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Volumn 123, Issue 6, 2011, Pages 189-201

The pharmacologic basis for clinical differences among GLP-1 receptor agonists and DPP-4 inhibitors

Author keywords

DPP 4 inhibitor; Exenatide; GLP 1 receptor agonist; Incretin; Linagliptin; Liraglutide; Pharmacology; Saxagliptin; Sitagliptin; Type 2 diabetes mellitus

Indexed keywords

DIPEPTIDYL PEPTIDASE IV INHIBITOR; EXENDIN 4; GASTRIC INHIBITORY POLYPEPTIDE; GLIBENCLAMIDE; GLIMEPIRIDE; GLIPIZIDE; GLUCAGON; GLUCAGON LIKE PEPTIDE 1; GLUCAGON LIKE PEPTIDE 1 RECEPTOR STIMULATING AGENT; GLUCOSE; HORMONE RECEPTOR STIMULATING AGENT; INCRETIN; INSULIN; LINAGLIPTIN; LIRAGLUTIDE; METFORMIN; ROSIGLITAZONE; SAXAGLIPTIN; SITAGLIPTIN; SULFONYLUREA; UNCLASSIFIED DRUG;

EID: 82155192702     PISSN: 00325481     EISSN: 19419260     Source Type: Journal    
DOI: 10.3810/pgm.2011.11.2508     Document Type: Article
Times cited : (29)

References (103)
  • 1
    • 64749100501 scopus 로고    scopus 로고
    • Medical management of hyperglycemia in type 2 diabetes: A consensus algorithm for the initiation and adjustment of therapy: A consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes
    • Nathan DM, Buse JB, Davidson MB, et al. Medical management of hyperglycemia in type 2 diabetes: A consensus algorithm for the initiation and adjustment of therapy: a consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes. Diabetes Care. 2009;32(1):193-203.
    • (2009) Diabetes Care , vol.32 , Issue.1 , pp. 193-203
    • Nathan, D.M.1    Buse, J.B.2    Davidson, M.B.3
  • 2
    • 84855864384 scopus 로고    scopus 로고
    • AACE/ACE diabetes algorithm for glycemic control
    • American Association of Clinical Endocrinologists/American College of Endocrinology, Published 2009. Accessed June 9
    • Rodbard HW, Jellinger PS, Davidson JA, et al. American Association of Clinical Endocrinologists/American College of Endocrinology. AACE/ACE diabetes algorithm for glycemic control. http://www.aace.com/publications. Published 2009. Accessed June 9, 2010.
    • (2010)
    • Rodbard, H.W.1    Jellinger, P.S.2    Davidson, J.A.3
  • 3
    • 33845344395 scopus 로고
    • Plasma insulin response to oral and intravenous glucose administration
    • Elrick H, Stimmler L, Hlad CJ, Arai Y. Plasma insulin response to oral and intravenous glucose administration. J Clin Endocrinol Metab. 1964;24(10):1076-1082.
    • (1964) J Clin Endocrinol Metab , vol.24 , Issue.10 , pp. 1076-1082
    • Elrick, H.1    Stimmler, L.2    Hlad, C.J.3    Arai, Y.4
  • 4
    • 67049155251 scopus 로고    scopus 로고
    • Unraveling the science of incretin biology
    • Nauck MA. Unraveling the science of incretin biology. Am J Med. 2009;122(6 suppl):S3-S10.
    • (2009) Am J Med , vol.122 , Issue.6 SUPPL.
    • Nauck, M.A.1
  • 5
    • 0037045845 scopus 로고    scopus 로고
    • Effect of 6-week course of glucagon-like peptide 1 on glycaemic control, insulin sensitivity, and beta-cell function in type 2 diabetes: A parallel-group study
    • Zander M, Madsbad S, Madsen JL, Holst JJ. Effect of 6-week course of glucagon-like peptide 1 on glycaemic control, insulin sensitivity, and beta-cell function in type 2 diabetes: a parallel-group study. Lancet. 2002;359(9309):824-830.
    • (2002) Lancet , vol.359 , Issue.9309 , pp. 824-830
    • Zander, M.1    Madsbad, S.2    Madsen, J.L.3    Holst, J.J.4
  • 6
    • 33644618433 scopus 로고    scopus 로고
    • The biology of incretin hormones
    • Drucker DJ. The biology of incretin hormones. Cell Metab. 2006;3(3):153-165.
    • (2006) Cell Metab , vol.3 , Issue.3 , pp. 153-165
    • Drucker, D.J.1
  • 7
    • 0032871230 scopus 로고    scopus 로고
    • GLP-1 slows solid gastric emptying and inhibits insulin, glucagon, and PYY release in humans
    • Naslund E, Bogefors J, Skogar S, et al. GLP-1 slows solid gastric emptying and inhibits insulin, glucagon, and PYY release in humans. Am J Physiol. 1999;277(3 pt 2):R910-R916.
    • (1999) Am J Physiol , vol.277 , Issue.3 Pt. 2
    • Naslund, E.1    Bogefors, J.2    Skogar, S.3
  • 8
    • 0026535588 scopus 로고
    • Insulinotropic hormone glucagon-like peptide-I(7-37) stimulation of proinsulin gene expression and proinsulin biosynthesis in insulinoma beta TC-1 cells
    • Fehmann HC, Habener JF. Insulinotropic hormone glucagon-like peptide-I(7-37) stimulation of proinsulin gene expression and proinsulin biosynthesis in insulinoma beta TC-1 cells. Endocrinology. 1992;130(1):159-166.
    • (1992) Endocrinology , vol.130 , Issue.1 , pp. 159-166
    • Fehmann, H.C.1    Habener, J.F.2
  • 9
    • 0023638829 scopus 로고
    • Glucagon-like peptide-1 7-36: A physiological incretin in man
    • Kreymann B, Williams G, Ghatei MA, Bloom SR. Glucagon-like peptide-1 7-36: a physiological incretin in man. Lancet. 1987;2(8571):1300-1304.
    • (1987) Lancet , vol.2 , Issue.8571 , pp. 1300-1304
    • Kreymann, B.1    Williams, G.2    Ghatei, M.A.3    Bloom, S.R.4
  • 10
    • 0036959991 scopus 로고    scopus 로고
    • Effects of glucagon-like peptide 1 on counterregulatory hormone responses, cognitive functions, and insulin secretion during hyperinsulinemic, stepped hypoglycemic clamp experiments in healthy volunteers
    • Nauck MA, Heimesaat MM, Behle K, et al. Effects of glucagon-like peptide 1 on counterregulatory hormone responses, cognitive functions, and insulin secretion during hyperinsulinemic, stepped hypoglycemic clamp experiments in healthy volunteers. J Clin Endocrinol Metab. 2002;87(3):1239-1246.
    • (2002) J Clin Endocrinol Metab , vol.87 , Issue.3 , pp. 1239-1246
    • Nauck, M.A.1    Heimesaat, M.M.2    Behle, K.3
  • 11
    • 0036086315 scopus 로고    scopus 로고
    • Effect of GLP-1 on gastric volume, emptying, maximum volume ingested, and postprandial symptoms in humans
    • Delgado-Aros S, Kim DY, Burton DD, et al. Effect of GLP-1 on gastric volume, emptying, maximum volume ingested, and postprandial symptoms in humans. Am J Physiol Gastrointest Liver Physiol. 2002;282(3):G424-G431.
    • (2002) Am J Physiol Gastrointest Liver Physiol , vol.282 , Issue.3
    • Delgado-Aros, S.1    Kim, D.Y.2    Burton, D.D.3
  • 12
    • 0002300343 scopus 로고    scopus 로고
    • Glucagon-like peptide-1: A potent regulator of food intake in humans
    • Gutzwiller JP, Göke B, Drewe J, et al. Glucagon-like peptide-1: a potent regulator of food intake in humans. Gut. 1999;44(1):81-86.
