Akt-centered amplification loop plays a critical role in vascular endothelial growth factor/stromal cell-derived factor 1-α cross-talk and cardioprotection

Chinese Medical Journal

Volumn 124, Issue 22, 2011, Pages 3800-3805

  Guo, Wen Yi ^a   Zhang, Dian Xin ^a   Li, Wei Jie ^a   Zhao, Zhi Jing ^a   Liu, Bing ^a   Wang, Hai Chang ^a   Li, Fei ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Cardiomyocyte; PI3K Akt; Stromal cell derived factor a; Survival; Vascular endothelial growth factor

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; CHEMOKINE RECEPTOR CXCR4; HYDROGEN PEROXIDE; LACTATE DEHYDROGENASE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PLERIXAFOR; PROTEIN KINASE B; STROMAL CELL DERIVED FACTOR 1ALPHA; TRYPAN BLUE; VASCULOTROPIN; VASCULOTROPIN RECEPTOR 2;

ANIMAL CELL; ARTICLE; CELL DAMAGE; CELL DEATH; CELL VIABILITY; ENZYME PHOSPHORYLATION; ENZYME RELEASE; GENE AMPLIFICATION; HEART CELL CULTURE; HEART PROTECTION; HEART VENTRICLE; IN VITRO STUDY; MOLECULAR INTERACTION; NEWBORN; NONHUMAN; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; STAINING; UPREGULATION; WESTERN BLOTTING;

ANIMALS; ANIMALS, NEWBORN; BLOTTING, WESTERN; CELL DEATH; CELL SURVIVAL; CELLS, CULTURED; CHEMOKINE CXCL12; ENZYME-LINKED IMMUNOSORBENT ASSAY; HYDROGEN PEROXIDE; MYOCYTES, CARDIAC; PHOSPHORYLATION; RATS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 82255173516     PISSN: 03666999     EISSN: None     Source Type: Journal    
DOI: 10.3760/cma.j.issn.0366-6999.2011.22.035     Document Type: Article

References (27)

