A synthetic peptide derived from NK-lysin with activity against mycobacterium tuberculosis and its structure-function relationship

International Journal of Peptide Research and Therapeutics

Volumn 17, Issue 4, 2011, Pages 301-306

  Hao, Gu ^a   Rongji, Dai ^a   Kui, Qiu ^b   Zhongqiu, Teng ^a   Heyao, Wang ^b  

^a BEIJING INSTITUTE OF TECHNOLOGY   (China)

^b CAPITAL MEDICAL UNIVERSITY   (China)

Author keywords

Active fragments; Antimycobacterial activity; Mycobacterium tuberculosis; NK lysin

Indexed keywords

ISONIAZID; TUBERCULOSTATIC AGENT; UNCLASSIFIED DRUG; VALYLCYSTINYLGLUTAMYLHYSTIDYLISOLEUCYLHYSTIDYLLEUCYLISOLEUCYLARGINYLGLYCYLLEUCYLCYSTINYLHYSTIDYLHYSTIDYLLEUCYLMETHIONYLHISTIDYLSERYLTYROSYLISOLEUCYLLYSYLARGININE;

ALPHA HELIX; ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL GROWTH; BIOLOGICAL ACTIVITY; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG DETERMINATION; DRUG STABILITY; DRUG SYNTHESIS; ERYTHROCYTE; GROWTH INHIBITION; HUMAN; HUMAN CELL; IN VITRO STUDY; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; STRUCTURE ACTIVITY RELATION; TRANSMISSION ELECTRON MICROSCOPY;

MYCOBACTERIUM TUBERCULOSIS; SUS;

EID: 81355161431     PISSN: 15733149     EISSN: 15733904     Source Type: Journal    
DOI: 10.1007/s10989-011-9268-6     Document Type: Article

References (25)

