Sinus floor augmentation with recombinant human growth and differentiation factor-5 (rhGDF-5): A histological and histomorphometric study in the Goettingen miniature pig

Clinical Oral Implants Research

Volumn 19, Issue 5, 2008, Pages 522-529

  Gruber, Rudolf M ^a   Ludwig, Arwed ^b   Merten, Hans Albert ^c   Achilles, Mirjam ^a   Poehling, Sylke ^b   Schliephake, Henning ^a  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

^b Hannover Medical School ^*

^c HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

BMP; Bone formation; Osteoinduction; Sinus augmentation

Indexed keywords

EID: 42149168493     PISSN: 09057161     EISSN: 16000501     Source Type: Journal    
DOI: 10.1111/j.1600-0501.2007.01494.x     Document Type: Article

References (43)

1. Arosarena, O.A. Collins, W.L. (2005) Bone regeneration in the rat mandible with bone morphogenetic protein-2: a comparison of two carriers. Otolaryngology - Head and Neck Surgery 132 : 592 597.
2. Boyne, P.J. James, R.A. (1980) Grafting of the maxillary sinus floor with autogenous marrow and bone. Journal of Oral Surgery 38 : 613 616.
3. Boyne, P.J., Lilly, L.C., Marx, R.E., Moy, P.K., Nevins, M., Spagnoli, D.B. Triplett, R.G. (2005) De novo bone induction by recombinant human bone morphogenetic protein-2 (rhBMP-2) in maxillary sinus floor augmentation. Journal of Oral and Maxillofacial Surgery 63 : 1693 1707.
4. Boyne, P.J., Marx, R.E., Nevins, M., Triplett, R.G., Lazaro, E., Lilly, L.C., Alder, M. Nummikoski, P. (1997) A feasibility study evaluating rhBMP-2/absorbable collagen sponge for maxillary sinus floor augmentation. The International Journal of Periodontics & Restorative Dentistry 17 : 11 25.
5. Buxton, P., Edwards, C., Archer, C.W. Francis-West, P. (2001) Growth/differentiation factor-5 (GDF-5) and skeletal development. The Journal of Bone and Joint Surgery 83 : S23 S30.
6. Donath, K. Breuner, G. (1982) A method for the study of undecalcified bones and teeth with attached soft tissues. Journal of Oral Pathology 11 : 318 326.
7. Francis-West, P.H., Abdelfattah, A., Chen, P., Allen, C., Parish, J., Ladher, R., Allen, S., MacPherson, S., Luyten, F.P. Archer, C.W. (1999) Mechanisms of GDF-5 action during skeletal development. Development 126 : 1305 1315.
8. Fuerst, G., Gruber, R., Tangl, S., Sanroman, F. Watzek, G. (2004) Effects of fibrin sealant protein concentrate with and without platelet released growth factors on bony healing of cortical mandibular defects. An experimental study in minipigs. Clinical Oral Implants Research 15 : 301 307.
9. Geiger, M., Li, R.H. Friess, W. (2003) Collagen sponges for bone regeneration with rhBMP-2. Advanced Drug Delivery Reviews 55 : 1613 1629.
10. Groeneveld, E.H.J. Burger, E.H. (2000) Bone morphogenetic proteins in human bone regeneration. European Journal of Endocrinology 142 : 9 21.
11. Groeneveld, E.H.J., van den Bergh, J.P.A., Holzmann, P., ten Bruggenkate, C.M., Tuinzing, B.D. Burge, E. (1999) Histomorphometrical analysis of bone formed in human maxillary sinus floor elevations grafted with OP-1 device, demineralized bone matrix or autogenous bone. Comparison with non-grafted sites in a series of case reports. Clinical Oral Implants Research 10 : 499 509.
12. Gulliksen, H. (1959) A balanced incomplete block design for paired comparisons. American Psychologist 14 : 415.
