Issues raised involving the copper hypotheses in the causation of Alzheimer's disease

International Journal of Alzheimer's Disease

Volumn , Issue , 2011, Pages

  Brewer, George J ^a,b  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b Adeona Pharmaceuticals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID PRECURSOR PROTEIN; CERULOPLASMIN; COPPER; DEFEROXAMINE; DRINKING WATER; EDETIC ACID; ZINC;

ALZHEIMER DISEASE; BLOOD BRAIN BARRIER; COGNITION; ENVIRONMENTAL FACTOR; EPIDEMIC; FAT INTAKE; GENETIC RISK; HUMAN; PATHOGENESIS; PRIORITY JOURNAL; REVIEW; RISK FACTOR;

EID: 81555207176     PISSN: None     EISSN: 20900252     Source Type: Journal    
DOI: 10.4061/2011/537528     Document Type: Review

References (58)

1. Alzheimer's Association,. Alzheimer's Disease Facts and Figures, 2010
2. Brewer G. J., Newsome D. A., Toxic Copper: The Newly Discovered Culprit in Alzheimer's Disease and Dementia 2010 Ann Arbor, Mich, USA Raisin Publishing, LLC
3. Mally W., Caldwell P., Alzheimer's Disease 1998 Toronto, Canada Key Porter Books
4. Atwood C. S., Moir R. D., Huang X., Scarpa R. C., Bacarra N. M. E., Romano D. M., Hartshorn M. A., Tanzi R. E., Bush A. I., Dramatic aggregation of alzheimer by Cu(II) is induced by conditions representing physiological acidosis Journal of Biological Chemistry 1998 273 21 12817 12826 (Pubitemid 28246837)
5. Bush A. I., Pettingell W. H., Multhaup G., Paradis D. M., Vonsattel J. P., Gusella J. F., Beyreuther K., Masters C. L., Tanzi R. E., Rapid induction of Alzheimer A amyloid formation by zinc Science 1994 265 5177 1464 1467 (Pubitemid 24306803)
6. Adlard P. A., Bica L., White A. R., Metal ionophore treatment restores dendritic spine density and synaptic protein levels in a mouse model of Alzheimer's disease PLoS ONE 2011 6 3, article e17669
7. Brewer G. J., Kanzer S. H., Zimmerman E. A., Molho E. S., Celmins D. F., Heckman S. M., Dick R., Subclinical zinc deficiency in Alzheimer's disease and Parkinson's disease American Journal of Alzheimer's Disease and other Dementias 2010 25 7 572 575
8. Religa D., Strozyk D., Cherny R. A., Volitakis I., Haroutunian V., Winblad B., Naslund J., Bush A. I., Elevated cortical zinc in Alzheimer disease Neurology 2006 67 1 69 75 (Pubitemid 44305464)
9. Brewer G. J., Askari F., Dick R., Treatment of Wilson's disease with tetrathiomolybdate: V. Control of free copper by tetrathiomolybdate and a comparison with trientine Translational Research 2009 154 2 70 77
10. Squitti R., Pasqualetti P., Dal Forno G., Moffa F., Cassetta E., Lupoi D., Vernieri F., Rossi L., Baldassini M., Rossini P. M., Excess of serum copper not related to ceruloplasmin in Alzheimer disease Neurology 2005 64 6 1040 1046 (Pubitemid 40388458)
11. Squitti R., Barbati G., Rossi L., Ventriglia M., Dal Forno G., Cesaretti S., Moffa F., Caridi I., Cassetta E., Pasqualetti P., Calabrese L., Lupoi D., Rossini P. M., Excess of nonceruloplasmin serum copper in AD correlates with MMSE, CSF -amyloid, and h-tau Neurology 2006 67 1 76 82 (Pubitemid 44305465)
12. Squitti R., Bressi F., Pasqualetti P., Bonomini C., Ghidoni R., Binetti G., Cassetta E., Moffa F., Ventriglia M., Vernieri F., Rossini P. M., Longitudinal prognostic value of serum "free" copper in patients with Alzheimer disease Neurology 2009 72 1 50 55
13. Sparks D. L., Schreurs B. G., Trace amounts of copper in water induce -amyloid plaques and learning deficits in a rabbit model of Alzheimer's disease Proceedings of the National Academy of Sciences of the United States of America 2003 100 19 11065 11069 (Pubitemid 37140153)
