N-biotinyl-S-(1,2-dichlorovinyl)-L-cysteine sulfoxide as a potential model for S-(1,2-Dichlorovinyl)-L-cysteine sulfoxide: Characterization of stability and reactivity with glutathione and kidney proteins in vitro

Chemical Research in Toxicology

Volumn 24, Issue 11, 2011, Pages 1915-1923

  Irving, Roy M ^a   Brownfield, Mark S ^b   Elfarra, Adnan A ^a,b  

^a Molecular and Environmental Toxicology Center   (United States)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROTEIN; CYSTEINE DERIVATIVE; GLUTATHIONE; GLUTATHIONE REDUCTASE; MALATE DEHYDROGENASE; N BIOTINYL S (1,2 DICHLOROVINYL)CYSTEINE SULFOXIDE; S (1,2 DICHLOROVINYL)CYSTEINE SULFOXIDE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; COVALENT BOND; CYTOSOL; DIASTEREOISOMER; ENZYME MODIFICATION; HALF LIFE TIME; IMMUNOBLOTTING; IN VITRO STUDY; INCUBATION TEMPERATURE; INCUBATION TIME; KIDNEY CELL; MALE; MOLECULAR WEIGHT; NEPHROTOXICITY; NONHUMAN; PROTEIN BINDING; RAT; SIGNAL TRANSDUCTION; SYNTHESIS;

ANIMALS; BINDING SITES; BINDING, COMPETITIVE; BIOTIN; BIOTINYLATION; BLOTTING, WESTERN; CYSTEINE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG STABILITY; ELECTROPHORESIS, POLYACRYLAMIDE GEL; GLUTATHIONE REDUCTASE; HALF-LIFE; HUMANS; INDICATORS AND REAGENTS; KIDNEY; KIDNEY NEOPLASMS; MALATE DEHYDROGENASE; PROTEIN BINDING; RATS, SPRAGUE-DAWLEY;

RATTUS;

EID: 81755173054     PISSN: 0893228X     EISSN: 15205010     Source Type: Journal    
DOI: 10.1021/tx200263n     Document Type: Article

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