DNA ligand designed to antagonize EBNA1 represses Epstein-Barr virus-induced immortalization

Cancer Science

Volumn 102, Issue 12, 2011, Pages 2221-2230

  Yasuda, Ai ^a   Noguchi, Kohji ^a   Minoshima, Masafumi ^b   Kashiwazaki, Gengo ^b   Kanda, Teru ^c   Katayama, Kazuhiro ^a   Mitsuhashi, Junko ^a   Bando, Toshikazu ^b   Sugiyama, Hiroshi ^b   Sugimoto, Yoshikazu ^a  

^a KEIO UNIVERSITY   (Japan)

^b KYOTO UNIVERSITY   (Japan)

^c AICHI CANCER CENTER HOSPITAL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CIS ACTING ELEMENT; DNA; EPSTEIN BARR VIRUS ANTIGEN 1; IMIDAZOLE; LIGAND; POLYAMIDE; PYRROLE; TRANSCRIPTION FACTOR;

ARTICLE; B LYMPHOCYTE; CELL IMMORTALIZATION; CELL PROLIFERATION; CONTROLLED STUDY; DNA SEQUENCE; DRUG DESIGN; DRUG SELECTIVITY; DRUG SYNTHESIS; DRUG TARGETING; EPISOME; EPSTEIN BARR VIRUS; GENE REPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LATENT VIRUS INFECTION; LYMPHOBLASTOID CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; ORIP GENE; PERIPHERAL BLOOD MONONUCLEAR CELL; PLASMID; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRANSACTIVATION; VIRUS CELL INTERACTION; VIRUS GENE; VIRUS GENOME;

ANIMALS; B-LYMPHOCYTES; BASE SEQUENCE; BINDING SITES; CALLITHRIX; CELL LINE; CELL TRANSFORMATION, VIRAL; DNA REPLICATION; DNA, VIRAL; EPSTEIN-BARR VIRUS NUCLEAR ANTIGENS; HERPESVIRUS 4, HUMAN; HUMANS; IMIDAZOLES; LEUKOCYTES, MONONUCLEAR; NYLONS; PYRROLES; REPLICATION ORIGIN; VIRUS REPLICATION;

EID: 81855166208     PISSN: 13479032     EISSN: 13497006     Source Type: Journal    
DOI: 10.1111/j.1349-7006.2011.02098.x     Document Type: Article

References (36)

