Effects of vegetative and flowering stages on the biosynthesis of artemisinin in Artemisia species

Archives of Pharmacal Research

Volumn 34, Issue 10, 2011, Pages 1657-1661

  Mannan, Abdul ^a,b   Ahmed, Ibrar ^a,c   Arshad, Waheed ^a   Hussain, Izhar ^b   Mirza, Bushra ^a  

^a QUAID I AZAM UNIVERSITY   (Pakistan)

^b Tobe Camp University Road Abbottabad   (Pakistan)

^c MASSEY UNIVERSITY   (New Zealand)

Author keywords

Artemisia species; Artemisinin; Flowering stage; Vegetative stage

Indexed keywords

ARTEMISININ;

ARTEMISIA; ARTICLE; DRUG SYNTHESIS; FLOWERING; PLANT GROWTH; PLANT LEAF; VEGETATIVE STAGE;

ANTIMALARIALS; ARTEMISIA; ARTEMISININS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; PAKISTAN; PLANT EXTRACTS; PLANT LEAVES; PLANT ROOTS; PLANT STEMS; SPECIES SPECIFICITY;

EID: 82055172157     PISSN: 02536269     EISSN: 19763786     Source Type: Journal    
DOI: 10.1007/s12272-011-1010-6     Document Type: Article

References (22)

