Infective and inflammatory diarrhoea: Mechanisms and opportunities for novel therapies

Current Opinion in Pharmacology

Volumn 11, Issue 6, 2011, Pages 634-639

  Sandle, Geoffrey I ^a  

^a ST JAMES S UNIVERSITY HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

2 [4 (2 CARBOXYETHYL)PHENETHYLAMINO]ADENOSINE 5' (N ETHYLCARBOXAMIDE); 3 ACYL 2 AMINOTHIOPHENE; 4 AMINO 2 (2 HYDROXY 1 DECYL)PYRAZOLE; 4 THIAZOLIDINONE DERIVATIVE; 5 ARYL 2 AMINOTHIAZOLE; 6 N (3 IODOBENZYL)ADENOSINE 5' N METHYLCARBOXAMIDE; ACETORPHAN; ANTIDIARRHEAL AGENT; APADENOSON; ATL 801; BOWMAN BIRK INHIBITOR; CHLORIDE CHANNEL; CHLORIDE ION; CODEINE; CORTICOSTEROID; DIPYRIDAMOLE; GENISTEIN; HYDRAZIDE DERIVATIVE; LOPERAMIDE; METHOTREXATE; NARCOTIC ANALGESIC AGENT; PENTOSTATIN; POTASSIUM CHANNEL; SEROTONIN TRANSPORTER; SODIUM CHANNEL; SODIUM ION; SODIUM PROTON EXCHANGE PROTEIN 3; TRANSIENT RECEPTOR POTENTIAL CHANNEL M6; UNCLASSIFIED DRUG; UNINDEXED DRUG; ZINC;

ACUTE DIARRHEA; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BLOATING; CHOLERA; COLITIS; COLON ABSORPTION; CONSTIPATION; CROHN DISEASE; CYTOKINE PRODUCTION; DIARRHEA; DIET SUPPLEMENTATION; DRUG EFFECT; DRUG TARGETING; ENTEROPATHOGENIC ESCHERICHIA COLI INFECTION; GIARDIASIS; HUMAN; IC 50; ILEITIS; INFANTILE DIARRHEA; INFECTIOUS DIARRHEA; INFLAMMATORY DIARRHEA; INTESTINE INFECTION; NONHUMAN; NOROVIRUS; ORAL REHYDRATION THERAPY; PRIORITY JOURNAL; PROTEIN EXPRESSION; SODIUM ABSORPTION; ULCERATIVE COLITIS; VIBRIO MIMICUS; WATER ABSORPTION;

EID: 82255162677     PISSN: 14714892     EISSN: 14714973     Source Type: Journal    
DOI: 10.1016/j.coph.2011.09.005     Document Type: Review

References (50)

