Virus replication strategies and the critical CTL numbers required for the control of infection

PLoS Computational Biology

Volumn 7, Issue 11, 2011, Pages

  Yates, Andrew J ^a   van Baalen, Minus ^b   Antia, Rustom ^c  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b CNRS   (France)

^c EMORY UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; CYTOLOGY; DYNAMICS; VACCINES;

ANTIBODIES RESPONSE; CRITICAL THRESHOLD; CYTOTOXIC T LYMPHOCYTES; INFECTED CELLS; INOCULUM SIZE; LIFE HISTORY; MEASUREMENTS OF; MINIMUM DENSITY; REPLICATION STRATEGIES; VIRUS REPLICATION;

VIRUSES;

MAJOR HISTOCOMPATIBILITY ANTIGEN;

ANALYTIC METHOD; ARTICLE; CALCULATION; CELL COUNT; CELL DENSITY; CELL LOSS; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; GROWTH RATE; IMMUNE RESPONSE; INFECTION CONTROL; INNATE IMMUNITY; INTERMETHOD COMPARISON; LIFE CYCLE; NONHUMAN; PREDICTION; PROBABILITY; SIMIAN IMMUNODEFICIENCY VIRUS; VIRUS IMMUNITY; VIRUS REPLICATION; ANIMAL; BIOLOGICAL MODEL; BIOLOGY; CYTOLOGY; HOST PATHOGEN INTERACTION; IMMUNOLOGY; MACACA MULATTA; PHYSIOLOGY; SIMIAN ACQUIRED IMMUNODEFICIENCY SYNDROME; VIRION; VIROLOGY; VIRUS INFECTION;

MACACA MULATTA; SIMIAN IMMUNODEFICIENCY VIRUS;

ANIMALS; CELL COUNT; COMPUTATIONAL BIOLOGY; HOST-PATHOGEN INTERACTIONS; MACACA MULATTA; MODELS, IMMUNOLOGICAL; SIMIAN ACQUIRED IMMUNODEFICIENCY SYNDROME; SIMIAN IMMUNODEFICIENCY VIRUS; T-LYMPHOCYTES, CYTOTOXIC; VIRION; VIRUS DISEASES; VIRUS REPLICATION;

EID: 81355150950     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1002274     Document Type: Article

References (45)

