메뉴 건너뛰기




Volumn 9, Issue 4, 2007, Pages 317-326

The incretin mimetic exenatide as a monotherapy in patients with type 2 diabetes

Author keywords

[No Author keywords available]

Indexed keywords

EXENDIN 4; GLYCOSYLATED HEMOGLOBIN; INCRETIN; METFORMIN;

EID: 34548321003     PISSN: 15209156     EISSN: None     Source Type: Journal    
DOI: 10.1089/dia.2006.0024     Document Type: Article
Times cited : (53)

References (36)
  • 1
    • 0026648961 scopus 로고
    • Isolation and characterization of exendin-4, an exendin-3 analogue, from Heloderma suspectum venom. Further evidence for an exendin receptor on dispersed acini from guinea pig pancreas
    • Eng J, Kleinman WA, Singh L, Singh G, Raufman JP: Isolation and characterization of exendin-4, an exendin-3 analogue, from Heloderma suspectum venom. Further evidence for an exendin receptor on dispersed acini from guinea pig pancreas. J Biol Chem 1992;267:7402-7405.
    • (1992) J Biol Chem , vol.267 , pp. 7402-7405
    • Eng, J.1    Kleinman, W.A.2    Singh, L.3    Singh, G.4    Raufman, J.P.5
  • 3
    • 0034857141 scopus 로고    scopus 로고
    • Development of glucagon-like peptide-1-based pharmaceuticals as therapeutic agents for the treatment of diabetes
    • Drucker DJ: Development of glucagon-like peptide-1-based pharmaceuticals as therapeutic agents for the treatment of diabetes. Curr Pharm Des 2001;7:1399-1412.
    • (2001) Curr Pharm Des , vol.7 , pp. 1399-1412
    • Drucker, D.J.1
  • 4
    • 28644443140 scopus 로고    scopus 로고
    • Glucagon-like peptide-1-based therapies for the treatment of type 2 diabetes mellitus
    • Gallwitz B: Glucagon-like peptide-1-based therapies for the treatment of type 2 diabetes mellitus. Treat Endocrinol 2005;4:361-370.
    • (2005) Treat Endocrinol , vol.4 , pp. 361-370
    • Gallwitz, B.1
  • 5
    • 0036869408 scopus 로고    scopus 로고
    • Therapy of type 2 diabetes mellitus based on the actions of glucagon-like peptide-1
    • Holst JJ: Therapy of type 2 diabetes mellitus based on the actions of glucagon-like peptide-1. Diabetes Metab Res Rev 2002;18:430-441.
    • (2002) Diabetes Metab Res Rev , vol.18 , pp. 430-441
    • Holst, J.J.1
  • 7
    • 0037850667 scopus 로고    scopus 로고
    • Effect on glycemic control of exenatide (synthetic exendin-4) additive to existing metformin and/or sulfonylurea treatment in patients with type 2 diabetes
    • Fineman MS, Bicsak TA, Shen LZ, Taylor K, Gaines E, Varns A, Kim D, Baron AD: Effect on glycemic control of exenatide (synthetic exendin-4) additive to existing metformin and/or sulfonylurea treatment in patients with type 2 diabetes. Diabetes Care 2003;26:2370-2377.
    • (2003) Diabetes Care , vol.26 , pp. 2370-2377
    • Fineman, M.S.1    Bicsak, T.A.2    Shen, L.Z.3    Taylor, K.4    Gaines, E.5    Varns, A.6    Kim, D.7    Baron, A.D.8
  • 8
    • 0038519125 scopus 로고    scopus 로고
    • Pharmacology of exenatide (synthetic exendin-4) for the treatment of type 2 diabetes
    • Nielsen LL, Baron AD: Pharmacology of exenatide (synthetic exendin-4) for the treatment of type 2 diabetes. Curr Opin Investig Drugs 2003;4:401-405.
