Shear stress, tip cells and regulators of endothelial migration

Biochemical Society Transactions

Volumn 39, Issue 6, 2011, Pages 1571-1575

  Zhuang, Xiaodong ^a   Cross, Darren ^b   Heath, Victoria L ^a   Bicknell, Roy ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^b ASTRAZENECA   (United Kingdom)

Author keywords

Angiogenesis; C type lectin 14A (CLEC14A); Endothelial cell specific chemotaxis regulator (ECSCR); Roundabout 4 (Robo4)

Indexed keywords

CLEC14A PROTEIN; ENDOTHELIAL CELL SPECIFIC CHEMOTAXIS REGULATOR; FOCAL ADHESION KINASE; PROTEIN C; REGULATOR PROTEIN; ROBO4 PROTEIN; SMALL INTERFERING RNA; THROMBOMODULIN; TRANSCRIPTOME; UNCLASSIFIED DRUG;

ANGIOGENESIS; BONE MARROW CELL; CELL ADHESION; CELL MEMBRANE; CELL MIGRATION; CELL MOTILITY; CONFERENCE PAPER; ENDOTHELIUM CELL; FILOPODIUM; GENE OVEREXPRESSION; GENE SILENCING; HUMAN; INTRACELLULAR SIGNALING; NONHUMAN; PHALANX CELL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN LOCALIZATION; REGULATORY MECHANISM; SHEAR STRESS; STALK CELL; STEM CELL; THROMBOCYTE; TIP CELL; ZEBRA FISH;

ANIMALS; CELL MOVEMENT; ENDOTHELIAL CELLS; HUMANS; NEOVASCULARIZATION, PHYSIOLOGIC; SIGNAL TRANSDUCTION; STRESS, MECHANICAL;

EID: 81855218086     PISSN: 03005127     EISSN: 14708752     Source Type: Journal    
DOI: 10.1042/BST20110746     Document Type: Conference Paper

References (39)

