The antifibrosis effect of adrenomedullin in human lung fibroblasts

Experimental Lung Research

Volumn 37, Issue 10, 2011, Pages 615-626

  Hao, Shu Ling ^a   Yu, Zhong He ^a   Qi, Bao Shen ^b   Luo, Ji Zheng ^a   Wang, Wei Ping ^c  

^a CHINESE PLA GENERAL HOSPITAL   (China)

^b INSTITUTE OF BASIC MEDICAL SCIENCES   (China)

^c PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

Author keywords

Adrenomedullin; Fibrosis; Hypoxia; Proliferation; TGF 1

Indexed keywords

ADRENOMEDULLIN; ADRENOMEDULLIN RECEPTOR; ANTIFIBROTIC AGENT; CALCITONIN RECEPTOR LIKE RECEPTOR; CALCIUM; COLLAGEN; PROLINE; RECEPTOR ACTIVITY MODIFYING PROTEIN 1; RECEPTOR ACTIVITY MODIFYING PROTEIN 2; RECEPTOR ACTIVITY MODIFYING PROTEIN 3; THIOMESYLIC ACID METHYL ESTER; TRANSFORMING GROWTH FACTOR BETA1;

ARTICLE; CALCIUM CELL LEVEL; CELL PROLIFERATION; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; HYPOXIA; LUNG FIBROBLAST; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; REAL TIME POLYMERASE CHAIN REACTION;

ADRENOMEDULLIN; CALCITONIN RECEPTOR-LIKE PROTEIN; CALCIUM; CELL GROWTH PROCESSES; CELL HYPOXIA; COLLAGEN; FIBROBLASTS; FIBROSIS; HUMANS; LUNG; RECEPTOR ACTIVITY-MODIFYING PROTEINS; RECEPTORS, ADRENOMEDULLIN; TRANSFORMING GROWTH FACTOR BETA1;

EID: 81355149386     PISSN: 01902148     EISSN: 15210499     Source Type: Journal    
DOI: 10.3109/01902148.2011.623823     Document Type: Article

References (51)