    • (2003) Curr Opin Investig Drugs , vol.4 , pp. 401-405
    • Nielsen, L.L.1    Baron, A.D.2
  • 9
    • 0032908654 scopus 로고    scopus 로고
    • Glucose-lowering and insulin-sensitizing actions of exendin-4: Studies in obese diabetic (ob/ob, db/db) mice, diabetic fatty Zucker rats, and diabetic rhesus monkeys (Macaca mulatta)
    • Young AA, Gedulin BR, Bhavsar S, Bodkin N, Jodka C, Hansen B, Denaro M: Glucose-lowering and insulin-sensitizing actions of exendin-4: studies in obese diabetic (ob/ob, db/db) mice, diabetic fatty Zucker rats, and diabetic rhesus monkeys (Macaca mulatta). Diabetes 1999;48:1026-1034.
    • (1999) Diabetes , vol.48 , pp. 1026-1034
    • Young, A.A.1    Gedulin, B.R.2    Bhavsar, S.3    Bodkin, N.4    Jodka, C.5    Hansen, B.6    Denaro, M.7
  • 10
    • 0035340019 scopus 로고    scopus 로고
    • Insulinotropic actions of exendin-4 and glucagon-like peptide-1 in vivo and in vitro
    • Parkes DG, Pittner R, Jodka C, Smith P, Young A: Insulinotropic actions of exendin-4 and glucagon-like peptide-1 in vivo and in vitro. Metabolism 2001;50:583-589.
    • (2001) Metabolism , vol.50 , pp. 583-589
    • Parkes, D.G.1    Pittner, R.2    Jodka, C.3    Smith, P.4    Young, A.5
  • 13
    • 0036965113 scopus 로고    scopus 로고
    • The insulinotropic effect of acute exendin-4 administered to humans: Comparison of nondiabetic state to type 2 diabetes
    • Egan JM, Clocquet AR, Elahi D: The insulinotropic effect of acute exendin-4 administered to humans: comparison of nondiabetic state to type 2 diabetes. J Clin Endocrinol Metab 2002;87:1282-1290.
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 1282-1290
    • Egan, J.M.1    Clocquet, A.R.2    Elahi, D.3
  • 14
    • 18144401971 scopus 로고    scopus 로고
    • Effects of exenatide (exendin-4) on glycemic control and weight over 30 weeks in metformin-treated patients with type 2 diabetes
    • DeFronzo RA, Ratner RE, Han J, Kim DD, Fineman MS, Baron AD: Effects of exenatide (exendin-4) on glycemic control and weight over 30 weeks in metformin-treated patients with type 2 diabetes. Diabetes Care 2005;28:1092-1100.
    • (2005) Diabetes Care , vol.28 , pp. 1092-1100
    • DeFronzo, R.A.1    Ratner, R.E.2    Han, J.3    Kim, D.D.4    Fineman, M.S.5    Baron, A.D.6
  • 15
    • 7444228521 scopus 로고    scopus 로고
    • Exenatide-113 Clinical Study Group: Effects of exenatide (exendin-4) on glycemic control over 30 weeks in sulfonylurea-treated patients with type 2 diabetes
    • Buse JB, Henry RR, Han J, Kim DD, Fineman MS, Baron AD; Exenatide-113 Clinical Study Group: Effects of exenatide (exendin-4) on glycemic control over 30 weeks in sulfonylurea-treated patients with type 2 diabetes. Diabetes Care 2004;27:2628-2635.
    • (2004) Diabetes Care , vol.27 , pp. 2628-2635
    • Buse, J.B.1    Henry, R.R.2    Han, J.3    Kim, D.D.4    Fineman, M.S.5    Baron, A.D.6
  • 16
    • 17144371646 scopus 로고    scopus 로고
    • Effects of exenatide (exendin-4) on glycemic control over 30 weeks in patients with type 2 diabetes treated with metformin and a sulfonylurea
    • Kendall DM, Riddle MC, Rosenstock J, Zhuang D, Kim DD, Fineman MS, Baron AD: Effects of exenatide (exendin-4) on glycemic control over 30 weeks in patients with type 2 diabetes treated with metformin and a sulfonylurea. Diabetes Care 2005;28:1083-1091.
