Conformationally restricted analogs of the direct thrombin inhibitor FM 19

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 24, 2011, Pages 7425-7434

  Girnys, Elizabeth A ^a   Porter, Vanessa R ^a   Mosberg, Henry I ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

Author keywords

Peptide synthesis; Structure based design; Thrombin inhibitor

Indexed keywords

3 AMIDINOBENZOIC ACID; 3 AMIDINOPHENYLACETIC ACID; 4 AMIDINOBENZOIC ACID; 4 AMIDINOPHENYLACETIC ACID; 4 GUANIDINO 1 CYCLOHEXANECARBOXYLIC ACID; 4 GUANIDINOBENZOIC ACID; 5 GUANIDINO 2 METHYLPENTANOIC ACID; ARGININE; BRADYKININ[1-5]; FM 19; PEPTIDE DERIVATIVE; THROMBIN; THROMBIN INHIBITOR; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ARTICLE; CONTROLLED STUDY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME CONFORMATION; IC 50; PROTEIN MODIFICATION;

AMINO ACID SEQUENCE; ANTITHROMBINS; BRADYKININ; DRUG DESIGN; HUMANS; MODELS, MOLECULAR; PEPTIDE FRAGMENTS; PEPTIDES; THROMBIN;

EID: 82255179112     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.10.045     Document Type: Article

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