Hormonal male contraception in men with normal and subnormal semen parameters

International Journal of Andrology

Volumn 34, Issue 6 PART 1, 2011, Pages 556-567

  Nieschlag, E ^a   Vorona, E ^a   Wenk, M ^a   Hemker, A K ^a   Kamischke, A ^a   Zitzmann, M ^a  

^a UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

Male contraception; Subnormal semen values; Testosterone

Indexed keywords

GESTAGEN; TESTOSTERONE UNDECANOATE;

ABSENCE OF SIDE EFFECTS; ADULT; ARTICLE; AZOOSPERMIA; CONTROLLED STUDY; CRYOPRESERVATION; EJACULATION; FOLLOW UP; HORMONAL CONTRACEPTION; HUMAN; MALE; NORMAL HUMAN; PRIORITY JOURNAL; SEMEN ANALYSIS; SPERM PRESERVATION; SPERMATOGENESIS; SPERMATOZOON COUNT;

ADULT; CASE-CONTROL STUDIES; CONTRACEPTIVE AGENTS, MALE; ENZYME-LINKED IMMUNOSORBENT ASSAY; GONADAL STEROID HORMONES; HUMANS; MALE; MIDDLE AGED; RECEPTORS, ANDROGEN; SEMEN;

EID: 81455141498     PISSN: 01056263     EISSN: 13652605     Source Type: Journal    
DOI: 10.1111/j.1365-2605.2011.01142.x     Document Type: Article

References (38)

