Cholecystokinin-8-induced hypoplasia of the rat pancreas: Influence of nitric oxide on cell proliferation and programmed cell death

Basic and Clinical Pharmacology and Toxicology

Volumn 95, Issue 4, 2004, Pages 183-190

  Trulsson, Lena M ^a   Gasslander, Thomas ^b   Svanvik, Joar ^a  

^a LINKÖPING UNIVERSITY HOSPITAL   (Sweden)

^b VRINNEVI HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; CHOLECYSTOKININ; CHOLECYSTOKININ OCTAPEPTIDE; DNA FRAGMENT; HISTONE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; N ACETYL S NITROSOPENICILLAMINE; N(G) NITROARGININE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; THYMIDINE DERIVATIVE;

ACINAR CELL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BODY WEIGHT; CELL DEATH; CELL PROLIFERATION; CELL REGENERATION; CELL RENEWAL; CELL VACUOLE; CONTROLLED STUDY; DNA CONTENT; DRUG ANTAGONISM; DRUG POTENTIATION; ENZYME LINKED IMMUNOSORBENT ASSAY; HYPOPLASIA; INFLAMMATION; MALE; MITOSIS RATE; NONHUMAN; PANCREAS; PANCREAS DUCT; PRIORITY JOURNAL; PROTEIN CONTENT; QUANTITATIVE ASSAY; RAT; TURNOVER TIME;

ANIMALIA;

EID: 8144225642     PISSN: 17427835     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1742-7843.2004.pto_950406.x     Document Type: Article

References (42)

