Rho kinase inhibition by fasudil has anti-inflammatory effects in hypercholesterolemic rats

Biological and Pharmaceutical Bulletin

Volumn 34, Issue 11, 2011, Pages 1684-1689

  Ma, Zhihong ^a   Zhang, Jianping ^a   Du, Rongpin ^b   Ji, Ensheng ^a   Chu, Li ^a  

^a HEBEI MEDICAL UNIVERSITY   (China)

^b HEBEI GENERAL HOSPITAL   (China)

Author keywords

Anti inflammation; Fasudil; Hypercholesterolemia; Rat; Rho kinase

Indexed keywords

C REACTIVE PROTEIN; CHOLESTEROL; FASUDIL; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 6; INTERLEUKIN 8; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MESSENGER RNA; RHO KINASE; SIMVASTATIN; TRIACYLGLYCEROL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTERIAL WALL THICKENING; ARTERY INTIMA PROLIFERATION; ARTERY MEDIA; ARTICLE; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL DIET; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG MEGADOSE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; HISTOPATHOLOGY; HYPERCHOLESTEROLEMIA; IN VIVO STUDY; LOW DRUG DOSE; MALE; NONHUMAN; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; RAT; THORACIC AORTA; TRIACYLGLYCEROL BLOOD LEVEL; UPREGULATION;

1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE; ANIMALS; ANTI-INFLAMMATORY AGENTS; AORTA, THORACIC; HYPERCHOLESTEROLEMIA; INFLAMMATION MEDIATORS; LIPID METABOLISM; LIPIDS; MALE; NF-KAPPA B; PROTEIN KINASE INHIBITORS; RATS; RATS, SPRAGUE-DAWLEY; RHO-ASSOCIATED KINASES; RNA, MESSENGER; SIMVASTATIN; TUNICA INTIMA; TUNICA MEDIA;

EID: 81455138091     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.34.1684     Document Type: Article

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