754.
    • (2009) J Clin Invest , vol.119 , pp. 1745-1754
    • Rehermann, B.1
  • 21
    • 68849124573 scopus 로고    scopus 로고
    • Interferon-lambdas: The modulators of antivirus, antitumor, and immune responses
    • Li M, Liu X, Zhou Y, Su SB. Interferon-lambdas: the modulators of antivirus, antitumor, and immune responses. J Leukoc Biol 2009; 86: 23-32.
    • (2009) J Leukoc Biol , vol.86 , pp. 23-32
    • Li, M.1    Liu, X.2    Zhou, Y.3    Su, S.B.4
  • 22
    • 1642370060 scopus 로고    scopus 로고
    • Viral infection and toll-like receptor agonists induce a differential expression of type I and λ interferons in humans plasmacytoid and monocyte-derived dendritic cells
    • DOI 10.1002/eji.200324610
    • Coccia EM, Severa M, Giacomini E, Monneron D, Remoli ME, Julkunen I et al. Viral infection and Toll-like receptor agonists induce a differential expression of type I and lambda interferons in human plasmacytoid and monocyte-derived dendritic cells. Eur J Immunol 2004; 34: 796-805. (Pubitemid 39255927)
    • (2004) European Journal of Immunology , vol.34 , Issue.3 , pp. 796-805
    • Coccia, E.M.1    Severa, M.2    Giacomini, E.3    Monneron, D.4    Remoli, M.E.5    Julkunen, I.6    Cella, M.7    Lande, R.8    Uze, G.9
  • 23
    • 33646185492 scopus 로고    scopus 로고
    • Lambda interferon (IFN-lambda), a type III IFN, is induced by viruses and IFNs and displays potent antiviral activity against select virus infections in vivo
    • Ank N, West H, Bartholdy C, Thomsen AR, Paludan SR. Lambda interferon (IFN-lambda), a type III IFN, is induced by viruses and IFNs and displays potent antiviral activity against select virus infections in vivo. J Virol 2006; 80: 4501-4509.
    • (2006) J Virol , vol.80 , pp. 4501-4509
    • Ank, N.1    West, H.2    Bartholdy, C.3    Thomsen, A.R.4    Paludan, S.R.5
  • 24
    • 61849126356 scopus 로고    scopus 로고
    • Human interferon-lambda3 is a potent member of the type III interferon family
    • Dellgren C, Gad HH, Hamming OJ, Melchjorsen J, Hartmann R. Human interferon-lambda3 is a potent member of the type III interferon family. Genes Immun 2009; 10: 125-131.
    • (2009) Genes Immun , vol.10 , pp. 125-131
    • Dellgren, C.1    Gad, H.H.2    Hamming, O.J.3    Melchjorsen, J.4    Hartmann, R.5
  • 25
    • 70349292099 scopus 로고    scopus 로고
    • Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance
    • Ge D, Fellay J, Thompson AJ, Simon JS, Shianna KV, Urban TJ et al. Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance. Nature 2009; 461: 399-401.
    • (2009) Nature , vol.461 , pp. 399-401
    • Ge, D.1    Fellay, J.2    Thompson, A.J.3    Simon, J.S.4    Shianna, K.V.5    Urban, T.J.6
  • 26
    • 70349548852 scopus 로고    scopus 로고
    • IL28B is associated with response to chronic hepatitis C interferon-alpha and ribavirin therapy
    • Suppiah V, Moldovan M, Ahlenstiel G, Berg T, Weltman M, Abate ML et al. IL28B is associated with response to chronic hepatitis C interferon-alpha and ribavirin therapy. Nat Genet 2009; 41: 1100-1104.
    • (2009) Nat Genet , vol.41 , pp. 1100-1104
    • Suppiah, V.1    Moldovan, M.2    Ahlenstiel, G.3    Berg, T.4    Weltman, M.5    Abate, M.L.6
  • 27
    • 70349533037 scopus 로고    scopus 로고
    • Genome-wide association of IL28B with response to pegylated interferon-alpha and ribavirin therapy for chronic hepatitis C
    • Tanaka Y, Nishida N, Sugiyama M, Kurosaki M, Matsuura K, Sakamoto N et al. Genome-wide association of IL28B with response to pegylated interferon-alpha and ribavirin therapy for chronic hepatitis C. Nat Genet 2009; 10: 1105-1109.
