Lipophosphonoxins: New modular molecular structures with significant antibacterial properties

Journal of Medicinal Chemistry

Volumn 54, Issue 22, 2011, Pages 7884-7898

  Rejman, Dominik ^a   Rabatinová, Alžbeta ^b   Pombinho, António R ^c   Kovačková, Soa ^a   Pohl, Radek ^a   Zbornóková, Eva ^a   Kolář, Milan ^d,e   Bogdanová, Kateřina ^e   Nyč, Otakar ^f   Šanderová, Hana ^b   Látal, Tomáš ^d   Bartůněk, Petr ^c   Krásný, Libor ^b  

^a INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY   (Czech Republic)

^b INSTITUTE OF MICROBIOLOGY   (Czech Republic)

^c INSTITUTE OF MOLECULAR GENETICS   (Czech Republic)

^d Trios Ltd   (Czech Republic)

^e PALACKÝ UNIVERSITY   (Czech Republic)

^f CHARLES UNIVERSITY   (Czech Republic)

Author keywords

[No Author keywords available]

Indexed keywords

2 PIVALOYLTHIOETHYL 2',3' ISOPROPYLIDENEURIDIN 5' YL VINYLPHOSPHONIC ACID; 2 PIVALOYLTHIOETHYL URIDIN 5' YL 2 ( 3,4 DIHYDROXYPYRROLIDIN 1 N YL)ETHYLPHOSPHONIC ACID; ALKANE; ANTIBIOTIC AGENT; CHLORAMPHENICOL; ETHYL 2',3' ISOPROPYLIDENEURIDIN 5' YL VINYLPHOSPHONIC ACID; ETHYL URIDIN 5' YL 2 ( 3,4 DIHYDROXYPYRROLIDIN 1 N YL)ETHYLPHOSPHONIC ACID; HEXADECYL 2',3' ISOPROPYLIDENEURIDIN 5' YL VINYLPHOSPHONIC ACID; HEXADECYL URIDIN 5' YL ( 3 HYDROXY 5 (HYDROXYMETHYL)PYRROLIDIN 1 N YL)ETHYLPHOSPHONIC ACID; HEXADECYL URIDIN 5' YL 2 ( 3,4 DIHYDROXYPYRROLIDIN 1 N YL)ETHYLPHOSPHONIC ACID; HEXADECYLOXCYPROPYL CYTIDIN 5' YL 2 ( 3,4 DIHYDROXYPYRROLIDIN 1 N YL)ETHYLPHOSPHONIC ACID; HEXADECYLOXYPROPYL 2',3' ISOPROPYLIDENEURIDIN 5' YL VINYLPHOSPHONIC ACID; HEXADECYLOXYPROPYL 4 N BENZOYL 2',3' ISOPROPYLIDENECYTIDIN 5' YL VINYLPHOSPHONIC ACID; HEXADECYLOXYPROPYL URIDIN 5' YL 2 ( 3,4 DIHYDROXYPIPERIDIN 1 N YL)ETHYLPHOSPHONIC ACID; HEXADECYLOXYPROPYL URIDIN 5' YL 2 ( 3,4 DIHYDROXYPYRROLIDIN 1 N YL)ETHYLPHOSPHONIC ACID; HEXADECYLOXYPROPYL URIDIN 5' YL 2 ( 3,4 TRIHYDROXYPIPERIDIN 1 N YL)ETHYLPHOSPHONIC ACID; ICOSANYL 2',3' ISOPROPYLIDENEURIDIN 5' YL VINYLPHOSPHONIC ACID; ICOSANYL URIDIN 5' YL 2 ( 3,4 DIHYDROXYPYRROLIDIN 1 N YL)ETHYLPHOSPHONIC ACID; IMINOSUGAR; LIPOPHOSPHONOXIN DERIVATIVE; NUCLEOSIDE; OCTADECYL 2',3' ISOPROPYLIDENEURIDIN 5' YL VINYLPHOSPHONIC ACID; OCTADECYL URIDIN 5' YL 2 ( 3,4 DIHYDROXYPYRROLIDIN 1 N YL)ETHYLPHOSPHONIC ACID; PHOSPHONIC ACID DERIVATIVE; TETRACYCLINE; TETRADECYL 2',3' ISOPROPYLIDENEURIDIN 5' YL VINYLPHOSPHONIC ACID; TETRADECYL URIDIN 5' YL 2 ( 3,4 DIHYDROXYPYRROLIDIN 1 N YL)ETHYLPHOSPHONIC ACID; UNCLASSIFIED DRUG; VANCOMYCIN;

ANTIBACTERIAL ACTIVITY; APOPTOSIS; ARTICLE; BACTERIAL STRAIN; CELL LINE; CELL VIABILITY; CHEMICAL MODIFICATION; CHEMICAL STRUCTURE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CROSS LINKING; CYTOTOXICITY; DRUG SYNTHESIS; GRAM POSITIVE BACTERIUM; HUMAN; HUMAN CELL; HYDROPHOBICITY; LIPOPHILICITY; MINIMUM INHIBITORY CONCENTRATION; MOLECULE; MULTIDRUG RESISTANCE;

ANTI-BACTERIAL AGENTS; APOPTOSIS; CELL SURVIVAL; CELLS, CULTURED; DRUG RESISTANCE, MULTIPLE, BACTERIAL; ERYTHROID PRECURSOR CELLS; FETAL BLOOD; GRAM-POSITIVE BACTERIA; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MICROBIAL SENSITIVITY TESTS; NUCLEOSIDES; PHOSPHONIC ACIDS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 81555228192     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm2009343     Document Type: Article

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