Regeneration of periodontal tissues in non-human primates with rhGDF-5 and beta-tricalcium phosphate

Journal of Dental Research

Volumn 90, Issue 12, 2011, Pages 1416-1421

  Emerton, K B ^a   Drapeau, S J ^a   Prasad, H ^b   Rohrer, M ^b   Roffe, P ^c   Hopper, K ^d   Schoolfield, J ^e   Jones, A ^e   Cochran, D L ^e  

^a Medtronic   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

^c MEDTRONIC INC   (United States)

^d Mannheimer Foundation   (United States)

^e UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

biological factors; bone regeneration; GDF 5; medical devices; periodontal disease; periodontal regeneration

Indexed keywords

BETA-TRICALCIUM PHOSPHATE; CALCIUM PHOSPHATE; DRUG CARRIER; GROWTH DIFFERENTIATION FACTOR 5; RECOMBINANT PROTEIN;

ANALYSIS OF VARIANCE; ANIMAL; ARTICLE; BABOON; CEMENTUM; CHRONIC PERIODONTITIS; DOSE RESPONSE; GROWTH, DEVELOPMENT AND AGING; HUMAN; JAW; MICRO-COMPUTED TOMOGRAPHY; PERIODONTAL LIGAMENT; PHYSIOLOGY; RADIOGRAPHY; RANDOMIZATION; REGENERATION;

ALVEOLAR PROCESS; ANALYSIS OF VARIANCE; ANIMALS; CALCIUM PHOSPHATES; CHRONIC PERIODONTITIS; DENTAL CEMENTUM; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG CARRIERS; GROWTH DIFFERENTIATION FACTOR 5; HUMANS; PAPIO; PERIODONTAL LIGAMENT; RANDOM ALLOCATION; RECOMBINANT PROTEINS; REGENERATION; X-RAY MICROTOMOGRAPHY;

EID: 81555203191     PISSN: 00220345     EISSN: 15440591     Source Type: Journal    
DOI: 10.1177/0022034511423665     Document Type: Article

References (28)

