"Add-on" domains of Drosophila β1,4-N- acetylgalactosaminyltransferase B in the stem region and its pilot protein

Cellular and Molecular Life Sciences

Volumn 68, Issue 24, 2011, Pages 4091-4100

  Kraft, Benjamin ^a   Johswich, Anita ^b   Kauczor, Gwenda ^a   Scharenberg, Meike ^c   Gerardy Schahn, Rita ^a   Bakker, Hans ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b MOUNT SINAI HOSPITAL   (Canada)

^c UNIVERSITY OF BASEL   (Switzerland)

Author keywords

DHHC; GABPI; Glycolipid; Glycosyltransferase

Indexed keywords

BETA1,4 N ACETYLGALACTOSAMINYLTRANSFERASE B; N ACETYLGALACTOSAMINE; N ACETYLGALACTOSAMINYLTRANSFERASE; UNCLASSIFIED DRUG; ZINC FINGER PROTEIN;

AMINO ACID SEQUENCE; ARTICLE; CELL MEMBRANE; CONTROLLED STUDY; DROSOPHILA MELANOGASTER; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME STRUCTURE; NONHUMAN; PALMITOYLATION; PROTEIN DOMAIN; PROTEIN INTERACTION;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ANIMALS; CONSERVED SEQUENCE; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; GOLGI APPARATUS; HEK293 CELLS; HUMANS; MEMBRANE PROTEINS; MOLECULAR SEQUENCE DATA; N-ACETYLGALACTOSAMINYLTRANSFERASES; PROTEIN STRUCTURE, TERTIARY; SEQUENCE ALIGNMENT; SEQUENCE ANALYSIS, PROTEIN;

DROSOPHILA MELANOGASTER;

EID: 82255191912     PISSN: 1420682X     EISSN: 14209071     Source Type: Journal    
DOI: 10.1007/s00018-011-0725-3     Document Type: Article

References (37)

