Polymeric carrier of proline analogue with antifibrotic effect in pulmonary vascular remodeling

American Journal of Respiratory and Critical Care Medicine

Volumn 155, Issue 4, 1997, Pages 1384-1390

  Poiani, George J ^a   Kemnitzer, John E ^a   Fox, James D ^a   Tozzi, Carol A ^a   Kohn, Joachim ^a   Riley, David J ^a  

^a Department of Medicine ^*

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOPECTIN; COLLAGEN; COPOLYMER; DRUG CARRIER; HYDROXYPROLINE; LIPOSOME; LYSINE; MACROGOL; POLYSACCHARIDE; PROLINE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG UPTAKE; ENCAPSULATION; ENDOTHELIUM CELL; FIBROBLAST; FIBROSIS; GROWTH INHIBITION; HEART RIGHT VENTRICLE PRESSURE; HYPOXIA; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; PULMONARY ARTERY; PULMONARY HYPERTENSION; RAT; SMOOTH MUSCLE FIBER;

EID: 0031002042     PISSN: 1073449X     EISSN: None     Source Type: Journal    
DOI: 10.1164/ajrccm.155.4.9105083     Document Type: Article

References (30)

1. Prockop, D. J., and K. I. Kivirikko. 1995. Collagens: molecular biology, diseases, and potentials for therapy. Annu. Rev. Biochem. 64: 403-434.
2. Fuller, G. C. 1981. Perspectives for the use of collagen synthesis inhibitors as antifibrotic agents. J. Med. Chem. 24:651-658.
3. Uitto, J., L. Ryhänen, E. M. L.Tan, A. I. Oikarinen, and E. J. Zaragoza. 1984. Pharmacological inhibition of excessive collagen deposition in fibrotic diseases. Fed. Proc. 43:2815-2820.
4. Eldridge, C. F., R. P. Bunge, and M. P. Bunge. 1988. Effects of cis 4-hydroxy-L-proline, an inhibitor of Schwann cell differentiation, on the secretion of collagenous and noncollagenous proteins by Schwann cells. Exp. Cell Res. 174:491-501.
5. Poiani, G. J., D. J. Riley, J. D. Fox, J. E. Kemnitzer, K. F. Gean, and J. Kohn. 1994. Conjugates of cis-4-hydroxy-L-proline and poly-(PEG-Lys), a water soluble poly(ether urethane): synthesis and evaluation of antifibrotic effects in vitro and in vivo. Bioconjug. Chem. 5:621-630.
6. Poiani, G. J., C. A. Tozzi, S. E. Yohn, R. A. Pierce, S. A. Belsky, R. A. Berg, S. Y. Yu, S. B. Deak, and D. J. Riley. 1990. Collagen and elastin metabolism in hypertensive pulmonary arteries of rats. Circ. Res. 60:968-978.
7. Kerr, J. S., C. L. Ruppert, C. A. Tozzi, J. A. Neubauer, H. M. Frankel, S. Y. Yu, and D. J. Riley. 1987. Reduction of chronic hypoxic pulmonary hypertension in the rat by an inhibitor of collagen production. Am. Rev. Respir. Dis. 135:300-306.
8. Poiani, G. J., F. J. Wilson, J. D. Fox, J. M. Sumka, B. W. Peng, W.-C. Liaxo, C. A. Tozzi, and D. J. Riley. 1992. Liposome-entrapped antifibrotic agents prevents collagen accumulation in hypertensive pulmonary arteries of rats. Circ. Res. 70:912-922.
9. Poste, G. 1983. Liposome targeting in vivo: problems and opportunities. Biol. Cell 47:19-37.
10. Allen, T. M., C. Hansen, F. Martin, C. Redemann, and A. Yau-Young. 1991. Liposomes containing synthetic lipid derivatives of poly(ethylene glycol) show prolonged circulation half-lifes in vivo. Biochem. Biophys. Acta 1066:29-36.
11. Gabizon, A., and D. Papahadjopoulos. 1988. Liposome formulations with prolonged circulation time in blood and enhanced uptake by tumors. Proc. Natl. Acad. Sci. U.S.A. 85:6949-6953.
