Some natural flavonoids are competitive inhibitors of caspase-1, -3, and -7 despite their cellular toxicity

Food Chemistry

Volumn 131, Issue 4, 2012, Pages 1453-1459

  White, J Brandon ^a   Beckford, Jeremy ^a   Yadegarynia, Sina ^a   Ngo, Nhi ^a   Lialiutska, Tetiana ^a   D'Alarcao, Marc ^a  

^a SAN JOSE STATE UNIVERSITY   (United States)

Author keywords

Apoptosis; Breast cancer; Caspase; Enzyme kinetics; Flavonoid; Small molecule inhibitor

Indexed keywords

APOPTOSIS PATHWAYS; BIOLOGICAL PROPERTIES; BREAST CANCER; CASPASE; CASPASES; CELLULAR TARGETS; CELLULAR TOXICITIES; COMMON FEATURES; CYSTEINE PROTEASE; CYTOTOXIC; FLAVONOID; POLYPHENOLIC COMPOUND; SELECTIVE INHIBITORS; SMALL MOLECULE INHIBITOR;

AMINO ACIDS; ENZYME KINETICS;

CELL DEATH;

APIGENIN; CASPASE 3; CASPASE 7; CATECHIN; CHRYSIN; DAIDZEIN; FLAVONOID; GENISTEIN; INTERLEUKIN 1BETA CONVERTING ENZYME; KAEMPFEROL; LUTEOLIN; MYRICETIN; NARINGENIN; QUERCETIN;

APOPTOSIS; ARTICLE; CELL DEATH; CONTROLLED STUDY; CYTOTOXICITY; HUMAN; HUMAN CELL;

EID: 81855164648     PISSN: 03088146     EISSN: 18737072     Source Type: Journal    
DOI: 10.1016/j.foodchem.2011.10.026     Document Type: Article

References (27)