    • (1999) Gut , vol.44 , Issue.1 , pp. 81-86
    • Gutzwiller, J.P.1    Göke, B.2    Drewe, J.3
  • 13
    • 0032966882 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 promotes satiety and reduces food intake in patients with diabetes mellitus type 2
    • Gutzwiller JP, Drewe J, Göke B, et al. Glucagon-like peptide-1 promotes satiety and reduces food intake in patients with diabetes mellitus type 2. Am J Physiol. 1999;276(5 pt 2):R1541-R1544.
    • (1999) Am J Physiol , vol.276 , Issue.5 Pt. 2
    • Gutzwiller, J.P.1    Drewe, J.2    Göke, B.3
  • 14
    • 34248223285 scopus 로고    scopus 로고
    • Biology of incretins: GLP-1 and GIP
    • Baggio LL, Drucker DJ. Biology of incretins: GLP-1 and GIP. Gastroenterology. 2007;132(6):2131-2157.
    • (2007) Gastroenterology , vol.132 , Issue.6 , pp. 2131-2157
    • Baggio, L.L.1    Drucker, D.J.2
  • 15
    • 77952309372 scopus 로고    scopus 로고
    • Liraglutide versus sitagliptin for patients with type 2 diabetes who did not have adequate glycaemic control with metformin: A 26-week, randomised, parallel-group, open-label trial
    • Pratley RE, Nauck M, Bailey T, et al. Liraglutide versus sitagliptin for patients with type 2 diabetes who did not have adequate glycaemic control with metformin: a 26-week, randomised, parallel-group, open-label trial. Lancet. 2010;375(9724):1447-1456.
    • (2010) Lancet , vol.375 , Issue.9724 , pp. 1447-1456
    • Pratley, R.E.1    Nauck, M.2    Bailey, T.3
  • 16
    • 34249868446 scopus 로고    scopus 로고
    • Dipeptidyl peptidase-4 inhibitors: Clinical data and clinical implications
    • Ahren B. Dipeptidyl peptidase-4 inhibitors: clinical data and clinical implications. Diabetes Care. 2007;30(6):1344-1350.
    • (2007) Diabetes Care , vol.30 , Issue.6 , pp. 1344-1350
    • Ahren, B.1
  • 17
    • 17844399596 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 mediates the therapeutic actions of DPP-IV inhibitors
    • Holst JJ, Deacon CF. Glucagon-like peptide-1 mediates the therapeutic actions of DPP-IV inhibitors. Diabetologia. 2005;48(4):612-615.
    • (2005) Diabetologia , vol.48 , Issue.4 , pp. 612-615
    • Holst, J.J.1    Deacon, C.F.2
  • 18
    • 33749871472 scopus 로고    scopus 로고
    • Effect of single oral doses of sitagliptin, a dipeptidyl peptidase-4 inhibitor, on incretin and plasma glucose levels after an oral glucose tolerance test in patients with type 2 diabetes
    • Herman GA, Bergman A, Stevens C, et al. Effect of single oral doses of sitagliptin, a dipeptidyl peptidase-4 inhibitor, on incretin and plasma glucose levels after an oral glucose tolerance test in patients with type 2 diabetes. J Clin Endocrinol Metab. 2006;91(11):4612-4619.
    • (2006) J Clin Endocrinol Metab , vol.91 , Issue.11 , pp. 4612-4619
    • Herman, G.A.1    Bergman, A.2    Stevens, C.3
  • 19
    • 77955573674 scopus 로고    scopus 로고
    • Efficacy and safety of exenatide once weekly versus sitagliptin or pioglitazone as an adjunct to metformin for treatment of type 2 diabetes (DURATION-2): A randomised trial
    • Bergenstal RM, Wysham C, MacConell L, et al. Efficacy and safety of exenatide once weekly versus sitagliptin or pioglitazone as an adjunct to metformin for treatment of type 2 diabetes (DURATION-2): a randomised trial. Lancet. 2010;376(9739):431-439.
    • (2010) Lancet , vol.376 , Issue.9739 , pp. 431-439
    • Bergenstal, R.M.1    Wysham, C.2    Macconell, L.3
  • 20
    • 55549136417 scopus 로고    scopus 로고
    • Effects of exenatide versus sitagliptin on postprandial glucose, insulin and glucagon secretion, gastric emptying, and caloric intake: A randomized, cross-over study
    • DeFronzo RA, Okerson T, Viswanathan P, Guan X, Holcombe JH, MacConell L. Effects of exenatide versus sitagliptin on postprandial glucose, insulin and glucagon secretion, gastric emptying, and caloric intake: a randomized, cross-over study. Curr Med Res Opin. 2008;24(10):2943-2952.
    • (2008) Curr Med Res Opin , vol.24 , Issue.10 , pp. 2943-2952
    • Defronzo, R.A.1    Okerson, T.2    Viswanathan, P.3    Guan, X.4    Holcombe, J.H.5    Macconell, L.6
  • 21
    • 34548321003 scopus 로고    scopus 로고
    • The incretin mimetic exenatide as a monotherapy in patients with type 2 diabetes
    • Nelson P, Poon T, Guan X, Schnabel C, Wintle M, Fineman M. The incretin mimetic exenatide as a monotherapy in patients with type 2 diabetes. Diabetes Technol Ther. 2007;9(4):317-326.
    • (2007) Diabetes Technol Ther , vol.9 , Issue.4 , pp. 317-326
    • Nelson, P.1    Poon, T.2    Guan, X.3    Schnabel, C.4    Wintle, M.5    Fineman, M.6
  • 22
    • 51549095571 scopus 로고    scopus 로고
    • Efficacy and tolerability of exenatide monotherapy over 24 weeks in antidiabetic drug-naive patients with type 2 diabetes: A randomized, double-blind, placebo-controlled, parallel-group study
    • Moretto TJ, Milton DR, Ridge TD, et al. Efficacy and tolerability of exenatide monotherapy over 24 weeks in antidiabetic drug-naive patients with type 2 diabetes: a randomized, double-blind, placebo-controlled, parallel-group study. Clin Ther. 2008;30(8):1448-1460.
    • (2008) Clin Ther , vol.30 , Issue.8 , pp. 1448-1460
    • Moretto, T.J.1    Milton, D.R.2    Ridge, T.D.3
  • 24
    • 59449101432 scopus 로고    scopus 로고
    • Liraglutide versus glimepiride monotherapy for type 2 diabetes (LEAD-3 Mono): A randomised, 52-week, phase III, double-blind, parallel-treatment trial
    • LEAD-3 Mono
    • Garber A, Henry R, Ratner R, et al; LEAD-3 Mono. Liraglutide versus glimepiride monotherapy for type 2 diabetes (LEAD-3 Mono): a randomised, 52-week, phase III, double-blind, parallel-treatment trial. Lancet. 2009;373(9662):473-481.
    • (2009) Lancet , vol.373 , Issue.9662 , pp. 473-481
    • Garber, A.1    Henry, R.2    Ratner, R.3
  • 25
    • 79951906623 scopus 로고    scopus 로고
    • Liraglutide, a once-daily human glucagon-like peptide-1 analogue, provides sustained improvements in glycaemic control and weight for 2 years as monotherapy compared with glimepiride in patients with type 2 diabetes
    • LEAD-3 (Mono) Study Group
    • Garber A, Henry RR, Ratner R, Hale P, Chang CT, Bode B; LEAD-3 (Mono) Study Group. Liraglutide, a once-daily human glucagon-like peptide-1 analogue, provides sustained improvements in glycaemic control and weight for 2 years as monotherapy compared with glimepiride in patients with type 2 diabetes. Diabetes Obes Metab. 2011;13(4):348-356.
    • (2011) Diabetes Obes Metab , vol.13 , Issue.4 , pp. 348-356
    • Garber, A.1    Henry, R.R.2    Ratner, R.3    Hale, P.4    Chang, C.T.5    Bode, B.6
  • 26
    • 33845472504 scopus 로고    scopus 로고
    • Effect of the dipeptidyl peptidase-4 inhibitor sitagliptin as monotherapy on glycemic control in patients with type 2 diabetes
    • Sitagliptin Study 021 Group
    • Aschner P, Kipnes MS, Lunceford JK, Sanchez M, Mickel C, Williams-Herman DE; Sitagliptin Study 021 Group. Effect of the dipeptidyl peptidase-4 inhibitor sitagliptin as monotherapy on glycemic control in patients with type 2 diabetes. Diabetes Care. 2006;29(12):2632-2637.
