Molecular basis for endotoxin neutralization by amphipathic peptides derived from the α-helical cationic core-region of NK-lysin

Biophysical Chemistry

Volumn 150, Issue 1-3, 2010, Pages 80-87

  Brandenburg, Klaus ^a   Garidel, Patrick ^b   Fukuoka, Satoshi ^c   Howe, Jörg ^a   Koch, Michel H J ^d   Gutsmann, Thomas ^a   Andrä, Jörg ^a  

^a RESEARCH CENTER BORSTEL   (Germany)

^b MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

^c National Institute of Advanced Industrial Science Technology   (Japan)

^d EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

Author keywords

Aggregate structure; Antimicrobial peptide; Calorimetry; Endotoxin; Lipopolysaccharide; Small angle X ray scattering

Indexed keywords

ANTIMICROBIAL CATIONIC PEPTIDE; BACTERIUM LIPOPOLYSACCHARIDE; PEPTIDE NK 2; PEPTIDE NK LYSIN; PEPTIDE NK10; PEPTIDE NK11; PEPTIDE NK14; PEPTIDE NK15; PEPTIDE NK19B; PEPTIDE NK22B; PEPTIDE NK23B; PEPTIDE NK27; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; ENDOTOXIN; NK-LYSIN; PEPTIDE; PEPTIDE NK-2; PROTEOLIPID;

ALPHA HELIX; ARTICLE; BACTERIAL STRAIN; BINDING AFFINITY; CONTROLLED STUDY; DRUG MECHANISM; DRUG SCREENING; ENTHALPY; HUMAN; HUMAN CELL; HYDROPHOBICITY; INFRARED SPECTROSCOPY; MICROCALORIMETRY; MOLECULAR INTERACTION; NONHUMAN; PHASE TRANSITION; PRIORITY JOURNAL; PROTEIN BINDING; SALMONELLA ENTERICA; STATIC ELECTRICITY; SURFACE CHARGE; X RAY CRYSTALLOGRAPHY; ZETA POTENTIAL; AMINO ACID SEQUENCE; ANTAGONISTS AND INHIBITORS; BINDING SITE; CHEMISTRY; DRUG EFFECTS; IMMUNOLOGY; MOLECULAR GENETICS; MONONUCLEAR CELL; SMALL ANGLE SCATTERING; X RAY DIFFRACTION;

AMINO ACID SEQUENCE; ANTI-BACTERIAL AGENTS; BINDING SITES; ENDOTOXINS; LEUKOCYTES, MONONUCLEAR; MOLECULAR SEQUENCE DATA; PEPTIDES; PHASE TRANSITION; PROTEOLIPIDS; SALMONELLA ENTERICA; SCATTERING, SMALL ANGLE; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; X-RAY DIFFRACTION;

BACTERIA (MICROORGANISMS);

EID: 77953702907     PISSN: 03014622     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bpc.2010.01.009     Document Type: Article

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