    • (2009) Nat Genet , vol.10 , pp. 1105-1109
    • Tanaka, Y.1    Nishida, N.2    Sugiyama, M.3    Kurosaki, M.4    Matsuura, K.5    Sakamoto, N.6
  • 28
    • 77949831342 scopus 로고    scopus 로고
    • Genetic variation in IL28B is associated with chronic hepatitis C and treatment failure-A genome-wide association study
    • Rauch A, Kutalik Z, Descombes P, Cai T, Di Iulio J, Mueller T et al. Genetic variation in IL28B is associated with chronic hepatitis C and treatment failure-a genome-wide association study. Gastroenteroloy 2010; 138: 1338-1345.
    • (2010) Gastroenteroloy , vol.138 , pp. 1338-1345
    • Rauch, A.1    Kutalik, Z.2    Descombes, P.3    Cai, T.4    Di Iulio, J.5    Mueller, T.6
  • 29
    • 70349966196 scopus 로고    scopus 로고
    • Genetic variation in IL28B and spontaneous clearance of hepatitis C virus
    • Thomas DL, Thio CL, Martin MP, Qi Y, Ge D, O'Huigin C et al. Genetic variation in IL28B and spontaneous clearance of hepatitis C virus. Nature 2009; 461: 798-801.
    • (2009) Nature , vol.461 , pp. 798-801
    • Thomas, D.L.1    Thio, C.L.2    Martin, M.P.3    Qi, Y.4    Ge, D.5    O'Huigin, C.6
  • 31
    • 14944375587 scopus 로고    scopus 로고
    • Immunology of hepatitis B virus and hepatitis C virus infection
    • DOI 10.1038/nri1573
    • Rehermann B, Nascimbeni M. Immunology of hepatitis B virus and hepatitis C virus infection. Nature Rev Immunol 2005; 5: 215-229. (Pubitemid 40364823)
    • (2005) Nature Reviews Immunology , vol.5 , Issue.3 , pp. 215-229
    • Rehermann, B.1    Nascimbeni, M.2
  • 32
    • 23944485662 scopus 로고    scopus 로고
    • Evasion of intracellular host defence by hepatitis C virus
    • DOI 10.1038/nature04078
    • Gale Jr M, Foy EM. Evasion of intracellular host defense by hepatitis C virus. Nature 2005; 436: 939-945. (Pubitemid 41191669)
    • (2005) Nature , vol.436 , Issue.7053 , pp. 939-945
    • Gale Jr., M.1    Foy, E.M.2
  • 33
    • 53349099559 scopus 로고    scopus 로고
    • Immune responses in hepatitis C virus infection and mechanisms of hepatitis C virus persistence
    • Hiroishi K, Ito T, Imawari M. Immune responses in hepatitis C virus infection and mechanisms of hepatitis C virus persistence. J Gastroenterol Hepatol 2008; 23: 1473-1482.
    • (2008) J Gastroenterol Hepatol , vol.23 , pp. 1473-1482
    • Hiroishi, K.1    Ito, T.2    Imawari, M.3
  • 34
    • 68949110201 scopus 로고    scopus 로고
    • Interferon-lambda is functionally an interferon but structurally related to the interleukin-10 family
    • Gad HH, Dellgren C, Hamming OJ, Vends S, Paludan SR, Hartmann R. Interferon-lambda is functionally an interferon but structurally related to the interleukin-10 family. J Biol Chem 2009; 284: 20869-20875.