1. Figg, W.D. and Forkman, J. (eds) (2008) Angiogenesis: an Integrative Approach from Science to Medicine, Springer Science and Business Media, New York
2. Chaplin, D.J., Trotter, M.J. and Dougherty, G.J. (1997) Microregional tumour blood flow: heterogeneity and therapeutic significance. In Tumour Angiogenesis (Bicknell, R., Lewis, C.E. and Ferrara, N., eds), pp. 61-70, Oxford University Press, Oxford
3. Helmlinger, G., Yuan, F., Dellian, M. and Jain, R.K. (1997) Interstitial pH and PO2 gradients in solid tumors in vivo: high-resolution measurements reveal a lack of correlation. Nat. Med. 3, 177-182 (Pubitemid 27064702)
4. Wasserman, S.M. and Topper, J.N. (2004) Adaptation of the endothelium to fluid flow: in vitro analyses of gene expression and in vivo implications. Vasc. Med. 9, 35-45 (Pubitemid 38878024)
5. Matharu, N.M., McGettrick, H.M., Salmon, M., Kissane, S., Vohra, R.K., Rainger, G.E. and Nash, G.B. (2008) Inflammatory responses of endothelial cells experiencing reduction in flow after conditioning by shear stress. J. Cell. Physiol. 216, 732-741
6. Ando, J. and Yamamoto, K. (2009) Vascular mechanobiology: endothelial cell responses to fluid shear stress. Circ. J. 73, 1983-1992
7. Chu, T.J. and Peters, D.G. (2008) Serial analysis of the vascular endothelial transcriptome under static and shear stress conditions. Physiol. Genomics 34, 185-192
8. Huminiecki, L., Gorn, M., Suchting, S., Poulsom, R. and Bicknell, R. (2002) Magic roundabout is a new member of the roundabout receptor family that is endothelial specific and expressed at sites of active angiogenesis. Genomics 79, 547-552 (Pubitemid 34274296)
9. Mura, M., Swain, R.K., Zhuang, X., Vorschmitt, H., Reynolds, G., Durant, S., Beesley, J.F., Herbert, J.M., Sheldon, H., Andre, M. et al. (2011) Identification and angiogenic role of the novel tumor endothelial marker CLEC14A. Oncogene, doi:10.1038/onc.2011.233
10. Rho, S.S., Choi, H.J., Min, J.K., Lee, H.W., Park, H., Park, H., Kim, Y.M. and Kwon, Y.G. (2011) Clec14a is specifically expressed in endothelial cells and mediates cell to cell adhesion. Biochem. Biophys. Res. Commun. 404, 103-108
11. Gerhardt, H., Golding, M., Fruttiger, M., Ruhrberg, C., Lundkvist, A., Abramsson, A., Jeltsch, M., Mitchell, C., Alitalo, K., Shima, D. and Betsholtz, C. (2003) VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia. J. Cell Biol. 161, 1163-1177 (Pubitemid 36870177)
12. Mazzone, M., Dettori, D., Leite de Oliveira, R., Loges, S., Schmidt, T., Jonckx, B., Tian, Y.M., Lanahan, A.A., Pollard, P., Ruiz de Almodovar, C. et al. (2009) Heterozygous deficiency of PHD2 restores tumor oxygenation and inhibits metastasis via endothelial normalization. Cell 136, 839-851
13. Legg, J.A., Herbert, J.M., Clissold, P. and Bicknell, R. (2008) Slits and Roundabouts in cancer, tumour angiogenesis and endothelial cell migration. Angiogenesis 11, 13-21
14. Sheldon, H., Andre, M., Legg, J.A., Heal, P., Herbert, J.M., Sainson, R., Sharma, A.S., Kitajewski, J.K., Heath, V.L. and Bicknell, R. (2009) Active involvement of Robo1 and Robo4 in filopodia formation and endothelial cell motility mediated via WASP and other actin nucleation-promoting factors. FASEB J. 23, 513-522
15. Kaur, S., Castellone, M.D., Bedell, V.M., Konar, M., Gutkind, J.S. and Ramchandran, R. (2006) Robo4 signaling in endothelial cells implies attraction guidance mechanisms. J. Biol. Chem. 281, 11347-11356 (Pubitemid 43855559)
16. Jones, C.A., London, N.R., Chen, H., Park, K.W., Sauvaget, D., Stockton, R.A., Wythe, J.D., Suh, W., Larrieu-Lahargue, F., Mukouyama, Y.S. et al. (2008) Robo4 stabilizes the vascular network by inhibiting pathologic angiogenesis and endothelial hyperpermeability. Nat. Med. 14, 448-453 (Pubitemid 351499393)
17. Koch, A.W., Mathivet, T., Larrivée, B., Tong, R.K., Kowalski, J., Pibouin-Fragner, L., Bouvrée, K., Stawicki, S., Nicholes, K., Rathore, N. et al. (2011) Robo4 maintains vessel integrity and inhibits angiogenesis by interacting with UNC5B. Dev. Cell 20, 33-46
18. Suchting, S., Heal, P., Tahtis, K., Stewart, L.M. and Bicknell, R. (2005) Soluble Robo4 receptor inhibits in vivo angiogenesis and endothelial cell migration. FASEB J. 19, 121-123 (Pubitemid 40069938)
19. Lu, X., Le Noble, F., Yuan, L., Jiang, Q., De Lafarge, B., Sugiyama, D., Bréant, C., Claes, F., De Smet, F., Thomas, J.L. et al. (2004) The netrin receptor UNC5B mediates guidance events controlling morphogenesis of the vascular system. Nature 432, 179-186 (Pubitemid 39545842)
20. Larrivée, B., Freitas, C., Trombe, M., Lv, X., Delafarge, B., Yuan, L., Bouvrée, K., Bréant, C., Del Toro, R., Bréchot, N. et al. (2007) Activation of the UNC5B receptor by Netrin-1 inhibits sprouting angiogenesis. Genes Dev. 21, 2433-2447 (Pubitemid 47533561)