1. G Abate RN Mshana H Miorner 1998 Evaluation of a colorimetric assay based on 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) for rapid detection of rifampicin resistance in Mycobacterium tuberculosis Int J Tuberc Lung D 2 1011 1016 1:STN:280:DyaK1M%2FosVClsQ%3D%3D (Pubitemid 29005219)
2. M Andersson H Gunne B Agerberth, et al. 1995 NK-lysin, a novel effector peptide of cytotoxic T-cells and NK-cells-structure and cDNA cloning of the porcine form, induction by interleukin-2, antibacterial and antitumor-activity EMBO J 14 1615 1625 7737114 1:CAS:528:DyaK2MXlsl2gsb4%3D
3. M Andersson T Curstedt H Jornvall J Johansson 1995 An amphipathic helical motif common to tumourolytic polypeptide NK-lysin and pulmonary surfactant polypeptide SP-B FEBS Lett 362 328 332 7729523 10.1016/0014-5793(95)00268-E 1:CAS:528:DyaK2MXltVyls74%3D
4. M Andersson H Gunne B Agerberth, et al. 1996 NK-lysin, structure and function of a novel effector molecule of porcine T and NK cells Vet Immunol Immunopathol 54 123 126 8988855 10.1016/S0165-2427(96)05677-2 1:CAS:528:DyaK2sXnt1OjtA%3D%3D (Pubitemid 27035578)
5. J Andra D Monreal GM de Tejada, et al. 2007 Rationale for the design of shortened derivatives of the NK-lysin-derived antimicrobial peptide NK-2 with improved activity against gram-negative pathogens J Biol Chem 282 14719 14728 17389605 10.1074/jbc.M608920200 (Pubitemid 47093359)
6. D Andreu C Carreno C Linde HG Boman M Andersson 1999 Identification of an anti-mycobacterial domain in NK-lysin and granulysin Biochem J 344 845 849 10585872 10.1042/0264-6021:3440845 1:CAS:528:DC%2BD3cXislCmtg%3D%3D (Pubitemid 30032533)
7. K Brandenburg P Garidel S Fukuoka, et al. 2010 Molecular basis for endotoxin neutralization by amphipathic peptides derived from the α-helical cationic core-region of NK-lysin Biophys Chem 150 80 87 20153101 10.1016/j.bpc.2010.01.009 1:CAS:528:DC%2BC3cXntlantrc%3D
8. JJ Endsley JL Furrer MA Endsley, et al. 2004 Characterization of bovine homologues of granulysin and NK-lysin J Immunol 173 2607 2614 15294977 1:CAS:528:DC%2BD2cXmt1Olurs%3D (Pubitemid 39063120)
9. WA Ernst S Thoma-Uszynski P Teitelbaum, et al. 2000 Granulysin, a T cell product, kills bacteria by altering membrane permeability J Immunol 165 7102 7108 11120840 1:CAS:528:DC%2BD3cXovFygs7g%3D (Pubitemid 32001185)
10. JL Gansert V Kiessler M Engele, et al. 2003 Human NKT cells express granulysin and exhibit antimycobacterial activity J Immunol 170 3154 3161 12626573 1:CAS:528:DC%2BD3sXhslOrsb4%3D (Pubitemid 36302192)
11. SH Jung DH Lim SH Jung, et al. 2009 Amphotericin B-entrapping lipid nanoparticles and their in vitro and in vivo characteristics Eur J Pharm Sci 37 313 320 19491021 10.1016/j.ejps.2009.02.021 1:CAS:528:DC%2BD1MXms1Oks7Y%3D
12. E Liepinsh M Andersson JM Ruysschaert G Otting 1997 Saposin fold revealed by the NMR structure of NK-lysin Nat Struct Biol 4 793 795 9334742 10.1038/nsb1297-975 1:CAS:528:DyaK2sXms1Smsb8%3D (Pubitemid 127742486)
13. CMA Linde S Grundstrom E Nordling E Refai PJ Brennan M Andersson 2005 Conserved structure and function in the granulysin and NK-lysin peptide family Infect Immun 73 6332 6339 16177304 10.1128/IAI.73.10.6332-6339.2005 1:CAS:528:DC%2BD2MXhtVyhurrP (Pubitemid 41368794)
14. J Michael W Michaela H Markus S Konrad K Horst 2006 Characterization of human saposins by NMR spectroscopy Biochemistry 45 5206 5216 10.1021/bi051944+
15. RS Munford PO Sheppard PJ Ohara 1995 Saposin-like proteins (SAPLIP) carry out diverse functions on a common backbone structure J Lipid Res 36 1653 1663 7595087 1:CAS:528:DyaK2MXnslOgsbo%3D
16. JM Ruysschaert E Goormaghigh F Homble M Andersson E Liepinsh G Otting 1998 Lipid membrane binding of NK-lysin FEBS Lett 1425 341 344 10.1016/S0014-5793(98)00261-0 (Pubitemid 28178918)
17. M Saleem M Nazir MS Ali, et al. 2010 Antimicrobial natural products: an update on future antibiotic drug candidates Nat Prod Rep 27 238 254 20111803 10.1039/b916096e 1:CAS:528:DC%2BC3cXht1Sntbo%3D
18. YM Sang F Blecha 2009 Porcine host defense peptides: expanding repertoire and functions Dev Comp Immunol 33 334 343 18579204 10.1016/j.dci.2008.05.006 1:CAS:528:DC%2BD1cXhsV2gtr%2FP
19. H Schroder-Borma R Willumeitb K Brandenburgc J Andra 2003 Molecular basis for membrane selectivity of NK-2, a potent peptide antibiotic derived from NK-lysin Biochim Biophys Acta Biomembr 1612 164 171 10.1016/S0005-2736(03)00115- 9 (Pubitemid 36629570)
20. Y Shai 2002 Mode of action of membrane active antimicrobial peptides Biopolymers 66 236 248 12491537 10.1002/bip.10260 1:CAS:528: DC%2BD3sXitlOrsA%3D%3D (Pubitemid 36098316)
21. S Stenger DA Hanson R Teitelbaum, et al. 1998 An antimicrobial activity of cytolytic T cells mediated by granulysin Science 282 121 125 9756476 10.1126/science.282.5386.121 1:CAS:528:DyaK1cXmsFOisL8%3D (Pubitemid 28471143)
22. AM Vaccaro R Salvioli M Tatti F Ciaffoni 1999 Saposins and their interaction with lipids Neurochem Res 24 307 314 9972880 10.1023/A:1022530508763 1:CAS:528:DyaK1MXmt1Orsw%3D%3D (Pubitemid 29067975)
23. JP Xie J Yue YL Xiong WY Wang SQ Yu HH Wang 2003 In vitro activities of small peptides from snake venom against clinical isolates of drug-resistant Mycobacterium tuberculosis Int J Antimicrob Agents 22 172 174 12927960 10.1016/S0924-8579(03)00110-9 1:CAS:528:DC%2BD3sXmsVKiur8%3D (Pubitemid 36970179)
24. GL Zhang CR Ross F Blecha 2000 Porcine antimicrobial peptides: new prospects for ancient molecules of host defense Vet Res 31 277 296 10863946 10.1051/vetres:2000121 1:CAS:528:DC%2BD3cXksVClsLs%3D
25. YA Zhang WY Lu M Hong 2010 The membrane-bound structure and topology of a human alpha-defensin indicate a dimer pore mechanism for membrane disruption Biochemistry 49 9770 9782 20961099 10.1021/bi101512j 1:CAS:528: DC%2BC3cXhtleiur%2FJ