13. Hanisch, O., Tatakis, D.N., Rohrer, M.D., Wohrle, P.S., Wozney, J.M. Wikesjo, U.M. (1997) Bone formation and osseointegration simulated by rhBMP-2 following subantral augmentation procedure in nonhuman primates. International Journal of Oral and Maxillofacial Implants 12 : 785 792.
14. ®) for bone regeneration in the reconstructive surgery of the jaws. International Journal of Oral and Maxillofacial Surgery 35 : 708 713.
15. Hotten, G.C., Matsumoto, T., Kimura, M., Bechtold, R.F., Kron, R., Ohara, T., Tanaka, H., Satoh, Y., Okazaki, M., Shirai, T., Pan, H., Kawai, S., Pohl, J.S. Kudo, A. (1996) Recombinant human growth/differentiation factor 5 stimulates mesenchyme aggregation and chondrogenesis responsible for the skeletal development of limbs. Growth Factors 13 : 65 74.
16. Jahng, T.A., Fu, T.S., Cunningham, B.W., Dmitriev, A.E. Kim, D.H. (2004) Endoscopic instrumented posterolateral lumbar fusion with Healos and recombinant human growth/differentiation factor-5. Neurosurgery 54 : 171 181.
17. Jensen, O.T., Shulman, L.B., Block, M.S. Iacono, V.J. (1998) Report of the sinus consensus conference of 1996. International Journal of Oral and Maxillofacial Implants 13 (Suppl.) : 11 32.
18. Khan, S.N. Lane, J.M. (2004) The use of recombinant human bone morphogenetic protein-2 (rhBMP-2) in orthopaedic applications. Expert Opinion on Biological Therapy 4 : 741 748.
19. Kuniyasu, H., Hirose, Y., Ochi, M., Yajima, A., Sakaguchi, K., Murata, M. Pohl, J. (2003) Bone augmentation using rhGDF-5-collagen composite. Clinical Oral Implants Research 14 : 490 499.
20. Magit, D.P., Maak, T., Trioano, N., Raphael, B., Hamouria, Q., Polzhofer, G., Drespe, I., Albert, T.J. Grauer, J.N. (2006) Healos/recombinant human growth and differentiation factor-5 induces posterolateral lumbar fusion in a New Zealand rabbit model. Spine 31 : 2180 2188.
21. Marukawa, E., Asahina, I., Oda, M., Seto, I., Alam, M.I. Enomoto, S. (2001) Bone regeneration using recombinant human bone morphogenetic protein-2 (rhBMP-2) in alveolar defects of primate mandibles. British Journal of Oral and Maxillofacial Surgery 39 : 452 459.
22. Moore, W.R., Graves, S.E. Bain, G.I. (2001) Synthetic bone graft substitutes. Australian and New Zealand Journal of Surgery 71 : 354 361.
23. Poehling, S., Jochims, K., Happersberger, P., Hellerbrand, K., Bolz, W. Kohnert, U. (2002) Enhancement of bone growth by coating of osteoinductive beta-tricalcium phosphate (beta-TCP) with recombinant human growth factor-5 (rhGDF-5). 2nd European Conference on Bone Morphogenetic Proteins, May 2002, Zagreb.
24. Rejda, B.V., Peelen, J.G. de Groot, K. (1977) Tri-calcium phosphate as a bone substitute. Journal of Bioengineering 1 : 93 97.
25. Rengachary, S.S. (2002) Bone morphogenetic proteins: basic concepts. Neurosurgical Focus 13 : 1 6.
26. Rupprecht, S., Merten, H.A., Kessler, P. Wiltfang, J. (2003) Hydroxyapatite cement (bonesource) for repair of critical sized calvarian defects - an experimental study. Journal of Cranio-Maxillofacial Surgery 31 : 149 153.
27. Schliephake, H., Kroly, C. Wüstenfeld, H. (1994) Experimental study by fluorescence microscopy and microangiography of remodeling and regeneration of bone inside alloplastic contour augmentations. International Journal of Oral and Maxillofacial Surgery 23 : 300 305.
28. Schliephake, H., Scharnweber, D., Dard, M., Sewing, A., Aref, A. Roessler, S. (2005) Functionalization of dental implant surfaces using adhesion molecules. Journal of Biomedical Materials Research Part B: Applied Biomaterials 73 : 88 96.