    • (2005) Diabetes Care , vol.28 , pp. 1083-1091
    • Kendall, D.M.1    Riddle, M.C.2    Rosenstock, J.3    Zhuang, D.4    Kim, D.D.5    Fineman, M.S.6    Baron, A.D.7
  • 18
    • 33748442464 scopus 로고    scopus 로고
    • Interim analysis of the effects of exenatide treatment on A1C, weight and cardiovascular risk factors over 82 weeks in 314 overweight patients with type 2 diabetes
    • Blonde L, Klein EJ, Han J, Zhang B, Mac SM, Poon TH, Taylor KL, Trautmann ME, Kim DD, Kendall DM: Interim analysis of the effects of exenatide treatment on A1C, weight and cardiovascular risk factors over 82 weeks in 314 overweight patients with type 2 diabetes. Diabetes Obes Metab 2006;8:436-447.
    • (2006) Diabetes Obes Metab , vol.8 , pp. 436-447
    • Blonde, L.1    Klein, E.J.2    Han, J.3    Zhang, B.4    Mac, S.M.5    Poon, T.H.6    Taylor, K.L.7    Trautmann, M.E.8    Kim, D.D.9    Kendall, D.M.10
  • 19
    • 4344713643 scopus 로고    scopus 로고
    • Effect of intravenous infusion of exenatide (synthetic exendin-4) on glucose-dependent insulin secretion and counterregulation during hypoglycemia
    • Degn KB, Brock B, Juhl CB, Djurhuus CB, Grubert J, Kim D, Han J, Taylor K, Fineman M, Schmitz O: Effect of intravenous infusion of exenatide (synthetic exendin-4) on glucose-dependent insulin secretion and counterregulation during hypoglycemia. Diabetes 2004;53:2397-2403.
    • (2004) Diabetes , vol.53 , pp. 2397-2403
    • Degn, K.B.1    Brock, B.2    Juhl, C.B.3    Djurhuus, C.B.4    Grubert, J.5    Kim, D.6    Han, J.7    Taylor, K.8    Fineman, M.9    Schmitz, O.10
  • 20
    • 20544476444 scopus 로고    scopus 로고
    • Exenatide improves glycemic control and reduces body weight in subjects with type 2 diabetes: A dose-ranging study
    • Poon T, Nelson P, Shen L, Mihm M, Taylor K, Fineman M, Kim D: Exenatide improves glycemic control and reduces body weight in subjects with type 2 diabetes: a dose-ranging study. Diabetes Technol Ther 2005;7:467-477.
    • (2005) Diabetes Technol Ther , vol.7 , pp. 467-477
    • Poon, T.1    Nelson, P.2    Shen, L.3    Mihm, M.4    Taylor, K.5    Fineman, M.6    Kim, D.7
  • 22
    • 0031578033 scopus 로고    scopus 로고
    • Declaration of Helsinski: Recommendations guiding medical physicians in biomedical research involving human subjects
    • Declaration of Helsinski: Recommendations guiding medical physicians in biomedical research involving human subjects. JAMA 1997;277:925-926.
    • (1997) JAMA , vol.277 , pp. 925-926
  • 23
    • 4644300651 scopus 로고    scopus 로고
    • Effectiveness of progressive dose-escalation of exenatide (exendin-4) in reducing dose-limiting side effects in subjects with type 2 diabetes
    • Fineman MS, Shen LZ, Taylor K, Kim DD, Baron AD: Effectiveness of progressive dose-escalation of exenatide (exendin-4) in reducing dose-limiting side effects in subjects with type 2 diabetes. Diabetes Metab Res Rev 2004;20:411-417.