1. Anderson RA & Baird DT. (2002) Male contraception. Endocr Rev 23, 735-762.
2. Behre HM & Zitzmann M. (2010) Imaging diagnostics. In: Andrology: Male Reproductive Health and Dysfunction, 3rd edn (eds E Nieschlag, HM Behre & S Nieschlag), pp. 101-107. Springer, Heidelberg.
3. Büchter D, Behre HM, Kliesch S & Nieschlag E. (1998) Pulsatile GnRH or human chorionic gonadotropin/human menopausal gonadotropin as effective treatment for men with hypogonadotropic hypogonadism: a review of 42 cases. Eur J Endocrinol 139, 298-303.
4. Cooper TG, Jockenhövel F & Nieschlag E. (1991) Variations in semen parameters from fathers. Hum Reprod 6, 859-866.
5. Cooper TG, Björndahl L, Vreeburg J & Nieschlag E. (2002) Semen analysis and external quality control schemes analysis need global standardisation. Int J Androl 25, 1-6.
6. Cooper TG, Hellenkemper B & Nieschlag E. (2007) External quality control for semen analysis in Germany: the first 5years. JRE 4, 331-335.
7. Cooper TG, Noonan E, von Eckardstein S, Auger J, Baker HW, Behre HM et al. (2010) World Health Organization reference values for human semen characteristics. Hum Reprod Update 16, 231-245.
8. von Eckardstein S, Syska A, Gromoll J, Kamischke A, Simoni M & Nieschlag E. (2001) Inverse correlation between sperm concentration and number of androgen receptor CAG repeats in normal men. J Clin Endocrinol Metab 86, 2585-2590.
9. von Eckardstein S, Schmidt A, Kamischke A, Simoni M, Gromoll J & Nieschlag E. (2002) CAG repeat length in the androgen receptor gene and gonadotropin suppression influence the effectiveness of hormonal male contraception. Clin Endocrinol 57, 647-655.
10. Gu YQ, Wang XH, Xu D, Peng l, Cheng LF, Huang MK, Huang ZJ & Zhang GY. (2003) A multicenter contraceptive efficacy study of injectable testosterone undecanoate in healthy Chinese men. J Clin Endocrinol Metab 88, 562-568.
11. Gu Y, Liang X, Wu W, Liu M, Song S, Cheng L et al. (2009) Multicenter contraceptive efficacy trial of injectable testosterone undecanoate in Chinese men. J Clin Endocrinol Metab 94, 1910-1915.
12. Handelsman DJ, Conway AJ, Boylan LM & Turtle JR. (1984) Testicular function in potential sperm donors: normal ranges and the effects of smoking and varicocele. Int J Androl 7, 369-382.
13. Heckel HJ, Rosso WA & Kestel L. (1951) Spermatogenic rebound phenomenon after administration of testosterone propionate. J Clin Endocrinol Metab 11, 235-245.
14. Kamischke A, Venherm S, Plöger D, von Eckardstein S & Nieschlag E. (2001) Intramuscular testosterone undecanoate and norethisterone enanthate in a clinical trial for male contraception. J Clin Endocrinol Metab 86, 303-309.
15. Kamischke A, Heuermann T, Krüger K, von Eckardstein S, Schellschmidt I, Rübig A & Nieschlag E. (2002) An effective hormonal male contraceptive using testosterone undecanoate with oral or injectable norethisterone preparations. J Clin Endocrinol Metab 87, 530-539.
16. Knuth UA, Maniera H & Nieschlag E. (1989) Anabolic steroids and semen parameters in bodybuilders. Fertil Steril 52, 1041-1047.
17. Lamensdorf H, Compere D & Begley G. (1975) Testosterone rebound therapy in the treatment of male infertility. Fertil Steril 26, 469-472.
18. Lemcke B, Behre HM & Nieschlag E. (1997) Frequently subnormal semen profiles of normal volunteers recruited over 17years. Int J Androl 20, 144-152.
19. Liu PY, Swerdloff RS, Christenson PD, Handelsman DJ & Wang C. (2006) Hormonal Male Contraception Summit Group. Rate, extent and modifiers of spermatogenic recovery after hormonal male contraception: an integrated analysis. Lancet 367, 1412-1420.
20. Meriggiola MC, Costantino A, Saad F, D'Emidio L, Morselli Labate AM, Bertaccini A et al. (2005) Norethisterone enanthate plus testosterone undecanoate for male contraception: effects of various injection intervals on spermatogenesis, reproductive hormones, testis and prostate. J Clin Endocrinol Metab 90, 2005-2014.
21. Mommers E, Kersemaekers WM, Elliesen J, Kepers M, Apter D, Behre HM et al. (2008) Male hormonal contraception: a double-blind, placebo-controlled study. J Clin Endocrinol Metab 93, 2572-2580.
22. Nieschlag E. (2006) Testosterone treatment comes of age: new options for hypogonadal men. Clin Endocrinol 65, 275-281.
23. Nieschlag E. (2010) Clinical trials in male hormonal contraception. Contraception 82, 457-470.
24. th Summit Meeting consensus: recommendations for regulatory approval for hormonal male contraception. Contraception 75, 166-167.
25. Nieschlag E & Behre HM. (2010) Approaches to hormonal male contraception. In: Andrology: Male Reproductive Health and Dysfunction, 3rd edn (eds E Nieschlag, HM Behre & S Nieschlag), pp. 577-588. Springer, Heidelberg.
26. Qoubaitary A, Meriggiola C, Ng CM, Lumbreras L, Cerpolini S, Pelusi G, Christensen PD, Hull L, Swerdloff RS & Wang C. (2006) Pharmacokinetics of testosterone undecanoate injected alone or in combination with norethisterone enanthate in healthy men. J Androl 27, 853-867.
27. Schirren C. (1982) Praktische Andrologie, 2nd edn. S. Karger Verlag, Basel.
28. Torres-Calleja J, González-Unzaga M, DeCelis-Carrillo T, Calzada-Sánchez L & Pedrón N. (2001) Effect of androgenic anabolic steroids on sperm quality and serum hormone levels in adult male bodybuilders. Life Sci 68, 1769-1774.
29. Waites GMH. (2003) Development of methods of male contraception: impact of the World Health Organization Task Force. Fertil Steril 80, 1-15.
30. WHO. (1980) Laboratory Manual for the Examination and Processing of Human Semen, 1st edn. Singapore Press, Singapore.
31. WHO. (1987) Laboratory Manual for the Examination and Processing of Human Semen, 2nd edn. Cambridge University Press, Cambridge.
32. WHO. (1992) Laboratory Manual for the Examination and Processing of Human Semen, 3rd edn. Cambridge University Press, Cambridge.
33. WHO. (1999) Laboratory Manual for the Examination and Processing of Human Semen, 4th edn. Cambridge University Press, Cambridge.
34. WHO. (2005) Controlled trials register NET-EN plus TU as a male contraceptive (WHO-HRP ID A25165) (accessed 2005-11-29).
35. WHO. (2010) Laboratory Manual for the Examination and Processing of Human Semen, 5th edn. World Health Organisation, Geneva.
36. World Health Organization Task Force on Methods for the Regulation of Male Fertility. (1990) Contraceptive efficacy of testosterone-induced azoospermia in normal men. Lancet 336, 955-959.
37. World Health Organization Task Force on Methods for the Regulation of Male Fertility. (1996) Contraceptive efficacy of testosterone-induced azoospermia and oligospermia in normal men. Fertil Steril 65, 821-829.
38. Zitzmann M & Nieschlag E. (2007) Androgen receptor gene CAG repeat length and body mass index modulate the safety of long-term intramuscular testosterone undecanoate therapy in hypogonadal men. J Clin Endocrinol Metab 92, 3844-3853.