Cardiovascular regulation in obstructive sleep apnea

Drug Discovery Today: Disease Models

Volumn 8, Issue 4, 2011, Pages 155-160

  Ziegler, Michael G ^a   Milic, Milos ^a   Elayan, Hamzeh ^a  

^a UCSD MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALDOSTERONE ANTAGONIST; ANGIOTENSIN ANTAGONIST; ANGIOTENSIN RECEPTOR ANTAGONIST; BETA 1 ADRENERGIC RECEPTOR BLOCKING AGENT; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT; ENDOTHELIN; NEUROTRANSMITTER;

ADRENERGIC SYSTEM; ARTICLE; CHEMORECEPTOR REFLEX; EXPERIMENTAL MODEL; FLUID BALANCE; HUMAN; HYPERTENSION; HYPOXIA; METABOLIC SYNDROME X; NONHUMAN; PRESSORECEPTOR REFLEX; SLEEP APNEA SYNDROME; TREATMENT RESPONSE;

EID: 82255175327     PISSN: None     EISSN: 17406757     Source Type: Journal    
DOI: 10.1016/j.ddmod.2011.03.003     Document Type: Review

References (42)

1. Punjabi, N. M. et al. (2009) Sleep-disordered breathing and mortality: a prospective cohort study. PLoS Med. 6, e1000132 PMCID: 2722083
2. Baguet, J. P. et al. (2009) Hypertension and obstructive sleep apnoea syndrome: current perspectives. J. Hum. Hypertens. 23, 431-443
3. O'Connor, G. T. et al. (2009) Prospective study of sleep-disordered breathing and hypertension: the Sleep Heart Health Study. Am. J. Respir. Crit. Care Med. 179, 1159-1164 PMCID: 2695498
4. Somers, V. K. et al. (2008) Sleep apnea and cardiovascular disease: an American Heart Association/American College of Cardiology Foundation Scientific Statement from the American Heart Association Council for High Blood Pressure Research Professional Education Committee, Council on Clinical Cardiology. Stroke Council, and Council on Cardiovascular Nursing. J. Am. Coll. Cardiol. 52, 686-717
5. Prabhakar, N. R. et al. (2009) Intermittent hypoxia-mediated plasticity of acute O2 sensing requires altered red-ox regulation by HIF-1 and HIF-2. Ann. N. Y. Acad Sci. 1177, 162-168
6. Drager, L. F. et al. (2010) Characteristics and predictors of obstructive sleep apnea in patients with systemic hypertension. Am. J. Cardiol. 105, 1135-1139
7. Farre, R. et al. (2008) Morbidity due to obstructive sleep apnea: insights from animal models. Curr. Opin. Pulm. Med. 14, 530-536
8. Kunze, D. L. et al. (2007) Hypertension in sleep apnea: the role of the sympathetic pathway. Cleve Clin. J. Med. 74(Suppl. 1), S34-S36
9. Prabhakar, N. R. and Kumar, G. K. (2010) Mechanisms of sympathetic activation and blood pressure elevation by intermittent hypoxia. Respir. Physiol. Neurobiol. 174, 156-161
10. Lambert, G. W. et al. (2010) Sympathetic nervous activation in obesity and the metabolic syndrome - causes, consequences and therapeutic implications. Pharmacol. Ther. 126, 159-172
11. Smith, M. L. et al. (1996) Role of hypoxemia in sleep apnea-induced sympathoexcitation. J. Auton. Nerv. Syst. 56, 184-190 (Pubitemid 26020979)
12. Peng, Y. J. et al. (2003) Induction of sensory long-term facilitation in the carotid body by intermittent hypoxia: implications for recurrent apneas. Proc. Natl. Acad. Sci. U. S. A. 100, 10073-10078 PMCID: 187770
13. Peng, Y. J. et al. (2006) Heterozygous HIF-1alpha deficiency impairs carotid body-mediated systemic responses and reactive oxygen species generation in mice exposed to intermittent hypoxia. J. Physiol. 577(Pt 2), 705-716 PMCID: 1890436
14. Prabhakar, N. R. et al. (2007) Altered carotid body function by intermittent hypoxia in neonates and adults: relevance to recurrent apneas. Respir. Physiol. Neurobiol. 157, 148-153 (Pubitemid 46617440)
15. Peng, Y. J. and Prabhakar, N. R. (2004) Effect of two paradigms of chronic intermittent hypoxia on carotid body sensory activity. J. Appl. Physiol. 96, 1236-1242 discussion 196 (Pubitemid 38248707)
16. Ziegler, M. G. et al. (2001) Effect of continuous positive airway pressure and placebo treatment on sympathetic nervous activity in patients with obstructive sleep apnea. Chest 120, 887-893 (Pubitemid 32885465)
17. Cooper, V. L. et al. (2005) Interaction of chemoreceptor and baroreceptor reflexes by hypoxia and hypercapnia - a mechanism for promoting hypertension in obstructive sleep apnoea. J. Physiol. 568(Pt 2), 677-687 PMCID: 1474745 (Pubitemid 41555466)
18. Somers, V. K. et al. (1991) Interaction of baroreceptor and chemoreceptor reflex control of sympathetic nerve activity in normal humans. J. Clin. Invest. 87, 1953-1957 PMCID: 296947