14. Sparks D. L., Friedland R., Petanceska S., Schreurs B. G., Shi J., Perry G., Smith M. A., Sharma A., Derosa S., Ziolkowski C., Stankovic G., Trace copper levels in the drinking water, but not zinc or aluminum influence CNS Alzheimer-like pathology Journal of Nutrition, Health and Aging 2006 10 4 247 254 (Pubitemid 44351819)
15. Deane R., Sagare A., Coma M., A novel role for copper: disruption of LRP-dependent brain Abeta clearence Proceedings of the Annual Meeting of the Society for Neuroscience 2007 San Diego, Calif, USA
16. Morris M. C., Evans D. A., Tangney C. C., Bienias J. L., Schneider J. A., Wilson R. S., Scherr P. A., Dietary copper and high saturated and trans fat intakes associated with cognitive decline Archives of Neurology 2006 63 8 1085 1088 (Pubitemid 44232313)
17. Quinn J. F., Crane S., Harris C., Wadsworth T. L., Copper in Alzheimer's disease: too much or too little? Expert Review of Neurotherapeutics 2009 9 5 631 637
18. Waldman M., Lamb M., Dying for a Hamburger: Modern Meat Processing and the Epidemic of Alzheimer's Disease 2005 New York, NY, USA Thomas Dune Books/St. Martin's Press
19. Osler W., Modern Medicine in Theory and Practice 1910 Philadelphia, Pa, USA Lea and Febiger
20. Gowers W. R., A Manual of Diseases of the Nervous System 1888 Philadelphia, Pa, USA P Blakiston, Son, and Co
21. Strachey J., Freud A., Strachey A., Tyson A., 24 Volumes Entitled, The Standard Edition of the Complete Psychological Works of Sigmund Freud, Written between 1895 and 1939 1966 London, UK The Hogarth Press and the Institute of Psycho-Analysis
22. Boyd W., A Textbook of Pathology: An Introduction to Medicine 1938 Philadelphia, Pa, USA Lea and Febiger
23. Ferri C. P., Prince M., Brayne C., Brodaty H., Fratiglioni L., Ganguli M., Hall K., Hasegawa K., Hendrie H., Huang Y., Jorm A., Mathers C., Menezes P. R., Rimmer E., Scazufca M., Global prevalence of dementia: a delphi consensus study Lancet 2005 366 9503 2112 2117 (Pubitemid 41797645)
24. Grant W. B., Dietary links to Alzheimer's disease Alzheimer's Disease Review 1997 2 42 55
25. Huang X., Atwood C. S., Hartshorn M. A., Multhaup G., Goldstein L. E., Scarpa R. C., Cuajungco M. P., Gray D. N., Lim J., Moir R. D., Tanzi R. E., Bush A. I., The A peptide of Alzheimer's disease directly produces hydrogen peroxide through metal ion reduction Biochemistry 1999 38 24 7609 7616 (Pubitemid 29289332)
26. Nelson T. J., Alkon D. L., Oxidation of cholesterol by amyloid precursor protein and -amyloid peptide Journal of Biological Chemistry 2005 280 8 7377 7387 (Pubitemid 40341296)
27. Multhaup G., Schlicksupp A., Hesse L., Beher D., Ruppert T., Masters C. L., Beyreuther K., The amyloid precursor protein of Alzheimer's disease in the reduction of copper(II) to copper(I) Science 1996 271 5254 1406 1409 (Pubitemid 26089474)
28. White A. R., Multhaup G., Galatis D., McKinstry W. J., Parker M. W., Pipkorn R. D., Beyreuther K., Masters C. L., Cappai R., Contrasting, species-dependent modulation of copper-mediated neurotoxicity by the Alzheimer's disease amyloid precursor protein Journal of Neuroscience 2002 22 2 365 376 (Pubitemid 34049074)
29. Sayre L. M., Perry G., Harris P. L. R., Liu Y., Schubert K. A., Smith M. A., In situ oxidative catalysis by neurofibrillary tangles and senile plaques in Alzheimer's disease: a central role for bound transition metals Journal of Neurochemistry 2000 74 1 270 279 (Pubitemid 30012778)
