Update on peripheral mechanisms of pain: Beyond prostaglandins and cytokines

Arthritis Research and Therapy

Volumn 13, Issue 2, 2011, Pages

  Schaible, Hans Georg ^a   Ebersberger, Andrea ^a   Natura, Gabriel ^a  

^a FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACID SENSING ION CHANNEL; ADENOSINE TRIPHOSPHATE; ANALGESIC AGENT; CYTOKINE; NERVE GROWTH FACTOR; PROSTAGLANDIN; VANILLOID RECEPTOR 1; VOLTAGE GATED SODIUM CHANNEL; SODIUM CHANNEL; TRPV1 PROTEIN, HUMAN; VANILLOID RECEPTOR;

HUMAN; MOLECULAR MECHANICS; NEUROPHYSIOLOGY; NOCICEPTION; NOCICEPTIVE RECEPTOR; NONHUMAN; PAIN; REVIEW; METABOLISM; PATHOPHYSIOLOGY;

CYTOKINES; HUMANS; NERVE GROWTH FACTOR; NOCICEPTORS; PAIN; PROSTAGLANDINS; SODIUM CHANNELS; TRPV CATION CHANNELS;

EID: 82155192241     PISSN: 14786354     EISSN: 14786362     Source Type: Journal    
DOI: 10.1186/ar3305     Document Type: Review

References (49)