1. H. Troeger, H.-J. Epple, T. Schneider, U. Wahnschaffe, R. Ullrich, G.-D. Burchard, T. Jelinek, M. Zeitz, M. Fromm, and J.-D. Schulzke Effect of chronic Giardia lamblia infection on epithelial transport and barrier function in human duodenum Gut 56 2007 328 335 (Pubitemid 46579759)
2. H. Troeger, C. Loddenkemper, T. Schneider, E. Schreier, H.-J. Epple, M. Zeitz, M. Fromm, and J.-D. Schulzke Structural and functional changes of the duodenum in human norovirus infection Gut 58 2009 1070 1077
3. C.-F. Flach, F. Qadri, T.R. Bhuiyan, N.H. Alam, E. Jennische, J. Holmgren, and I. Lönnroth Differential expression of intestinal membrane transporters in cholera patients FEBS Lett 581 2007 3183 3188 (Pubitemid 46977359)
4. - secretory pathways in cultured intestinal-like Caco-2 cells Cell Microbiol 9 2007 583 595 (Pubitemid 46231966)
5. T.K. Lapointe, P.M. C'Connor, and A.G. Buret The role of epithelial malfunction in the pathogenesis of enteropathogenic E. coli-induced diarrhea Lab Invest 89 2009 964 970
6. R.K. Gill, A. Borthakur, K. Hodges, J.R. Turner, D.R. Clayburgh, S. Saksena, A. Zaheer, K. Ramaswamy, G. Hecht, and P.K. Dudeja Mechanism underlying inhibition of intestinal apical Cl/OH exchange following infection with enteropathogenic E. coli J Clin Invest 117 2007 428 437 (Pubitemid 46203971)
7. K. Hodges, N.M. Alto, K. Ramaswamy, P.K. Dudeja, and G. Hecht The enteropathogenic Escherichia coli effector protein EspF decreases sodium hydrogen exchanger 3 activity Cell Microbiol 10 2008 1735 1745 (Pubitemid 352006153)
8. A. Thanabalasuriar, A. Koutsouris, G. Hecht, and S. Gruenheid The bacterial virulence factor NleA's involvement in intestinal tight junction disruption during enteropathogenic E. coli infection is independent of its putative PDZ binding domain Gut Microbes 1 2010 114 118
9. V.K. Viswanathan, A. Weflen, A. Koutsouris, J.L. Roxas, and G. Hecht Enteropathogenic E. coli-induced barrier function alteration is not a consequence of host cell apoptosis Am J Physiol 294 2008 G1165 G1170
10. V.K. Viswanathan, K. Hodges, and G. Hecht Enteric infection meets intestinal function: how bacterial pathogens cause diarrhoea Nat Rev Microbiol 7 2009 110 119
11. K. Hodges, and R. Gill Infectious diarrhea: cellular and molecular mechanisms Gut Microbes 1 2010 4 21
12. +-ATPase in ulcerative colitis J Pathol 204 2004 84 92 (Pubitemid 39214485)
13. S. Amasheh, C. Barmeyer, C.S. Koch, S. Tavalali, J. Mankertz, H.J. Epple, M.M. Gehring, P. Florian, A.J. Kroesen, and M. Zeitz Cytokine-dependent transcriptional down-regulation of epithelial sodium channel in ulcerative colitis Gastroenterology 126 2004 1711 1720 (Pubitemid 38736336)
14. H. Yang, W. Jiang, E.E. Furth, X. Wen, J.P. Katz, R.K. Sellon, D.G. Silberg, T.M. Antalis, C.W. Schweinfest, and G.D. Wu Intestinal inflammation reduces expression of DRA, a transporter responsible for congenital chloride diarrhea Am J Physiol 275 1998 G1445 G1453
15. + exchangers NHE2 and NHE3 in rat intestine and human Caco-2/bbe cells Am J Physiol 280 2001 C1224 C1232
16. C. Barmeyer, M. Harren, H. Schmitz, U. Heinzel-Pleines, J. Mankertz, U. Seidler, I. Horak, B. Wiedenmann, M. Fromm, and J.D. Schulzke Mechanisms of diarrhea in the interleukin-2-deficient mouse model of colonic inflammation Am J Physiol 286 2004 G244 G252
17. S. Zeissig, T. Bergann, A. Fromm, C. Bojarski, F. Heller, U. Guenther, M. Zeitz, M. Fromm, and J.D. Schulzke Altered ENaC expression leads to impaired sodium absorption in the noninflamed intestine in Crohn's disease Gastroenterology 134 2008 1436 1447 (Pubitemid 351615367)