12. Sharon, N., and H. Lis. 1989. Lectins as cell recognition molecules. Science 246:227-234.
13. Takada, M., T. Yuziriha, K. Katayama, K. Iwamoto, and J. Sunamoto. 1984. Increased lung uptake of liposomes coated with polysaccharides. Biochim Biophys. Acta 802:237-244.
14. Poiani, G. J., K. F. Gean, J. D. Fox, J. Kohn, and D. J. Riley. 1993. Antifibrotic effect of a proline analogue delivered in liposomes to cells in culture. Amino Acids 4:237-248.
15. Sato, T., and J. Sunamoto. 1992. Recent aspects in the use of liposomes in biotechnology and medicine. Prog. Lipid Res. 31:345-372.
16. Chen, P. S., T. Y. Toribara, and H. Werner. 1956. Microdetermination of phosphorus. Anal. Chem. 28:1756-1758.
17. Iwamoto, K., T. Kato, M. Kawahara, N. Koyama, S. Watanabe, Y. Miyake, and J. Sunamoto. 1991. Polysaccharide-coated oil droplets in oil-in-water emulsions as targetable carriers for lipophilic drugs. J. Pharm. Sci. 80:219-224.
18. Kao, W. W.-Y., and D. J. Prockop. 1997. Proline analogue removes fibroblasts from cultured mixed cell populations. Nature 266:63-64.
19. Gabizon, A., and D. Papahadjopoulus. 1988. Liposome formulations with prolonged circulation time in blood and enhanced uptake by tumors. Proc. Natl. Acad. Sci. U.S.A. 85:6949-6953.
20. SAS/STAT®. 1990. User's Guide, Vol. 2, 4th ed. SAS Institute, Cary, NC. 891-996.
21. Duncan, D. B. 1975. t Tests and intervals for comparisons suggested by the data. Biometrics 31:339-359.
22. Tozzi, C. A., D. L. Christiansen, G. J. Poiani, and D. J. Riley. 1994. Excess collagen in hypertensive pulmonary arteries decreases vascular distensibility. Am. Rev. Respir. Crit. Care Med. 149:1317-1326.
23. Inouye, K., S. Sakakibara, and D. J. Prockop. 1976. Effects of the stereoconfiguration of the hydroxyl group in 4-hydroxyproline in the triple-helical structures formed by homogeneous peptides resembling collagen. Biochim. Biophys. Acta 420:133-141.
24. Berg, R. A., M. L. Schwartz, and R. G. Crystal. 1980. Regulation of the production of secretory proteins: intracellular degradation of newly synthesized "defective" collagen. Proc. Natl. Acad. Sci. U.S.A. 77: 4746-4750.
25. Tan, E. M. L, L. Ryhänen, and J. Uitto. 1983. Proline analogues inhibit human skin fibroblast growth and collagen production in culture. J. Invest. Dermatol. 80:261-267.
26. King, G. M., and I. Y. R. Adamson. 1987. Effects of cis-hydroxyproline on type II cell development in fetal rat lung. Exp. Lung Res. 12:347-362.
27. Ingber, D., and J. Folkman. 1988. Inhibition of angiogenesis through modulation of collagen metabolism. Lab. Invest. 59:44-51.
28. Lewko, W. M., L. A. Liotta, M. S. Wicha, B. K. Vonderhaar, and W. R. Kidwell. 1981. Sensitivity of N-nitrosomethylurea-induced rat mammary tumors to cis-hydroxyproline, an inhibitor of collagen production. Cancer Lett. 41:2855-2862.
29. Freeman, B. A., S. L. Young, and J. D. Crapo. 1983. Liposome-mediated augmentation of superoxide dismutase in endothelial cells prevents oxygen injury. J. Biol. Chem. 258:12534-12542.
30. Hodis, H. N., J. K. Amartey, D. W. Crawford, E. Wickham, and D. H. Blankenhorn. 1990. In vivo hypertensive arterial wall uptake of radiolabeled liposome. Hypertension 15:600-605.