1. Breivik H, Beverly C, Ventafridda V, Cohen R, Gallacher D. Survey of chronic pain in Europe: prevalence, impact on daily life, and treatment. Eur J Pain 2006, 10:287-333. 10.1016/j.ejpain.2005.06.009, 16095934.
2. Gold MS, Gebhart GF. Nociceptor sensitization in pain pathogenesis. Nat Med 2010, 16:1248-1257. 10.1038/nm.2235, 20948530.
3. Schaible H-G, Richter F. Pathophysiology of pain. Langenbecks Arch Surg 2004, 389:237-243.
4. Belmonte C, Cervero E, . (Eds) Neurobiology of Nociceptors 1996, Oxford: Oxford University Press, (Eds).
5. Basbaum AI, Bautista DM, Scherrer G, Julius D. Cellular and molecular mechanisms of pain. Cell 2009, 139:267-284. 10.1016/j.cell.2009.09.028, 2852643, 19837031.
6. Schaible H-G, Del Rosso A, Matucci-Cerinic M. Neurogenic aspects of inflammation. Rheum Dis Clin North Am 2005, 31:77-101.
7. Schmidt R, Schmelz M, Forster C, Ringkamp M, Torebjork E, Handwerker H. Novel classes of responsive and unresponsive C nociceptors in human skin. J Neurosci 1995, 15:333-341.
8. Cervero F. Spinal cord hyperexcitablity and its role in pain and hyperalgesia. Exp Brain Res 2009, 196:129-137. 10.1007/s00221-009-1789-2, 19350227.
9. Sandkuhler J. Models and mechanisms of hyperalgesia and allodynia. Physiol Rev 2009, 89:707-758. 10.1152/physrev.00025.2008, 19342617.
10. Devor M. Ectopic discharge in Aβ afferents as a source of neuropathic pain. Exp Brain Res 2009, 196:115-128. 10.1007/s00221-009-1724-6, 19242687.
11. Janig W, Grossmann L, Gorodetskaya N. Mechano- and thermosensitivity of regenerating cutaneous afferent nerve fi bers. Exp Brain Res 2009, 196:101-114. 10.1007/s00221-008-1673-5, 19139872.
12. Wu G, Ringkamp M, Hartke TV, Murinson BB, Campbell JN, Griffin JW, Meyer RA. Early onset of spontaneous activity in uninjured C-fiber nociceptors after injury to neighbouring nerve fi bers. J Neurosci 2001, 21:RC140. 1-5.
13. Gold MS. Na+ channel blockers for the treatment of pain; context is everything, almost. Exp Neurol 2008, 210:1-6. 10.1016/j.expneurol.2007.12.001, 2312090, 18234194.
14. Sommer C, Kress M. Recent findings on how proinflammatory cytokines cause pain: peripheral mechanisms in infl ammatory and neuropathic hyperalgesia. Neurosci Lett 2004, 361:184-187. 10.1016/j.neulet.2003.12.007, 15135924.
15. Janig W, Levine JD, Michaelis M. Interactions of sympathetic and primary afferent neurons following nerve injury and tissue trauma. The Polymodal Receptor: A Gateway to Pathological Pain. Progress in Brain Research 1996, 113:161-184. Amsterdam: Elsevier Science, Kumazawa T, Kruger L, Mizumura K.
16. Bondeson J, Blom AB, Wainwright S. The role of synovial macrophages and macrophage-produced mediators in driving inflammatory and destructive responses in osteoarthritis. Arthritis Rheum 2010, 62:647-657.
17. Im H-J, Kim J-S, Li X, Kotwal N, Sumner DR, van Wijnen AJ, Davis FJ, Yan D, Levine B, Henry JL, Desevre J, Krin JS. Alteration of sensory neurons and spinal response to an experimental osteoarthritis pain model. Arthritis Rheum 2010, 62:2995-3005. 10.1002/art.27608, 20556813.
18. Nakajima T, Ohtori S, Inoue G, Koshi T, Yamamoto J, Takahashi K, Harada Y. The characteristics of dorsal-root-ganglia and sensory innervation of the hip in rats. J Bone Joint Surg Br 2008, 90:254-257.
19. Jimenez-Andrade JM, Mantyh WG, Bloom AP, Xu H, Ferng AS, Dussor G, Vanderah TW, Mantyh PW. A phenotypically restricted set of primary afferent nerve fibres innervate the bone versus skin: therapeutic opportunity for treating skeletal pain. Bone 2010, 46:306-313. 10.1016/j.bone.2009.09.013, 2852192, 19766746.
20. McDougall J. Arthritis and pain: neurogenic origin of joint pain. Arthritis Res Ther 2006, 8:220-229. 10.1186/ar2069, 1794504, 17118212.
21. Schaible H-G, Richter F, Ebersberger A, Boettger MK, Vanegas H, Natura G, Vazquez E, Segond von Banchet G. Joint pain. Exp Brain Res 2009, 196:153-162. 10.1007/s00221-009-1782-9, 19363606.
22. Bielefeldt K, Gebhart GF. Visceral pain: basic mechanisms. Wall and Melzack's Textbook of Pain 2006, 721-736. Edinburgh: Elsevier Churchill Livingstone, McMahon SB, Koltzenburg M.
23. St Pierre M, Reeh PW, Zimmermann K. Differential role of TRPV channel block on polymodal activation of rat cutaneous nociceptors in vitro. Exp Brain Res 2009, 196:31-44. 10.1007/s00221-009-1808-3, 19404626.
24. Hucho T, Levine JD. Signaling pathways in sensitization: toward a nociceptor cell biology. Neuron 2007, 55:365-376. 10.1016/j.neuron.2007.07.008, 17678851.
25. Linley JE, Rose K, Ooi L, Gamper N. Understanding inflammatory pain: ion channels contributing to acute and chronic nociception. Pflügers Arch 2010, 459:657-669. 10.1007/s00424-010-0784-6, 20162302.
26. McCleskey EW, Gold MS. Ion channels of nociception. Annu Rev Physiol 1999, 61:835-856. 10.1146/annurev.physiol.61.1.835, 10099712.