    • (2006) Diabetes Care , vol.29 , Issue.12 , pp. 2632-2637
    • Aschner, P.1    Kipnes, M.S.2    Lunceford, J.K.3    Sanchez, M.4    Mickel, C.5    Williams-Herman, D.E.6
  • 27
    • 33845489598 scopus 로고    scopus 로고
    • Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin as monotherapy in patients with type 2 diabetes mellitus
    • Sitagliptin Study 023 Group
    • Raz I, Hanefeld M, Xu L, Caria C, Williams-Herman D, Khatami H; Sitagliptin Study 023 Group. Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin as monotherapy in patients with type 2 diabetes mellitus. Diabetologia. 2006;49(11):2564-2571.
    • (2006) Diabetologia , vol.49 , Issue.11 , pp. 2564-2571
    • Raz, I.1    Hanefeld, M.2    Xu, L.3    Caria, C.4    Williams-Herman, D.5    Khatami, H.6
  • 28
    • 34347219401 scopus 로고    scopus 로고
    • Once-daily sitagliptin, a dipeptidyl peptidase-4 inhibitor, for the treatment of patients with type 2 diabetes
    • Sitagliptin Study 014 Investigators
    • Hanefeld M, Herman GA, Wu M, Mickel C, Sanchez M, Stein PP; Sitagliptin Study 014 Investigators. Once-daily sitagliptin, a dipeptidyl peptidase-4 inhibitor, for the treatment of patients with type 2 diabetes. Curr Med Res Opin. 2007;23(6):1329-1339.
    • (2007) Curr Med Res Opin , vol.23 , Issue.6 , pp. 1329-1339
    • Hanefeld, M.1    Herman, G.A.2    Wu, M.3    Mickel, C.4    Sanchez, M.5    Stein, P.P.6
  • 29
    • 42149194313 scopus 로고    scopus 로고
    • Glucose-lowering activity of the dipeptidyl peptidase-4 inhibitor saxagliptin in drug-naive patients with type 2 diabetes
    • Rosenstock J, Sankoh S, List JF. Glucose-lowering activity of the dipeptidyl peptidase-4 inhibitor saxagliptin in drug-naive patients with type 2 diabetes. Diabetes Obes Metab. 2008;10(5):376-386.
    • (2008) Diabetes Obes Metab , vol.10 , Issue.5 , pp. 376-386
    • Rosenstock, J.1    Sankoh, S.2    List, J.F.3
  • 30
    • 78851472527 scopus 로고    scopus 로고
    • Effect of linagliptin monotherapy on glycaemic control and markers of beta-cell function in patients with inadequately controlled type 2 diabetes: A randomized controlled trial
    • Del Prato S, Barnett AH, Huisman H, Neubacher D, Woerle HJ, Dugi KA. Effect of linagliptin monotherapy on glycaemic control and markers of beta-cell function in patients with inadequately controlled type 2 diabetes: a randomized controlled trial. Diabetes Obes Metab. 2011;13(3):258-267.
    • (2011) Diabetes Obes Metab , vol.13 , Issue.3 , pp. 258-267
    • Del Prato, S.1    Barnett, A.H.2    Huisman, H.3    Neubacher, D.4    Woerle, H.J.5    Dugi, K.A.6
  • 31
    • 38549162147 scopus 로고    scopus 로고
    • Exenatide effects on diabetes, obesity, cardiovascular risk factors and hepatic biomarkers in patients with type 2 diabetes treated for at least 3 years
    • Klonoff DC, Buse JB, Nielsen LL, et al. Exenatide effects on diabetes, obesity, cardiovascular risk factors and hepatic biomarkers in patients with type 2 diabetes treated for at least 3 years. Curr Med Res Opin. 2008;24(1):275-286.
    • (2008) Curr Med Res Opin , vol.24 , Issue.1 , pp. 275-286
    • Klonoff, D.C.1    Buse, J.B.2    Nielsen, L.L.3
  • 32
    • 18144401971 scopus 로고    scopus 로고
    • Effects of exenatide (exendin-4) on glycemic control and weight over 30 weeks in metformin-treated patients with type 2 diabetes
    • DeFronzo RA, Ratner RE, Han J, Kim DD, Fineman MS, Baron AD. Effects of exenatide (exendin-4) on glycemic control and weight over 30 weeks in metformin-treated patients with type 2 diabetes. Diabetes Care. 2005;28(5):1092-1100.
    • (2005) Diabetes Care , vol.28 , Issue.5 , pp. 1092-1100
    • Defronzo, R.A.1    Ratner, R.E.2    Han, J.3    Kim, D.D.4    Fineman, M.S.5    Baron, A.D.6
  • 33
    • 37349008890 scopus 로고    scopus 로고
    • Tolerability and efficacy of exenatide and titrated insulin glargine in adult patients with type 2 diabetes previously uncontrolled with metformin or a sulfonylurea: A multinational, randomized, open-label, two-period, crossover noninferiority trial
    • Barnett AH, Burger J, Johns D, et al. Tolerability and efficacy of exenatide and titrated insulin glargine in adult patients with type 2 diabetes previously uncontrolled with metformin or a sulfonylurea: a multinational, randomized, open-label, two-period, crossover noninferiority trial. Clin Ther. 2007;29(11):2333-2348.
    • (2007) Clin Ther , vol.29 , Issue.11 , pp. 2333-2348
    • Barnett, A.H.1    Burger, J.2    Johns, D.3
  • 34
    • 34249891874 scopus 로고    scopus 로고
    • Effects of once-weekly dosing of a long-acting release formulation of exenatide on glucose control and body weight in subjects with type 2 diabetes
    • Kim D, MacConell L, Zhuang D, et al. Effects of once-weekly dosing of a long-acting release formulation of exenatide on glucose control and body weight in subjects with type 2 diabetes. Diabetes Care. 2007;30(6):1487-1493.
    • (2007) Diabetes Care , vol.30 , Issue.6 , pp. 1487-1493
    • Kim, D.1    Macconell, L.2    Zhuang, D.3
  • 35
    • 62449169287 scopus 로고    scopus 로고
    • Efficacy and safety comparison of liraglutide, glimepiride, and placebo, all in combination with metformin, in type 2 diabetes: The LEAD (liraglutide effect and action in diabetes)-2 study
    • Nauck M, Frid A, Hermansen K, et al. Efficacy and safety comparison of liraglutide, glimepiride, and placebo, all in combination with metformin, in type 2 diabetes: the LEAD (liraglutide effect and action in diabetes)-2 study. Diabetes Care. 2009;32(1):84-90.
    • (2009) Diabetes Care , vol.32 , Issue.1 , pp. 84-90
    • Nauck, M.1    Frid, A.2    Hermansen, K.3
  • 36
    • 33845476757 scopus 로고    scopus 로고
    • Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin added to ongoing metformin therapy in patients with type 2 diabetes inadequately controlled with metformin alone
    • Sitagliptin Study 020 Group
    • Charbonnel B, Karasik A, Liu J, Wu M, Meininger G; Sitagliptin Study 020 Group. Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin added to ongoing metformin therapy in patients with type 2 diabetes inadequately controlled with metformin alone. Diabetes Care. 2006;29(12):2638-2643.
    • (2006) Diabetes Care , vol.29 , Issue.12 , pp. 2638-2643
    • Charbonnel, B.1    Karasik, A.2    Liu, J.3    Wu, M.4    Meininger, G.5
  • 37
    • 39749184723 scopus 로고    scopus 로고
    • Efficacy and safety of sitagliptin added to ongoing metformin therapy in patients with type 2 diabetes
    • Raz I, Chen Y, Wu M, et al. Efficacy and safety of sitagliptin added to ongoing metformin therapy in patients with type 2 diabetes. Curr Med Res Opin. 2008;24(2):537-550.
