MDR-1 gene polymorphisms in steroid-responsive versus steroid-resistant nephrotic syndrome in children

Nephrology Dialysis Transplantation

Volumn 26, Issue 12, 2011, Pages 3968-3974

  Jafar, Tabrez ^a   Prasad, Narayan ^a   Agarwal, Vikas ^a   Mahdi, Abbas ^b   Gupta, Amit ^a   Sharma, Raj K ^a   Negi, Mahendra Pal Singh ^c   Agrawal, Suraksha ^a  

^a SANJAY GANDHI POSTGRADUATE INSTITUTE OF MEDICAL SCIENCES   (India)

^b KING GEORGE'S MEDICAL UNIVERSITY   (India)

^c CENTRAL DRUG RESEARCH INSTITUTE   (India)

Author keywords

multidrug resistance gene; nephrotic syndrome; polymorphisms; steroid resistance

Indexed keywords

PREDNISOLONE; PREDNISONE;

ADOLESCENT; ALLELE; ARTICLE; CHILD; CONTROLLED STUDY; EXON; FEMALE; GENE; GENOTYPE; HAPLOTYPE; HOMOZYGOSITY; HUMAN; MAJOR CLINICAL STUDY; MALE; MDR 1 GENE; MUTANT; NEPHROTIC SYNDROME; POLYMERASE CHAIN REACTION; PRESCHOOL CHILD; PRIORITY JOURNAL; RELAPSE; REMISSION; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SCHOOL CHILD; SINGLE NUCLEOTIDE POLYMORPHISM; TREATMENT RESPONSE;

ADOLESCENT; CASE-CONTROL STUDIES; CHILD; CHILD, PRESCHOOL; DRUG RESISTANCE; FEMALE; GENOTYPE; HUMANS; INFANT; MALE; NEPHROTIC SYNDROME; P-GLYCOPROTEIN; POLYMORPHISM, GENETIC;

EID: 82255164317     PISSN: 09310509     EISSN: 14602385     Source Type: Journal    
DOI: 10.1093/ndt/gfr150     Document Type: Article

References (28)