1. Kutok JL, Wang F. Spectrum of Epstein-Barr virus-associated diseases. Annu Rev Pathol 2006; 1: 375-404.
2. Noguchi K, Fukazawa H, Murakami Y, Takahashi N, Yamagoe S, Uehara Y. Gamma-herpesviruses and cellular signaling in AIDS-associated malignancies. Cancer Sci 2007; 98: 1288-96.
3. Rawlins DR, Milman G, Hayward SD, Hayward GS. Sequence-specific DNA binding of the Epstein-Barr virus nuclear antigen (EBNA-1) to clustered sites in the plasmid maintenance region. Cell 1985; 42: 859-68.
4. Schepers A, Ritzi M, Bousset K et al. Human origin recognition complex binds to the region of the latent origin of DNA replication of Epstein-Barr virus. EMBO J 2001; 20: 4588-602.
5. Chaudhuri B, Xu H, Todorov I, Dutta A, Yates JL. Human DNA replication initiation factors, ORC and MCM, associate with oriP of Epstein-Barr virus. Proc Natl Acad Sci USA 2001; 98: 10085-9.
6. Reisman D, Yates J, Sugden B. A putative origin of replication of plasmids derived from Epstein-Barr virus is composed of two cis-acting components. Mol Cell Biol 1985; 5: 1822-32.
7. Kanda T, Otter M, Wahl GM. Coupling of mitotic chromosome tethering and replication competence in Epstein-Barr virus-based plasmids. Mol Cell Biol 2001; 21: 3576-88.
8. Kanda T, Kamiya M, Maruo S, Iwakiri D, Takada K. Symmetrical localization of extrachromosomally replicating viral genomes on sister chromatids. J Cell Sci 2007; 120: 1529-39.
9. Kirchmaier AL, Sugden B. Dominant-negative inhibitors of EBNA-1 of Epstein-Barr virus. J Virol 1997; 71: 1766-75.
10. Nasimuzzaman M, Kuroda M, Dohno S et al. Eradication of Epstein-Barr virus episome and associated inhibition of infected tumor cell growth by adenovirus vector-mediated transduction of dominant-negative EBNA1. Mol Ther 2005; 11: 578-90.
11. Dervan PB, Burli RW. Sequence-specific DNA recognition by polyamides. Curr Opin Chem Biol 1999; 3: 688-93.
12. White S, Baird EE, Dervan PB. On the pairing rules for recognition in the minor groove of DNA by pyrrole Pyrrole-imidazole polyamides. Chem Biol 1997; 4: 569-78.
13. Dervan PB, Edelson BS. Recognition of the DNA minor groove by pyrrole-imidazole polyamides. Curr Opin Struct Biol 2003; 13: 284-99.
14. Zhang W, Bando T, Sugiyama H. Discrimination of hairpin polyamides with an alpha-substituted-gamma-aminobutyric acid as a 5′-TG-3′ reader in DNA minor groove. J Am Chem Soc 2006; 128: 8766-76.
15. Minoshima M, Bando T, Sasaki S, Fujimoto J, Sugiyama H. Pyrrole-imidazole hairpin polyamides with high affinity at 5′-CGCG-3′ DNA sequence; influence of cytosine methylation on binding. Nucleic Acids Res 2008; 36: 2889-94.
16. Ali AK, Saito S, Shibata S, Takada K, Kanda T. Distinctive effects of the Epstein-Barr virus family of repeats on viral latent gene promoter activity and B-lymphocyte transformation. J Virol 2009; 83: 9163-74.
17. Wada K, Kubota N, Ito Y et al. Simultaneous quantification of Epstein-Barr virus, cytomegalovirus, and human herpesvirus 6 DNA in samples from transplant recipients by multiplex real-time PCR assay. J Clin Microbiol 2007; 45: 1426-32.
18. Sternas L, Middleton T, Sugden B. The average number of molecules of Epstein-Barr nuclear antigen 1 per cell does not correlate with the average number of Epstein-Barr virus (EBV) DNA molecules per cell among different clones of EBV-immortalized cells. J Virol 1990; 64: 2407-10.
19. Kubota N, Wada K, Ito Y et al. One-step multiplex real-time PCR assay to analyse the latency patterns of Epstein-Barr virus infection. J Virol Methods 2008; 147: 26-36.
20. Noguchi K, Vassilev A, Ghosh S, Yates JL, DePamphilis ML. The BAH domain facilitates the ability of human Orc1 protein to activate replication origins in vivo. EMBO J 2006; 25: 5372-82.
21. Tempera I, Deng Z, Atanasiu C, Chen CJ, D'Erme M, Lieberman PM. Regulation of Epstein-Barr virus OriP replication by poly(ADP-ribose) polymerase 1. J Virol 2010; 84: 4988-97.
22. Szeles A, Falk KI, Imreh S, Klein G. Visualization of alternative Epstein-Barr virus expression programs by fluorescent in situ hybridization at the cell level. J Virol 1999; 73: 5064-9.
23. Chodosh J, Holder VP, Gan YJ, Belgaumi A, Sample J, Sixbey JW. Eradication of latent Epstein-Barr virus by hydroxyurea alters the growth-transformed cell phenotype. J Infect Dis 1998; 177: 1194-201.
24. Kieff E, Rickinson AB. Epstein-Barr virus and its replication. In: Knipe DM, Howley PM, eds. Fields Virology. Philadelphia: Lippincott Williams and Wilkins, 2007; 2603-54.
25. Puglielli MT, Woisetschlaeger M, Speck SH. oriP is essential for EBNA gene promoter activity in Epstein-Barr virus-immortalized lymphoblastoid cell lines. J Virol 1996; 70: 5758-68.
26. Humme S, Reisbach G, Feederle R et al. The EBV nuclear antigen 1 (EBNA1) enhances B cell immortalization several thousandfold. Proc Natl Acad Sci USA 2003; 100: 10989-94.
27. Herman DM, Baird EE, Dervan PB. Stereochemical Control of the DNA Binding Affinity, Sequence Specificity, and Orientation Preference of Chiral Hairpin Polyamides in the Minor Groove. J Am Chem Soc 1998; 120: 1382-91.
28. Canaan A, Haviv I, Urban AE et al. EBNA1 regulates cellular gene expression by binding cellular promoters. Proc Natl Acad Sci USA 2009; 106: 22421-6.
29. Dresang LR, Vereide DT, Sugden B. Identifying sites bound by Epstein-Barr virus nuclear antigen 1 (EBNA1) in the human genome: defining a position-weighted matrix to predict sites bound by EBNA1 in viral genomes. J Virol 2009; 83: 2930-40.
30. Sun X, Barlow EA, Ma S et al. Hsp90 inhibitors block outgrowth of EBV-infected malignant cells in vitro and in vivo through an EBNA1-dependent mechanism. Proc Natl Acad Sci USA 2010; 107: 3146-51.
31. Norseen J, Johnson FB, Lieberman PM. Role for G-quadruplex RNA binding by Epstein-Barr virus nuclear antigen 1 in DNA replication and metaphase chromosome attachment. J Virol 2009; 83: 10336-46.
32. Li N, Thompson S, Schultz DC et al. Discovery of selective inhibitors against EBNA1 via high throughput in silico virtual screening. PLoS ONE 2010; 5: e10126.
33. Thompson S, Messick T, Schultz DC, Reichman M, Lieberman PM. Development of a high-throughput screen for inhibitors of Epstein-Barr virus EBNA1. J Biomol Screen 2010; 15: 1107-15.
34. Kang MS, Lee EK, Soni V et al. Roscovitine inhibits EBNA1 serine 393 phosphorylation, nuclear localization, transcription, and episome maintenance. J Virol 2011; 85: 2859-68.
35. Katano H, Pesnicak L, Cohen JI. Simvastatin induces apoptosis of Epstein-Barr virus (EBV)-transformed lymphoblastoid cell lines and delays development of EBV lymphomas. Proc Natl Acad Sci USA 2004; 101: 4960-5.
36. Miyake A, Dewan MZ, Ishida T et al. Induction of apoptosis in Epstein-Barr virus-infected B-lymphocytes by the NF-kappaB inhibitor DHMEQ. Microbes Infect 2008; 10: 748-56.