1. Algül, H., Y. Tando, M. Beil, C. K. Weber, C. Von Weyhern, G. Schneider, G. Adler & R. M. Schmid: Different modes of NF-kappaB/Rel activation in pancreatic lobules. Amer. J. Physiol. Gastrointest. Liver Physiol. 2001, 283, G270-G281.
2. Axelson, J., R. Håkanson, I. Ihse, I. Lilja, F. Rehfeld & F. Sundler: Effects of endogenous and exogenous cholecystokinin and of infusion with the cholecystokinin antagonist L-364,718 on pancreatic and gastrointesinal growth. Scand. J. Gastroenterol. 1990, 25, 471-480.
3. ω-Nitro- L-Arginine, and drug-induced increase in cerebellar cyclic GMP in vivo. Neurochem. Res. 1993, 18, 1063-1066.
4. Borner, C. & L. Monney: Apoptosis without caspases: an inefficient molecular guillotine? Dell Death and Differentiation 1999, 6, 497-507.
5. Buga, G. M., L. H. Wei, P. M. Bauer, J. M. Fukuto & L. J. Ignarro: NG-hydroxy-L-arginine and nitric oxide inhibit Caco-2 tumor cell proliferation by distinct mechanisms. Amer. J. Physiol. 1998, 275, R1256-R1264.
6. Bursch, W., A. Ellinger, C. Gerner, U. Frohwein & R. Schulte-Hermann: Programmed cell death (PCD). Apoptosis, autophagic PCD, or others? Ann. N. Y. Acad. Sci. 2000, 926, 1-12.
7. Chiarugi, A.: Characterization of the molecular events following impairment of NF-κB-driven transcription in neurons. Mol. Brain Res. 2002, 109, 179-188.
8. Chung, H.-T., H.-O. Pae, B.-M. Choi, T. R. Billiar & Y.-M. Kim: Nitric oxide as a bioregulator of apoptosis. Biochem. Biophys. Res. Commun. 2001, 282, 1075-1079.
9. Cordelier, P., J.-P. Esteve, N. Rivard, M. Marletta, N. Vaysse, C. Susini & L. Buscail: The activation of neuronal NO synthase is mediated by G-protein βγ subunit and the tyrosine phosphatase SHP-2. FASEB J. 1999, 13, 2037-2050.
10. Dusetti, N., Y. Jiang, M. Vaccaro, R. Tomasini, A. A. Samir, E. Calvo, A. Ropolo, F. Fiedler, G. Mallo, J.-C. Dagorn & J. Iovanna: Cloning and expression of the rat vacuole membrane protein 1 (VMP1), a new gene activated in pancreas with acute pancreatitis, which promotes vacuole formation. Biochem. Biophys. Res. Commun. 2002, 290, 641-649.
11. Ekblad, E., P. Alm & F. Sundler: Distribution, origin and projections of nitric oxide synthase-containing neurons in gut and pancreas. Neuroscience 1994, 63, 233-248.
12. Fiscus, R. R.: Involvement of cyclic GMP and protein kinase G in the regulation of apoptosis and survival in neural cells. Neurosignals 2002, 11, 175-190.
13. Gasslander, T., J. Axelson, R. Håkanson, I Ihse, I. Lilja & J. F. Rehfeld: Cholecystocinin is responsible for growth of the pancreas after pancreaticobiliary diversion in rats. Scand. J. Gastroenterol. 1990, 25, 1060-1065.
14. Greten, F, C. Weber, T. Greten, G. Schneider, M. Wagner, G. Adler & R. Schmid: Stat3 and NF-κB activation prevents apoptosis in pancreatic carcinogensis. Gastroenterology 2002, 123, 2052-2063.
15. Gukovskaya, A. & S. Pandol: Nitric oxide production regulates cGMP formation and calcium influx in pancreatic acinar cells. Amer. J. Physiol. 1994, 266, G350-G366.
16. Hinz, M., D. Krappmann, A. Eichten, A. Heder, C. Scheidereit & M. Strauss: NF-κB function in growth control: Regulation of cyclin D1 expression and G0/G1-to-S-phase transition. Mol. Cell. Biol. 1999, 19, 2690-2698.
17. Ignarro, L., G. Buga, L. H. Wei, P. Bauer, G. Wu & P. del Soldato: Role of the arginine-nitric oxide pathway in the regulation of vascular smooth muscle cell proliferation. Proc. Natl. Acad. Sci. USA 2001 98, 4202-4208.
18. Janssen, Y. M., R. Soultanakis, K. Steece, E. Heerdt, R. J. Singh, J. Joseph & B. Kalyanaraman: Depletion of nitric oxide causes cell cycle alterations, apoptosis, and oxidative stress in pulmonary cells. Amer. J. Physiol. 1998, 275, L1100-L1109.
19. Kim, P. K. M., R. Zamora, P. Petrosko & T. R. Billiar: The regulatory role of nitric oxide in apoptosis. Int. Immunopharmacol. 2001, 1, 1421-1441.
20. Kim, Y. M., T. H. Kim, D. W. Seol, R. V. Talanian & T. R. Billiar: Nitric oxide supression of apoptosis occurs in association with an inhibition of Bcl-2 cleavage and cytochrome c release. J. Biol. Chem. 1998, 273, 31437-31441.
21. Kitanaka, C. & Y. Kuchino: Caspase-independent programmed cell death with necrotic morphology. Cell Death Differ. 1999, 6, 508-515.
22. Kowaluk, E. A., R. Poliszczuk & H. L. Fung: Tolerance to relaxation in rat aorta: comparison of an S-nitrosothiol with nitroglycerin. Eur. J. Pharm. 1987, 144, 379-383.
23. Labarca, C. & K. Paigen: A simple, rapid, and sensitive DNA assay procedure. Analytical Biochem. 1980, 102, 344-352.
24. Li, J., C. A. Bombeck, S. Yang, Y. M. Kim & T.R. Billiar: Nitric oxide suppresses apoptosis via interrupting caspase activation and mitochondrial dysfunction in cultured hepatocytes. J. Biol. Chem. 1999, 274, 17325-17333.
25. Liddle, R.: Cholecystokinin cells. Annu. Rev. Physiol. 1997, 59, 221-42.
26. Li, X. & G. Stark: NF-κB-dependent signaling pathways. Exp. Hematol. 2002, 30, 285-296.
27. Lorenzo, H. K., S. A. Susin, J. Penninger & G. Kroemer: Apoptosis inducing factor (AIF): a phylogenetically old, caspase-independent effector of cell death. Cell Death Differ. 1999, 6, 516-524.
28. Lowry, O., N. Rosebrough, L. Farr & R. Randall: Protein measurement with the folin phenol reagent. J. Biol. Chem. 1951, 193, 265-275.
29. Nathan, C.: Inducible nitric oxide synthase: what difference does it make? J. Clin. Invest. 1997, 100, 2417-2423.
30. Ohlsson, B., K. Borg, J. F. Rehfeld, I. Ihse & J. Axelson: The method of administration of cholecystokinin determines the effects evoked in the pancreas. Pancreas 2001, 23, 94-101.
31. Plomp, P. J., P. B. Gordon, A. J. Meijer, H. Hoyvik & P. O. Seglen: Energy dependence of different steps in the autophagic-lysosomal pathway. J. Biol. Chem. 1989, 264, 6699-6704.
32. Satoh, A., T. Shimosegawa, T. Abe, Y. Kikuchi, R. Abe, M. Koizumi & T. Toyota: Role of nitric oxide in the pancreatic blood flow response to caerulein. Pancreas 1994, 9, 574-579.
33. Sperandio, S., I. de Belle & D. E. Bredesen: An alternative, non-apoptotic form of programmed cell death. Proc. Natl. Acad. Sci. USA 2000, 97, 14376-14381.
34. Stuehr, D. J.: Mammalian nitric oxide synthases. Biochim. Biophys. Acta 1999, 1411, 217-230.
35. Trulsson, L. M., J. Svanvik, J. Permert & T. Gasslander: Cholecystokinin octapeptide induces both proliferation and apoptosis in the rat pancreas. Regul. Pept. 2001, 98, 41-48.
36. Trulsson, L. M., T. Gasslander, T. Sundqvist & J. Svanvik: The influence of nitric oxide on basal and cholecystokinin-8 induced proliferation and apoptosis in the rat pancreas. Regul. Pept. 2002, 106, 97-104.
37. Vallance, P., & J. Leiper: Blocking NO synthesis: how, where, and why. Nat. Rev. Drug Discov. 2002, 1, 939-950.
38. Wank, S., R. Harkins, R. T. Jensen, H. Shapira, A. de Weerth & T. Slattery: Purification, molecular cloning, and functional expression of the cholecystokinin receptor from rat pancreas. Proc. Natl. Acid. Sci. USA 1992, 89, 3125-3129.
39. Williams, J. A., M. D. Sans, M. Tashiro, C. Schäfer, M. J. Bragado & A. Dabrowski: Cholecystokinin activates a variety of intracellular signal transduction mechanisms in rodent pancreatic acinar cells. Pharmacology & Toxicology 2002, 91, 297-303.
40. Wu, G. & S. M. Morris Jr.: Arginine metabolism: nitric oxide and beyond. Biochem. J. 1998, 336, 1-17.
41. Xu, X., R. A. Star R, G. Tortorici & S. Muallem: Depletion of intracellular Ca2+ stores activates nitric-oxide synthase to generate cGMP and regulate Ca2+ influx. J. Biol. Chem. 1994, 269, 12645-12653.
42. Xu, X., W Zeng, J. Diaz, K. S. Lau, A. C. Gukuvskaya, R. J. Brown, S. J. Pandol & S. Muallem: nNOS and Ca2+ influx in rat pancreatic acinar and supmandibular salivary gland cells. Cell. Calcium 1997, 22, 217-228.