    • (2008) Curr Med Res Opin , vol.24 , Issue.2 , pp. 537-550
    • Raz, I.1    Chen, Y.2    Wu, M.3
  • 38
    • 77649176059 scopus 로고    scopus 로고
    • Effects of colesevelam, rosiglitazone, or sitagliptin on glycemic control and lipid profile in patients with type 2 diabetes mellitus inadequately controlled by metformin monotherapy
    • Rigby SP, Handelsman Y, Lai YL, Abby SL, Tao B, Jones MR. Effects of colesevelam, rosiglitazone, or sitagliptin on glycemic control and lipid profile in patients with type 2 diabetes mellitus inadequately controlled by metformin monotherapy. Endocr Pract. 2010;16(1):53-63.
    • (2010) Endocr Pract , vol.16 , Issue.1 , pp. 53-63
    • Rigby, S.P.1    Handelsman, Y.2    Lai, Y.L.3    Abby, S.L.4    Tao, B.5    Jones, M.R.6
  • 39
    • 43449096512 scopus 로고    scopus 로고
    • Efficacy and safety of sitagliptin when added to ongoing metformin therapy in patients with type 2 diabetes
    • Sitagliptin Study 801 Group
    • Scott R, Loeys T, Davies MJ, Engel SS; Sitagliptin Study 801 Group. Efficacy and safety of sitagliptin when added to ongoing metformin therapy in patients with type 2 diabetes. Diabetes Obes Metab. 2008;10(10):959-969.
    • (2008) Diabetes Obes Metab , vol.10 , Issue.10 , pp. 959-969
    • Scott, R.1    Loeys, T.2    Davies, M.J.3    Engel, S.S.4
  • 40
    • 69549135336 scopus 로고    scopus 로고
    • The efficacy and safety of saxagliptin when added to metformin therapy in patients with inadequately controlled type 2 diabetes on metformin alone
    • Saxagliptin 014 Study Group
    • DeFronzo RA, Hissa MN, Garber AJ, et al; Saxagliptin 014 Study Group. The efficacy and safety of saxagliptin when added to metformin therapy in patients with inadequately controlled type 2 diabetes on metformin alone. Diabetes Care. 2009;32(9):1649-1655.
    • (2009) Diabetes Care , vol.32 , Issue.9 , pp. 1649-1655
    • Defronzo, R.A.1    Hissa, M.N.2    Garber, A.J.3
  • 41
    • 78649691630 scopus 로고    scopus 로고
    • Safety and efficacy of linagliptin as add-on therapy to metformin in patients with type 2 diabetes: A randomized, double-blind, placebo-controlled study
    • Taskinen MR, Rosenstock J, Tamminen I, et al. Safety and efficacy of linagliptin as add-on therapy to metformin in patients with type 2 diabetes: a randomized, double-blind, placebo-controlled study. Diabetes Obes Metab. 2011;13(1):65-74.
    • (2011) Diabetes Obes Metab , vol.13 , Issue.1 , pp. 65-74
    • Taskinen, M.R.1    Rosenstock, J.2    Tamminen, I.3
  • 42
    • 79953044464 scopus 로고    scopus 로고
    • Linagliptin (BI 1356), a potent and selective DPP-4 inhibitor, is safe and efficacious in combination with metformin in patients with inadequately controlled Type 2 diabetes
    • Forst T, Uhlig-Laske B, Ring A, et al. Linagliptin (BI 1356), a potent and selective DPP-4 inhibitor, is safe and efficacious in combination with metformin in patients with inadequately controlled Type 2 diabetes. Diabet Med. 2010;27(12):1409-1419.
    • (2010) Diabet Med , vol.27 , Issue.12 , pp. 1409-1419
    • Forst, T.1    Uhlig-Laske, B.2    Ring, A.3
  • 43
    • 67649666737 scopus 로고    scopus 로고
    • Liraglutide once a day versus exenatide twice a day for type 2 diabetes: A 26-week randomised, parallel-group, multinational, open-label trial (LEAD-6)
    • LEAD-6 Study Group
    • Buse JB, Rosenstock J, Sesti G, et al; LEAD-6 Study Group. Liraglutide once a day versus exenatide twice a day for type 2 diabetes: a 26-week randomised, parallel-group, multinational, open-label trial (LEAD-6). Lancet. 2009;374(9683):39-47.
    • (2009) Lancet , vol.374 , Issue.9683 , pp. 39-47
    • Buse, J.B.1    Rosenstock, J.2    Sesti, G.3
  • 44
    • 77956076972 scopus 로고    scopus 로고
    • Switching to once-daily liraglutide from twice-daily exenatide further improves glycemic control in patients with type 2 diabetes using oral agents
    • Liraglutide Effect Action in Diabetes-6 Study Group
    • Buse JB, Sesti G, Schmidt WE, et al; Liraglutide Effect Action in Diabetes-6 Study Group. Switching to once-daily liraglutide from twice-daily exenatide further improves glycemic control in patients with type 2 diabetes using oral agents. Diabetes Care. 2010;33(6):1300-1303.
    • (2010) Diabetes Care , vol.33 , Issue.6 , pp. 1300-1303
    • Buse, J.B.1    Sesti, G.2    Schmidt, W.E.3
  • 45
    • 77958030736 scopus 로고    scopus 로고
    • Efficacy and safety of saxagliptin in combination with metformin compared with sitagliptin in combination with metformin in adult patients with type 2 diabetes mellitus
    • Scheen AJ, Charpentier G, Ostgren CJ, Hellqvist A, Gause-Nilsson I. Efficacy and safety of saxagliptin in combination with metformin compared with sitagliptin in combination with metformin in adult patients with type 2 diabetes mellitus. Diabetes Metab Res Rev. 2010;26(7):540-549.
    • (2010) Diabetes Metab Res Rev , vol.26 , Issue.7 , pp. 540-549
    • Scheen, A.J.1    Charpentier, G.2    Ostgren, C.J.3    Hellqvist, A.4    Gause-Nilsson, I.5
  • 46
    • 79952755181 scopus 로고    scopus 로고
    • One year of liraglutide treatment offers sustained and more effective glycaemic control and weight reduction compared with sitagliptin, both in combination with metformin, in patients with type 2 diabetes: A randomised, parallel-group, open-label trial
    • Pratley R, Nauck M, Bailey T, et al. One year of liraglutide treatment offers sustained and more effective glycaemic control and weight reduction compared with sitagliptin, both in combination with metformin, in patients with type 2 diabetes: a randomised, parallel-group, open-label trial. Int J Clin Pract. 2011;65(4):397-407.
    • (2011) Int J Clin Pract , vol.65 , Issue.4 , pp. 397-407
    • Pratley, R.1    Nauck, M.2    Bailey, T.3
  • 47
    • 17144371646 scopus 로고    scopus 로고
    • Effects of exenatide (exendin-4) on glycemic control over 30 weeks in patients with type 2 diabetes treated with metformin and a sulfonylurea
    • Kendall DM, Riddle MC, Rosenstock J, et al. Effects of exenatide (exendin-4) on glycemic control over 30 weeks in patients with type 2 diabetes treated with metformin and a sulfonylurea. Diabetes Care. 2005;28(5):1083-1091.
    • (2005) Diabetes Care , vol.28 , Issue.5 , pp. 1083-1091
    • Kendall, D.M.1    Riddle, M.C.2    Rosenstock, J.3
  • 48
    • 33748442464 scopus 로고    scopus 로고
    • Interim analysis of the effects of exenatide treatment on A1C, weight and cardiovascular risk factors over 82 weeks in 314 overweight patients with type 2 diabetes
    • Blonde L, Klein EJ, Han J, et al. Interim analysis of the effects of exenatide treatment on A1C, weight and cardiovascular risk factors over 82 weeks in 314 overweight patients with type 2 diabetes. Diabetes Obes Metab. 2006;8(4):436-447.