    • (2009) J Biol Chem , vol.284 , pp. 20869-20875
    • Gad, H.H.1    Dellgren, C.2    Hamming, O.J.3    Vends, S.4    Paludan, S.R.5    Hartmann, R.6
  • 35
    • 33845605155 scopus 로고    scopus 로고
    • Interferons α and λ Inhibit Hepatitis C Virus Replication With Distinct Signal Transduction and Gene Regulation Kinetics
    • DOI 10.1053/j.gastro.2006.09.052, PII S0016508506022207
    • Marcello T, Grakoui A, Barba-Spaeth G, Machlin ES, Kotenko SV, MacDonald MR et al. Interferons alpha and lambda inhibit hepatitis C virus replication with distinct signal transduction and gene regulation kinetics. Gastroenter-ology 2006; 131: 1887-1898. (Pubitemid 44958521)
    • (2006) Gastroenterology , vol.131 , Issue.6 , pp. 1887-1898
    • Marcello, T.1    Grakoui, A.2    Barba-Spaeth, G.3    Machlin, E.S.4    Kotenko, S.V.5    Macdonald, M.R.6    Rice, C.M.7
  • 36
    • 14744276042 scopus 로고    scopus 로고
    • Lambda interferon inhibits hepatitis B and C virus replication
    • DOI 10.1128/JVI.79.6.3851-3854.2005
    • Robek MD, Boyd BS, Chisari FV. Lambda interferon inhibits hepatitis B and C virus replication. J Virol 2005; 79: 3851-3854. (Pubitemid 40327973)
    • (2005) Journal of Virology , vol.79 , Issue.6 , pp. 3851-3854
    • Robek, M.D.1    Boyd, B.S.2    Chisari, F.V.3
  • 37
    • 33646265745 scopus 로고    scopus 로고
    • Novel type i interferon IL-28A suppresses hepatitis C viral RNA replication
    • Zhu H, Butera M, Nelson DR, Liu C. Novel type I interferon IL-28A suppresses hepatitis C viral RNA replication. Virol J 2005; 2: 80.
    • (2005) Virol J , vol.2 , pp. 80
    • Zhu, H.1    Butera, M.2    Nelson, D.R.3    Liu, C.4
  • 38
    • 57649148762 scopus 로고    scopus 로고
    • Interleukin-29 functions cooperatively with inter-feron to induce antiviral gene expression and inhibit hepatitis C virus replication
    • Pagliaccetti NE, Eduardo R, Kleinstein SH, Mu XJ, Bandi P, Robek MD. Interleukin-29 functions cooperatively with inter-feron to induce antiviral gene expression and inhibit hepatitis C virus replication. J Biol Chem 2008; 283: 30079-30089.
    • (2008) J Biol Chem , vol.283 , pp. 30079-30089
    • Pagliaccetti, N.E.1    Eduardo, R.2    Kleinstein, S.H.3    Mu, X.J.4    Bandi, P.5    Robek, M.D.6
  • 39
    • 42149152139 scopus 로고    scopus 로고
    • An important role for type III interferon (IFN-lambda/IL-28) in TLR-induced antiviral activity
    • Ank N, Iversen MB, Bartholdy C, Staeheli P, Hartmann R, Jensen UB et al. An important role for type III interferon (IFN-lambda/IL-28) in TLR-induced antiviral activity. J Immunol 2008; 180: 2474-2485.
    • (2008) J Immunol , vol.180 , pp. 2474-2485
    • Ank, N.1    Iversen, M.B.2    Bartholdy, C.3    Staeheli, P.4    Hartmann, R.5    Jensen, U.B.6
  • 43
    • 68949117721 scopus 로고    scopus 로고
    • Variants in interferon-alpha pathway genes and response to pegylated interferon-Alpha2a plus ribavirin for treatment of chronic hepatitis C virus infection in the hepatitis C antiviral long-term treatment against cirrhosis trial HALT-C Trial Group
    • Welzel TM, Morgan TR, Bonkovsky HL, Naishadham D, Pfeiffer RM, Wright EC et al. Variants in interferon-alpha pathway genes and response to pegylated interferon-Alpha2a plus ribavirin for treatment of chronic hepatitis C virus infection in the hepatitis C antiviral long-term treatment against cirrhosis trial. HALT-C Trial Group. Hepatology 2009; 49: 1847-1858.
    • (2009) Hepatology , vol.49 , pp. 1847-1858
    • Welzel, T.M.1    Morgan, T.R.2    Bonkovsky, H.L.3    Naishadham, D.4    Pfeiffer, R.M.5    Wright, E.C.6
  • 44
    • 46149096203 scopus 로고    scopus 로고
    • Association of single nucleotide polymorphisms in interferon signaling pathway genes and interferon-stimulated genes with the response to interferon therapy for chronic hepatitis C. Virahep-C Study Group
    • Su X, Yee LJ, Im K, Rhodes SL, Tang Y, Tong X et al. Association of single nucleotide polymorphisms in interferon signaling pathway genes and interferon-stimulated genes with the response to interferon therapy for chronic hepatitis C. Virahep-C Study Group. J Hepatol 2008; 49: 184-191.