1. Assuma R, Oates T, Cochran D, Amar S, Graves DT. IL-1 and TNF antagonists inhibit the inflammatory response and bone loss in experimental periodontitis. J Immunol. 1998 ; 160: 403-409 (Pubitemid 28116755)
2. Bodde EW, Wolke JG, Kowalski RS, Jansen JA. Bone regeneration of porous beta-tricalcium phosphate (Conduit TCP) and of biphasic calcium phosphate ceramic (Biosel) in trabecular defects in sheep. J Biomed Mater Res A. 2007 ; 82: 711-722 (Pubitemid 47258585)
3. Boughner JC, Dean MC. Does space in the jaw influence the timing of molar crown initiation? A model using baboons (Papio anubis) and great apes (Pan troglodytes, Pan paniscus). J Hum Evol. 2004 ; 46: 255-277 (Pubitemid 38454208)
4. Caton J, Mota L, Gandini L, Laskaris B. Non-human primate models for testing the efficacy and safety of periodontal regeneration procedures. J Periodontol. 1994 ; 65: 1143-1150
5. Cochran DL, King GN, Schoolfield J, Velasquez-Plata D, Mellonig JT, Jones A. The effect of enamel matrix proteins on periodontal regeneration as determined by histological analyses. J Periodontol. 2003a ; 74: 1043-1055 (Pubitemid 37038540)
6. Cochran DL, Jones A, Heijl L, Mellonig JT, Schoolfield J, King GN. Periodontal regeneration with a combination of enamel matrix proteins and autogenous bone grafting. J Periodontol. 2003b ; 74: 1269-1281 (Pubitemid 37345089)
7. Forslund C, Rueger D, Aspenberg P. A comparative dose-response study of cartilage-derived morphogenetic protein (CDMP)-1, -2 and -3 for tendon healing in rats. J Orthop Res. 2003 ; 21: 617-621 (Pubitemid 36758205)
8. Giannobile WV, Finkelman RD, Lynch SE. Comparison of canine and non-human primate animal models for periodontal regenerative therapy: results following a single administration of PDGF/IGF-I. J Periodontol. 1994 ; 65: 1158-1168
9. Giannobile WV, Hernandez RA, Finkelman RD, Ryan S, Kiritsy CP, D'Andrea M, et al. Comparative effects of platelet-derived growth factor-BB and insulin-like growth factor-I, individually and in combination, on periodontal regeneration in Macaca fascicularis. J Periodontal Res. 1996 ; 31: 301-312
10. Gruber RM, Ludwig A, Merten HA, Achilles M, Poehling S, Schliephake H. Sinus floor augmentation with recombinant human growth and differentiation factor-5 (rhGDF-5): a histological and histomorphometric study in the Goettingen miniature pig. Clin Oral Implants Res. 2008 ; 19: 522-529
11. Gruber RM, Ludwig A, Merten HA, Pippig S, Kramer FJ, Schliephake H. Sinus floor augmentation with recombinant human growth and differentiation factor-5 (rhGDF-5): a pilot study in the Goettingen miniature pig comparing autogenous bone and rhGDF-5. Clin Oral Implants Res. 2009 ; 20: 175-182
12. Horch HH, Sader R, Pautke C, Neff A, Deppe H, Kolk A. Synthetic, pure-phase beta-tricalcium phosphate ceramic granules (Cerasorb) for bone regeneration in the reconstructive surgery of the jaws. Int J Oral Maxillofac Surg. 2006 ; 35: 708-713 (Pubitemid 43906179)
13. Kadomatsu H, Matsuyama T, Yoshimoto T, Negishi Y, Sekiya H, Yamamoto M, et al. Injectable growth/differentiation factor-5-recombinant human collagen composite induces endochondral ossification via Sry-related HMG box 9 (Sox9)expression and angiogenesis in murine calvariae. J Periodontal Res. 2008 ; 43: 483-489
14. Koch FP, Becker J, Terheyden H, Capsius B, Wagner W. A prospective, randomized pilot study on the safety and efficacy of recombinant human growth and differentiation factor-5 coated onto beta-tricalcium phosphate for sinus lift augmentation. Clin Oral Implants Res. 2010 ; 21: 1301-1308
15. Kuniyasu H, Hirose Y, Ochi M, Yajima A, Sakaguchi K, Murata M, et al. Bone augmentation using rhGDF-5-collagen composite. Clin Oral Implants Res. 2003 ; 14: 490-499 (Pubitemid 37485605)
16. Lee JS, Wikesjö UM, Jung UW, Choi SH, Pippig S, Siedler M, et al. Periodontal wound healing/regeneration following implantation of recombinant human growth/differentiation factor-5 in a beta-tricalcium phosphate carrier into one-wall intrabony defects in dogs. J Clin Periodontol. 2010 ; 37: 382-389
17. Magit DP, Maak T, Trioano N, Raphael B, Hamouria Q, Polzhofer G, et al. Healos/recombinant human growth and differentiation factor-5 induces posterolateral lumbar fusion in a New Zealand white rabbit model. Spine. 2006 ; 31: 2180-2188 (Pubitemid 44337853)
18. Miller DR, Aufdemorte TB, Fox WC, Waldrop TC, Mealey BL, Brunsvold MA. Periodontitis in the baboon: a potential model for human disease. J Periodontal Res. 1995 ; 30: 404-409
19. Morotome Y, Goseki-Sone M, Ishikawa I, Oida S. Gene expression of growth and differentiation factors-5, -6, and -7 in developing bovine tooth at the root forming stage. Biochem Biophys Res Commun. 1998 ; 244: 85-90 (Pubitemid 28419904)
20. Nakamura T, Yamamoto M, Tamura T, Izumi Y. Effects of growth/differentiation factor-5 on human periodontal ligament cells. J Periodontal Res. 2003 ; 38: 597-605 (Pubitemid 37494410)
21. Poehling S, Pippig SD, Hellerbrand K, Siedler M, Schutz A, Dony C. Superior effect of MD05, beta-tricalcium phosphate coated with recombinant human growth/differentiation factor-5, compared to conventional bone substitutes in the rat calvarial defect model. J Periodontol. 2006 ; 77: 1582-1590 (Pubitemid 44740769)
22. Rickert M, Jung M, Adiyaman M, Richter W, Simank HG. A growth and differentiation factor-5 (GDF-5)-coated suture stimulates tendon healing in an Achilles tendon model in rats. Growth Factors. 2001 ; 19: 115-126 (Pubitemid 33133369)
23. Rohrer M, Schubert C. The cutting-grinding technique for histological preparation of undecalcified bone and bone-anchored implants: improvement in instrumentation and procedures. Oral Surg Oral Med Oral Pathol Oral Pathol. 1992 ; 74: 73-78
24. Spiro RC, Liu L, Heidaran MA, Thompson AY, Ng CK, Pohl J, et al. Inductive activity of recombinant human growth and differentiation factor-5. Biochem Soc Trans. 2000 ; 28: 362-368
25. Takayama S, Murakami S, Shimabukuro Y, Kitamura M, Okada H. Periodontal regeneration by FGF-2 (bFGF) in primate models. J Dent Res. 2001 ; 80: 2075-2079
26. Tashiro T, Hiraoka H, Ikeda Y, Ohnuki T, Suzuki R, Ochi T, et al. Effect of GDF-5 on ligament healing. J Orthop Res. 2006 ; 24: 71-79 (Pubitemid 43772610)
27. Walsh WR, Vizesi F, Michael D, Auld J, Langdown A, Oliver R, et al. Beta-TCP bone graft substitutes in a bilateral rabbit tibial defect model. Biomaterials. 2008 ; 29: 266-271 (Pubitemid 350060984)
28. Yamashita M, Lazarov M, Jones AA, Mealey BL, Mellonig JT, Cochran DL. Periodontal regeneration using an anabolic peptide with two carriers in baboons. J Periodontol. 2010 ; 81: 727-736