1. Amado M, Almeida R, Carneiro F, Levery SB, Holmes EH, Nomoto M, Hollingsworth MA, Hassan H, Schwientek T, Nielsen PA, Bennett EP, Clausen H (1998) A family of human β3-galactosyltransferases. Characterization of four members of a UDP-galactose: β-N-acetyl-glucosamine/β-N-acetyl- galactosamine β-1, 3-galactosyltransferase family. J Biol Chem 273:12770-12778. doi:10.1074/jbc.273.21.12770 (Pubitemid 28246831)
2. Claros MG, von Heijne G (1994) TopPred II: an improved software for membrane protein structure predictions. Comput Appl Biosci 10:685-686. doi:10.1093/bioinformatics/10.6.685
3. Dietrich LE, Ungermann C (2004) On the mechanism of protein palmitoylation. EMBO Rep 5:1053-1057. doi:10.1038/sj.embor. 7400277 (Pubitemid 39600203)
4. Dighe SA, Kozminski KG (2008) Swf1p, a member of the DHHC-CRD family of palmitoyltransferases, regulates the actin cytoskeleton and polarized secretion independently of its DHHC motif. Mol Biol Cell 19:4454-4468. doi:10.1091/mbc. E08-03-0252
5. Eckhardt M, Gotza B, Gerardy-Schahn R (1999) Membrane topology of the mammalian CMP-sialic acid transporter. J Biol Chem 274:8779-8787. doi:10.1074/jbc.274.13.8779 (Pubitemid 29164676)
6. Fernandez-Hernando C, Fukata M, Bernatchez PN, Fukata Y, Lin MI, Bredt DS, Sessa WC (2006) Identification of Golgi-localized acyl transferases that palmitoylate and regulate endothelial nitric oxide synthase. J Cell Biol 174:369-377. doi:10.1083/jcb. 200601051 (Pubitemid 44156767)
7. Fritz TA, Raman J, Tabak LA (2006) Dynamic association between the catalytic and lectin domains of human UDP-Gal-NAc:polypeptide α-N-acetylgalactosaminyltransferase-2. J Biol Chem 281:8613-8619. doi:10.1074/jbc. M513590200 (Pubitemid 44537031)
8. Greaves J, Prescott GR, Fukata Y, Fukata M, Salaun C, Chamberlain LH (2009) The hydrophobic cysteine-rich domain of SNAP25 couples with downstream residues to mediate membrane interactions and recognition by DHHC palmitoyl transferases. Mol Biol Cell 20:1845-1854. doi:10.1091/mbc. E08-08-0880
9. Haines N, Irvine KD (2005) Functional analysis of Drosophila β1, 4-N-acetlygalactosaminyltransferases. Glycobiology 15:335-346. doi:10.1093/glycob/cwi017 (Pubitemid 41214164)
10. Ho SN, Hunt HD, Horton RM, Pullen JK, Pease LR (1989) Sitedirected mutagenesis by overlap extension using the polymerase chain reaction. Gene 77:51-59. doi:10.1016/0378-1119 (89) 90358-2 (Pubitemid 19125653)
11. Johswich A, Kraft B, Wuhrer M, Berger M, Deelder AM, Hokke CH, Gerardy-Schahn R, Bakker H (2009) Golgi targeting of Drosophila melanogaster β4GalNAcTB requires a DHHC protein family-related protein as a pilot. J Cell Biol 184:173-183. doi:10.1083/jcb.200801071
12. Katz J, Wals PA (1985) Studies with digitonin-treated rat hepatocytes (nude cells). J Cell Biochem 28:207-228. doi:10.1002/jcb.240280304 (Pubitemid 15058716)
13. Kubota T, Shiba T, Sugioka S, Furukawa S, Sawaki H, Kato R, Wakatsuki S, Narimatsu H (2006) Structural basis of carbohydrate transfer activity by human UDP-GalNAc: polypeptide α-N-acetylgalactosaminyltransferase (pp-GalNAc-T10). J Mol Biol 359:708-727. doi:10.1016/j.jmb.2006.03.061 (Pubitemid 43767270)
14. Kumagai T, Sato T, Natsuka S, Kobayashi Y, Zhou D, Shinkai T, Hayakawa S, Furukawa K (2010) Involvement of murine β-1, 4-galactosyltransferase V in lactosylceramide biosynthesis. Glycoconj J 27:685-695. doi:10.1007/s10719-010- 9313-2
15. Linder ME, Deschenes RJ (2007) Palmitoylation: policing protein stability and traffic. Nat Rev Mol Cell Biol 8:74-84. doi: 10.1038/nrm2084 (Pubitemid 46012016)
16. Lobo S, Greentree WK, Linder ME, Deschenes RJ (2002) Identification of a Ras palmitoyltransferase in Saccharomyces cerevisiae. J Biol Chem 277:41268-41273. doi:10.1074/jbc. M206573200 (Pubitemid 35215719)
17. Mitchell DA, Mitchell G, Ling Y, Budde C, Deschenes RJ (2010) Mutational analysis of Saccharomyces cerevisiae Erf2 reveals a two-step reaction mechanism for protein palmitoylation by DHHC enzymes. J Biol Chem 285:38104-38114. doi:10.1074/jbc. M110.169102
18. Mitchell DA, Vasudevan A, Linder ME, Deschenes RJ (2006) Protein palmitoylation by a family of DHHC protein S-acyltransferases. J Lipid Res 47:1118-1127. doi:10.1194/jlr. R600007-JLR200 (Pubitemid 43830703)
19. Nishie T, Hikimochi Y, Zama K, Fukusumi Y, Ito M, Yokoyama H, Naruse C, Ito M, Asano M (2010) β4-galactosyltransferase-5 is a lactosylceramide synthase essential for mouse extra-embryonic development. Glycobiology 20:1311-1322. doi:10.1093/glycob/cwq098