1. Hogg RJ, Portman RJ, Milliner D et al. Evaluation and management of proteinuria and nephrotic syndrome in children: recommendations from a pediatric nephrology panel established at the National Kidney Foundation conference on proteinuria, albuminuria, risk, assessment, detection, and elimination (PARADE). Pediatrics 2000; 105: 1242-1249 (Pubitemid 30346893)
2. Ahmad H, Tejani A. Predictive value of repeat renal biopsies in children with nephrotic syndrome. Nephron 2000; 84: 342-346 (Pubitemid 30179459)
3. Fan Q, Xing Y, Ding J et al. The relationship among nephrin, podocin, CD2AP and a-actinin might not be a true interaction in podocyte. Kidney Int 2005; 69: 1207-1215
4. Wasilewska A, Zalewski G, Chyczewski L et al. MDR-1 gene polymorphisms and clinical course of steroid-responsive nephrotic syndrome in children. Pediatr Nephrol 2007; 22: 44-51 (Pubitemid 46138359)
5. Ho GT, Nimmo ER, Tenesa A et al. Allelic variations of the multidrug resistance gene determines susceptibility and disease behavior in ulcerative colitis. Gastroenterology 2005; 128: 288-296 (Pubitemid 40431082)
6. Brant S, Panhuysen CIM, Nicolae D et al. MDR1 Ala893 polymorphism is associated with inflammatory bowel disease. Am J Hum Genet 2003; 73: 1282-1292 (Pubitemid 38037422)
7. Kirkham BW, Corkill MM, Davison SC et al. Response to glucocorticoid treatment in rheumatoid arthritis: in vitro cell mediated immune assay predicts in vivo responses. J Rheumatol 1991; 18: 821-825
8. Lande MB, Gullion C, Hogg RJ et al. Long versus standard initial steroid therapy for children with the nephrotic syndrome. A report from the Southwest Pediatric Nephrology Study Group. Pediatr Nephrol 2003; 18: 342-346 (Pubitemid 36790071)
9. Sakaeda T, Nakamura T, Okumura K. Pharmacogenetics of drug transporters and its impact on the pharmacotherapy. Curr Top Med Chem 2004; 4: 1385-1398 (Pubitemid 39242880)
10. Dilger K, Schwab M, Fromm MF. Identification of budesonide and prednisone as substrates of the intestinal drug efflux pump P-glycoprotein. Inflamm Bowel Dis 2004; 10: 578-583 (Pubitemid 39276465)
11. Farrell RJ, Menconi MJ, Keates AC et al. P-glycoprotein-170 inhibition significantly reduces cortisol and cyclosporin efflux from human intestinal epithelial cells and T lymphocytes. Aliment Pharmacol Ther 2002; 16: 1021-1031 (Pubitemid 34461774)
12. Klimecki WT, Futscher BW, Grogan TM et al. P-glycoprotein expression and function in circulating blood cells from normal volunteers. Blood 1994; 83: 2451-2458 (Pubitemid 24135836)
13. Ieiri I, Takane H, Otsubo K. The MDR1 (ABCB1) gene polymorphism and its clinical implications. Clin Pharmacokinet 2004; 43: 553-557
14. Woodahl EL, Ho RJ. The role of MDR1 genetic polymorphisms in interindividual variability in P-glycoprotein expression and function. Curr Drug Metab 2004; 5: 11-19 (Pubitemid 38279406)
15. Anglicheau D, Verstuyft C, Laurent-Puig P et al. Association of the multidrug resistance-1 gene single nucleotide polymorphisms with the tacrolimus dose requirement in renal transplant recipients. J Am Soc Nephrol 2003; 14: 1889-1896 (Pubitemid 36750485)
16. Soranzo N, Cavalleri GL, Weale ME et al. Identifying candidate causal variants responsible for altered activity of the ABCB1 multidrug resistance gene. Genome Res 2004; 14: 1333-1344 (Pubitemid 39029230)
17. International Study of Kidney Disease in Children. The primary nephrotic syndrome in children. Identification of patients with minimal change neprotic syndrome from initial response to prednisone. J Pediatr 1981; 98: 561-564
18. Barrett JC, Fry B, Maller J et al. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 2005; 21: 263-265 (Pubitemid 40202029)
19. Schwartz GJ, Haycock GB, Edelmann CM Jr et al. A simple estimate of glomerular filtration rate in children derived from body length and plasma creatinine. Pediatrics 1976; 58: 259-263
20. Hoffmeyer S, Burk O, von Richter O et al. Fuctional polymorphism of multidrug-resistant gene: multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo. Proc Natl Acad Sci USA 2000; 97: 3473-3478 (Pubitemid 30183327)
21. Hitzl M, Drescher S, Kuip H et al. The C3435T mutation in the human MDR1 gene is associated with altered efflux of the Pglycoprotein substrate rhodamine 123 from CD561 natural killer cells. Pharmacogenetics 2001; 11: 293-298 (Pubitemid 32537402)
22. TanabeM, Ieri I, Nagata N et al. Expression of P-glycoprotein in human placenta: relation to genetic polymorphism of the multidrug resistance (MDR1) gene. J Pharmacol Exp Ther 2001; 297: 1137-1143 (Pubitemid 32472514)
23. Von Ahsen N, Ritcher M, grupp C et al. No influence of the MDR 1C3435T polymorphism or a CYP3A4 promoter polymorphism (CYP3A4-V allele) on dose adjusted cyclosporine trough concentration or rejection incidence in stable renal transplant recipients. Clin Chem 2001; 47: 1048-1052 (Pubitemid 32493590)
24. Kim RB, Leake BF, Choo EF et al. Identification of functionally variant MDR-1 allele among European Americans and African Americans. Clin Pharmacol Ther 2001; 70: 189-199 (Pubitemid 32777772)
25. Ameyaw MM, Regaterio F, Li T et al. MDR1 pharmacogenetics: frequency of the C3435T mutation in exon 26 is significantly influenced by ethnicity. Pharmacogenetics 2001; 11: 217-221 (Pubitemid 32319871)
26. Marzolini C, Paus E, Buclin T et al. Polymorphisms in human MDR-1(P-glycoprotein in recent advances and clinical relevance. Clin Pharmacol Ther 2004; 75: 13-33 (Pubitemid 38130115)
27. Tang K, Ngoi SM, Gwee PC et al. Distinct haplotype profiles and strong linkage disequilibrium at the MDR-1 multidrug transporter gene locus in three ethnic Asian populations. Pharmacogenetics 2002; 12: 437-450 (Pubitemid 34913526)
28. Salama NN, Yang Z, Bui T et al. MDR-1 haplotypes significantly minimize intracellular uptake and transcellular P-gp substrate transport in recombinant [LC-PK] cells. J Pharm Sci 2006; 95: 2293-2308 (Pubitemid 44568538)