Wnt/β-catenin signaling pathway and thioredoxin-interacting protein (TXNIP) mediate the "glucose sensor" mechanism in metastatic breast cancer-derived cells MDA-MB-231

Journal of Cellular Physiology

Volumn 227, Issue 2, 2012, Pages 578-586

  Vaira, Sergio ^a   Friday, Ellen ^a   Scott, Keith ^a   Conrad, Steven ^a   Turturro, Francesco ^a,b  

^a Louisiana State University School of Medicine Shreveport   (United States)

^b LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; CYCLIN D1; DICKKOPF 1 PROTEIN; GLUCOSE; GLYCOGEN SYNTHASE KINASE 3BETA; HEXOSAMINE; MESSENGER RNA; SECRETED FRIZZLED RELATED PROTEIN 1; THIOREDOXIN INTERACTING PROTEIN; WNT PROTEIN;

AMINO TERMINAL SEQUENCE; ARTICLE; BREAST CANCER; CANCER CELL; CANCER CELL CULTURE; CELL LEVEL; CELL NUCLEUS; CONTROLLED STUDY; GLUCOSE BLOOD LEVEL; GLUCOSE SENSING; GLYCOSYLATION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; HYPERGLYCEMIA; IN VITRO STUDY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

BETA CATENIN; BREAST NEOPLASMS; CARRIER PROTEINS; CELL LINE, TUMOR; CYCLIN D1; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GLUCOSE; GLYCOGEN SYNTHASE KINASE 3; HUMANS; SIGNAL TRANSDUCTION; WNT PROTEINS;

EID: 82155192306     PISSN: 00219541     EISSN: 10974652     Source Type: Journal    
DOI: 10.1002/jcp.22757     Document Type: Article

References (36)