21. MacFadyen, J.R., Haworth, O., Roberston, D., Hardie, D., Webster, M.T., Morris, H.R., Panico, M., Sutton-Smith, M., Dell, A., van der Geer, P. et al. (2005) Endosialin (TEM1, CD248) is a marker of stromal fibroblasts and is not selectively expressed on tumour endothelium. FEBS Lett. 579, 2569-2575 (Pubitemid 40615660)
22. Lax, S., Hou, T.Z., Jenkinson, E., Salmon, M., MacFadyen, J.R., Isacke, C.M., Anderson, G., Cunningham, A.F. and Buckley, C.D. (2007) CD248/Endosialin is dynamically expressed on a subset of stromal cells during lymphoid tissue development, splenic remodeling and repair. FEBS Lett. 581, 3550-3556 (Pubitemid 47048202)
23. Nanda, A., Karim, B., Peng, Z., Liu, G., Qiu, W., Gan, C., Vogelstein, B., St Croix, B., Kinzler, K.W. and Huso, D.L. (2006) Tumor endothelial marker 1 (Tem1) functions in the growth and progression of abdominal tumors. Proc. Natl. Acad. Sci. U.S.A. 103, 3351-3356 (Pubitemid 43346473)
24. Maia, M., DeVriese, A., Janssens, T., Moons, M., Lories, R.J., Tavernier, J. and Conway, E.M. (2011) CD248 facilitates tumor growth via its cytoplasmic domain. BMC Cancer 11, 162
25. Bohlson, S.S., Silva, R., Fonseca, M.I. and Tenner, A.J. (2005) CD93 is rapidly shed from the surface of human myeloid cells and the soluble form is detected in human plasma. J. Immunol. 175, 1239-1247 (Pubitemid 41095013)
26. Maruyama, I., Bell, C.E. and Majerus, P.W. (1985) Thrombomodulin is found on endothelium of arteries, veins, capillaries, and lymphatics, and on syncytiotrophoblast of human placenta. J. Cell Biol. 101, 363-371 (Pubitemid 15239110)
27. Esmon, C.T. (1995) Thrombomodulin as a model of molecular mechanisms that modulate protease specificity and function at the vessel surface. FASEB J. 9, 946-955
28. Sumanas, S., Jorniak, T. and Lin, S. (2005) Identification of novel vascular endothelial-specific genes by the microarray analysis of the zebrafish cloche mutants. Blood 106, 534-541 (Pubitemid 40981248)
29. Gomez, G.A., Veldman, M.B., Zhao, Y., Burgess, S. and Lin, S. (2009) Discovery and characterization of novel vascular and hematopoietic genes downstream of etsrp in zebrafish. PLoS ONE 4, e4994
30. Huminiecki, L. and Bicknell, R. (2000) In silico cloning of novel endothelial-specific genes. Genome Res. 10, 1796-1806
31. Armstrong, L.-J., Heath, V.L., Sanderson, S., Kaur, S., Beesley, J.F., Herbert, J.M., Legg, J.A., Poulsom, R. and Bicknell, R. (2008) ECSM2, an endothelial specific filamin a binding protein that mediates chemotaxis. Arterioscler. Thromb. Vasc. Biol. 28, 1640-1646
32. Ma, F., Zhang, D., Yang, H., Sun, H., Wu, W., Gan, Y., Balducci, J., Wei, Y.Q., Zhao, X. and Huang, Y. (2009) Endothelial cell-specific molecule 2 (ECSM2) modulates actin remodeling and epidermal growth factor receptor signaling. Genes Cells 14, 281-293
33. Ikeda, K., Nakano, R., Uraoka, M., Nakagawa, Y., Koide, M., Katsume, A., Minamino, K., Yamada, E., Yamada, H., Quertermous, T. and Matsubara, H. (2009) Identification of ARIA regulating endothelial apoptosis and angiogenesis by modulating proteasomal degradation of cIAP-1 and cIAP-2. Proc. Natl. Acad. Sci. U.S.A. 106, 8227-8232
34. Shi, C., Lu, J., Wu, W., Ma, F., Georges, J., Huang, H., Balducci, J., Chang, Y. and Huang, Y. (2011) Endothelial cell-specific molecule 2 (ECSM2) localizes to cell-cell junctions and modulates bFGF-directed cell migration via the ERK-FAK pathway. PLoS ONE 6, e21482
35. Armstrong, L.-J. (2005) Characterisation of the endothelial specific molecule ECSM2. D.Phil. Thesis, University of Oxford, Oxford, U.K.
36. Verma, A., Bhattacharya, R., Remadevi, I., Li, K., Pramanik, K., Samant, G.V., Horswill, M., Chun, C.Z., Zhao, B., Wang, E. et al. (2010) Endothelial cell-specific chemotaxis receptor (ECSCR) promotes angioblast migration during vasculogenesis and enhances VEGF receptor sensitivity. Blood 115, 4614-4622
37. Koide, M., Ikeda, K., Akakabe, Y., Kitamura, Y., Ueyama, T., Matoba, S., Yamada, H., Okigaki, M. and Matsubara, H. (2011) Apoptosis regulator through modulating IAP expression (ARIA) controls the PI3K/Akt pathway in endothelial and endothelial progenitor cells. Proc. Natl. Acad. Sci. U.S.A. 108, 9472-9477
38. Park, K.W., Morrison, C.M., Sorensen, L.K., Jones, C.A., Rao, Y., Chien, C.B., Wu, J.Y., Urness, L.D. and Li, D.Y. (2003) Robo4 is a vascular-specific receptor that inhibits endothelial migration. Dev. Biol. 261, 251-267 (Pubitemid 36993830)
39. Krugmann, S., Jordens, I., Gevaert, K., Driessens, M., Vandekerckhove, J. and Hall, A. (2001) Cdc42 induces filopodia by promoting the formation of an IRSp53:Mena complex. Curr. Biol. 11, 1645-1655 (Pubitemid 33037775)