    • (2006) Diabetes Obes Metab , vol.8 , Issue.4 , pp. 436-447
    • Blonde, L.1    Klein, E.J.2    Han, J.3
  • 49
    • 34247259577 scopus 로고    scopus 로고
    • The effect of adding exenatide to a thiazolidinedione in suboptimally controlled type 2 diabetes: A randomized trial
    • Zinman B, Hoogwerf BJ, Garcia SD, et al. The effect of adding exenatide to a thiazolidinedione in suboptimally controlled type 2 diabetes: a randomized trial. Ann Intern Med. 2007;146(7):477-485.
    • (2007) Ann Intern Med , vol.146 , Issue.7 , pp. 477-485
    • Zinman, B.1    Hoogwerf, B.J.2    Garcia, S.D.3
  • 50
    • 69949117621 scopus 로고    scopus 로고
    • Liraglutide vs insulin glargine and placebo in combination with metformin and sulfonylurea therapy in type 2 diabetes mellitus (LEAD-5 met+SU): A randomised controlled trial
    • Russell-Jones D, Vaag A, Schmitz O, et al. Liraglutide vs insulin glargine and placebo in combination with metformin and sulfonylurea therapy in type 2 diabetes mellitus (LEAD-5 met+SU): a randomised controlled trial. Diabetologia. 2009;52(10):2046-2055.
    • (2009) Diabetologia , vol.52 , Issue.10 , pp. 2046-2055
    • Russell-Jones, D.1    Vaag, A.2    Schmitz, O.3
  • 51
    • 67650066860 scopus 로고    scopus 로고
    • Efficacy and safety of the human glucagon-like peptide-1 analog liraglutide in combination with metformin and thiazolidinedione in patients with type 2 diabetes (LEAD-4 Met+TZD)
    • LEAD-4 Study Investigators
    • Zinman B, Gerich J, Buse JB, et al; LEAD-4 Study Investigators. Efficacy and safety of the human glucagon-like peptide-1 analog liraglutide in combination with metformin and thiazolidinedione in patients with type 2 diabetes (LEAD-4 Met+TZD). Diabetes Care. 2009;32(7):1224-1230.
    • (2009) Diabetes Care , vol.32 , Issue.7 , pp. 1224-1230
    • Zinman, B.1    Gerich, J.2    Buse, J.B.3
  • 52
    • 33847024333 scopus 로고    scopus 로고
    • Efficacy and tolerability of the dipeptidyl peptidase-4 inhibitor sitagliptin as monotherapy over 12 weeks in patients with type 2 diabetes
    • Scott R, Wu M, Sanchez M, Stein P. Efficacy and tolerability of the dipeptidyl peptidase-4 inhibitor sitagliptin as monotherapy over 12 weeks in patients with type 2 diabetes. Int J Clin Pract. 2007;61(1):171-180.
    • (2007) Int J Clin Pract , vol.61 , Issue.1 , pp. 171-180
    • Scott, R.1    Wu, M.2    Sanchez, M.3    Stein, P.4
  • 53
    • 34547863123 scopus 로고    scopus 로고
    • Efficacy and safety of the dipeptidyl peptidase-4 inhibitor, sitagliptin, in patients with type 2 diabetes mellitus inadequately controlled on glimepiride alone or on glimepiride and metformin
    • Sitagliptin Study 035 Group
    • Hermansen K, Kipnes M, Luo E, Fanurik D, Khatami H, Stein P; Sitagliptin Study 035 Group. Efficacy and safety of the dipeptidyl peptidase-4 inhibitor, sitagliptin, in patients with type 2 diabetes mellitus inadequately controlled on glimepiride alone or on glimepiride and metformin. Diabetes Obes Metab. 2007;9(5):733-745.
    • (2007) Diabetes Obes Metab , vol.9 , Issue.5 , pp. 733-745
    • Hermansen, K.1    Kipnes, M.2    Luo, E.3    Fanurik, D.4    Khatami, H.5    Stein, P.6
  • 54
    • 73149084956 scopus 로고    scopus 로고
    • Saxagliptin added to a thiazolidinedione improves glycemic control in patients with type 2 diabetes and inadequate control on thiazolidinedione alone
    • Hollander P, Li J, Allen E, Chen R. Saxagliptin added to a thiazolidinedione improves glycemic control in patients with type 2 diabetes and inadequate control on thiazolidinedione alone. J Clin Endocrinol Metab. 2009;94(12):4810-4819.
    • (2009) J Clin Endocrinol Metab , vol.94 , Issue.12 , pp. 4810-4819
    • Hollander, P.1    Li, J.2    Allen, E.3    Chen, R.4
  • 55
    • 68949212458 scopus 로고    scopus 로고
    • Saxagliptin added to a submaximal dose of sulphonylurea improves glycaemic control compared with uptitration of sulphonylurea in patients with type 2 diabetes: A randomised controlled trial
    • Chacra AR, Tan GH, Apanovitch A, Ravichandran S, List J, Chen R. Saxagliptin added to a submaximal dose of sulphonylurea improves glycaemic control compared with uptitration of sulphonylurea in patients with type 2 diabetes: a randomised controlled trial. Int J Clin Pract. 2009;63(9):1395-1406.
    • (2009) Int J Clin Pract , vol.63 , Issue.9 , pp. 1395-1406
    • Chacra, A.R.1    Tan, G.H.2    Apanovitch, A.3    Ravichandran, S.4    List, J.5    Chen, R.6
  • 56
    • 77958184434 scopus 로고    scopus 로고
    • Exenatide affects circulating cardiovascular risk biomarkers independently of changes in body composition
    • Bunck MC, Diamant M, Eliasson B, et al. Exenatide affects circulating cardiovascular risk biomarkers independently of changes in body composition. Diabetes Care. 2010;33(8):1734-1737.
    • (2010) Diabetes Care , vol.33 , Issue.8 , pp. 1734-1737
    • Bunck, M.C.1    Diamant, M.2    Eliasson, B.3
  • 58
    • 77956920722 scopus 로고    scopus 로고
    • Liraglutide: Effects beyond glycaemic control in diabetes treatment
    • McGill JB. Liraglutide: effects beyond glycaemic control in diabetes treatment. Int J Clin Pract Suppl. 2010;64(167):28-34.
    • (2010) Int J Clin Pract Suppl , vol.64 , Issue.167 , pp. 28-34
    • McGill, J.B.1
  • 59
    • 70450190143 scopus 로고    scopus 로고
    • Weight loss with liraglutide, a once-daily human glucagon-like peptide-1 analogue for type 2 diabetes treatment as monotherapy or added to metformin, is primarily as a result of a reduction in fat tissue
    • Jendle J, Nauck MA, Matthews DR, et al. Weight loss with liraglutide, a once-daily human glucagon-like peptide-1 analogue for type 2 diabetes treatment as monotherapy or added to metformin, is primarily as a result of a reduction in fat tissue. Diabetes Obes Metab. 2009;11(12):1163-1172.
    • (2009) Diabetes Obes Metab , vol.11 , Issue.12 , pp. 1163-1172
    • Jendle, J.1    Nauck, M.A.2    Matthews, D.R.3
  • 60
    • 73249116246 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 agonists protect pancreatic beta-cells from lipotoxic endoplasmic reticulum stress through upregulation of BiP and JunB
    • Cunha DA, Ladriere L, Ortis F, et al. Glucagon-like peptide-1 agonists protect pancreatic beta-cells from lipotoxic endoplasmic reticulum stress through upregulation of BiP and JunB. Diabetes. 2009;58(12):2851-2862.
    • (2009) Diabetes , vol.58 , Issue.12 , pp. 2851-2862
    • Cunha, D.A.1    Ladriere, L.2    Ortis, F.3
  • 61
    • 65949122087 scopus 로고    scopus 로고
    • One-year treatment with exenatide improves beta-cell function, compared with insulin glargine, in metformin-treated type 2 diabetic patients: A randomized, controlled trial
    • Bunck MC, Diamant M, Corner A, et al. One-year treatment with exenatide improves beta-cell function, compared with insulin glargine, in metformin-treated type 2 diabetic patients: a randomized, controlled trial. Diabetes Care. 2009;32(5):762-768.
