Construction of amphiphilic copolymer nanoparticles based on hyperbranched Poly (Amine-Ester) and 1,2-Dipalmitoyl-Sn-Glycero-3-Phosphoethanolamine as drug carriers for cancer therapy

Nanomedicine: Nanotechnology, Biology, and Medicine

Volumn 7, Issue 6, 2011, Pages 945-954

  Wu, Yan ^a   Jiao, Fang ^a,b   Han, Siyuan ^a,c   Fan, Tengfei ^a   Liu, Ying ^a   Li, Wei ^b   Hu, Liming ^c   Zhao, Yuliang ^a,b   Chen, Chunying ^a,b  

^a NATIONAL CENTER FOR NANOSCIENCE AND TECHNOLOGY   (China)

^b INSTITUTE OF HIGH ENERGY PHYSICS   (China)

^c BEIJING UNIVERSITY OF TECHNOLOGY   (China)

Author keywords

Anti tumor activity; Biocompatibility; Controlled drug release; Drug delivery; Hyperbranched copolymer

Indexed keywords

AMPHIPHILIC COPOLYMERS; ANTI-TUMOR ACTIVITIES; ANTI-TUMORS; ANTITUMOR DRUGS; CANCER THERAPY; CONTROLLED DRUG RELEASE; DOXORUBICIN; DRUG CARRIER; ENCAPSULATION EFFICIENCY; HYPERBRANCHED COPOLYMERS; HYPERBRANCHED POLY(AMINE-ESTER); IN-VITRO; IN-VIVO; INTRACELLULAR DELIVERY; MODEL DRUGS; NANOCARRIERS; POLY LACTIDE;

BIOCOMPATIBILITY; CHEMOTHERAPY; CONFOCAL MICROSCOPY; COPOLYMERS; CYTOLOGY; DRUG DELIVERY; DRUG PRODUCTS; EFFICIENCY; ENZYME INHIBITION; ESTERIFICATION; ESTERS; NANOPARTICLES; TIN;

ENCAPSULATION;

1,2 DIPALMITOYL SN GLYCERO 3 PHOSPHOETHANOLAMINE; AMPHOPHILE; COPOLYMER; DOXORUBICIN; DRUG CARRIER; NANOCARRIER; NANOPARTICLE; POLYAMINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER; CANCER THERAPY; CONFOCAL MICROSCOPY; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; CYTOPLASM; DRUG DELIVERY SYSTEM; DRUG EFFICACY; FEMALE; HUMAN; HUMAN CELL; LYSOSOME; MOUSE; NANOENCAPSULATION; NONHUMAN; PH;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; CELL LINE, TUMOR; DELAYED-ACTION PREPARATIONS; DOXORUBICIN; FEMALE; HUMANS; MICE; MICE, INBRED BALB C; NANOPARTICLES; NEOPLASMS; PHOSPHATIDYLETHANOLAMINES;

EID: 82255191847     PISSN: 15499634     EISSN: 15499642     Source Type: Journal    
DOI: 10.1016/j.nano.2011.04.010     Document Type: Article

References (29)