20. Nomura T, Takizawa M, Aoki J, Arai H, Inoue K, Wakisaka E, Yoshizuka N, Imokawa G, Dohmae N, Takio K, Hattori M, Matsuo N (1998) Purification, cDNA cloning, and expression of UDP-Gal: glucosylceramide β-1, 4-galactosyltransferase from rat brain. J Biol Chem 273:13570-13577. doi:10.1074/jbc.273.22. 13570 (Pubitemid 28268399)
21. Politis EG, Roth AF, Davis NG (2005) Transmembrane topology of the protein palmitoyl transferase Akr1. J Biol Chem 280:10156-10163. doi:10.1074/jbc. M411946200 (Pubitemid 40395869)
22. Putilina T, Wong P, Gentleman S (1999) The DHHC domain: a new highly conserved cysteine-rich motif. Mol Cell Biochem 195:219-226. doi:10.1023/A:1006932522197 (Pubitemid 29259786)
23. Qasba PK, Ramakrishnan B (2007) Letter to the Glyco-Forum: catalytic domains of glycosyltransferases with 'add-on' domains. Glycobiology 17:7G-9G. doi:10.1093/glycob/cwm013 (Pubitemid 47049933)
24. Qasba PK, Ramakrishnan B, Boeggeman E (2008) Structure and function of β-1, 4-galactosyltransferase. Curr Drug Targets 9:292-309. doi:10.2174/138945008783954943 (Pubitemid 351836430)
25. Ramakrishnan B, Boeggeman E, Qasba PK (2002) β-1, 4-galactosyltransferase and lactose synthase: molecular mechanical devices. Biochem Biophys Res Commun 291:1113-1118. doi: 10.1006/bbrc.2002.6506 (Pubitemid 34694303)
26. Ramakrishnan B, Shah PS, Qasba PK (2001) a-Lactalbumin (LA) stimulates milk β-1, 4-galactosyltransferase I (β4Gal-T1) to transfer glucose from UDP-glucose to N-acetylglucosamine. Crystal structure of β4Gal-T1 x LA complex with UDP-Glc. J Biol Chem 276:37665-37671. doi:10.1074/jbc. M102458200
27. Roth AF, Feng Y, Chen L, Davis NG (2002) The yeast DHHC cysteine-rich domain protein Akr1p is a palmitoyl transferase. J Cell Biol 159:23-28. doi:10.1083/jcb.200206120 (Pubitemid 35191514)
28. Sasaki N, Yoshida H, Fuwa TJ, Kinoshita-Toyoda A, Toyoda H, Hirabayashi Y, Ishida H, Ueda R, Nishihara S (2007) Drosophila β1, 4-N- acetylgalactosaminyltransferase-A synthesizes the LacdiNAc structures on several glycoproteins and glycosphingolipids. Biochem Biophys Res Commun 354:522-527. doi: 10.1016/j.bbrc.2007.01.015 (Pubitemid 46164841)
29. Sato T, Guo S, Furukawa K (2000) Involvement of recombinant human β1, 4-galactosyltransferase V in lactosylceramide biosynthesis. Res Commun Biochem Cell Molec Biol 4:3-10
30. Schwientek T, Keck B, Levery SB, Jensen MA, Pedersen JW, Wandall HH, Stroud M, Cohen SM, Amado M, Clausen H (2002) The Drosophila gene brainiac encodes a glycosyltransferase putatively involved in glycosphingolipid synthesis. J Biol Chem 277:32421-32429. doi:10.1074/jbc. M206213200 (Pubitemid 34984742)
31. Seeman P (1967) Transient holes in the erythrocyte membrane during hypotonic hemolysis and stable holes in the membrane after lysis by saponin and lysolecithin. J Cell Biol 32:55-70. doi: 10.1083/jcb.32.1.55
32. Sharma C, Yang XH, Hemler ME (2008) DHHC2 affects palmitoylation, stability, and functions of tetraspanins CD9 and CD151. Mol Biol Cell 19:3415-3425. doi:10.1091/mbc. E07-11-1164
33. Speel EJ, Hopman AH, Komminoth P (2006) Tyramide signal amplification for DNA and mRNA in situ hybridization. Methods Mol Biol 326:33-60. doi:10.1385/1-59745-007-3:33
34. Steffensen R, Carlier K, Wiels J, Levery SB, Stroud M, Cedergren B, Nilsson SB, Bennett EP, Jersild C, Clausen H (2000) Cloning and expression of the histo-blood group Pk UDP-galactose: Galβ-4Glcβ1-cer α1, 4-galactosyltransferase. Molecular genetic basis of the p phenotype. J Biol Chem 275:16723-16729. doi:10.1074/jbc. M000728200 (Pubitemid 30398903)
35. Stolz A, Haines N, Pich A, Irvine KD, Hokke CH, Deelder AM, Gerardy-Schahn R, Wuhrer M, Bakker H (2007) Distinct contributions of β4GalNAcTA and β4GalNAcTB to Drosophila glycosphingolipid biosynthesis. Glycoconj J 25:167-175. doi: 10.1007/s10719-007-9069-5 (Pubitemid 351238193)
36. Tu L, Banfield DK (2010) Localization of Golgi-resident glycosyltransferases. Cell Mol Life Sci 67:29-41. doi:10.1007/s00018-009-0126-z
37. van Remoortere A, Hokke CH, van Dam GJ, van Die I, Deelder AM, van den Eijnden DH (2000) Various stages of schistosoma express Lewis (x), LacdiNAc, GalNAcβ1-4 (Fucα1-3) GlcNAc and GalNAcβ1-4 (Fucα1- 2Fucα1-3) GlcNAc carbohydrate epitopes: detection with monoclonal antibodies that are characterized by enzymatically synthesized neoglycoproteins. Glycobiology 10:601-609. doi:10.1093/glycob/10.6.601 (Pubitemid 30398415)