1. Perelson AS, (2002) Modelling viral and immune system dynamics. Nat Rev Immunol 2: 28-36.
2. Althaus CL, De Boer RJ, (2008) Dynamics of immune escape during HIV/SIV infection. PLoS Comput Biol 4: e1000103.
3. Wodarz D, Nowak MA, (2000) Correlates of cytotoxic T-lymphocyte-mediated virus control: implications for immunosuppressive infections and their treatment. Philos Trans R Soc Lond B Biol Sci 355: 1059-70.
4. Wodarz D, Page KM, Arnaout RA, Thomsen AR, Lifson JD, et al. (2000) A new theory of cytotoxic T-lymphocyte memory: implications for HIV treatment. Philos Trans R Soc Lond B Biol Sci 355: 329-43.
5. Asquith B, McLean AR, (2007) In vivo CD8+ T cell control of immunodeficiency virus infection in humans and macaques. Proc Natl Acad Sci U S A 104: 6365-70.
6. Sud D, Bigbee C, Flynn JL, Kirschner DE, (2006) Contribution of CD8+ T cells to control of Mycobacterium tuberculosis infection. J Immunol 176: 4296-314.
7. Ganusov VV, De Boer RJ, (2008) Estimating in vivo death rates of targets due to CD8 T-cellmediated killing. J Virol 82: 11749-57.
8. Regoes RR, Barber DL, Ahmed R, Antia R, (2007) Estimation of the rate of killing by cytotoxic T lymphocytes in vivo. Proc Natl Acad Sci U S A 104: 1599-603.
9. Yates A, Graw F, Barber DL, Ahmed R, Regoes RR, et al. (2007) Revisiting estimates of CTL killing rates in vivo. PLoS One 2: e1301.
10. Mempel TR, Pittet MJ, Khazaie K, Weninger W, Weissleder R, et al. (2006) Regulatory T cells reversibly suppress cytotoxic T cell function independent of effector differentiation. Immunity 25: 129-41.
11. Pilyugin SS, Antia R, (2000) Modeling immune responses with handling time. Bull Math Biol 62: 869-90.
12. Graw F, Richter K, Oxenius A, Regoes RR, (2011) Comparison of cytotoxic T lymphocyte efficacy in acute and persistent lymphocytic choriomeningitis virus infection. Proc Biol Sci 278: 3395-3402.
13. Ganusov VV, Lukacher AE, Byers AM, (2010) Persistence of viral infection despite similar killing efficacy of antiviral CD8(+) T cells during acute and chronic phases of infection. Virology 405: 193-200.
14. Althaus CL, De Vos AS, De Boer RJ, (2009) Reassessing the human immunodeficiency virus type 1 life cycle through age-structured modeling: life span of infected cells, viral generation time, and basic reproductive number, R0. J Virol 83: 7659-7667.
15. Cushing JM, (1998) An Introduction to Structured Population Dynamics, volume 71 Philadelphia Society of Industrial and Applied Mathematics.
16. Valitutti S, Müller S, Cella M, Padovan E, Lanzavecchia A, (1995) Serial triggering of many T-cell receptors by a few peptide-MHC complexes. Nature 375: 148-51.
17. Spira AI, Marx PA, Patterson BK, Mahoney J, Koup RA, et al. (1996) Cellular targets of infection and route of viral dissemination after an intravaginal inoculation of simian immunodeficiency virus into rhesus macaques. J Exp Med 183: 215-25.
18. Zhang Z, Schuler T, Zupancic M, Wietgrefe S, Staskus KA, et al. (1999) Sexual transmission and propagation of SIV and HIV in resting and activated CD4+ T cells. Science 286: 1353-7.
19. Schmitz JE, Kuroda MJ, Santra S, Sasseville VG, Simon MA, et al. (1999) Control of viremia in simian immunodeficiency virus infection by CD8+ lymphocytes. Science 283: 857-60.
20. Matano T, Shibata R, Siemon C, Connors M, Lane HC, et al. (1998) Administration of an anti-CD8 monoclonal antibody interferes with the clearance of chimeric simian/human immunodeficiency virus during primary infections of rhesus macaques. J Virol 72: 164-9.
21. Regoes RR, Antia R, Garber DA, Silvestri G, Feinberg MB, et al. (2004) Roles of target cells and virus-specific cellular immunity in primary simian immunodeficiency virus infection. J Virol 78: 4866-75.
22. Elemans M, Thiébaut R, Kaur A, Asquith B, (2011) Quantification of the relative importance of CTL, B cell, NK cell, and target cell limitation in the control of primary SIV-infection. PLoS Comput Biol 7: e1001103.
23. Li Q, Duan L, Estes JD, Ma ZM, Rourke T, et al. (2005) Peak SIV replication in resting memory CD4+ T cells depletes gut lamina propria CD4+ T cells. Nature 434: 1148-52.
24. Ho DD, Huang Y, (2002) The HIV-1 vaccine race. Cell 110: 135-8.
25. Ganusov VV, De Boer RJ, (2006) Estimating Costs and Benefits of CTL Escape Mutations in SIV/HIV Infection. PLoS Comput Biol 2: e24.
26. Mandl JN, Regoes RR, Garber DA, Feinberg MB, (2007) Estimating the effectiveness of simian immunodeficiency virus-specific CD8+ T cells from the dynamics of viral immune escape. J Virol 81: 11982-91.
27. Reilly C, Wietgrefe S, Sedgewick G, Haase A, (2007) Determination of simian immunodeficiency virus production by infected activated and resting cells. AIDS 21: 163-8.
28. Ganusov VV, Barber DL, De Boer RJ, (2011) Killing of targets by CD8 T cells in the mouse spleen follows the law of mass action. PLoS One 6: e15959.
29. Finzi D, Blankson J, Siliciano JD, Margolick JB, Chadwick K, et al. (1999) Latent infection of CD4+ T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effiective combination therapy. Nat Med 5: 512-7.
30. Petravic J, Davenport MP, (2010) Vaccination-induced noncytolytic effects in the acute phase of SHIV infection. PLoS One 5: e15083.
31. Klatt NR, Shudo E, Ortiz AM, Engram JC, Paiardini M, et al. (2010) CD8+ lymphocytes control viral replication in SIVmac239-infected rhesus macaques without decreasing the lifespan of productively infected cells. PLoS Pathog 6: e1000747.
32. Wong JK, Strain MC, Porrata R, Reay E, Sankaran-Walters S, et al. (2010) In vivo CD8+ T-cell suppression of SIV viremia is not mediated by CTL clearance of productively infected cells. PLoS Pathog 6: e1000748.
33. Wick WD, Yang OO, Corey L, Self SG, (2005) How many human immunodeficiency virus type 1-infected target cells can a cytotoxic T-lymphocyte kill? J Virol 79: 13579-86.
34. Graw F, Regoes RR, (2009) Investigating CTL mediated killing with a 3D cellular automaton. PLoS Comput Biol 5: e1000466.
35. Beltman JB, Maree AFM, Lynch JN, Miller MJ, de Boer RJ, (2007) Lymph node topology dictates T cell migration behavior. J Exp Med 204: 771-780.
36. Linderman JJ, Riggs T, Pande M, Miller M, Marino S, et al. (2010) Characterizing the dynamics of CD4+ T cell priming within a lymph node. J Immunol 184: 2873-85.
37. Handel A, Yates A, Pilyugin SS, Antia R, (2007) Gap junction-mediated antigen transport in immune responses. Trends Immunol 28: 463-6.
38. Handel A, Yates A, Pilyugin SS, Antia R, (2009) Sharing the burden: antigen transport and firebreaks in immune responses. J R Soc Interface 6: 447-54.
39. Scherer A, Salathé M, Bonhoeffer S, (2006) High epitope expression levels increase competition between T cells. PLoS Comput Biol 2: e109.
40. Perelson AS, Macken CA, Grimm EA, Roos LS, Bonavida B, (1984) Mechanism of cell-mediated cytotoxicity at the single cell level. VIII. Kinetics of lysis of target cells bound by more than one cytotoxic T lymphocyte. J Immunol 132: 2190-8.
41. van Baalen CA, Guillon C, van Baalen M, Verschuren EJ, Boers PHM, et al. (2002) Impact of antigen expression kinetics on the effectiveness of HIV-specific cytotoxic T lymphocytes. Eur J Immunol 32: 2644-52.
42. Wick WD, (2008) On modeling the effects of T-cell vaccines on HIV acquisition and disease. Stat Med 27: 4805-16.
43. Schmidt NW, Podyminogin RL, Butler NS, Badovinac VP, Tucker BJ, et al. (2008) Memory CD8 T cell responses exceeding a large but definable threshold provide long-term immunity to malaria. Proc Natl Acad Sci U S A 105: 14017-22.
44. Vezys V, Yates A, Casey KA, Lanier G, Ahmed R, et al. (2009) Memory CD8 T-cell compartment grows in size with immunological experience. Nature 457: 196-9.
45. R Development Core Team (2011) R: A Language and Environment for Statistical Computing. R Foundation for Statistical Computing, Vienna, Austria. Available: http://www.R-project.org.