27. Mizumura K, Sugiura T, Katanosaka K, Banik RK, Kozaki Y. Excitation and sensitization of nociceptors by bradykinin: what do we know?. Exp Brain Res 2009, 196:53-65. 10.1007/s00221-009-1814-5, 19396590.
28. Schaible H-G, Segond von Banchet G, Boettger MK, Bräuer R, Gajda M, Richter F, Hensellek S, Brenn D, Natura G. The role of proinflammatory cytokines in the generation and maintenance of joint pain. Ann N Y Acad Sci 2010, 1193:60-69. 10.1111/j.1749-6632.2009.05301.x, 20398009.
29. Üceyler N, Schäfers M, Sommer C. Mode of action of cytokines on nociceptive neurons. Exp Brain Res 2009, 196:67-78. 10.1007/s00221-009-1755-z, 19290516.
30. Stein C, Clark JD, Oh U, Vasko MR, Wilcox GL, Overland AC, Vanderah TW, Spencer RH. Peripheral mechanisms of pain and analgesia. Brain Res Rev 2009, 60:90-113. 10.1016/j.brainresrev.2008.12.017, 2730351, 19150465.
31. Levine JD, Alessandri-Haber N. TRP channels: targets for the relief of pain. Biochim Biophys Acta 2007, 1772:989-1003.
32. Szabo A, Helyes Z, Sandor K, Bite A, Pinter E, Nemeth J, Banvolgyi A, Bolcskei K, Elekes K, Szolcsanyi J. Role of transient receptor potential vanilloid 1 receptors in adjuvant-induced chronic arthritis: in vivo study using genedeficient mice. J Pharmacol Exp Ther 2005, 314:111-119. 10.1124/jpet.104.082487, 15831443.
33. Belmonte C, Brock JA, Viana F. Converting cold into pain. Exp Brain Res 2009, 196:13-30. 10.1007/s00221-009-1797-2, 19399484.
34. Mense S. Algesic agents exciting muscle nociceptors. Exp Brain Res 2009, 196:89-100. 10.1007/s00221-008-1674-4, 19139871.
35. Rush AM, Cummins TR, Waxman SG. Multiple sodium channels and their roles in electrogenesis within dorsal root ganglion neurons. J Physiol 2007, 579:1-14. 10.1113/jphysiol.2006.121483, 2075388, 17158175.
36. Pinto V, Derkach VA, Safronov BV. Role of TTX-sensitive and TTX-resistant sodium channels in Aδ and C-fiber conduction and synaptic transmission. J Neurophysiol 2008, 99:617-628. 10.1152/jn.00944.2007, 18057109.
37. Wada A, Wanke E, Gullo F, Schiavon E. Voltage-dependent Nav1.7 sodium channels: multiple roles in adrenal chromaffin cells and peripheral nervous system. Acta Physiol (Oxf) 2008, 192:221-231.
38. McMahon SB, Bennet DLH, Bevan S. Inflammatory mediators and modulators. Wall and Melzack's Textbook of Pain 2006, 49-72. Edinburgh: Elsevier Churchill Livingstone, McMahon SB, Koltzenburg M.
39. Segond von Banchet G, Boettger MK, Fischer N, Bräuer R, Schaible H-G. Experimental arthritis causes tumor necrosis factor-α dependent infiltration of macrophages in rat dorsal root ganglia which correlates with pain-related behavior. Pain 2009, 145:151-159. 10.1016/j.pain.2009.06.002, 19560272.
40. Inglis JJ, Notley CA, Essex D, Wilson AW, Feldmann M, Anand P, Williams R. Collagen-induced arthritis as a model of hyperalgesia: functional and cellular analysis of the analgesic actions of tumor necrosis factor blockade. Arthritis Rheum 2007, 56:4015-4023. 10.1002/art.23063, 18050216.
41. Lane NE, Schnitzer TJ, Birbara CA, Mokhtarani M, Shelton DL, Smith MD, Brown MT. Tanezumab for the treatment of pain from osteoarthritis of the knee. N Engl J Med 2010, 363:1521-1531. 10.1056/NEJMoa0901510, 20942668.
42. Bennett D. NGF, sensitization of nociceptors. Encyclopedia of Pain 2007, 2:1338-1342. Berlin: Springer, Schmidt RF, Willis WD.
43. Bär K-J, Schurigt U, Scholze A, Segond von Banchet G, Stopfel N, Bräuer R, Halbhuber K-J, Schaible H-G. The expression and localisation of somatostatin receptors in dorsal root ganglion neurons of normal and monoarthritic rats. Neuroscience 2004, 127:197-206. 10.1016/j.neuroscience.2004.04.051, 15219682.
44. Agarwal N, Pacher P, Tegeder I, Amaya F, Constantin CE, Brenner GJ, Rubino T, Michalski CW, Marsicano G, Monory K, Mackie K, Marian C, Batkai S, Parolaro D, Fischer MJ, Reeh P, Kunos G, Kress M, Lutz B, Woolf CJ, Kuner R. Cannabinoids mediate analgesia largely via peripheral type 1 cannabinoid receptors in nociceptors. Nat Neurosci 2007, 10:870-879. 10.1038/nn1916, 2234438, 17558404.
45. Kress M, Kuner R. Mode of action of cannabinoids on nociceptive nerve endings. Exp Brain Res 2009, 196:79-88. 10.1007/s00221-009-1762-0, 19306092.
46. Helyes Z, Szabó A, Németh J, Jakab B, Pintér E, Bánvölgyi T, Kereskai L, Kéri G, Szolcsányi J. Anti-inflammatory and analgesic effects of somatostatin released from capsaicin-sensitive sensory nerve terminals in a Freund's adjuvant-induced chronic arthritis model in the rat. Arthritis Rheum 2004, 50:1677-1685. 10.1002/art.20184, 15146439.
47. Treede RD, Kenshalo DR, Gracely RH, Jones A. The cortical representation of pain. Pain 1999, 79:105-111. 10.1016/S0304-3959(98)00184-5, 10068155.
48. Vogt BA. Pain and emotion. Interactions in subregions of the cingulated cortex. Nat Rev Neurosci 2005, 6:533-544. 2659949, 15995724.
49. Willis WD. The role of TRPV1 receptors in pain evoked by noxious thermal and chemical stimuli. Exp Brain Res 2009, 196:5-11. 10.1007/s00221-009-1760-2, 19294370.