    • (2009) Diabetes Care , vol.32 , Issue.5 , pp. 762-768
    • Bunck, M.C.1    Diamant, M.2    Corner, A.3
  • 62
    • 62449129181 scopus 로고    scopus 로고
    • Liraglutide, a once-daily human GLP-1 analogue, added to a sulphonylurea over 26 weeks produces greater improvements in glycaemic and weight control compared with adding rosiglitazone or placebo in subjects with Type 2 diabetes (LEAD-1 SU)
    • LEAD-1 SU study group
    • Marre M, Shaw J, Brändle M, et al; LEAD-1 SU study group. Liraglutide, a once-daily human GLP-1 analogue, added to a sulphonylurea over 26 weeks produces greater improvements in glycaemic and weight control compared with adding rosiglitazone or placebo in subjects with Type 2 diabetes (LEAD-1 SU). Diabet Med. 2009;26(3):268-278.
    • (2009) Diabet Med , vol.26 , Issue.3 , pp. 268-278
    • Marre, M.1    Shaw, J.2    Brändle, M.3
  • 63
    • 33846796143 scopus 로고    scopus 로고
    • Effect of adding sitagliptin, a dipeptidyl peptidase-4 inhibitor, to metformin on 24-h glycaemic control and beta-cell function in patients with type 2 diabetes
    • Brazg R, Xu L, Dalla MC, Cobelli C, Thomas K, Stein PP. Effect of adding sitagliptin, a dipeptidyl peptidase-4 inhibitor, to metformin on 24-h glycaemic control and beta-cell function in patients with type 2 diabetes. Diabetes Obes Metab. 2007;9(2):186-193.
    • (2007) Diabetes Obes Metab , vol.9 , Issue.2 , pp. 186-193
    • Brazg, R.1    Xu, L.2    Dalla, M.C.3    Cobelli, C.4    Thomas, K.5    Stein, P.P.6
  • 64
    • 34247195226 scopus 로고    scopus 로고
    • A comparison of twice-daily exenatide and biphasic insulin aspart in patients with type 2 diabetes who were suboptimally controlled with sulfonylurea and metformin: A non-inferiority study
    • Nauck MA, Duran S, Kim D, et al. A comparison of twice-daily exenatide and biphasic insulin aspart in patients with type 2 diabetes who were suboptimally controlled with sulfonylurea and metformin: a non-inferiority study. Diabetologia. 2007;50(2):259-267.
    • (2007) Diabetologia , vol.50 , Issue.2 , pp. 259-267
    • Nauck, M.A.1    Duran, S.2    Kim, D.3
  • 65
    • 50649110233 scopus 로고    scopus 로고
    • Beneficial effects of once-daily liraglutide, a human glucagon-like peptide-1 analogue, on cardiovascular risk biomarkers in patients with Type 2 diabetes
    • Courrèges JP, Vilsboll T, Zdravkovic M, et al. Beneficial effects of once-daily liraglutide, a human glucagon-like peptide-1 analogue, on cardiovascular risk biomarkers in patients with Type 2 diabetes. Diabet Med. 2008;25(9):1129-1131.
    • (2008) Diabet Med , vol.25 , Issue.9 , pp. 1129-1131
    • Courrèges, J.P.1    Vilsboll, T.2    Zdravkovic, M.3
  • 66
    • 82155190557 scopus 로고    scopus 로고
    • Byetta [package insert]. San Diego, CA: Amylin Pharmaceuticals, Inc
    • Byetta [package insert]. San Diego, CA: Amylin Pharmaceuticals, Inc; 2010.
    • (2010)
  • 67
    • 82155161106 scopus 로고    scopus 로고
    • Victoza [package insert]. Princeton, NJ: Novo Nordisk Inc
    • Victoza [package insert]. Princeton, NJ: Novo Nordisk Inc; 2010.
    • (2010)
  • 68
    • 82155190552 scopus 로고    scopus 로고
    • Januvia [package insert]. Whitehouse Station, NJ: Merck and Co, Inc
    • Januvia [package insert]. Whitehouse Station, NJ: Merck and Co, Inc; 2010.
    • (2010)
  • 69
    • 82155193676 scopus 로고    scopus 로고
    • Onglyza [package insert]. Princeton, NJ: Bristol-Myers Squibb Company
    • Onglyza [package insert]. Princeton, NJ: Bristol-Myers Squibb Company; 2009.
    • (2009)
  • 70
    • 82155200014 scopus 로고    scopus 로고
    • Tradjenta [package insert]. Ridgefield, CT: Boehringer-Ingelheim Pharmaceuticals, Inc
    • Tradjenta [package insert]. Ridgefield, CT: Boehringer-Ingelheim Pharmaceuticals, Inc; 2011.
    • (2011)
  • 71
    • 75549091263 scopus 로고    scopus 로고
    • Statement by an American Association of Clinical Endocrinologists/American College of Endocrinology consensus panel on type 2 diabetes mellitus: An algorithm for glycemic control
    • Published 2009. Accessed June 28, 2011
    • Rodbard HW, Jellinger PS, Davidson JA, et al. Statement by an American Association of Clinical Endocrinologists/American College of Endocrinology consensus panel on type 2 diabetes mellitus: an algorithm for glycemic control. Endocr Pract. 2009;15(6):540-559. https://www.aace.com/sites/default/files/GlycemicControlAlgorithm.pdf. Published 2009. Accessed June 28, 2011.
    • (2009) Endocr Pract , vol.15 , Issue.6 , pp. 540-559
    • Rodbard, H.W.1    Jellinger, P.S.2    Davidson, J.A.3
  • 72
    • 53249142132 scopus 로고    scopus 로고
    • Exenatide once weekly versus twice daily for the treatment of type 2 diabetes: A randomised, open-label, non-inferiority study
    • DURATION-1 Study Group
    • Drucker DJ, Buse JB, Taylor K, et al; DURATION-1 Study Group. Exenatide once weekly versus twice daily for the treatment of type 2 diabetes: a randomised, open-label, non-inferiority study. Lancet. 2008;372(9645):1240-1250.
    • (2008) Lancet , vol.372 , Issue.9645 , pp. 1240-1250
    • Drucker, D.J.1    Buse, J.B.2    Taylor, K.3
  • 73
    • 0027248866 scopus 로고
    • Normalization of fasting hyperglycaemia by exogenous glucagon-like peptide 1 (7-36 amide) in type 2 (non-insulin-dependent) diabetic patients
    • Nauck MA, Kleine N, Orskov C, Holst JJ, Willms B, Creutzfeldt W. Normalization of fasting hyperglycaemia by exogenous glucagon-like peptide 1 (7-36 amide) in type 2 (non-insulin-dependent) diabetic patients. Diabetologia. 1993;36(8):741-744.
    • (1993) Diabetologia , vol.36 , Issue.8 , pp. 741-744
    • Nauck, M.A.1    Kleine, N.2    Orskov, C.3    Holst, J.J.4    Willms, B.5    Creutzfeldt, W.6
  • 74
    • 0027391607 scopus 로고
    • Preserved incretin activity of glucagon-like peptide 1 [7-36 amide] but not of synthetic human gastric inhibitory polypeptide in patients with type-2 diabetes mellitus
    • Nauck MA, Heimesaat MM, Orskov C, Holst JJ, Ebert R, Creutzfeldt W. Preserved incretin activity of glucagon-like peptide 1 [7-36 amide] but not of synthetic human gastric inhibitory polypeptide in patients with type-2 diabetes mellitus. J Clin Invest. 1993;91(1):301-307.
    • (1993) J Clin Invest , vol.91 , Issue.1 , pp. 301-307
    • Nauck, M.A.1    Heimesaat, M.M.2    Orskov, C.3    Holst, J.J.4    Ebert, R.5    Creutzfeldt, W.6
  • 75
    • 67649523294 scopus 로고    scopus 로고
    • Treatment with the human once-weekly glucagon-like peptide-1 analog taspoglutide in combination with metformin improves glycemic control and lowers body weight in patients with type 2 diabetes inadequately controlled with metformin alone: A double-blind placebo-controlled study
    • Nauck MA, Ratner RE, Kapitza C, Berria R, Boldrin M, Balena R. Treatment with the human once-weekly glucagon-like peptide-1 analog taspoglutide in combination with metformin improves glycemic control and lowers body weight in patients with type 2 diabetes inadequately controlled with metformin alone: a double-blind placebo-controlled study. Diabetes Care. 2009;32(7):1237-1243.
