Molecular insights into human monoamine oxidase (MAO) inhibition by 1,4-naphthoquinone: Evidences for menadione (vitamin K3) acting as a competitive and reversible inhibitor of MAO

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 24, 2011, Pages 7416-7424

  Coelho Cerqueira, Eduardo ^a   Netz, Paulo Augusto ^b   Diniz, Cristiane ^a   Petry Do Canto, Vanessa ^b   Follmer, Cristian ^a  

^a FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^b FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

Author keywords

1,4 Naphthoquinone; Docking; Flavin; Menadione; Monoamine oxidase

Indexed keywords

1,4 NAPHTHOQUINONE; 2,3,6 TRIMETHYL 1,4 NAPHTHOQUINONE; AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME A; AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME B; MENADIONE; MONOAMINE OXIDASE INHIBITOR; QUERCETIN DERIVATIVE; RASAGILINE; TYROSINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DISPERSION; DRUG DESIGN; DRUG DETERMINATION; DRUG MECHANISM; DRUG SELECTIVITY; ENZYME ACTIVE SITE; ENZYME INHIBITION; FLUORESCENCE ANALYSIS; MOLECULAR DOCKING; MOLECULAR MODEL; NONHUMAN;

ANIMALS; HUMANS; KINETICS; MODELS, MOLECULAR; MONOAMINE OXIDASE; MONOAMINE OXIDASE INHIBITORS; NAPHTHOQUINONES; PROTEIN BINDING; VITAMIN K 3; VITAMINS;

EID: 82255175466     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.10.049     Document Type: Article

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