    • (2004) Diabetes Metab Res Rev , vol.20 , pp. 411-417
    • Fineman, M.S.1    Shen, L.Z.2    Taylor, K.3    Kim, D.D.4    Baron, A.D.5
  • 24
    • 33644932611 scopus 로고    scopus 로고
    • International Prandial Glucose Regulation Study Group: Postprandial glucose regulation: new data and new implications
    • Leiter LA, Ceriello A, Davidson JA, Hanefeld M, Monnier L, Owens DR, Tajima N, Tuomilehto J; International Prandial Glucose Regulation Study Group: Postprandial glucose regulation: new data and new implications. Clin Ther 2005;27(Suppl B):S42-S56.
    • (2005) Clin Ther , vol.27 , Issue.SUPPL. B
    • Leiter, L.A.1    Ceriello, A.2    Davidson, J.A.3    Hanefeld, M.4    Monnier, L.5    Owens, D.R.6    Tajima, N.7    Tuomilehto, J.8
  • 25
    • 22244445150 scopus 로고    scopus 로고
    • Prandial glucose regulation in the glucose triad: Emerging evidence and insights
    • Beisswenger P, Heine RJ, Leiter LA, Moses A, Tuomilehto J: Prandial glucose regulation in the glucose triad: emerging evidence and insights. Endocrine 2004;25:195-202.
    • (2004) Endocrine , vol.25 , pp. 195-202
    • Beisswenger, P.1    Heine, R.J.2    Leiter, L.A.3    Moses, A.4    Tuomilehto, J.5
  • 27
    • 0038455703 scopus 로고    scopus 로고
    • STOP-NIDDM Trial Research Group: Acarbose treatment and the risk of cardiovascular disease and hypertension in patients with impaired glucose tolerance: the STOP-NIDDM trial
    • Chiasson JL, Josse RG, Gomis R, Hanefeld M, Karasik A, Laakso M; STOP-NIDDM Trial Research Group: Acarbose treatment and the risk of cardiovascular disease and hypertension in patients with impaired glucose tolerance: the STOP-NIDDM trial. JAMA 2003;290:486-494.
    • (2003) JAMA , vol.290 , pp. 486-494
    • Chiasson, J.L.1    Josse, R.G.2    Gomis, R.3    Hanefeld, M.4    Karasik, A.5    Laakso, M.6
  • 28
    • 0037097039 scopus 로고    scopus 로고
    • STOP-NIDDM Trial Research Group: Acarbose for prevention of type 2 diabetes mellitus: the STOP-NIDDM randomised trial
    • Chiasson JL, Josse RG, Gomis R, Hanefeld M, Karasik A, Laakso M; STOP-NIDDM Trial Research Group: Acarbose for prevention of type 2 diabetes mellitus: the STOP-NIDDM randomised trial. Lancet 2002;359:2072-2077.
    • (2002) Lancet , vol.359 , pp. 2072-2077
    • Chiasson, J.L.1    Josse, R.G.2    Gomis, R.3    Hanefeld, M.4    Karasik, A.5    Laakso, M.6
  • 29
    • 0346727578 scopus 로고    scopus 로고
    • Acarbose reduces the risk for myocardial infarction in type 2 diabetic patients: Meta-analysis of seven long-term studies
    • Hanefeld M, Cagatay M, Petrowitsch T, Neuser D, Petzinna D, Rupp M: Acarbose reduces the risk for myocardial infarction in type 2 diabetic patients: meta-analysis of seven long-term studies. Eur Heart J 2004;25:10-16.
    • (2004) Eur Heart J , vol.25 , pp. 10-16
    • Hanefeld, M.1    Cagatay, M.2    Petrowitsch, T.3    Neuser, D.4    Petzinna, D.5    Rupp, M.6
  • 30
    • 3142760075 scopus 로고    scopus 로고
    • Regression of carotid atherosclerosis by control of postprandial hyperglycemia in type 2 diabetes mellitus
    • Esposito K, Giugliano D, Nappo F, Marfella R: Regression of carotid atherosclerosis by control of postprandial hyperglycemia in type 2 diabetes mellitus. Circulation 2004;110:214-219.