30. Ma Q., Li Y., Du J., Liu H., Kanazawa K., Nemoto T., Nakanishi H., Zhao Y., Copper binding properties of a tau peptide associated with Alzheimer's disease studied by CD, NMR, and MALDI-TOF MS Peptides 2006 27 4 841 849
31. Hill G. M., Brewer G. J., Prasad A. S., Treatment of Wilson's disease with zinc. I. Oral zinc therapy regimens Hepatology 1987 7 3 522 528 (Pubitemid 17073159)
32. Holden J. M., Wolf W. R., Mertz W., Zinc and copper in self-selected diets Journal of the American Dietetic Association 1979 75 1 23 28
33. Klevay L. M., Reck S. J., Barcome D. F., Evidence of dietary copper and zinc deficiencies Journal of the American Medical Association 1979 241 18 1916 1918 (Pubitemid 9228273)
34. Reiser S., Smith J. C., Mertz W., Indices of copper status in humans consuming a typical American diet containing either fructose or starch American Journal of Clinical Nutrition 1985 42 2 242 251 (Pubitemid 16246355)
35. Brewer G. J., Danzeisen R., Stern B. R., Aggett P. J., Deveau M., Plunkett L., Chambers A., Krewski D., Levy L. S., McArdle H. J., Keen C. L., Araya M., Solioz M., Letter to the editor and reply: toxicity of copper in drinking water Journal of Toxicology and Environmental Health 2010 13 6 449 459
36. Danzeisen R., Stern B. R., Aggett P. J., Reply to George Brewer letter to the editor: toxicity of copper in drinking water Journal of Toxicology and Environmental Health 2010 13 6 449 459
37. National Research Council (U.S.). Committee on Copper in Drinking Water, Copper in Drinking Water 2000 Washington, D.C., USA National Academy Press
38. Kessler H., Bayer T. A., Bach D., Schneider-Axmann T., Supprian T., Herrmann W., Haber M., Multhaup G., Falkai P., Pajonk F. G., Intake of copper has no effect on cognition in patients with mild Alzheimer's disease: a pilot phase 2 clinical trial Journal of Neural Transmission 2008 115 8 1181 1187
39. Miyata M., Smith J. D., Apolipoprotein E allele-specific antioxidant activity and effects on cytotoxicity by oxidative insults and -amyloid peptides Nature Genetics 1996 14 1 55 61 (Pubitemid 26301547)
40. Moalem S., Percy M. E., Andrews D. F., Kruck T. P. A., Wong S., Dalton A. J., Mehta P., Fedor B., Warren A. C., Are hereditary hemochromatosis mutations involved in Alzheimer disease? American Journal of Medical Genetics 2000 93 1 58 66 (Pubitemid 30350273)
41. Zambenedetti P., De Bellis G., Biunno I., Musicco M., Zatta P., Transferrin C2 variant does confer a risk for Alzheimer's disease in caucasians Journal of Alzheimer's Disease 2003 5 6 423 427 (Pubitemid 38101229)
42. Seshadri S., Beiser A., Selhub J., Jacques P. F., Rosenberg I. H., D'Agostino R. B., Wilson P. W. F., Wolf P. A., Plasma homocysteine as a risk factor for dementia and Alzheimer's disease New England Journal of Medicine 2002 346 7 476 483 (Pubitemid 34441738)
43. Nakano E., Williamson M. P., Williams N. H., Powers H. J., Copper-mediated LDL oxidation by homocysteine and related compounds depends largely on copper ligation Biochimica et Biophysica Acta 2004 1688 1 33 42 (Pubitemid 38372098)
44. Crouch P. J., Lin W. H., Adlard P. A., Cortes M., Lal V., Filiz G., Perez K. A., Nurjono M., Caragounis A., Du T., Laughton K., Volitakis I., Bush A. I., Li Q. X., Masters C. L., Cappai R., Cherny R. A., Donnelly P. S., White A. R., Barnham K. J., Increasing Cu bioavailability inhibits A oligomers and tau phosphorylation Proceedings of the National Academy of Sciences of the United States of America 2009 106 2 381 386