    • (2009) Diabetes Care , vol.32 , Issue.7 , pp. 1237-1243
    • Nauck, M.A.1    Ratner, R.E.2    Kapitza, C.3    Berria, R.4    Boldrin, M.5    Balena, R.6
  • 76
    • 0031916924 scopus 로고    scopus 로고
    • Dipeptidyl peptidase IV inhibition potentiates the insulinotropic effect of glucagon-like peptide 1 in the anesthetized pig
    • Deacon CF, Hughes TE, Holst JJ. Dipeptidyl peptidase IV inhibition potentiates the insulinotropic effect of glucagon-like peptide 1 in the anesthetized pig. Diabetes. 1998;47(5):764-769.
    • (1998) Diabetes , vol.47 , Issue.5 , pp. 764-769
    • Deacon, C.F.1    Hughes, T.E.2    Holst, J.J.3
  • 77
    • 34249869806 scopus 로고    scopus 로고
    • Liraglutide, a long-acting human glucagon-like peptide-1 analog, given as monotherapy significantly improves glycemic control and lowers body weight without risk of hypoglycemia in patients with type 2 diabetes
    • Vilsboll T, Zdravkovic M, Le Thi T, et al. Liraglutide, a long-acting human glucagon-like peptide-1 analog, given as monotherapy significantly improves glycemic control and lowers body weight without risk of hypoglycemia in patients with type 2 diabetes. Diabetes Care. 2007;30(6):1608-1610.
    • (2007) Diabetes Care , vol.30 , Issue.6 , pp. 1608-1610
    • Vilsboll, T.1    Zdravkovic, M.2    Lethi, T.3
  • 78
    • 70349333861 scopus 로고    scopus 로고
    • Effect of saxagliptin monotherapy in treatment-naïve patients with type 2 diabetes
    • CV181-011 Study Investigators
    • Rosenstock J, Aguilar-Salinas C, Klein E, Nepal S, List J, Chen R; CV181-011 Study Investigators. Effect of saxagliptin monotherapy in treatment-naïve patients with type 2 diabetes. Curr Med Res Opin. 2009;25(10):2401-2411.
    • (2009) Curr Med Res Opin , vol.25 , Issue.10 , pp. 2401-2411
    • Rosenstock, J.1    Aguilar-Salinas, C.2    Klein, E.3    Nepal, S.4    List, J.5    Chen, R.6
  • 79
    • 33845405222 scopus 로고    scopus 로고
    • Glycemic durability of rosiglitazone, metformin, or glyburide monotherapy
    • ADOPT Study Group
    • Kahn SE, Haffner SM, Heise MA, et al; ADOPT Study Group. Glycemic durability of rosiglitazone, metformin, or glyburide monotherapy. N Engl J Med. 2006;355(23):2427-2443.
    • (2006) N Engl J Med , vol.355 , Issue.23 , pp. 2427-2443
    • Kahn, S.E.1    Haffner, S.M.2    Heise, M.A.3
  • 80
    • 33846690465 scopus 로고    scopus 로고
    • A systematic review and meta-analysis of hypoglycemia and cardiovascular events: A comparison of glyburide with other secretagogues and with insulin
    • Gangji AS, Cukierman T, Gerstein HC, Goldsmith CH, Clase CM. A systematic review and meta-analysis of hypoglycemia and cardiovascular events: a comparison of glyburide with other secretagogues and with insulin. Diabetes Care. 2007;30(2):389-394.
    • (2007) Diabetes Care , vol.30 , Issue.2 , pp. 389-394
    • Gangji, A.S.1    Cukierman, T.2    Gerstein, H.C.3    Goldsmith, C.H.4    Clase, C.M.5
  • 81
    • 0035667081 scopus 로고    scopus 로고
    • Lower incidence of severe hypoglycaemia in patients with type 2 diabetes treated with glimepiride versus glibenclamide
    • Holstein A, Plaschke A, Egberts EH. Lower incidence of severe hypoglycaemia in patients with type 2 diabetes treated with glimepiride versus glibenclamide. Diabetes Metab Res Rev. 2001;17(6):467-473.
    • (2001) Diabetes Metab Res Rev , vol.17 , Issue.6 , pp. 467-473
    • Holstein, A.1    Plaschke, A.2    Egberts, E.H.3
  • 82
    • 33644798145 scopus 로고    scopus 로고
    • Resistance to insulin therapy among patients and providers: Results of the cross-national Diabetes Attitudes, Wishes, and Needs (DAWN) study
    • Peyrot M, Rubin RR, Lauritzen T, et al. Resistance to insulin therapy among patients and providers: results of the cross-national Diabetes Attitudes, Wishes, and Needs (DAWN) study. Diabetes Care. 2005;28(11):2673-2679.
    • (2005) Diabetes Care , vol.28 , Issue.11 , pp. 2673-2679
    • Peyrot, M.1    Rubin, R.R.2    Lauritzen, T.3
  • 83
    • 79955661908 scopus 로고    scopus 로고
    • DURATION-5: Exenatide once weekly resulted in greater improvements in glycemic control compared with exenatide twice daily in patients with type 2 diabetes
    • Blevins T, Pullman J, Malloy J, et al. DURATION-5: exenatide once weekly resulted in greater improvements in glycemic control compared with exenatide twice daily in patients with type 2 diabetes. J Clin Endocrinol Metab. 2011;96(5):1301-1310.
    • (2011) J Clin Endocrinol Metab , vol.96 , Issue.5 , pp. 1301-1310
    • Blevins, T.1    Pullman, J.2    Malloy, J.3
  • 84
    • 77953859640 scopus 로고    scopus 로고
    • Once weekly exenatide compared with insulin glargine titrated to target in patients with type 2 diabetes (DURATION-3): An open-label randomised trial
    • Diamant M, Van GL, Stranks S, et al. Once weekly exenatide compared with insulin glargine titrated to target in patients with type 2 diabetes (DURATION-3): an open-label randomised trial. Lancet. 2010;375(9733):2234-2243.
    • (2010) Lancet , vol.375 , Issue.9733 , pp. 2234-2243
    • Diamant, M.1    Van, G.L.2    Stranks, S.3
  • 85
    • 84856573743 scopus 로고    scopus 로고
    • Adverse events of pancreatitis
    • US Food and Drug Administration. Saxagliptin, Published 2010. Accessed October 26
    • US Food and Drug Administration. Saxagliptin. Adverse events of pancreatitis. http://www.fda.gov/downloads/AdvisoryCommittees/CommitteesMeetingMaterials/Drugs/EndocrinologicandMetabolicDrugsAdvisoryCommittee/UCM149589.pdf. Published 2010. Accessed October 26, 2010.
    • (2010)
  • 86
    • 65949111736 scopus 로고    scopus 로고
    • Increased risk of acute pancreatitis and biliary disease observed in patients with type 2 diabetes: A retrospective cohort study
    • Noel RA, Braun DK, Patterson RE, Bloomgren GL. Increased risk of acute pancreatitis and biliary disease observed in patients with type 2 diabetes: a retrospective cohort study. Diabetes Care. 2009;32(5):834-838.
    • (2009) Diabetes Care , vol.32 , Issue.5 , pp. 834-838
    • Noel, R.A.1    Braun, D.K.2    Patterson, R.E.3    Bloomgren, G.L.4
  • 87
    • 79951704452 scopus 로고    scopus 로고
    • Acute pancreatitis in type 2 diabetes treated with exenatide or sitagliptin: A retrospective observational pharmacy claims analysis
    • Garg R, Chen W, Pendergrass M. Acute pancreatitis in type 2 diabetes treated with exenatide or sitagliptin: a retrospective observational pharmacy claims analysis. Diabetes Care. 2010;33(11):2349-2354.