    • (2004) Circulation , vol.110 , pp. 214-219
    • Esposito, K.1    Giugliano, D.2    Nappo, F.3    Marfella, R.4
  • 31
    • 23744444000 scopus 로고    scopus 로고
    • Improvements in cardiovascular risk factors accompanied sustained effects on glycemia and weight reduction in patients with type 2 diabetes treated with exenatide for 82 wk [abstract 16-OR]
    • Kendall DM, Kim D, Poon T, Han J, Schnabel C, Fineman M, Trautmann M, Maggs D: Improvements in cardiovascular risk factors accompanied sustained effects on glycemia and weight reduction in patients with type 2 diabetes treated with exenatide for 82 wk [abstract 16-OR]. Diabetes 2005;54:A4-A5.
    • (2005) Diabetes , vol.54
    • Kendall, D.M.1    Kim, D.2    Poon, T.3    Han, J.4    Schnabel, C.5    Fineman, M.6    Trautmann, M.7    Maggs, D.8
  • 32
    • 14744287394 scopus 로고    scopus 로고
    • Glycemic management of type 2 diabetes: An emerging strategy with oral agents, insulins, and combinations
    • Riddle MC: Glycemic management of type 2 diabetes: an emerging strategy with oral agents, insulins, and combinations. Endocrinol Metab Clin North Am 2005;34:77-98.
    • (2005) Endocrinol Metab Clin North Am , vol.34 , pp. 77-98
    • Riddle, M.C.1
  • 33
    • 0033578476 scopus 로고    scopus 로고
    • Pharmacologic therapy for type 2 diabetes mellitus
    • DeFronzo RA: Pharmacologic therapy for type 2 diabetes mellitus. Ann Intern Med 1999;131:281-303.
    • (1999) Ann Intern Med , vol.131 , pp. 281-303
    • DeFronzo, R.A.1
  • 34
    • 0028817815 scopus 로고
    • UK Prospective Study 16. Overview of 6 years' therapy of type II diabetes: A progressive disease
    • UK Prospective Diabetes Study Group
    • UK Prospective Diabetes Study Group: UK Prospective Study 16. Overview of 6 years' therapy of type II diabetes: a progressive disease. Diabetes 1995;44:1249-1258.
    • (1995) Diabetes , vol.44 , pp. 1249-1258
  • 35
    • 0031972156 scopus 로고    scopus 로고
    • UKPDS 26: Sulphonylurea failure in non-insulin-dependent diabetic patients over six years. UK Prospective Diabetes Study (UKPDS) Group
    • Matthews DR, Cull CA, Stratton IM, Holman RR, Turner RC: UKPDS 26: Sulphonylurea failure in non-insulin-dependent diabetic patients over six years. UK Prospective Diabetes Study (UKPDS) Group. Diabet Med 1998;15:297-303.
    • (1998) Diabet Med , vol.15 , pp. 297-303
    • Matthews, D.R.1    Cull, C.A.2    Stratton, I.M.3    Holman, R.R.4    Turner, R.C.5
  • 36
    • 0032983666 scopus 로고    scopus 로고
    • Glycemic control with diet, sulfonylurea, metformin, or insulin in patients with type 2 diabetes mellitus: Progressive requirement for multiple therapies (UKPDS 49). UK Prospective Diabetes Study (UKPDS) Group
    • Turner RC, Cull CA, Frighi V, Holman RR: Glycemic control with diet, sulfonylurea, metformin, or insulin in patients with type 2 diabetes mellitus: progressive requirement for multiple therapies (UKPDS 49). UK Prospective Diabetes Study (UKPDS) Group. JAMA 1999;281:2005-2012.
    • (1999) JAMA , vol.281 , pp. 2005-2012
    • Turner, R.C.1    Cull, C.A.2    Frighi, V.3    Holman, R.R.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.