    • (2008) J Hepatol , vol.49 , pp. 184-191
    • Su, X.1    Yee, L.J.2    Im, K.3    Rhodes, S.L.4    Tang, Y.5    Tong, X.6
  • 45
    • 76249129136 scopus 로고    scopus 로고
    • ISG15, a ubiquitin-like interferon-stimulated gene, promotes hepatitis C virus production in vitro: Implications for chronic infection and response to treatment
    • Chen L, Sun J, Meng L, Heathcote J, Edwards AM, McGilvray ID. ISG15, a ubiquitin-like interferon-stimulated gene, promotes hepatitis C virus production in vitro: implications for chronic infection and response to treatment. J Gen Virol 2010; 91: 382-388.
    • (2010) J Gen Virol , vol.91 , pp. 382-388
    • Chen, L.1    Sun, J.2    Meng, L.3    Heathcote, J.4    Edwards, A.M.5    McGilvray, I.D.6
  • 46
    • 47149116458 scopus 로고    scopus 로고
    • Hepatitis C virus-infected hepatocytes extrinsically modulate dendritic cell maturation to activate T cells and natural killer cells
    • DOI 10.1002/hep.22337
    • Ebihara T, Shingai M, Matsumoto M, Wakita T, Seya T. Hepatitis C virus-infected hepatocytes extrinsically modulate dendritic cell maturation to activate T cells and natural killer cells. Hepatology 2008; 48: 48-58. (Pubitemid 351975530)
    • (2008) Hepatology , vol.48 , Issue.1 , pp. 48-58
    • Ebihara, T.1    Shingai, M.2    Matsumoto, M.3    Wakita, T.4    Seya, T.5
  • 48
    • 73149093219 scopus 로고    scopus 로고
    • Modulation of human plasmacytoid DC function by IFN-\{lambda\} 1 (IL-29)
    • Megjugorac NJ, Gallagher GE, Gallagher G. Modulation of human plasmacytoid DC function by IFN-\{lambda\}1 (IL-29). J Leukoc Biol 2009; 86: 1359-1363.
    • (2009) J Leukoc Biol , vol.86 , pp. 1359-1363
    • Megjugorac, N.J.1    Gallagher, G.E.2    Gallagher, G.3
  • 50
    • 55449093555 scopus 로고    scopus 로고
    • Interferon-lambda1 (interleukin-29) preferentially down-regulates interleukin-13 over other T helper type 2 cytokine responses in vitro
    • Srinivas S, Dai J, Eskdale J, Gallagher GE, Megjugorac NJ, Gallagher G. Interferon-lambda1 (interleukin-29) preferentially down-regulates interleukin-13 over other T helper type 2 cytokine responses in vitro. Immunology 2008; 125: 492-502.
    • (2008) Immunology , vol.125 , pp. 492-502
    • Srinivas, S.1    Dai, J.2    Eskdale, J.3    Gallagher, G.E.4    Megjugorac, N.J.5    Gallagher, G.6
  • 51
    • 33744492302 scopus 로고    scopus 로고
    • Interferon-λ-treated dendritic cells specifically induce proliferation of FOXP3-expressing suppressor T cells
    • DOI 10.1182/blood-2005-10-4129
    • Mennechet FJ, Uzé G. Interferon-lambda-treated dendritic cells specifically induce proliferation of FOXP3-expressing suppressor T cells. Blood 2006; 107: 4417-4423. (Pubitemid 43801368)
    • (2006) Blood , vol.107 , Issue.11 , pp. 4417-4423
    • Mennechet, F.J.D.1    Uze, G.2
  • 52
    • 67651115867 scopus 로고    scopus 로고
    • Comparative ability of IL-12 and IL-28B to regulate Treg populations and enhance adaptive cellular immunity
    • Morrow MP, Pankhong P, Laddy DJ, Schoenly KA, Yan J, Cisper N et al. Comparative ability of IL-12 and IL-28B to regulate Treg populations and enhance adaptive cellular immunity. Blood 2009; 113: 5868-5877.
    • (2009) Blood , vol.113 , pp. 5868-5877
    • Morrow, M.P.1    Pankhong, P.2    Laddy, D.J.3    Schoenly, K.A.4    Yan, J.5    Cisper, N.6
  • 54
    • 42949160129 scopus 로고    scopus 로고
    • IFN-lambda (IFN-lambda) is expressed in a tissue-dependent fashion and primarily acts on epithelial cells in vivo
    • Sommereyns C, Paul S, Staeheli P, Michiels T. IFN-lambda (IFN-lambda) is expressed in a tissue-dependent fashion and primarily acts on epithelial cells in vivo. PLoS Pathog 2008; 4: e1000017.