18. G.I. Sandle, M.D. Perry, T. Mathialahan, J.E. Linley, P. Robinson, M. Hunter, and K.A. MacLennan Altered cryptal expression of luminal potassium (BK) channels in ulcerative colitis J Pathol 212 2007 66 73 (Pubitemid 46746291)
19. H.H. Wang, M.J. Shieh, and K.F. Liao A blind, randomized comparison of racecadotril and loperamide for stopping acute diarrhea in adults World J Gastroenterol 11 2005 1540 1543
20. E. Salazar-Lindo, J. Santisteban-Ponce, E. Chea-Woo, and M. Gutierrez Racecadotril in the treatment of acute watery diarrhea in children N Engl J Med 343 2000 463 467 (Pubitemid 30646485)
21. T. Ma, J.R. Thiagarajah, H. Yang, N.D. Sonawane, C. Folli, L.J.V. Galietta, and A.S. Verkman Thiazolidinone CFTR inhibitor identified by high-throughput screening blocks cholera toxin-induced intestinal fluid secretion J Clin Invest 110 2002 1651 1658 (Pubitemid 35424243)
22. 347 mutagenesis Biochem J 413 2008 135 142 (Pubitemid 351946869)
23. N.D. Sonawane, C. Muanprasat, R. Nagatani, Y. Song, and A.S. Verkman In vivo pharmacology and antidiarrheal efficacy of a thiazolidinone CFTR inhibitor in rodents J Pharm Sci 94 2005 134 143 (Pubitemid 40116377)
24. J.R. Thiagarajah, T. Broadbent, E. Hseih, and A.S. Verkman Prevention of toxin-induced intestinal ion and fluid secretion by a small-molecule CFTR inhibitor Gastroenterology 126 2004 511 519 (Pubitemid 38182308)
25. N. Sonawane, and A.S. Verkman Thiazolidinone CFTR inhibitors with improved water solubility identified by structure-activity analysis Bioorg Med Chem 16 2008 8187 8195
26. C. Muanprasat, N.D. Sonawane, D. Salinas, A. Taddei, L.J. Galietta, and A.S. Verkman Discovery of glycine hydrazide pore-occluding CFTR inhibitors: mechanism, structure-activity analysis, and in vivo efficacy J Gen Physiol 124 2004 125 137 (Pubitemid 39038187)
27. N.D. Sonawane, J. Hu, C. Muanprasat, and A.S. Verkman Luminally-active, nonabsorbable CFTR inhibitors as potential therapy to reduce intestinal fluid losses in cholera FASEB J 20 2006 130 132 (Pubitemid 43100490)
28. N. Sonawane, D. Zhao, O. Zegarra-Moran, L.J.V. Galietta, and A.S. Verkman Lectin conjugates as potent, nonabsorbable CFTR inhibitors for reducing intestinal fluid secretion in cholera Gastroenterology 132 2007 1234 1244 (Pubitemid 46627584)
29. R. De La Fuente, W. Namkung, A. Mills, and A.S. Verkman Small-molecule screen identifies inhibitors of a human intestinal calcium-activated chloride channel Mol Pharmacol 73 2008 758 768 (Pubitemid 351397881)
30. R. Bahl, N. Bhandari, M. Saksena, T. Strand, G.T. Kumar, M.K. Bhan, and H. Sommerfelt Efficacy of zinc-fortified oral rehydration solution in 6- to 35-month-old children with acute diarrhea J Paediatr 141 2002 677 682 (Pubitemid 35292767)
31. D. Carlson, J. Sehested, and H.D. Poulsen Zinc reduces the electrophysiological responses in vitro to basolateral receptor mediated secretagogues in piglet small intestinal epithelium Comp Biochem Physiol 144 2006 514 519 (Pubitemid 43994511)
32. R.B. Canani, P. Cirillo, V. Buccigrossi, S. Ruotolo, A. Passariello, P. De Luca, F. Porcaro, G. De Marco, and A. Guarino Zinc inhibits cholera toxin-induced, but not Escherichia coli heat-stable enterotoxin-induced, ion secretion in human enterocytes J Infect Dis 191 2005 1072 1077 (Pubitemid 40409507)
33. K.M. Hoque, V.M. Rajendran, and H.J. Binder Zinc inhibits cAMP-stimulated Cl secretion via basolateral K-channel blockade in rat ileum Am J Physiol 288 2005 G956 G963
34. K.A. Bowley, M.J. Morton, M. Hunter, and G.I. Sandle Non-genomic regulation of intermediate conductance potassium channels by aldosterone in human colonic crypt cells Gut 52 2003 854 860 (Pubitemid 36613493)