1. M. Z. Abdin M. Israr R. U. Rehman S. K. Jain 2003 Artemisinin, a novel antimalarial drug: biochemical and molecular approaches for enhanced production Planta Med. 69 289 299 12709893 10.1055/s-2003-38871 1:CAS:528: DC%2BD3sXjvVyqurs%3D (Pubitemid 36577992)
2. A. K. K. Achakzai P. Achakzai A. Masood S. A. Kayani R. B. Tareen 2009 Response of plant parts and age on the distribution of secondary metabolites on plants found in Quetta Pak. J. Bot. 41 2129 2135
3. N. Acton D. L. Klayman 1985 Artemisitene, a new sesquiterpene lactone endoperoxide from Artemisia annua Planta Med. 51 441 442 17342606 10.1055/s-2007-969543 1:STN:280:DC%2BD2s7kt1GlsQ%3D%3D (Pubitemid 16253785)
4. P. R. Arsenault D. Vail K. K. Wobbe K. Erickson P. J. Weathers 2010 Reproductive development modulates gene expression and metabolite levels with possible feedback inhibition of artemisinin in Artemisia annua Plant Physiol. 154 958 968 20724645 10.1104/pp.110.162552 1:CAS:528:DC%2BC3cXhtlCkt7bM
5. W. Banyai M. Mii K. Supaibulwatana 2011 Enhancement of artemisinin content and biomass in Artemisia annua by exogenous GA3 treatment Plant Growth Regul. 63 45 54 10.1007/s10725-010-9510-9 1:CAS:528:DC%2BC3cXhsFKjurjN
6. R. Baraldi B. Isacchi S. Predieri G. Marconi F. F. Vincieri A. R. Bilia 2008 Distribution of artemisinin and bioactive flavonoids from Artemisia annua L. during plant growth Biochem. Syst. Ecol. 36 340 348 10.1016/j.bse.2007.11.002 1:CAS:528:DC%2BD1cXks12hsrw%3D
7. J. F. Ferreira J. E. Simon J. Janick 1995 Developmental studies of Artemisia annua: flowering and artemisinin production under greenhouse and field conditions Planta Med. 61 167 170 17238070 10.1055/s-2006-958040 1:CAS:528:DyaK2MXlsVCqsLc%3D
8. J. F. S. Ferreira J. Janick 1996 Roots as an enhancing factor for the production of artemisinin in shoot cultures of Artemisia annua Plant Cell Tissue Organ Cult. 44 211 217 10.1007/BF00048526 1:CAS:528:DyaK28Xkslekur8%3D (Pubitemid 26263186)
9. Ghafoor, A., Asteraceae. In Ali, S. I. and Qaiser, M. (Eds.). Flora of Pakistan, Vol. 207. Missuri Botanical Press, Pakistan, pp. 93-142, (2002).
10. J. C. Laughlin 1994 Agricultural production of artemisinin-a review Trans. R. Soc. Trop. Med. Hyg. 88 21 22 10.1016/0035-9203(94)90465-0 1:CAS:528:DyaK2cXmtFaksbg%3D (Pubitemid 124018818)
11. Laughlin, J. C., Heazlewood, G. N., and Beattie, B. M., Cultivation of Artemisia annua L. In Wright, C. W. (Ed.). Artemisia. Taylor & Francis, London, pp. 160-195, (2002).
12. Mannan, A., Determination of artemisinin content of various Artemisia species of Pakistan and its enhancement in Artemisia annua. Ph.D. Thesis, Quaid-i-Azam University, Islamabad, Pakistan, pp. 3-8, (2009).
13. A. Mannan I. Ahmed W. Arshad M. F. Asim R. A. Qureshi I. Hussain B. Mirza 2010 Survey of artemisinin production by diverse Artemisia species in northern Pakistan Malar. J. 9 310 21047440 10.1186/1475-2875-9-310
14. M. R. Morales D. J. Charles J. E. Simon 1993 Seasonal accumulation of artemisinin in Artemisia annua L Acta Hortic. 334 416 420
15. M. E. Olsson L. M. Olofsson A. L. Lindahl A. Lundgren M. Brodelius P. E. Brodelius 2009 Localization of enzymes of artemisinin biosynthesis to the apical cells of glandular secretory trichomes of Artemisia annua L Phytochemistry 70 1123 1128 19664791 10.1016/j.phytochem.2009.07.009 1:CAS:528:DC%2BD1MXhtVSgur7P
16. N. Pras J. F. Visser S. Batterman H. J. Woerdenbag T. M. Malingré C. B. Lugt 1991 Laboratory selection of Artemisia annua L. for high artemisinin yielding types Phytochem. Anal. 2 80 83 10.1002/pca.2800020208 1:CAS:528:DyaK3MXmtVehurk%3D
17. R. A. Qureshi A. Mushtaq A. Muhammad 2002 Taxonomic study and medicinal importance of three selected species of the genus Artemisia Linn Asian J. Plant Sci. 1 712 714 10.3923/ajps.2002.712.714
18. A. Singh R. A. Vishwakarma A. Husain 1988 Evaluation of Artemisia annua strains for higher artemisinin production Planta Med. 54 475 476 17265330 10.1055/s-2006-962515 1:CAS:528:DyaL1MXksVOruw%3D%3D
19. H. Wang L. Ge H. C. Ye K. Chong B. Y. Liu G. F. Li 2004 Studies on the effects of fpf1 gene on Artemisia annua flowering time and on the linkage between flowering and artemisinin biosynthesis Planta Med. 70 347 352 15095151 10.1055/s-2004-818947 1:CAS:528:DC%2BD2cXjvVejtb0%3D (Pubitemid 38594607)
20. H. Wang Y. Liu K. Chong B. Y. Liu H. C. Ye Z. Q. Li F. Yan G. F. Li 2007 Earlier flowering induced by overexpression of CO gene does not accompany increase of artemisinin biosynthesis in Artemisia annua Plant Biol. (Stuttg) 9 442 446 10.1055/s-2006-924634 1:CAS:528:DC%2BD2sXotFantrk%3D (Pubitemid 46841743)
21. H. J. Woerdenbag J. F. J. Lüers W. Uden N. Pras T. M. Malingré A. W. Alfermann 1993 Production of the new antimalarial drug artemisinin in shoot cultures of Artemisia annua L Plant Cell Tissue Organ Cult. 32 247 257 10.1007/BF00029850 1:CAS:528:DyaK3sXisFegsLg%3D
22. L. Zhang H.-C. Ye G.-F. Li 2006 Effect of development stage on the artemisinin content and the sequence characterized amplified region (SCAR) marker of high-artemisinin yielding strains of Artemisia annua L J. Integr. Plant Biol. 48 1054 1062 10.1111/j.1744-7909.2006.00288.x 1:CAS:528: DC%2BD28XhtVWgsr7I (Pubitemid 44314397)