45. Ueda K., Kawano H., Hasuo Y., Fujishima M., Prevalence and etiology of dementia in a Japanese community Stroke 1992 23 6 798 803
46. White L., Petrovitch H., Ross G. W., Masaki K. H., Abbott R. D., Teng E. L., Rodriguez B. L., Blanchette P. L., Havlik R. J., Wergowske G., Chiu D., Foley D. J., Murdaugh C., Curb J. D., Prevalence of dementia in older Japanese-American men in Hawaii: the Honolulu-Asia aging study Journal of the American Medical Association 1996 276 12 955 960 (Pubitemid 26318224)
47. Hill G. M., Brewer G. J., Juni J. E., Treatment of Wilson's disease with zinc. II. Validation of oral 64coppper with copper balance American Journal of the Medical Sciences 1986 292 6 344 349 (Pubitemid 17040561)
48. Nose Y., Kim B. E., Thiele D. J., Ctr1 drives intestinal copper absorption and is essential for growth, iron metabolism, and neonatal cardiac function Cell Metabolism 2006 4 3 235 244 (Pubitemid 44283961)
49. Salustri C., Barbati G., Ghidoni R., Quintiliani L., Ciappina S., Binetti G., Squitti R., Is cognitive function linked to serum free copper levels? A cohort study in a normal population Clinical Neurophysiology 2010 121 4 502 507
50. Brewer G. J., Kanzer S. H., Zimmerman E. A., Celmins D. F., Heckman S. M., Dick R., Copper and ceruloplasmin abnormalities in Alzheimers disease American Journal of Alzheimer's Disease and other Dementias 2010 25 6 490 497
51. Arnal N., Cristalli D. O., de Alaniz M. J. T., Marra C. A., Clinical utility of copper, ceruloplasmin, and metallothionein plasma determinations in human neurodegenerative patients and their first-degree relatives Brain Research 2010 1319 C 118 130
52. Danzeisen R., Araya M., Harrison B., Keen C., Solioz M., Thiele D., Mcardle H. J., How reliable and robust are current biomarkers for copper status? British Journal of Nutrition 2007 98 4 676 683 (Pubitemid 47487934)
53. Brewer G. J., Dick R. D., Johnson V. D., Treatment of Wilson's disease with zinc: XV long-term follow-up studies The Journal of Laboratory and Clinical Medicine 1998 132 4 264 278 (Pubitemid 28490259)
54. Kessler H., Pajonk F. G., Meisser P., Schneider-Axmann T., Hoffmann K. H., Supprian T., Herrmann W., Obeid R., Multhaup G., Falkai P., Bayer T. A., Cerebrospinal fluid diagnostic markers correlate with lower plasma copper and ceruloplasmin in patients with Alzheimer's disease Journal of Neural Transmission 2006 113 11 1763 1769 (Pubitemid 44657672)
55. Bayer T. A., Schfer S., Simons A., Kemmling A., Kamer T., Tepest R., Eckert A., Schssel K., Eikenberg O., Sturchler-Pierrat C., Abramowski D., Staufenbiel M., Multhaup G., Dietary Cu stabilizes brain superoxide dismutase 1 activity and reduces amyloid A production in APP23 transgenic mice Proceedings of the National Academy of Sciences of the United States of America 2003 100 2 14187 14192 (Pubitemid 37499212)
56. Klevay L. M., Alzheimer's disease as copper deficiency Medical Hypotheses 2008 70 4 802 807 (Pubitemid 351318084)
57. Hedera P., Fink J. K., Bockenstedt P. L., Brewer G. J., Myelopolyneuropathy and pancytopenia due to copper deficiency and high zinc levels of unknown origin: further support for existence of a new zinc overload syndrome Archives of Neurology 2003 60 9 1303 1306 (Pubitemid 37099640)
58. Hedera P., Peltier A., Fink J. K., Wilcock S., London Z., Brewer G. J., Myelopolyneuropathy and pancytopenia due to copper deficiency and high zinc levels of unknown origin II. The denture cream is a primary source of excessive zinc NeuroToxicology 2009 30 6 996 999