1. Mühlhauser J, Merrill MJ, Pili R, Maeda H, Bacic M, Bewig B, et al. VEGF165 expressed by a replication-deficient recombinant adenovirus vector induces angiogenesis in vivo. Circ Res 1995; 77: 1077-1086.
2. Kornowski R, Fuchs S, Leon MB, Epstein SE. Delivery strategies to achieve therapeutic myocardial angiogenesis. Circulation 2000; 101: 454-458.
3. Khurana R, Simons M, Martin JF, Zachary IC. Role of angiogenesis in cardiovascular disease: a critical appraisal. Circulation 2005; 112: 1813-1824.
4. Tammela T, Enholm B, Alitalo K, Paavonen K. The biology of vascular endothelial growth factors. Cardiovasc Res 2005; 65: 550-563.
5. Wick A, Wick W, Waltenberger J, Weller M, Dichgans J, Schulz JB. Neuroprotection by hypoxic preconditioning requires sequential activation of vascular endothelial growth factor receptor and Akt. J Neurosci 2002; 22: 6401-6407.
6. Feng Y, Rhodes PG, Bhatt AJ. Dexamethasone pre-treatment protects brain against hypoxic-ischemic injury partially through up-regulation of vascular endothelial growth factor A in neonatal rats. Neuroscience 2011; 179: 223-232.
7. Compernolle V, Brusselmans K, Acker T, Hoet P, Tjwa M, Beck H, et al. Loss of HIF-2 alpha and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice. Nat Med 2002; 8: 702-710.
8. Li F, Zhao H, Liao Y, Takashima S, Asano Y, Shintani Y, et al. Higher mortality in heterozygous neuropilin-1 mice after cardiac pressure overload. Biochem Biophys Res Commun 2008; 370: 317-321.
9. Takahashi N, Seko Y, Noiri E, Tobe K, Kadowaki T, Sabe H, et al. Vascular endothelial growth factor induces activation and subcellular translocation of focal adhesion kinase (p125FAK) in cultured rat cardiac myocytes. Circ Res 1999; 84: 1194-1202.
10. Vera Janavel G, Crottogini A, Cabeza Meckert P, Cuniberti L, Mele A, Papouchado M, et al. Plasmid-mediated VEGF gene transfer induces cardiomyogenesis and reduces myocardial infarct size in sheep. Gene Ther 2006; 15:1133-1142.
11. Ferrarini M, Arsic N, Recchia FA, Zentilin L, Zacchigna S, Xu X, et al. Adeno-associated virus-mediated transduction of VEGF165 improves cardiac tissue viability and functional recovery after permanent coronary occlusion in conscious dogs. Circ Res 2006; 98: 954-961.
12. Hiasa K, Egashira K, Kitamoto S, Ishibashi M, Inoue S, Ni W, et al. Bone marrow mononuclear cell therapy limits myocardial infarct size through vascular endothelial growth factor. Basic Res Cardiol 2004; 99:165-172.
13. Ruiz de Almodovar C, Luttun A, Carmeliet P. An SDF-1 trap for myeloid cells stimulates angiogenesis. Cell 2006; 124: 18-21.
14. Agarwal U, Ghalayini W, Dong F, Weber K, Zou YR, Rabbany SY, et al. Role of cardiac myocyte CXCR4 expression in development and left ventricular remodeling after acute myocardial infarction. Circ Res 2010; 107: 667-676.
15. Hu X, Dai S, Wu WJ, Tan W, Zhu X, Mu J, et al. Stromal cell derived factor-1 alpha confers protection against myocardial ischemia/reperfusion injury: role of the cardiac stromal cell derived factor-1 alpha CXCR4 axis. Circulation 2007; 116: 654-663.
16. Kumar P, Miller AI, Polverini PJ. p38 MAPK mediates gamma-irradiation-induced endothelial cell apoptosis, and vascular endothelial growth factor protects endothelial cells through the phosphoinositide 3-kinase-Akt-Bcl-2 pathway. J Biol Chem 2004; 279: 43352-43360.
17. Yamaji-Kegan K, Su Q, Angelini DJ, Champion HC, Johns RA. Hypoxia-induced mitogenic factor has proangiogenic and proinflammatory effects in the lung via VEGF and VEGF receptor-2. Am J Physiol Lung Cell Mol Physiol 2006; 291: L1159-L1168.
18. Zagzag D, Lukyanov Y, Lan L, Ali MA, Esencay M, Mendez O, et al. Hypoxia-inducible factor 1 and VEGF upregulate CXCR4 in glioblastoma: implications for angiogenesis and glioma cell invasion. Lab Invest 2006; 86: 1221-1232.
19. Zachary I. Neuroprotective role of vascular endothelial growth factor: signalling mechanisms, biological function, and therapeutic potential. Neurosignals 2005; 14: 207-221.
20. Zachary I. Signaling mechanisms mediating vascular protective actions of vascular endothelial growth factor. Am J Physiol Cell Physiol 2001; 280: C1375-C1386.
21. Abid MR, Guo S, Minami T, Spokes KC, Ueki K, Skurk C, et al. Vascular endothelial growth factor activates PI3K/Akt/forkhead signaling in endothelial cells. Arterioscler Thromb Vasc Biol 2004; 24: 294-300.
22. Guzman MJ, Crisostomo PR, Wang M, Markel TA, Wang Y, Meldrum DR. Vascular endothelial growth factor improves myocardial functional recovery following ischemia/ reperfusion injury. J Surg Res 2008; 150: 286-292.
23. Kucia M, Reca R, Miekus K, Wanzeck J, Wojakowski W, Janowska-Wieczorek A, et al. Trafficking of normal stem cells and metastasis of cancer stem cells involve similar mechanisms: pivotal role of the SDF-1-CXCR4 axis. Stem Cells 2005; 23: 879-894.
24. Lis R, Touboul C, Mirshahi P, Ali F, Mathew S, Nolan DJ, et al. Tumor associated mesenchymal stem cells protects ovarian cancer cells from hyperthermia through CXCL12. Int J Cancer 2011; 128: 715-725.
25. Dziembowska M, Tham TN, Lau P, Vitry S, Lazarini F, Dubois-Dalcq M. A role for CXCR4 signaling in survival and migration of neural and oligodendrocyte precursors. Glia 2005; 50: 258-269.
26. Zhou Y, Larsen PH, Hao C, Yong VW. CXCR4 is a major chemokine receptor on glioma cells and mediates their survival. J Biol Chem 2002; 277: 49481-49487.
27. Yang SX, Chen JH, Jiang XF, Wang QL, Chen ZQ, Zhao W, et al. Activation of chemokine receptor CXCR4 in malignant glioma cells promotes the production of vascular endothelial growth factor. Biochem Biophys Res Commun 2005; 335: 523-528.