35. T. Bergann, S. Zeissig, A. Fromm, J.F. Richter, M. Fromm, and J.D. Schulzke Glucocorticoids and tumor necrosis factor-α synergise to induce absorption by the epithelial sodium channel in colon Gastroenterology 136 2009 933 942
36. L. Antonioli, M. Fornai, R. Colucci, N. Ghisu, M. Tuccori, M. Del Tacca, and C. Blandizzi Regulation of enteric functions by adenosine: pathophysiological and pharmacological implications Pharmacol Ther 120 2008 233 253
37. A. Fortin, D. Harbour, M. Fernandes, P. Borgeat, and S. Bourgoin Differential expression of adenosine receptors in human neutrophils: up-regulation of specific Th1 cytokines and lipopolysaccharide J Leukoc Biol 79 2006 574 585 (Pubitemid 44831234)
38. M.C. Montesinos, M. Takedachi, L.F. Thompson, T.F. Wilder, P. Fernánddez, and B.N. Cronstein The antiinflammatory mechanism of methotrexate depends on extracellular conversion of adenine nucleotides to adenosine by ecto-5′-nucleotidase: findings in a study of ecto-5′-nucleotidase gene-deficient mice Arthritis Rheum 56 2007 1440 1445 (Pubitemid 46764071)
39. M. Naganuma, E.B. Wiznerowicz, C.M. Lappas, J. Linden, M.T. Worthington, and P.B. Ernst Cutting edge: critical role for A2A adenosine receptors in the T cell mediated regulation of colitis J Immunol 177 2006 2765 2769 (Pubitemid 44277790)
40. L. Antonioli, M. Fornai, R. Colucci, N. Ghisu, F. Da Settimo, G. Natale, O. Kastsiuchenka, E. Duranti, A. Virdis, and C. Vassalle Inhibition of adenosine deaminase attenuates inflammation in experimental colitis J Pharmacol Exp Ther 322 2007 435 442 (Pubitemid 47105786)
41. B. Csóka, Z.H. Németh, L. Virág, P. Gergely, S.J. Leibovich, P. Pacher, C.X. Sun, M.R. Blackburn, E.S. Vizi, and E.A. Deitch A2A adenosine receptors and C/EBPbeta are crucially required for IL-10 production by macrophages exposed to Escherichia coli Blood 110 2007 2685 2695 (Pubitemid 47523193)
42. M. Odashima, G. Bamias, J. Rivera-Nieves, J. Linden, C.C. Nast, C.A. Moskaluk, M. Marini, K. Sugawara, K. Kozaiwa, and M. Otaka Activation of A2A adenosine receptor attenuates intestinal inflammation in animals models of inflammatory bowel disease Gastroenterology 129 2005 26 33 (Pubitemid 41002039)
43. Z. Selmeczy, B. Csóka, P. Pacher, E.S. Vizi, and G. Haskó The adenosine A2A receptor agonist CGS 21680 fails to ameliorate the course of dextran sulphate-induced colitis in mice Inflamm Res 56 2007 204 209 (Pubitemid 46985835)
44. V.L. Kolachala, B.K. Ruble, M. Vijay-Kumar, L. Wang, S. Mwangi, H.E. Figler, R.A. Figler, S. Srinivasan, A.T. Gewirtz, and J. Linden Blockade of adenosine A2B receptors ameliorates murine colitis Br J Pharmacol 155 2008 127 137
45. S. Gessi, S. Merighi, K. Varani, E. Leung, S. MacLennan, and P.A. Borea The A3 adenosine receptor: an enigmatic player in cell biology Pharmacol Ther 117 2008 123 140 (Pubitemid 350192673)
46. J.B. Brown, G. Lee, G.R. Grimm, and T.A. Barrett Therapeutic benefit of pentostatin in severe IL-10(-/-) colitis Inflamm Bowel Dis 14 2008 880 887
47. S. Poturoglu, S. Kaymakoglu, N.G. Polat, D. Ibrisim, E. Ahishali, F. Akyuz, S. Badur, K. Demir, and Z. Mungan A new agent for tumor necrosis factor-alpha inhibition Scand J Clin Lab Invest 69 2009 696 702
48. T. Sergent, N. Piront, J. Meurice, O. Toussaint, and Y.J. Schneider Anti-inflammatory effects of dietary phenolic compounds in an in vitro model of inflamed human intestinal epithelium Chem Biol Interact 188 2010 659 667
49. 2 pathways in lipopolysaccharide-induced macrophages J Agric Food Chem 56 2008 11707 11717
50. J. Seibel, A.F. Molzberger, T. Hertrampf, U. Laudenbach-Leschowski, and P. Diel Oral treatment with genistein reduces the expression of molecular and biochemical markers of inflammation in a rat model of chronic TNBS-induced colitis Eur J Nutr 48 2009 213 220