1. E.S.A. Arafa, Q.Z. Zhu, B.M. Barakat, G. Wani, Q. Zhao, and M.A. El-Mahdy Tangeretin sensitizes cisplatin-resistant human ovarian cancer cells through downregulation of phosphoinositide 3-kinase/Akt signaling pathway Cancer Research 69 23 2009 8910 8917
2. T.M. Caserta, A.N. Smith, A.D. Gultice, M.A. Reedy, and T.L. Brown Q-VD-OPh, a broad spectrum caspase inhibitor with potent antiapoptotic properties Apoptosis 8 4 2003 345 352 (Pubitemid 36935206)
3. S.Y. Chien, Y.C. Wu, J.G. Chung, J.S. Yang, H.F. Lu, and M.F. Tsou Quercetin-induced apoptosis acts through mitochondrial - and caspase-3-dependent pathways in human breast cancer MDA-MB-231 cells Human and Experimental Toxicology 28 8 2009 493 503
4. A. Das, N.L. Banik, and S.K. Ray Flavonoids activated caspases for apoptosis in human glioblastoma T98G and U87MG cells but not in human normal astrocytes Cancer 116 1 2010 164 176
5. C.A. Dinarello Therapeutic strategies to reduce IL-1 activity in treating local and systemic inflammation Current Opinion in Pharmacology 4 4 2004 378 385 (Pubitemid 38987065)
6. W.C. Earnshaw, L.M. Martins, and S.H. Kaufmann Mammalian caspases: Structure, activation, substrates, and functions during apoptosis Annual Review of Biochemistry 68 1999 383 424 (Pubitemid 29449198)
7. L. Eckhart, W. Declercq, J. Ban, M. Rendl, B. Lengauer, and C. Mayer Terminal differentiation of human keratinocytes and stratum corneum formation is associated with caspase-14 activation Journal of Investigative Dermatology 115 6 2000 1148 1151 (Pubitemid 32037463)
8. U. Fischer, and K. Schulze-Osthoff Apoptosis-based therapies and drug targets Cell Death and Differentiation 12 Suppl. 1 2005 942 961 (Pubitemid 41030608)
9. B. Howley, and H.O. Fearnhead Caspases as therapeutic targets Journal of Cellular and Molecular Medicine 12 5A 2008 1502 1516
10. G. Kroemer, and S.J. Martin Caspase-independent cell death Nature medicine 11 7 2005 725 730 (Pubitemid 41021204)
11. S.A. Lakhani, A. Masud, K. Kuida, G.A. Porter Jr. , C.J. Booth, and W.Z. Mehal Caspases 3 and 7: Key mediators of mitochondrial events of apoptosis Science 311 5762 2006 847 851 (Pubitemid 43228848)
12. D. Lee, S.A. Long, J.L. Adams, G. Chan, K.S. Vaidya, and T.A. Francis Potent and selective nonpeptide inhibitors of Caspases 3 and 7 inhibit apoptosis and maintain cell functionality Journal of Biological Chemistry 275 21 2000 16007 16014 (Pubitemid 30366906)
13. A.U. Luthi, and S.J. Martin The CASBAH: A searchable database of caspase substrates Cell Death and Differentiation 14 4 2007 641 650 (Pubitemid 46444502)
14. C. Manach, A. Scalbert, C. Morand, C. Remesy, and L. Jimenez Polyphenols: Food sources and bioavailability The American Journal of Clinical Nutrition 79 5 2004 727 747 (Pubitemid 41103873)
15. P.R.E. Mittl, S. Di Marco, J.F. Krebs, X. Bai, D.S. Karanewsky, and J.P. Priestle Structure of recombinant human CPP32 in complex with the tetrapeptide acetyl-Asp-Val-Ala-Asp fluoromethyl ketone Journal of Biological Chemistry 272 10 1997 6539 6547 (Pubitemid 27118135)
16. C. Pop, and G.S. Salvesen Human caspases: Activation, specificity, and regulation Journal of Biological Chemistry 284 33 2009 21777 21781
17. S. Prasad, K. Phromnoi, V.R. Yadav, M.M. Chaturvedi, and B.B. Aggarwal Targeting inflammatory pathways by flavonoids for prevention and treatment of cancer Planta Medica 76 11 2010 1044 1063
18. S. Ramos Effects of dietary flavonoids on apoptotic pathways related to cancer chemoprevention Journal of Nutritional Biochemistry 18 7 2007 427 442 (Pubitemid 46874924)
19. T.A. Rano, T. Timkey, E.P. Peterson, J. Rotonda, D.W. Nicholson, and J.W. Becker A combinatorial approach for determining protease specificities: Application to interleukin-1[beta] converting enzyme (ICE) Chemistry & Biology 4 2 1997 149 155 (Pubitemid 27164601)
20. K. Sakao, M. Fujii, and D.X. Hou Clarification of the role of quercetin hydroxyl groups in superoxide generation and cell apoptosis by chemical modification Bioscience Biotechnology and Biochemistry 73 9 2009 2048 2053
21. G.S. Salvesen, and V.M. Dixit Caspase activation: The induced-proximity model Proceedings of the National Academy of Sciences of the United States of America 96 20 1999 10964 10967 (Pubitemid 29487313)
22. H. Schroeter, J.P. Spencer, C. Rice-Evans, and R.J. Williams Flavonoids protect neurons from oxidized low-density-lipoprotein-induced apoptosis involving c-Jun N-terminal kinase (JNK), c-Jun and caspase-3 Biochemical Journal 358 3 2001 547 557 (Pubitemid 32896942)
23. S.C. Shen, Y.C. Chen, F.L. Hsu, and W.R. Lee Differential apoptosis-inducing effect of quercetin and its glycosides in human promyeloleukemic HL-60 cells by alternative activation of the caspase 3 cascade Journal of Cellular Biochemistry 89 5 2003 1044 1055
24. Y. Shimmyo, T. Kihara, A. Akaike, T. Niidome, and H. Sugimoto Three distinct neuroprotective functions of myricetin against glutamate-induced neuronal cell death: Involvement of direct inhibition of caspase-3 Journal of Neuroscience Research 86 8 2008 1836 1845 (Pubitemid 351859433)
25. J.P.E. Spencer, D. Vauzour, K. Vafeiadou, A. Rodriguez-Mateos, and C. Rendeiro The neuroprotective potential of flavonoids: A multiplicity of effects Genes and Nutrition 3 3-4 2008 115 126
26. I.K. Wang, S.Y. Lin-Shiau, and J.K. Lin Induction of apoptosis by apigenin and related flavonoids through cytochrome c release and activation of caspase-9 and caspase-3 in leukaemia HL-60 cells European Journal of Cancer 35 10 1999 1517 1525
27. T.D. Way, M.C. Kao, and J.K. Lin Degradation of HER2/neu by apigenin induces apoptosis through cytochrome c release and caspase-3 activation in HER2/neu-overexpressing breast cancer cells FEBS Letters 579 1 2005 145 152