    • (2010) Diabetes Care , vol.33 , Issue.11 , pp. 2349-2354
    • Garg, R.1    Chen, W.2    Pendergrass, M.3
  • 88
    • 67649304917 scopus 로고    scopus 로고
    • Use of a claims-based active drug safety surveillance system to assess the risk of acute pancreatitis with exenatide or sitagliptin compared to metformin or glyburide
    • Dore DD, Seeger JD, Arnold CK. Use of a claims-based active drug safety surveillance system to assess the risk of acute pancreatitis with exenatide or sitagliptin compared to metformin or glyburide. Curr Med Res Opin. 2009;25(4):1019-1027.
    • (2009) Curr Med Res Opin , vol.25 , Issue.4 , pp. 1019-1027
    • Dore, D.D.1    Seeger, J.D.2    Arnold, C.K.3
  • 89
    • 77649294607 scopus 로고    scopus 로고
    • Weighing risks and benefits of liraglutide-the FDA's review of a new antidiabetic therapy
    • Parks M, Rosebraugh C. Weighing risks and benefits of liraglutide-the FDA's review of a new antidiabetic therapy. N Engl J Med. 2010;362(9):774-777.
    • (2010) N Engl J Med , vol.362 , Issue.9 , pp. 774-777
    • Parks, M.1    Rosebraugh, C.2
  • 90
    • 84856586697 scopus 로고    scopus 로고
    • US Food and Drug Administration. Byetta. NDA approval. Supplemental approval, Published 2009. Accessed January 12
    • US Food and Drug Administration. Byetta. NDA approval. Supplemental approval. http://www.accessdata.fda.gov/drugsatfda_docs/appletter/2009/021773s009s011s017s018s022s025021919ltr.pdf. Published 2009. Accessed January 12, 2010.
    • (2010)
  • 91
    • 84856561636 scopus 로고    scopus 로고
    • US Food and Drug Administration. Victoza. NDA approval, Published 2010. Accessed July 15
    • US Food and Drug Administration. Victoza. NDA approval. http://www.accessdata.fda.gov/drugsatfda_docs/appletter/2010/022341s000ltr.pdf. Published 2010. Accessed July 15, 2010.
    • (2010)
  • 92
    • 84856561635 scopus 로고    scopus 로고
    • US Food and Drug Administration. Januvia. Supplement approval, Published 2010. Accessed June 7
    • US Food and Drug Administration. Januvia. Supplement approval. http://www.accessdata.fda.gov/drugsatfda_docs/appletter/2010/021995s010s011s012s014ltr.pdf. Published 2010. Accessed June 7, 2010.
    • (2010)
  • 93
    • 84856586699 scopus 로고    scopus 로고
    • US Food and Drug Administration. Onglyza. NDA approval, Published 2009. Accessed July 15
    • US Food and Drug Administration. Onglyza. NDA approval. http://www.accessdata.fda.gov/drugsatfda_docs/appletter/2009/022350s000ltr.pdf. Published 2009. Accessed July 15, 2010.
    • (2010)
  • 94
    • 84856586696 scopus 로고    scopus 로고
    • US Food and Drug Administration. Tradjenta. NDA approval, Published 2011. Accessed May 23
    • US Food and Drug Administration. Tradjenta. NDA approval. http://www.accessdata.fda.gov/drugsatfda_docs/appletter/2011/201280s000ltr.pdf. Published 2011. Accessed May 23, 2011.
    • (2011)
  • 95
    • 82155190550 scopus 로고    scopus 로고
    • Frequency and magnitude of antibody formation are lower with liraglutide than exenatide: LEAD-6 results
    • Paper presented at: American Diabetes Association 70th Scientific Sessions; June 25-29, Orlando, FL
    • Buse J, Montanya E, Sesti G, et al. Frequency and magnitude of antibody formation are lower with liraglutide than exenatide: LEAD-6 results. Paper presented at: American Diabetes Association 70th Scientific Sessions; June 25-29, 2010; Orlando, FL.
    • (2010)
    • Buse, J.1    Montanya, E.2    Sesti, G.3
  • 96
    • 0032511583 scopus 로고    scopus 로고
    • Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes
    • (UKPDS 33). UK Prospective Diabetes Study (UKPDS) Group
    • Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). UK Prospective Diabetes Study (UKPDS) Group. Lancet. 1998;352(9131):837-853.
    • (1998) Lancet , vol.352 , Issue.9131 , pp. 837-853
  • 97
    • 79959692519 scopus 로고    scopus 로고
    • Mild renal impairment has no effect on the efficacy and safety of liraglutide
    • Davidson JA, Brett J, Falahati A, Scott D. Mild renal impairment has no effect on the efficacy and safety of liraglutide. Endocr Pract. 2011;17(3):345-355.
    • (2011) Endocr Pract , vol.17 , Issue.3 , pp. 345-355
    • Davidson, J.A.1    Brett, J.2    Falahati, A.3    Scott, D.4
  • 98
    • 72249116214 scopus 로고    scopus 로고
    • Guidance for industry: Diabetes mellitus-evaluating cardiovascular risk in new antidiabetic therapies to treat type 2 diabetes
    • US Food and Drug Administration, Published 2008. Accessed April 14
    • US Food and Drug Administration. Guidance for industry: diabetes mellitus-evaluating cardiovascular risk in new antidiabetic therapies to treat type 2 diabetes. http://www.fda.gov/downloads/Drugs/GuidanceComplianceRegulatoryInformation/Guidances/ucm071627.pdf. Published 2008. Accessed April 14, 2010.
    • (2010)
  • 99
    • 77950228684 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 receptor agonists activate rodent thyroid C-cells causing calcitonin release and C-cell proliferation
    • Bjerre KL, Madsen LW, Andersen S, et al. Glucagon-like peptide-1 receptor agonists activate rodent thyroid C-cells causing calcitonin release and C-cell proliferation. Endocrinology. 2010;151(4):1473-1486.
    • (2010) Endocrinology , vol.151 , Issue.4 , pp. 1473-1486
    • Bjerre, K.L.1    Madsen, L.W.2    Andersen, S.3
  • 100
    • 79952284556 scopus 로고    scopus 로고
    • GLP-1 and calcitonin concentration in humans: Lack of evidence of calcitonin release from sequential screening in over 5000 subjects with type 2 diabetes or nondiabetic obese subjects treated with the human GLP-1 analog, liraglutide
    • Hegedus L, Moses AC, Zdravkovic M, Le TT, Daniels GH. GLP-1 and calcitonin concentration in humans: lack of evidence of calcitonin release from sequential screening in over 5000 subjects with type 2 diabetes or nondiabetic obese subjects treated with the human GLP-1 analog, liraglutide. J Clin Endocrinol Metab. 2011;96(3):853-860.
    • (2011) J Clin Endocrinol Metab , vol.96 , Issue.3 , pp. 853-860
    • Hegedus, L.1    Moses, A.C.2    Zdravkovic, M.3    Le, T.T.4    Daniels, G.H.5
  • 102
    • 84857729092 scopus 로고    scopus 로고
    • Does saxagliptin reduce the risk of cardiovascular events when used alone or added to other diabetes medications (SAVOR-TIMI 53)
    • ClinicalTrials.gov., Published 2011. Accessed February 9
    • ClinicalTrials.gov. Does saxagliptin reduce the risk of cardiovascular events when used alone or added to other diabetes medications (SAVOR-TIMI 53). http://www.clinicaltrials.gov/ct2/show/NCT01107886?term=cardiovascular+AND+saxagliptin&rank=1. Published 2011. Accessed February 9, 2011.
    • (2011)
  • 103
    • 84856564451 scopus 로고    scopus 로고
    • CAROLINA: Cardiovascular outcomes study of linagliptin versus glimepiride in patients with type 2 diabetes
    • ClinicalTrials.gov, Published 2011. Accessed September 21
    • ClinicalTrials.gov. CAROLINA: Cardiovascular outcomes study of linagliptin versus glimepiride in patients with type 2 diabetes. http://www.clinicaltrials.gov/ct2/show/NCT01243424?term=linagliptin&rank=13. Published 2011. Accessed September 21, 2011.
    • (2011)


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.