1. Fine A, Goldstein RH: The effect of TGF-β on cell proliferation and collagen formation by lung fibroblast. J Biol Chem. 1987;262:3897-3902. (Pubitemid 17136452)
2. Kitamura K, Kangawa K, Kawamoto M, Ichiki Y, Nakamura S, Matsuo H, Eto T: Adrenomedullin: a novel hypotensive peptide isolated from human pheochromocytoma. Biochem Biophys Res Commun. 1993;192:553-560. (Pubitemid 23227359)
3. Parameswaran N, Spielman WS, Brooks DP, Nambi P: SB203580 reverses adrenomedullins effect on proliferation and apoptosis in cultured mesangial cells. Eur J Pharmacol. 1999;371:75-82. (Pubitemid 29206465)
4. Tsuruda T, Kato J, Kitamura K, Kawamoto M, Kuwasako K, Imamura T, Koiwaya Y, Tsuji T, Kangawa K, Eto T: An autocrine or a paracrine role of adrenomedullin in modulating cardiac fibroblast growth. Cardiovasc Res. 1999;43:958-967. (Pubitemid 29413195)
5. NakayamaM, Takahashi K, Murakami O, Shirato K, Shibahara S: Induction of adrenomedullin by hypoxia in cultured human coronary artery endothelial cells. Peptides. 1999;20:769-772. (Pubitemid 29378341)
6. Udono T, Takahashi K, NakayamaM, Yoshinoya A, Totsune K, Murakami O, Durlu YK, Tamai M, Shibahara S: Induction of adrenomedullin by hypoxia in cultured retinal pigment epithelial cells. Invest Ophthalmol Vis Sci. 2001;42:1080-1086. (Pubitemid 32289807)
7. Ogita T, Hashimoto E, Yamasaki M, Nakaoka T, Matsuoka R, Kira Y, Fujita T: Hypoxic induction of adrenomedullin in cultured human umbilical vein endothelial cells. J Hypertens. 2001;19(3 Pt 2):603-608. (Pubitemid 32280953)
8. Hofbauer KH, Jensen BL, Kurtz A, Sandner P: Tissue hypoxygenation activates the adrenomedullin system in vivo. Am J Physiol Regul Integr Comp Physiol. 2000;278:R513-R519. (Pubitemid 30129644)
9. Isumi Y, Minamino N, Katafuchi T, Yoshioka M, Tsuji T, Kangawa K, Matsuo H: Adrenomedullin production in fibroblasts: its possible function as a growth regulator of Swiss 3T3 cells. Endocrinology. 1998;39:2552-2563. (Pubitemid 28513785)
10. Brenner RE, Felger D, Winter C, Christiansen A, Hofmann D, Bartmann P: Effects of dexamethasone on proliferation, chemotaxis, collagen I, and fibronectin-metabolism of human fetal lung fibroblasts. Pediatr Pulmonol. 2001;32:1-7.
11. Falanga V, Martin TA, Takagi H, Kirsner RS, Helfman T, Pardes J, Ochoa MS: Low oxygen tension increases mRNA levels of alpha 1 (I) procollagen in human dermal fibroblasts. J Cell Physiol. 1993;157:408-412. (Pubitemid 23332786)
12. [11a] Falanga V, Kirsner RS: Low oxygen stimulates proliferation of fibroblasts seeded as single cells. J Cell Physiol. 1993;154:506-510. (Pubitemid 23076318)
13. Falanga V, Zhou L, Yufit T: Low oxygen tension stimulates collagen synthesis and COL1A1 transcription through the action of TGF-beta1. J Cell Physiol. 2002;191:42-50. (Pubitemid 34195216)
14. [12a] Falanga V, Qian SW, Danielpour D, Katz MH, Roberts AB, Sporn MB: Hypoxia upregulates the synthesis of TGFbeta 1 by human dermal fibroblasts. J Invest Dermatol. 1991;97: 634-637.
15. Peterkofsky B, Diegelmann R: Use of a mixture of proteinasefree collagenases for the specific assay of radioactive collagen in the presence of other proteins. Biochemistry. 1997;10:988-994.
16. Cairns JA, Walls AF: Mast cell tryptase stimulates the synthesis of type I collagen in human lung fibroblasts. J Clin Invest. 1997;99:1313-1321. (Pubitemid 27142769)
17. Goulet S, Bihl MP, Gambazzi F, Tamm M, Roth M: Opposite effect of corticosteroids and long-acting β2-agonists on serumand TGF-β1-induced extracellular matrix deposition by primary human lung fibroblasts. J Cell Physiol. 2007;210:167-176. (Pubitemid 44904712)
18. Hunt TK, Pai MP: The effect of varying ambient oxygen tensions on wound metabolism and collagen synthesis. Surg Gynecol Obstet. 1972;135:561-567.
19. Knighton DR, Fiegel VD: Regulation of cutaneous wound healing by growth factors and the microenvironment. Invest Radiol. 1991;26:604-611.
20. Kerr JS, Ruppert CL, Tozzi CA, Neubauer JA, Frankel HM, Yu SY, Riley DJ: Reduction of chronic hypoxic pulmonary hypertension in the rat by an inhibitor of collagen production. Am Rev Respir Dis. 1987;135:300-306. (Pubitemid 17012085)
21. Poiani GJ, Tozzi CA, Choe JK, Yohn SE, Riley DJ: An antifibrotic agent reduces blood pressure in established pulmonary hypertension in the rat. J Appl Physiol. 1990;68:1542-1547. (Pubitemid 20151879)
22. Poiani GJ, Wilson FJ, Fox JD, Sumka JM, Peng BW, Liao WC, Tozzi CA, Riley DJ: Liposome-entrapped antifibrotic agent prevents collagen accumulation in hypertensive pulmonary arteries of rats. Circ Res. 1992;70:912-922.
23. Poiani GJ, Kemnitzer JE, Fox JD, Tozzi CA, Kohn J, Riley DJ: Polymeric carrier of proline analogue with antifibrotic effect in pulmonary vascular remodeling. Am J Respir Crit Care Med. 1997;155:1384-1390. (Pubitemid 27172787)
24. Mansbridge J, Murphy B, Morhenn V, Hillman K, Hillman K, Sutherland R, Karasek M: The response of human dermal microvascular endothelial cells to hypoxia. Biochim Biophys Acta. 1994;1223:209-218. (Pubitemid 24278280)
25. Zhou L, Dosanjh A, Chen H, Karasek M: Divergent effects of extracellular oxygen on the growth, morphology, and function of human skin microvascular endothelial cells. J Cell Physiol. 2000;182:134-140. (Pubitemid 129710508)