    • (2008) PLoS Pathog , vol.4
    • Sommereyns, C.1    Paul, S.2    Staeheli, P.3    Michiels, T.4
  • 55
    • 2542590982 scopus 로고    scopus 로고
    • Peginterferon alfa-2a (40 kd) and ribavirin for Black American patients with chronic HCV genotype 1
    • DOI 10.1002/hep.20212
    • Jeffers LJ, Cassidy W, Howell CD, Hu S, Reddy KR. Peginterferon alfa-2a (40 kd) and ribavirin for black American patients with chronic HCV genotype 1. Hepatology 2004; 39: 1702-1708. (Pubitemid 38702672)
    • (2004) Hepatology , vol.39 , Issue.6 , pp. 1702-1708
    • Jeffers, L.J.1    Cassidy, W.2    Howell, C.D.3    Hu, S.4    Reddy, K.R.5
  • 56
    • 2442665224 scopus 로고    scopus 로고
    • Peginterferon alfa-2b and ribavirin for the treatment of chronic hepatitis C in blacks and non-Hispanic whites
    • DOI 10.1056/NEJMoa032502
    • Muir AJ, Bornstein JD, Killenberg PG. Peginterferon alfa-2b and ribavirin for the treatment of chronic hepatitis C in blacks and non-Hispanic whites. N Engl J Med 2004; 350: 2265-2271. (Pubitemid 38669209)
    • (2004) New England Journal of Medicine , vol.350 , Issue.22 , pp. 2265-2271
    • Muir, A.J.1    Bornstein, J.D.2    Killenberg, P.G.3
  • 58
    • 84984562129 scopus 로고    scopus 로고
    • Pegylated interferon-alpha-2a plus ribavirin for treatment-nä?ve Asian patients with hepatitis C virus genotype 1 infection: A multicenter, randomized controlled trial
    • Liu CH, Liu CJ, Lin CL, Liang CC, Hsu SJ, Yang SS et al. Pegylated interferon-alpha-2a plus ribavirin for treatment-nä?ve Asian patients with hepatitis C virus genotype 1 infection: a multicenter, randomized controlled trial. Clin Infect Dis 2008; 47: 1260-1269.
    • (2008) Clin Infect Dis , vol.47 , pp. 1260-1269
    • Liu, C.H.1    Liu, C.J.2    Lin, C.L.3    Liang, C.C.4    Hsu, S.J.5    Yang, S.S.6
  • 59
    • 75349095069 scopus 로고    scopus 로고
    • Prolonged PEG-IFN and RBV is effective in patients with HCV genotype 1 and high viral load who achieved virological response later than 24 weeks
    • Ueda T, Chung H, Kudo M, Kitai S, Ishikawa E, Yada N et al. Prolonged PEG-IFN and RBV is effective in patients with HCV genotype 1 and high viral load who achieved virological response later than 24 weeks. Intervirology 2010; 53: 55-59.
    • (2010) Intervirology , vol.53 , pp. 55-59
    • Ueda, T.1    Chung, H.2    Kudo, M.3    Kitai, S.4    Ishikawa, E.5    Yada, N.6
  • 60
    • 33845601238 scopus 로고    scopus 로고
    • Association of a transmembrane polymorphism of Fcγ receptor IIb (FCGR2B) with systemic lupus erythematosus in Taiwanese patients
    • DOI 10.1002/art.22220
    • Chen JY, Wang CM, Ma CC, Luo SF, Edberg JC, Kimberly RP et al. Association of a transmembrane polymorphism of Fcgamma receptor IIb (FCGR2B) with systemic lupus erythematosus in Taiwanese patients. Arthritis Rheum 2006; 54: 3908-3917. (Pubitemid 44955894)
    • (2006) Arthritis and Rheumatism , vol.54 , Issue.12 , pp. 3908-3917
    • Chen, J.-Y.1    Wang, C.M.2    Ma, C.-C.3    Luo, S.-F.4    Edberg, J.C.5    Kimberly, R.P.6    Wu, J.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.