19. Milic, M. et al. (2009) A comparison of pharmacologic and spontaneous baroreflex methods in aging and hypertension. J. Hypertens. 27, 1243-1251 PMCID: 2745725
20. Lai, C. J. et al. (2006) Enhanced sympathetic outflow and decreased baroreflex sensitivity are associated with intermittent hypoxia-induced systemic hypertension in conscious rats. J. Appl. Physiol. 100, 1974-1982 (Pubitemid 43845873)
21. Narkiewicz, K. et al. (1998) Baroreflex control of sympathetic nerve activity and heart rate in obstructive sleep apnea. Hypertension 32, 1039-1043 (Pubitemid 29001433)
22. Parati, G. et al. (1997) Autonomic cardiac regulation in obstructive sleep apnea syndrome: evidence from spontaneous baroreflex analysis during sleep. J. Hypertens. 15(Pt 2), 1621-1626 (Pubitemid 28029655)
23. Cooper, V. L. et al. (2007) Daytime variability of baroreflex function in patients with obstructive sleep apnoea: implications for hypertension. Exp. Physiol. 92, 391-398 (Pubitemid 46376329)
24. Souvannakitti, D. et al. (2010) NADPH oxidase-dependent regulation of T-type Ca2+ channels and ryanodine receptors mediate the augmented exocytosis of catecholamines from intermittent hypoxia-treated neonatal rat chromaffin cells. J. Neurosci. 30, 10763-10772
25. Heitmann, J. et al. (2010) Comparison of the effects of nebivolol and valsartan on BP reduction and sleep apnoea activity in patients with essential hypertension and OSA. Curr. Med. Res. Opin. 26, 1925-1932
26. Gjorup, P. H. et al. (2007) Abnormally increased endothelin-1 in plasma during the night in obstructive sleep apnea: relation to blood pressure and severity of disease. Am. J. Hypertens. 20, 44-52 (Pubitemid 46014056)
27. Allahdadi, K. J. et al. (2005) Augmented endothelin vasoconstriction in intermittent hypoxia-induced hypertension. Hypertension 45, 705-709 (Pubitemid 40418369)
28. Bucca, C. B. et al. (2007) Diuretics in obstructive sleep apnea with diastolic heart failure. Chest 132, 440-446 (Pubitemid 47282374)
29. Friedman, O. et al. (2010) Relationship between overnight rostral fluid shift and obstructive sleep apnea in drug-resistant hypertension. Hypertension 56, 1077-1082
30. Di Murro, A. et al. (2010) Renin-angiotensin-aldosterone system in patients with sleep apnoea: prevalence of primary aldosteronism. J. Renin Angiotensin Aldosterone Syst. 11, 165-172
31. Marney, A. M. and Brown, N. J. (2007) Aldosterone and end-organ damage. Clin Sci (Lond). 113, 267-278 (Pubitemid 47372685)
32. Goldbart, A. D. et al. (2010) B-type natriuretic peptide and cardiovascular function in young children with obstructive sleep apnea. Chest 138, 528-535
33. Kita, H. et al. (1998) The nocturnal secretion of cardiac natriuretic peptides during obstructive sleep apnoea and its response to therapy with nasal continuous positive airway pressure. J. Sleep Res. 7, 199-207 (Pubitemid 28442702)
34. Pimenta, E. et al. (2009) Sleep apnea, aldosterone, and resistant hypertension. Prog. Cardiovasc. Dis. 51, 371-380
35. Pelttari, L. H. et al. (1998) Little effect of ordinary antihypertensive therapy on nocturnal high blood pressure in patients with sleep disordered breathing. Am. J. Hypertens. 11(Pt 1), 272-279 (Pubitemid 28186737)
36. Cockcroft, J. R. et al. (1995) Nebivolol vasodilates human forearm vasculature: evidence for an L-arginine/NO-dependent mechanism. J. Pharmacol. Exp. Ther. 274, 1067-1071
37. Zou, D. et al. (2010) A double-blind, crossover study of Doxazosin and Enalapril on peripheral vascular tone and nocturnal blood pressure in sleep apnea patients. Sleep Med. 11, 325-328
38. Mayer, J. et al. (1990) Influence of metoprolol and cilazapril on blood pressure and on sleep apnea activity. J. Cardiovasc. Pharmacol. 16, 952-961
39. Borgel, J. et al. (2010) Unrecognized secondary causes of hypertension in patients with hypertensive urgency/emergency: prevalence and coprevalence. Clin. Res. Cardiol. 99, 499-506
40. Pimenta, E. et al. (2008) Mechanisms and treatment of resistant hypertension. J. Clin. Hypertens. (Greenwich) 10, 239-244
41. Gaddam, K. et al. (2010) Spironolactone reduces severity of obstructive sleep apnoea in patients with resistant hypertension: a preliminary report. J. Hum. Hypertens. 24, 532-537 PMCID: 2891919
42. Lam, J. C. and Ip, M. S. (2010) Sleep & the metabolic syndrome. Indian J. Med. Res. 131, 206-216