Targeting chaperone-mediated autophagy in cancer

Science Translational Medicine

Volumn 3, Issue 109, 2011, Pages

  Thorburn, Andrew ^a   Debnath, Jayanta ^b  

^a UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHAPERONE; CHLOROQUINE; HEAT SHOCK COGNATE PROTEIN 70; HYDROXYCHLOROQUINE; LYSOSOME ASSOCIATED MEMBRANE PROTEIN; LYSOSOME ASSOCIATED MEMBRANE PROTEIN TYPE 2A; UNCLASSIFIED DRUG;

APOPTOSIS; AUTOPHAGY; CANCER INHIBITION; CANCER RESEARCH; CARCINOGENESIS; CHAPERONE MEDIATED AUTOPHAGY; CONTROL STRATEGY; DISTANT METASTASIS; DRUG TARGETING; GLYCOLYSIS; HUMAN; METASTASIS POTENTIAL; NEOPLASM; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; SHORT SURVEY; TUMOR REGRESSION; TUMOR XENOGRAFT; ANIMAL; MALE; METABOLISM; NOTE; PATHOLOGY; PHYSIOLOGY;

ANIMALS; AUTOPHAGY; HUMANS; MALE; MOLECULAR CHAPERONES; NEOPLASMS;

EID: 81455150065     PISSN: 19466234     EISSN: 19466242     Source Type: Journal    
DOI: 10.1126/scitranslmed.3003390     Document Type: Short Survey

References (16)

1. B. Levine, G. Kroemer, Autophagy in the pathogenesis of disease. Cell 132, 27-42 (2008).
2. A. C. Kimmelman, The dynamic nature of autophagy in cancer. Genes Dev. 25, 1999-2010 (2011).
3. M. Kon, R. Kiffin, H. Koga, J. Chapochnick, F. Macian, L. Vartikovski, A. M. Cuervo, Chaperone-mediated autophagy is required for tumor growth. Sci. Transl. Med. 3, 109ra117 (2011).
4. A. Takamura, M. Komatsu, T. Hara, A. Sakamoto, C. Kishi, S. Waguri, Y. Eishi, O. Hino, K. Tanaka, N. Mizushima, Autophagy-deficient mice develop multiple liver tumors. Genes Dev. 25, 795-800 (2011).
5. C. M. Kenific, A. Thorburn, J. Debnath, Autophagy and metastasis: Another double-edged sword. Curr. Opin. Cell Biol. 22, 241-245 (2010).
6. P. Maycotte, A. Thorburn, Autophagy and cancer therapy. Cancer Biol. Ther. 11, 127-137 (2011).
7. E. Arias, A. M. Cuervo, Chaperone-mediated autophagy in protein quality control. Curr. Opin. Cell Biol. 23, 184-189 (2011).
8. S. Kaushik, U. Bandyopadhyay, S. Sridhar, R. Kiffin, M. Martinez-Vicente, M. Kon, S. J. Orenstein, E. Wong, A. M. Cuervo, Chaperone-mediated autophagy at a glance. J. Cell Sci. 124, 495-499 (2011).
9. A. C. Massey, S. Kaushik, G. Sovak, R. Kiffin, A. M. Cuervo, Consequences of the selective blockage of chaperone-mediated autophagy. Proc. Natl. Acad. Sci. U.S.A. 103, 5805-5810 (2006).
10. Y. Wang, R. Singh, A. C. Massey, S. S. Kane, S. Kaushik, T. Grant, Y. Xiang, A. M. Cuervo, M. J. Czaja, Loss of macroautophagy promotes or prevents fibroblast apoptosis depending on the death stimulus. J. Biol. Chem. 283, 4766-4777 (2008).
11. M. G. Vander Heiden, L. C. Cantley, C. B. Thompson, Understanding the Warburg effect: The metabolic requirements of cell proliferation. Science 324, 1029-1033 (2009).
12. R. Mathew, C. M. Karp, B. Beaudoin, N. Vuong, G. Chen, H. Y. Chen, K. Bray, A. Reddy, G. Bhanot, C. Gelinas, R. S. Dipaola, V. Karantza-Wadsworth, E. White, Autophagy suppresses tumorigenesis through elimination of p62. Cell 137, 1062-1075 (2009).
13. R. K. Amaravadi, J. Lippincott-Schwartz, X.-M. Yin, W. A. Weiss, N. Takebe, W. Timmer, R. S. DiPaola, M. T. Lotze, E. White, Principles and current strategies for targeting autophagy for cancer treatment. Clin. Cancer Res. 17, 654-666 (2011).
14. R. Lock, S. Roy, C. M. Kenific, J. S. Su, E. Salas, S. M. Ronen, J. Debnath, Autophagy facilitates glycolysis during Ras-mediated oncogenic transformation. Mol. Biol. Cell 22, 165-178 (2011).
15. J. Y. Guo, H.-Y. Chen, R. Mathew, J. Fan, A. M. Strohecker, G. Karsli-Uzunbas, J. J. Kamphorst, G. Chen, J. M. S. Lemons, V. Karantza, H. A. Coller, R. S. Dipaola, C. Gelinas, J. D. Rabinowitz, E. White, Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis. Genes Dev. 25, 460-470 (2011).
16. S. Yang, X. Wang, G. Contino, M. Liesa, E. Sahin, H. Ying, A. Bause, Y. Li, J. M. Stommel, G. Dell'antonio, J. Mautner, G. Tonon, M. Haigis, O. S. Shirihai, C. Doglioni, N. Bardeesy, A. C. Kimmelman, Pancreatic cancers require autophagy for tumor growth. Genes Dev. 25, 717-729 (2011).