1. Torchilin VP Structure and design of polymeric surfactant-based drug delivery systems. J Control Release 2001, 73:137-172.
2. Vakil R, Kwon GS Effect of cholesterol on the release of amphotericin B from PEG-phospholipid micelles. Mol Pharmaceut 2008, 5:98-104.
3. Kataoka K, Harada A, Nagasaki Y Block copolymer micelles for drug delivery: design, characterization and biological significance. Adv Drug Deliv Rev 2001, 47:113-131.
4. Layre A, Couvreur P, Chacun H, Richard J, Passirani C, Requier D, et al. Novel composite core-shell NPs as busulfan carriers. J Control Release 2006, 111:271-280.
5. Savic R, Luo L, Eisenberg A, Maysinger D Micellar nanocontainers distribute to defined cytoplasmic organelles. Science 2003, 300:615-618.
6. Li YY, Zhang XZ, Kim GC, Cheng H, Cheng SX, Zhuo RX Thermosensitive Y-shaped micelles of poly(oleic acid-Y-N-isopropylacrylamide) for drug delivery. Small 2006, 2:917-923.
7. Miao QH, Xu DX, Wang Z, Xu L, Wang TW, Wu Y, et al. Amphiphilic hyper-branched co-polymer nanoparticles for the controlled delivery of anti-tumor agents. Biomaterials 2010, 31:7364-7375.
8. Bikiaris DN, Karayannidis GP Synthesis and characterization of branched and partially crosslinked poly(ethylene terephthalate). Polym Int 2003, 52:1230-1239.
9. Duncan R Polymer conjugates as anticancer nanomedicines. Nat Rev Cancer 2006, 6:688-701.
10. Gao C, Yan D Hyperbranched polymers: from synthesis to applications. Prog Polym Sci 2004, 29:183-275.
11. Tian HY, Deng C, Lin H, Sun JR, Deng MX, Chen XS, et al. Biodegradable cationic PEG-PEI-PBLG hyperbranched block copolymer: synthesis and micelle characterization. Biomaterials 2005, 26:4209-4217.
12. Karger-Kocsis J, Frohlich J, Gryshchuk O, Kautz H, Frey H, Mulhaupt R Synthesis of reactive hyperbranched and star-like polyethers and their use for toughening of vinylester-urethane hybrid resins. Polymer 2004, 45:1185-1195.
13. Jeong B, Bae YH, Kim SW Drug release from biodegradable injectable thermosensitive hydrogel of PEG-PLGA-PEG triblock copolymers. J Control Release 2000, 63:155-163.
14. Yang R, Yang SG, Shim WS, Cui FD, Cheng G, Kim IW, et al. Lung-specific delivery of paclitaxel by chitosan-modified PLGA NPs via transient formation of microaggregates. J Pharma Sci-US 2009, 98:970-984.
15. Wang TW, Zhang CL, Liang XJ, Liang W, Wu Y Hydroxypropyl-β-cyclodextrin copolymers and their nanoparticles as doxorubicin delivery system. J Pharm Sci 2011, 100:1067-1079.
16. Gao Z, Lukyanov AN, Anurag Singhal A, Torchilin VP Diacyllipid-polymer micelles as nanocarriers for poorly soluble anticancer drugs. Nano Lett 2002, 2:979-982.
17. Wang X, Yang L, Chen Z., Shin DM Application of nanotechnology in cancer therapy and imaging. CA Cancer J Clin 2008, 58:97-110.
18. Yoo HS, Park TG Biodegradable polymeric micelles composed of doxorubicin conjugated PLGA-PEG block copolymer. J Control Release 2001, 70:63-70.
19. Yoo HS, Park TG Folate receptor targeted biodegradable polymeric doxorubicin micelles. J Control Release 2004, 96:273-283.
20. Jiang M, Wu Y, He Y, Nie J Micelles formed by self-assembly of hyperbranched poly (amine-ester)-co-(D,L-lactide) (HPAE-co-PLA) copolymers for protein drug delivery. Polym Int 2009, 58:31-39.
21. Yoo HS, Oh JE, Lee KH, Park TG Biodegradable nanoparticles containing doxorubicin-PLGA conjugate for sustained release. Pharm Res 1999, 16:1114-1118.
22. Rodrigues JS, Santos-Magalhães NS, Coelho LCBB, Couvreur P, Ponchel G, Gref R Novel core (polyester)-shell (polysaccharide) nanoparticles: protein loading and surface modification with lectins. J Control Release 2003, 92:103-112.
23. Govender T, Stolnik S, Garnett MC, Illum L, Davis SS PLGA nanoparticles prepared by nanoprecipitation: drug loading and release studies of a water soluble drug. J Control Release 1999, 57:171-185.
24. Percot A, Briane D, Coudert R, Reynier P, Bouchemal N, Lièvre N, et al. A hydroxyethylated cholesterol-based cationic lipid for DNA delivery: effect of conditioning. Int J Pharm 2004, 278:143-163.
25. Verrecchia T, Spenlehauer G, Bazile DV, Murry-Brelier A, Archimbaud Y, Veillard M Non-stealth (poly(lactic acid/albumin)) and stealth (poly(lactic acidpolyethylene glycol)) nanoparticles as injectable drugs carriers. J Control Release 1995, 36:49-61.
26. Ferdous AJ, Stembridge NY, Singh M Role of monensin PLGA polymer nanoparticles and liposomes as potentiator of ricin A immunotoxins in vitro. J Control Release 1998, 50:71-78.
27. Zambaux MF, Bonneaux F, Gref F, Dellacherie E, Vigneron C MPEO-PLA nanoparticles: effect of mPEO content on some of their surface properties. J Biomed Mater Res A 1999, 44:109-115.
28. Gerasimov OV, Boomer JA, Qualls MM, Thompson DH Cytosolic drug delivery using pH- and light-sensitive liposomes. Adv Drug Deliv Rev 1999, 38:317-338.
29. Bae Y, Fukushima S, Harada A, Kataoka K. Design of environment-sensitive supramolecular assemblies for intracellular drug delivery: Polymeric micelles that are responsive to intracellular pH change. Angew Chem Int Edit 2003, 42:4640-4643.