1. Anagnostou SH, Shepherd PR. 2008. Glucose induces an autocrine activation of the Wnt/β-catenin pathway in macrophage cell lines. Biochem J 416: 211-218.
2. Bafico A, Liu G, Goldin L, Harris V, Aaronson SA. 2004. An autocrine mechanism for constitutive Wnt pathway activation in human cancer cells. Cancer Cell 6: 497-506.
3. Cadenas C, Franckenstein D, Schmidt M, Gehrmann M, Hermes M, Geppert B, Schormann W, Maccoux LJ, Schug M, Schumann A, Wilhelm C, Freis E, Ickstadt K, Rahnenfuhrer J, Baumbach JI, Sickmann A, Hengstler JG. 2010. Role of thioredoxin reductase 1 and thioredoxin interacting protein in prognosis of breast cancer. Breast Cancer Res 12: R44-R59.
4. DeBerardinis RJ, Sayed N, Ditsworth D, Thompson GB. 2008. Brick by brick: Metabolism and tumor cell growth. Curr Opin Genet Dev 18: 54-61.
5. De Candia P, Blekman R, Chabot AE, Oshlack A, Gilad Y. 2008. A combination of genomic approaches reveals the role of FOXO1a in regulating an oxidative stress response pathway. PloS ONE 27: e1670.
6. Dennis JW, Nabi IR, Demetriou M. 2009. Metabolism cell surface organization. Cell 139: 1229-1241.
7. Dwarkanath BS. 2009. Cytotoxicity, radiosensitization, and chemosensitization of tumor cells by 2-deoxy-D-glucose in vitro. J Cancer Res Ther 5: S27-S31.
8. Friday E, Oliver R, Welbourne T, Turturro F. 2011. Glutaminolysis and glycolysis regulation by troglitazone in breast cancer cells: Relationship to mitochondrial membrane potential. J Cell Physiol 226: 511-519.
9. Gatenby RA, Gillies RJ. 2004. Why do cancers have high aerobic glycolysis. Nat Rev Cancer 4: 891-899.
10. Jeong M, Piao ZH, Kim MS, Lee SH, Yun S, Sun H, Yoon SR, Chung JW, Kim TD, Jeon JH, Lee J, Kim HN, Choi JY, Choi I. 2009. Thioredoxin-interacting protein regulates hematopoietic stem cell quiescence and mobilization under stress condition. J Immunol 183: 2495-2505.
11. Kaadige MR, Looper RE, Kamalanaadhan S, Ayer DE. 2009. Glutamine-dependent anapleurosis dictates glucose uptake and cell growth by regulating MondoA transcriptional activity. Proc Natl Acad Sci USA 106: 14878-14883.
12. Komekado H, Yamamoto H, Chiba T, Kikuchi A. 2007. Glycosylation and palmitoylation of Wnt-3a are coupled to produce an active form of Wnt-3a. Genes Cells 12: 521-534.
13. Kurayoshi M, Yamamoto H, Izumi S, Kikuchi A. 2007. Post-translational palmitoylation and glycosylation of Wnt-5a are necessary for its signaling. Biochem J 402: 515-523.
14. Lin SL, Xia W, Wang JC, Kwong KY, Spohn B, Wen Y, Pestell RG, Hung MC. 2000. β-catenin, a novel prognostic marker for breast cancer: Its roles in cyclin D1 expression and cancer progression. Proc Natl Acad Sci USA 97: 4262-4266.
15. MacDonald BT, Tamai K, He X. 2009. Wnt/β-catenin signaling: Components, mechanisms, and diseases. Dev Cell 17: 9-26.
16. Manolagas SC, Almeida M. 2007. Gone with the Wnts: beta-catenin, T-cell factor, forkhead box O and oxidative stress in age-dependent diseases of bone, lipid, and glucose metabolism. Mol Endocrinol 21: 2605-2614.
17. Muoio DM. 2007. TXNIP links redox circuitry to glucose control. Cell Metab 5: 412-414.
18. Parikh H, Carlsson E, Chutkow WA, Johansson LE, Storgaard H, Poulsen P, Saxena R, Ladd C, Schulze C, Mazzini MJ, Jensen CB, Krook A, Bjornholm M, Tornqvist H, Zierath JR, Riddestrale M, Altshuler D, Lee RT, Vaag A, Groop LC, Mootha VK. 2007. TXNIP regulates peripheral glucose metabolism in humans. PLoS Med 4: e158.
19. Paul S, Dey A. 2008. Wnt signaling and cancer development: Therapeutic implication. Neoplasma 55: 165-176.
20. Pinho SS, Osorio H, Nita-Lazar M, Gomes J, Lopes C, Gartner F, Reis CA. 2009. Role of E-cadherin N-glycosylation profile in a mammary tumor model. Biochem Biophys Res Commun 379: 1091-1096.
21. Prasad CP, Rath G, Mathur S, Bhatnagar D, Parshad R, Ralhan R. 2009. Expression analysis of E-cadherin, Slug and GSK3β in invasive ductal carcinoma of breast. BMC Cancer 9: 325-334.
22. Rayasam GV, Tulasi VK, Sodhi R, Davis JA, Ray A. 2009. Glycogen synthase kinase 3: More than a namesake. Br J Pharmacol 156: 885-898.
23. Samudio I, Fiegl M, Andreeff M. 2009. Mitochondrial uncoupling and the Warburg effect: Molecular basis for the reprogramming of cancer cell metabolism. Cancer Res 69: 2163-2166.
24. Seth JK, Vidal-Puig J. 2008. Wnt signaling at the crossroads of nutritional regulation. Biochem J 416: e11-e13.
25. Schlange T, Matsuda Y, Lienhard S, Huber A, Hynes NE. 2007. Autocrine WNT signaling contributes to breast cancer cell proliferation via the canonical WNT pathway and EGFR transactivation. Breast Cancer Res 9: R63-R77.
26. Slawson C, Copeland RJ, Hart GW. 2010. O-GLcNac signaling: A metabolic link between diabetes and cancer? Trends Biochem Sci 35: 547-555.
27. Stoltzman CA, Peterson CW, Breen KT, Muoio DM, Billin AN, Ayer DE. 2008. Glucose sensing by MondoA:Mlx complexes: A role for hexokinases and direct regulation of thioredoxin-interacting protein expression. Proc Natl Acad Sci USA 105: 6912-6917.
28. Thornton TM, Pedraza-Alva G, Deng B, Wood CD, Aronshtam A, Clemens JL, Sabio G, Davis RJ, Matthews DE, Doble B, Rincon M. 2008. Phosphorylation by p38 MAPK as an alternative pathway for GSK3β inactivation. Science 320: 667-670.
29. Turturro F, Friday E, Fowler R, Surie D, Welbourne T. 2004. Troglitazone acts on cellular pH and DNA synthesis through a peroxisome proliferator-activated receptor γ-independent mechanism in breast cancer-derived cell lines. Clin Cancer Res 10: 7022-7030.
30. Turturro F, Friday E, Welbourne T. 2007a. Hyperglycemia regulates thioredoxin-ROS activity through induction of thioredoxin-interacting protein (TXNIP) in metastatic breast cancer-derived cells MDA-MB-231. BMC Cancer 7: 96-102.
31. Turturro F, Burton GV, Friday E. 2007b. Hyperglycemia-induced thioredoxin-interacting protein expression differs in breast cancer-derived cells. Clin Cancer Res 13: 3724-3730.
32. Vigneri P, Frasca F, Sciacca L, Pandini G, Riccardo V. 2009. Diabetes and cancer. Endocr Relat Cancer 16: 1103-1123.
33. Vosseller K, Sakabe K, Wells L, Har GW. 2002. Diverse regulation of protein function by O-GlcNAc: A nuclear and cytoplasmic carbohydrate post-translational modification. Curr Opin Chem Biol 6: 851-857.
34. Xue F, Michels KB. 2007. Diabetes, metabolic syndrome, and breast cancer: A review of the current evidence. Am J Clin Nutr 86: 823S-835S.
35. Ye Y, Xiao Y, Wang W, Yearsley K, Gao JX, Shetuni B, Barsky SH. 2010. ERα signaling through slug regulates E-cadherin and EMT. Oncogene 29: 1451-1462.
36. Zhao YY, Takahashi M, Gu JG, Miyoshi E, Matsumoto A, Kitazume S, Taniguchi N. 2008. Functional roles of N-glycans in cell signaling and cell adhesion in cancer. Cancer Sci 99: 1304-1310.