26. Packer L, Fuehr K: Low oxygen concentration extends the lifespan of cultured human diploid cells. Nature. 1977;267:423-425. (Pubitemid 8105518)
27. Norman JT,Clark IM,Garcia PL: Hypoxia promotes fibrogenesis in human renal fibroblasts. Kidney Int. 2000;58:2351-2366.
28. WelshDJ, Scott P, Plevin R,Wadsworth R, Peacock AJ:Hypoxia enhances cellular proliferation and inositol 1,4,5-triphosphate generation in fibroblasts from bovine pulmonary artery but not from mesenteric artery. Am J Respir Crit Care Med. 1998;158:1757-1762. (Pubitemid 29008811)
29. Kourembanas S, Marsden PA, McQuillan LP, Faller DV: Hypoxia induces endothelin gene expression and secretion in cultured human endothelium. J Clin Invest. 1991;88:1054-1057.
30. Shweiki D, Itin A, Soffer D, Keshet E: Vascular endothelial growth factor induced by hypoxiamay mediate hypoxia-initiated angiogenesis. Nature. 1992;359:843-845.
31. Detmar M, Brown LF, Berse B, Jackman RW, Elicker BM, Dvorak HF, Claffey KP: Hypoxia regulates the expression of vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) and its receptors in human skin. J Invest Dermatol. 1997;108:263-268. (Pubitemid 27116221)
32. Constant JS, Feng JJ, Zabel DD, Yuan H, Suh DY, Scheuenstuhl H, Hunt TK, Hussain MZ: Lactate elicits vascular endothelial growth factor from macrophages: a possible alternative to hypoxia. Wound Repair Regen. 2000;8:353-360.
33. Battegay EJ: Angiogenesis: mechanistic insights, neovascular diseases, and therapeutic prospects. J Mol Med. 1995;73:333-346.
34. Falanga V: Growth factors and wound healing. J Dermatol Surg Oncol. 1993;19:711-714. (Pubitemid 24182890)
35. Steinbrech DS, Longaker MT, Mehrara BJ, Saadeh PB, Chin GS, Gerrets RP, Chau DC, Rowe NM, Gittes GK: Fibroblast response to hypoxia: the relationship between angiogenesis and matrix regulation. J Surg Res. 1999;84:127-133. (Pubitemid 29389987)
36. Roberts AB, Sporn MB, Assoian RK, Smith JM, Roche NS, Wakefield LM, Heine UI, Liotta LA, Falanga V, Kehrl JH, et al.: Transforming growth factor type beta: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro. Proc Natl Acad Sci U S A. 1986;83:4167-4171. (Pubitemid 16057012)
37. Border WA, Noble NA: Transforming growth factor beta in tissue fibrosis. N Engl J Med. 1994;331:1286-1292. (Pubitemid 24333194)
38. Agocha A, Lee HW, Eghbali WM: Hypoxia regulates basal and induced DNA synthesis and collagen type I production in human cardiac fibroblasts: effects of transforming growth factor-beta1, thyroid hormone, angiotensin II and basic fibroblast growth factor. J Mol Cell Cardiol. 1997;29: 2233-2244. (Pubitemid 27348532)
39. Kikumoto K, Katafuchi T, Minamino N: Specificity of porcine calcitonin receptor and calcitonin receptor-like receptor in the presence of receptor-activity-modifying proteins. Hypertens Res. 2003;26(Suppl):S15-S23.
40. Garayoa M, Martínez A, Lee S, Pío R, An WG, Neckers L, Trepel J, Montuenga LM, Ryan H, Johnson R, Gassmann M, Cuttitta F: Hypoxia-inducible factor-1 (HIF-1) up-regulates adrenomedullin expression in human tumor cell lines during oxygen deprivation: a possible promotion mechanism of carcinogenesis. Mol Endocrinol. 2000;14:848-862. (Pubitemid 32260498)
41. Kobayashi H, Yanagita T, Yokoo H, Wada A: Pathophysiological function of adrenomedullin and proadrenomedullin Nterminal peptides in adrenal chromaffin cells. Hypertens Res. 2003;26(Supp1):s71-s78. (Pubitemid 36372319)
42. Autelitano DJ, Ridings R, Tang F: Adrenomedullin is a regulatedmodulator of neonatal cardiomyocyte hypertrophy in vitro. Cardiovasc Res. 2001;51:255-264. (Pubitemid 32695536)
43. Montuenga LM, Mariano JM, Prentice MA, Cuttitta F, Jakowlew SB: Coordinate expression of transforming growth factor beta 1 and adrenomedullin in rodent embryogenesis. Endocrinology. 1998;139:3946-3957. (Pubitemid 28512278)
44. + and other ions as extracellular (first) messengers. Physiol Rev. 1991;71:371-411.
45. Morgan TL, Yang DJ, Fry DG, Hurlin PJ, Kohler SK, Maher VM, McCormick JJ: Characteristics of an infinite life span diploid human fibroblast cell strain and a near-diploid strain arising from a clone of cells expressing a transfected v-myc oncogene. Exp Cell Res. 1991;197:125-136.
46. + stimulates the activation of mitogen-activated protein kinase and cell growth in human fibroblasts. Biochem J. 1995;310(Pt 3):881-885.
47. Mattson MP: Neuroprotective signal transduction: relevance to stroke. Neurosci Biobehav Rev. 1997;21:193-206. (Pubitemid 27102565)
48. 2+-sensitivity in pig coronary arterial smooh muscle. Biochem Biophys Res Commun. 1995;212:572-579.
49. Gumusel B, Hao Q, Hyman AL, Kadowitz PJ, Champion HC, Chang JK, Mehta JL, Lippton H: Analysis of responses to adrenomedullin-(13-52) in the pulmonary vascular bed of rats. Am J Physiol. 1998;274(4 Pt 2):H1255-H1263.
50. Falanga V, Qian SW, Danielpour D, Katz MH, Roberts AB, Sporn MB: Hypoxia upregulates the synthesis of TGFbeta 1 by human dermal fibroblasts. J Invest Dermatol. 1991;97:634-637.
51. Falanga V, Kirsner RS: Low oxygen stimulates proliferation of fibroblasts seeded as single cells. J Cell Physiol. 1993;154:506-510. (Pubitemid 23076318)