29. Shimaoka, H., Dohi, Y., Ohgushi, H., Ikeuchi, M., Okamoto, M., Kudo, A., Kirita, T. Yonemasu, K. (2004) Recombinant growth/differentiation factor-5 (GDF-5) stimulates osteogenic differentiation of marrow mesenchymal stem cells in porous hydroxyapatite ceramic. Journal of Biomedical Materials Research 68A : 168 176.
30. Simank, H.G., Sergi, C., Jung, M., Adolf, S., Eckhardt, C., Ehemann, V., Ries, R., Lill, C. Richter, W. (2004) Effect of local application of growth and differentiation factor-5 (GDF-5) in a full-thickness cartilage defect model. Growth Factors 22 : 35 43.
31. Spiro, R.C., Liu, L., Heidaran, M.A., Thompson, A.Y., Ng, C.K., Pohl, J. Poser, J.W. (2000) Inductive activity of recombinant human growth and differentiation factor. Biochemical Society Transactions 28 : 362 368.
32. Spiro, R.C., Thompson, A.Y. Poser, J.W. (2001) Spinal fusion with recombinant human growth and differentiation factor-5 combined with a mineralized collagen matrix. The Anatomical Record 263 : 388 395.
33. Storm, E.E., Huynh, T.V., Copeland, N.G., Jenkins, N.A., Kingsley, D.M. Lee, S.J. (1994) Limb alterations in brachypodism mice due to mutations in a new member of the TGF beta-superfamily. Nature 368 : 639 643.
34. Storm, E.E. Kingsley, D.M. (1999) GDF5 coordinates bone and joint formation during digit development. Developmental Biology 209 : 11 27.
35. Szpalski, M. Gunzburg, R. (2005) Recombinant human bone morphogenetic protein-2: a novel osteoinductive alternative to autogenous bone graft. Acta Orthopaedica Belgica 71 : 133 148.
36. Takahashi, Y., Yamamoto, M. Tabata, Y. (2005) Enhanced osteoinduction by controlled release of bone morphogenetic protein-2 from biodegradable sponge composed of gelatin and β-tricalcium phosphate. Biomaterials 26 : 4856 4865.
37. Terheyden, H., Jepsen, S., Moller, B., Tucker, M.M. Rueger, D.C. (1999) Sinus floor augmentation with simultaneous placement of dental implants using a combination of deproteinized bone xenografts and recombinant human osteogenic protein-1. A histometric study in miniature pigs. Clinical Oral Implants Research 10 : 510 521.
38. Varma, A.A.O., Chilton, N.W. Kutscher, A.H. (1970) Studies in the design and analysis of dental experiments: 13. Balanced incomplete block design. Journal of Dental Research 49 : 1166 1171.
39. ® and machined-surface titanium implants in membrane covered critical-sized defects: a histologic and histometric study in dogs. Clinical Oral Implants Research 18 : 153 160.
40. Weng, D., Zuhr, O., Bell, M., Richter, E.J. Hürzeler, M.B. (2004) Peri-implant bone regeneration with bone growth factor rhGDF-5. IADR Honolulu 2004. Journal of Dental Research 83 (Suppl. 1) : 1570.
41. Woo, B.H., Fink, B.F., Page, R., Schrier, J.A., Jo, Y.W., Jiang, G., DeLuca, M., Vasconez, H.C. DeLuca, P.P. (2001) Enhancement of bone growth by sustained delivery of recombinant human bone morphogenetic protein-2 in a polymeric matrix. Pharmaceutical Research 18 : 1747 1753.
42. Wozney, J.M. (1998) The bone morphogenetic protein family: multifunctional cellular regulators in the embryo and adult. European Journal of Oral Sciences 106 (Suppl. 1) : 160 166.
43. Würzler, K.K., Emmert, J., Eichelsbacher, F., Kübler, N.R. Reuther, J.F. (2004) Evaluation der osteoinduktiven Potenz von genetisch modifizierten BMP-2-Varianten. Mund-, Kiefer- und Gesichtschirurgie 8 : 83 92.